Gsk3a (glycogen synthase kinase 3 alpha)

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Gene: Gsk3a (glycogen synthase kinase 3 alpha) Chinchilla lanigera

Analyze

Symbol:

Gsk3a

Name:

glycogen synthase kinase 3 alpha

RGD ID:

8816741

Description:

ENCODES a protein that exhibits protein kinase A catalytic subunit binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN aging (ortholog); cardiac left ventricle morphogenesis (ortholog); cell migration (ortholog); PARTICIPATES IN glycogen biosynthetic pathway; nuclear factor, erythroid 2 like 2 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); bipolar disorder (ortholog); FOUND IN cytoplasm (ortholog); microtubule (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glycogen synthase kinase-3 alpha

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	667,973 - 676,351 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	668,641 - 676,351 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

bipolar disorder (ISO)

craniosynostosis (ISO)

dilated cardiomyopathy (ISO)

Experimental Diabetes Mellitus (ISO)

Left Ventricular Hypertrophy (ISO)

Macrocephaly (ISO)

mental depression (ISO)

Parkinsonism (ISO)

schizophrenia (ISO)

syndromic intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

cardiac left ventricle morphogenesis (ISO)

cell migration (ISO)

cellular response to glucocorticoid stimulus (ISO)

cellular response to insulin stimulus (ISO)

cellular response to interleukin-3 (ISO)

cellular response to lithium ion (ISO)

cellular response to organic cyclic compound (ISO)

extrinsic apoptotic signaling pathway (ISO)

extrinsic apoptotic signaling pathway in absence of ligand (ISO)

hypermethylation of CpG island (ISO)

insulin receptor signaling pathway (ISO)

negative regulation of cell growth involved in cardiac muscle cell development (ISO)

negative regulation of dendrite development (ISO)

negative regulation of glucose import (ISO)

negative regulation of glycogen synthase activity, transferring glucose-1-phosphate (ISO)

negative regulation of insulin receptor signaling pathway (ISO)

negative regulation of TOR signaling (ISO)

peptidyl-serine phosphorylation (ISO)

peptidyl-threonine phosphorylation (ISO)

positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (ISO)

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of amyloid-beta formation (ISO)

positive regulation of autophagy (ISO)

positive regulation of gene expression (ISO)

positive regulation of glycogen (starch) synthase activity (ISO)

positive regulation of heart contraction (ISO)

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (ISO)

positive regulation of neuron apoptotic process (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of peptidyl-threonine phosphorylation (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

positive regulation of protein targeting to mitochondrion (ISO)

positive regulation of protein ubiquitination (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein phosphorylation (ISO)

regulation of autophagy of mitochondrion (ISO)

regulation of gene expression by genomic imprinting (ISO)

regulation of systemic arterial blood pressure (ISO)

Cellular Component

cytoplasm (ISO)

microtubule (ISO)

Molecular Function

protein binding (ISO)

protein kinase A catalytic subunit binding (ISO)

protein kinase activity (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activity (ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycogen biosynthetic pathway (ISO)

nuclear factor, erythroid 2 like 2 signaling pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data

Gsk3a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	667,973 - 676,351 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	668,641 - 676,351 (+)	NCBI	ChiLan1.0	ChiLan1.0

GSK3A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	42,230,190 - 42,242,602 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	19	42,226,225 - 42,242,625 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	42,734,342 - 42,746,754 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	47,426,178 - 47,438,576 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	47,426,177 - 47,438,576	NCBI
Celera	19	39,535,133 - 39,547,532 (-)	NCBI
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	39,164,764 - 39,177,148 (-)	NCBI		HuRef
CHM1_1	19	42,736,013 - 42,748,418 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	45,049,564 - 45,061,976 (-)	NCBI

Gsk3a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	24,927,683 - 24,937,276 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	24,927,683 - 24,937,276 (-)	Ensembl
GRCm38	7	25,228,258 - 25,237,851 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	25,228,258 - 25,237,851 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	26,013,278 - 26,022,870 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	24,937,019 - 24,946,611 (-)	NCBI			mm8
Celera	7	19,843,563 - 19,853,655 (-)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI

