Gsk3a (glycogen synthase kinase 3 alpha) - Rat Genome Database

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Gene: Gsk3a (glycogen synthase kinase 3 alpha) Chinchilla lanigera
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Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
RGD ID: 8816741
Description: ENCODES a protein that exhibits protein kinase A catalytic subunit binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN aging (ortholog); cardiac left ventricle morphogenesis (ortholog); cell migration (ortholog); PARTICIPATES IN glycogen biosynthetic pathway; nuclear factor, erythroid 2 like 2 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); bipolar disorder (ortholog); FOUND IN cytoplasm (ortholog); microtubule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glycogen synthase kinase-3 alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cell migration  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-3  (ISO)
cellular response to lithium ion  (ISO)
cellular response to organic cyclic compound  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
hypermethylation of CpG island  (ISO)
insulin receptor signaling pathway  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of dendrite development  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of TOR signaling  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycogen (starch) synthase activity  (ISO)
positive regulation of heart contraction  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein phosphorylation  (ISO)
regulation of autophagy of mitochondrion  (ISO)
regulation of gene expression by genomic imprinting  (ISO)
regulation of systemic arterial blood pressure  (ISO)

Cellular Component
cytoplasm  (ISO)
microtubule  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Gsk3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBIChiLan1.0ChiLan1.0
GSK3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,230,190 - 42,242,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1942,226,225 - 42,242,625 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,734,342 - 42,746,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,426,178 - 47,438,576 (-)NCBINCBI36hg18NCBI36
Build 341947,426,177 - 47,438,576NCBI
Celera1939,535,133 - 39,547,532 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1939,164,764 - 39,177,148 (-)NCBIHuRef
CHM1_11942,736,013 - 42,748,418 (-)NCBICHM1_1
T2T-CHM13v2.01945,049,564 - 45,061,976 (-)NCBI
Gsk3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,927,683 - 24,937,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl724,927,683 - 24,937,276 (-)Ensembl
GRCm38725,228,258 - 25,237,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,013,278 - 26,022,870 (-)NCBIGRCm37mm9NCBIm37
MGSCv36724,937,019 - 24,946,611 (-)NCBImm8
Celera719,843,563 - 19,853,655 (-)NCBICelera
Cytogenetic Map7A3NCBI
Gsk3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)Ensembl
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Celera175,259,483 - 75,269,362 (-)NCBICelera
Cytogenetic Map1q21NCBI
GSK3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11947,710,197 - 47,722,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,710,197 - 47,726,948 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBIMhudiblu_PPA_v0panPan3
GSK3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,129,116 - 112,138,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,103,825 - 112,138,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,555,288 - 111,565,002 (+)NCBI
ROS_Cfam_1.01112,741,760 - 112,751,476 (+)NCBI
ROS_Cfam_1.0 Ensembl1112,741,641 - 112,751,092 (+)Ensembl
UMICH_Zoey_3.11112,295,962 - 112,305,677 (+)NCBI
UNSW_CanFamBas_1.01111,931,910 - 111,941,621 (+)NCBI
UU_Cfam_GSD_1.01112,858,454 - 112,868,171 (+)NCBI
Gsk3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,919,119 - 15,929,912 (+)NCBI
SpeTri2.0NW_004936706266,462 - 277,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,690,370 - 49,701,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,690,319 - 49,700,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,607,906 - 45,618,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,434,966 - 36,447,676 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl636,435,578 - 36,447,633 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607314,679,200 - 14,692,630 (-)NCBIVero_WHO_p1.0
Gsk3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907511,889 - 522,168 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624907511,919 - 522,106 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004042   ⟹   ENSCLAP00000003962
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)Ensembl
RefSeq Acc Id: XM_013508754   ⟹   XP_013364208
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013364208 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013364208   ⟸   XM_013508754
- Sequence:
RefSeq Acc Id: ENSCLAP00000003962   ⟸   ENSCLAT00000004042
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002825 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000003962 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004042 ENTREZGENE, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_GSK3 UniProtKB/TrEMBL
NCBI Gene Gsk3a ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2UQD2_CHILA UniProtKB/TrEMBL