GSK3A (glycogen synthase kinase 3 alpha) - Rat Genome Database

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Gene: GSK3A (glycogen synthase kinase 3 alpha) Pan paniscus
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Symbol: GSK3A
Name: glycogen synthase kinase 3 alpha
RGD ID: 11729864
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN aging (ortholog); cell migration (ortholog); cellular response to lithium ion (ortholog); PARTICIPATES IN glycogen biosynthetic pathway; nuclear factor, erythroid 2 like 2 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); bipolar disorder (ortholog); FOUND IN cytoplasm (ortholog); microtubule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glycogen synthase kinase-3 alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11947,710,197 - 47,722,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,710,197 - 47,726,948 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
carbohydrate metabolic process  (IEA)
cardiac left ventricle morphogenesis  (IEA)
cell migration  (IEA,ISO)
cellular response to glucocorticoid stimulus  (IEA)
cellular response to insulin stimulus  (IEA)
cellular response to interleukin-3  (IEA)
cellular response to lithium ion  (IEA,ISO)
cellular response to organic cyclic compound  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
glycogen metabolic process  (IEA)
hypermethylation of CpG island  (IEA)
insulin receptor signaling pathway  (IEA)
negative regulation of cell growth involved in cardiac muscle cell development  (IEA)
negative regulation of dendrite development  (ISO)
negative regulation of developmental process  (IEA)
negative regulation of glucose import  (IEA)
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of signal transduction  (IEA)
negative regulation of TOR signaling  (IEA)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (IEA)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of glycogen (starch) synthase activity  (IEA)
positive regulation of heart contraction  (IEA)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein targeting to mitochondrion  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein phosphorylation  (IEA,ISO)
regulation of autophagy of mitochondrion  (IEA)
regulation of cellular component organization  (IEA)
regulation of gene expression by genomic imprinting  (IEA)
regulation of systemic arterial blood pressure  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References

Genomics

Comparative Map Data
GSK3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11947,710,197 - 47,722,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,710,197 - 47,726,948 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBIMhudiblu_PPA_v0panPan3
GSK3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,230,190 - 42,242,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1942,226,225 - 42,242,625 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,734,342 - 42,746,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,426,178 - 47,438,576 (-)NCBINCBI36hg18NCBI36
Build 341947,426,177 - 47,438,576NCBI
Celera1939,535,133 - 39,547,532 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1939,164,764 - 39,177,148 (-)NCBIHuRef
CHM1_11942,736,013 - 42,748,418 (-)NCBICHM1_1
T2T-CHM13v2.01945,049,564 - 45,061,976 (-)NCBI
Gsk3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,927,683 - 24,937,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl724,927,683 - 24,937,276 (-)Ensembl
GRCm38725,228,258 - 25,237,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,013,278 - 26,022,870 (-)NCBIGRCm37mm9NCBIm37
MGSCv36724,937,019 - 24,946,611 (-)NCBImm8
Celera719,843,563 - 19,853,655 (-)NCBICelera
Cytogenetic Map7A3NCBI
Gsk3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)Ensembl
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Celera175,259,483 - 75,269,362 (-)NCBICelera
Cytogenetic Map1q21NCBI
Gsk3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBIChiLan1.0ChiLan1.0
GSK3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,129,116 - 112,138,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,103,825 - 112,138,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,555,288 - 111,565,002 (+)NCBI
ROS_Cfam_1.01112,741,760 - 112,751,476 (+)NCBI
ROS_Cfam_1.0 Ensembl1112,741,641 - 112,751,092 (+)Ensembl
UMICH_Zoey_3.11112,295,962 - 112,305,677 (+)NCBI
UNSW_CanFamBas_1.01111,931,910 - 111,941,621 (+)NCBI
UU_Cfam_GSD_1.01112,858,454 - 112,868,171 (+)NCBI
Gsk3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,919,119 - 15,929,912 (+)NCBI
SpeTri2.0NW_004936706266,462 - 277,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,690,370 - 49,701,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,690,319 - 49,700,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,607,906 - 45,618,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,434,966 - 36,447,676 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl636,435,578 - 36,447,633 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607314,679,200 - 14,692,630 (-)NCBIVero_WHO_p1.0
Gsk3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907511,889 - 522,168 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624907511,919 - 522,106 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003811765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000049942   ⟹   ENSPPAP00000027106
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1947,710,197 - 47,722,531 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000049946   ⟹   ENSPPAP00000027110
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1947,710,789 - 47,726,948 (-)Ensembl
RefSeq Acc Id: XM_003811765   ⟹   XP_003811813
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11947,710,197 - 47,722,531 (-)NCBI
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003811813 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003811813   ⟸   XM_003811765
- Sequence:
RefSeq Acc Id: ENSPPAP00000027110   ⟸   ENSPPAT00000049946
RefSeq Acc Id: ENSPPAP00000027106   ⟸   ENSPPAT00000049942
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036611 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000027106 UniProtKB/TrEMBL
  ENSPPAP00000027110 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049942 UniProtKB/TrEMBL
  ENSPPAT00000049946 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_GSK3 UniProtKB/TrEMBL
NCBI Gene GSK3A ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BFP3_PANPA UniProtKB/TrEMBL
  A0A2R9BK42_PANPA UniProtKB/TrEMBL