Gsk3a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	80,815,843 - 80,825,732 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	1	80,815,850 - 80,825,802 (-)	Ensembl
Rnor_6.0	1	82,097,244 - 82,108,238 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	82,097,247 - 82,108,203 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	83,365,717 - 83,374,707 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	80,505,517 - 80,514,139 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	80,583,627 - 80,592,250 (-)	NCBI
Celera	1	75,259,483 - 75,269,362 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

GSK3A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	47,710,197 - 47,722,531 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	47,710,197 - 47,726,948 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	39,118,330 - 39,130,768 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

GSK3A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	112,129,116 - 112,138,714 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	112,103,825 - 112,138,559 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	111,555,288 - 111,565,002 (+)	NCBI
ROS_Cfam_1.0	1	112,741,760 - 112,751,476 (+)	NCBI
ROS_Cfam_1.0 Ensembl	1	112,741,641 - 112,751,092 (+)	Ensembl
UMICH_Zoey_3.1	1	112,295,962 - 112,305,677 (+)	NCBI
UNSW_CanFamBas_1.0	1	111,931,910 - 111,941,621 (+)	NCBI
UU_Cfam_GSD_1.0	1	112,858,454 - 112,868,171 (+)	NCBI

Gsk3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	15,919,119 - 15,929,912 (+)	NCBI
SpeTri2.0	NW_004936706	266,462 - 277,256 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSK3A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	49,690,370 - 49,701,189 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	49,690,319 - 49,700,735 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	45,607,906 - 45,618,432 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSK3A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	36,434,966 - 36,447,676 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	6	36,435,578 - 36,447,633 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666073	14,679,200 - 14,692,630 (-)	NCBI	Vero_WHO_p1.0

Gsk3a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	511,889 - 522,168 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624907	511,919 - 522,106 (+)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013508754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01073043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01086213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01081429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000004042 ⟹ ENSCLAP00000003962

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955555	667,973 - 676,351 (+)	Ensembl

RefSeq Acc Id:

XM_013508754 ⟹ XP_013364208

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955555	668,641 - 676,351 (+)	NCBI

Sequence:

show sequence

GCGGCGGCGGCGGCAGCAGCAGCGGCGAGTGCAGCCTAAGCAGCCCGAGCCCCGCGGCCTGGGC
CTGCGCTCGGCGCCATGAGCGGCGGCGGGCCTTCGGGAGGCGGCCCTGGGGGCTCGGGCCGGGC
GCGGACCAGCTCGTTCGCGGAGCCAGGCGGCGGAGGCGGCGGAGGCGGTGGCGGCCCTGGGGGC
TCGGCCTCTGGCCCGGGCGGCACCGGCGGCGGGAAGGCGTCTGTCGGGGCCATGGGTGGGGGCG
TGGGAGCCTCGAGTTCCGGGGGCGGCCCCAGCGGCAGCGGCGGAGGCGGCAGCGGCGGCCCCGG
CGCGGGCACTAGCTTCCCGCCGCCTGGAGTGAAGCTGGGCCGTGACAGCGGGAAGGTGACCACA
GTGGTAGCCACTCTAGGACAAGGCCCAGAGCGCTCTCAAGAAGTGGCTTACACAGACATCAAAG
TGATTGGCAATGGCTCATTTGGGGTCGTGTACCAGGCACGGCTGGCAGAGACAAGGGAGCTGGT
GGCTATCAAGAAGGTTCTTCAGGACAAGAGGTTCAAGAATCGAGAGCTGCAGATTATGCGTAAG
CTAGACCACTGCAATATTGTGAGACTGCGGTACTTTTTCTACTCCAGTGGGGAGAAGAAAGATG
AGCTTTACCTAAATCTGGTGCTGGAATATGTGCCCGAGACAGTGTACCGGGTGGCCCGCCATTT
CACCAAGGCCAAATTGACCATCCCTATCATCTATGTCAAGGTGTACATGTACCAACTCTTCCGG
AGCTTGGCCTACATCCACTCCCAGGGTGTGTGTCACCGTGACATCAAACCCCAGAACCTGCTGG
TGGACCCCGACACTGCTGTCCTCAAGCTCTGCGATTTTGGCAGTGCAAAGCAGTTGGTCCGGGG
GGAGCCCAATGTTTCCTACATCTGTTCTCGCTACTACCGAGCCCCAGAGCTCATCTTCGGAGCC
ACCGATTATACCTCGTCCATCGATGTTTGGTCAGCTGGCTGCGTCCTGGCCGAGCTCCTCCTTG
GCCAGCCCATCTTCCCTGGGGACAGTGGGGTAGACCAGCTGGTGGAGATCATCAAGGTACTGGG
AACACCAACCCGGGAACAAATCCGAGAGATGAACCCCAACTATACAGAGTTCAAGTTCCCCCAG
ATTAAAGCTCACCCCTGGACAAAGGTGTTCAAATCTCGGACGCCGCCTGAGGCCATCGCCCTCT
GTTCAAGCCTGCTAGAGTACACTCCGTCCTCCAGACTCTCGCCACTAGAGGCCTGTGCCCACAG
CTTCTTTGATGAACTCCGATGTCTTGGAACCCAGCTCCCCAACAACCGCCCGCTTCCCCCTCTC
TTCAACTTCAGTCCTGGTGAACTCTCGATCCAACCGTCTCTCAACGCCATTCTCATCCCTCCTC
ATTTGAGGTCCCCAGCGGGCACTACTCCACTCACTCCGTCCTCACAAGCTTTAAATGAGAATCA
GACCGGCTCAGACTGGCAGGCGCCTGATGCCACACCTACCCTCACTAACTCTTCCTGAGGACCC
CACCAGCTACTCTCTCCCATGTCTATCTGGGAGCCCTAAGGGGGGTTGGGAAGGGGGAGGTGTA
GCCCATCAAACTTCTATCCTGGCTGGGCCCCTAGACTAGAGGGCAGAGGTAAATGAGTCCCTAC
CCCCACCTCTAGTCCCTCCGTTACCAGCCTGACTCCTATGATGGGCTTTTTAAGAGGATTTTAA
CTGGTTGTGGGGAGGGAAGACATGGAAGGAAGGATGGGGTTGGGGGCATGAGGAACTCCTACCC
CTTTTGTGCCCTCATATTCCCCAGCCTCCACTTCTTCCAAACGCCCCTCCCGTCCTATGACCCT
TGTAAATAGAATCAGCCCTCTCCATCTTTTCCCTTCCCTGGTCCCCAGGTGTAAATAGATTGTT
ATAATTTTTTTCTTAAAGAAAACGTTGATTCACACCATCCATCCTGGCCCTGCCCACTCCTACA
GCTGTATCTCCACTCCTGTCCTCTGCTCCCAAGGCCTCCTCACTCCCATCCCTGTCCTGGAGGG
CCTGGGGGAATGAGGAGAACTCCTGATGTCTTAAGTTTCCACAGTAAGGTTTGCCTGTGTACAG
ACCTCCGTTCAATAAATTATTGGCATGAAAACCTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013364208	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_013364208 ⟸ XM_013508754

- Sequence:

show sequence

MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASS
SGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNG
SFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLN
LVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDT
AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF
PGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLL
EYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSP
AGTTPLTPSSQALNENQTGSDWQAPDATPTLTNSS

hide sequence

RefSeq Acc Id:

ENSCLAP00000003962 ⟸ ENSCLAT00000004042

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002825	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000003962	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000004042	ENTREZGENE, UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	STKc_GSK3	UniProtKB/TrEMBL
NCBI Gene	Gsk3a	ENTREZGENE
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2UQD2_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)