Gsk3a (glycogen synthase kinase 3 alpha) - Rat Genome Database

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Gene: Gsk3a (glycogen synthase kinase 3 alpha) Mus musculus
Analyze
Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
RGD ID: 1618666
MGI Page MGI
Description: Enables protein serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of G protein-coupled receptor signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to lithium ion; positive regulation of protein phosphorylation; and protein phosphorylation. Predicted to be located in microtubule. Predicted to be active in axon; cytosol; and nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; tongue; and upper jaw. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700086H06Rik; glycogen synthase kinase-3 alpha; GSK-3 alpha; RIKEN cDNA 2700086H06 gene; serine/threonine-protein kinase GSK3A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm6275  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,927,683 - 24,937,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl724,927,683 - 24,937,276 (-)Ensembl
GRCm38725,228,258 - 25,237,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,013,278 - 26,022,870 (-)NCBIGRCm37mm9NCBIm37
MGSCv36724,937,019 - 24,946,611 (-)NCBImm8
Celera719,843,563 - 19,853,655 (-)NCBICelera
Cytogenetic Map7A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-bromoindirubin-3'-oxime  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clozapine  (ISO)
cocaine  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
elemental selenium  (ISO)
fenthion  (EXP)
folic acid  (EXP)
Fusaric acid  (EXP)
haloperidol  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
IC-87114  (EXP)
indometacin  (ISO)
kenpaullone  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
LY294002  (EXP,ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (EXP)
microcystin-LR  (EXP,ISO)
N-acetylsphingosine  (ISO)
nicotine  (EXP,ISO)
paraquat  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium atom  (ISO)
prostaglandin E2  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
risperidone  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
ruthenium atom  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sphingosine 1-phosphate  (ISO)
sucrose  (ISO)
tacrolimus hydrate  (ISO)
urethane  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
carbohydrate metabolic process  (IEA)
cardiac left ventricle morphogenesis  (IMP)
cell migration  (IGI)
cellular response to glucocorticoid stimulus  (IGI)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-3  (IDA)
cellular response to lithium ion  (IDA)
cellular response to organic cyclic compound  (IDA)
extrinsic apoptotic signaling pathway  (IGI)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IDA)
glycogen metabolic process  (IEA)
hypermethylation of CpG island  (IMP)
insulin receptor signaling pathway  (IBA,IDA)
negative regulation of canonical Wnt signaling pathway  (IBA)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of dendrite development  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of signal transduction  (IEA)
negative regulation of TOR signaling  (IBA,IMP)
nervous system development  (IEA)
peptidyl-serine phosphorylation  (IDA,IGI)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (IEA)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (IMP)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of autophagy  (IDA)
positive regulation of gene expression  (IGI)
positive regulation of glycogen (starch) synthase activity  (IMP)
positive regulation of heart contraction  (IMP)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IDA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IDA)
positive regulation of peptidyl-threonine phosphorylation  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IC,IDA)
protein phosphorylation  (IDA,IMP,ISO)
regulation of autophagy of mitochondrion  (ISO)
regulation of gene expression by genomic imprinting  (IMP)
regulation of neuron projection development  (IBA)
regulation of systemic arterial blood pressure  (IMP)
signal transduction  (IBA)
Wnt signaling pathway  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavioral response to xenobiotic  (IAGP)
abnormal gait  (IEA)
abnormal glycogen homeostasis  (IAGP)
abnormal long term depression  (IAGP)
abnormal sperm head morphology  (IAGP)
abnormal sperm midpiece morphology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
amyloid beta deposits  (IAGP)
asthenozoospermia  (IAGP)
cleft palate  (IAGP)
decreased body length  (IEA)
decreased body weight  (IEA)
decreased circulating glucose level  (IEA)
decreased circulating glycerol level  (IEA)
decreased coping response  (IAGP)
decreased exploration in new environment  (IEA)
decreased lumbar vertebrae number  (IEA)
decreased mean platelet volume  (IEA)
decreased percent body fat/body weight  (IAGP)
decreased startle reflex  (IEA)
decreased total body fat amount  (IEA)
enhanced contextual conditioning behavior  (IAGP)
hyperactivity  (IAGP)
impaired cued conditioning behavior  (IAGP)
improved glucose tolerance  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating corticosterone level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased exploration in new environment  (IAGP)
increased insulin sensitivity  (IAGP)
increased lean body mass  (IAGP)
increased liver glycogen level  (IAGP)
increased sacral vertebrae number  (IEA)
increased thigmotaxis  (IAGP)
male infertility  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
prolonged QRS complex duration  (IEA)
wide metopic suture  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
2. Glycogen synthase kinase 3: a key regulator of cellular fate. Forde JE and Dale TC, Cell Mol Life Sci. 2007 Aug;64(15):1930-44.
3. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
4. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. Hurtado DE, etal., J Neurosci. 2012 May 23;32(21):7392-402. doi: 10.1523/JNEUROSCI.0889-12.2012.
5. Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Morris JK, etal., Brain Res. 2008 Nov 13;1240:185-95. doi: 10.1016/j.brainres.2008.08.089. Epub 2008 Sep 11.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver. Rao PV, etal., Biochem Biophys Res Commun. 1995 Dec 5;217(1):250-6.
8. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Rezai-Zadeh K, etal., J Cell Mol Med. 2009 Mar;13(3):574-88. doi: 10.1111/j.1582-4934.2008.00344.x. Epub 2008 Apr 9.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. Zhai P, etal., J Biol Chem. 2007 Nov 9;282(45):33181-91. Epub 2007 Sep 12.
Additional References at PubMed
PMID:8889548   PMID:9601641   PMID:11217851   PMID:11812828   PMID:12055200   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14502571   PMID:14730361   PMID:15057752   PMID:15192701  
PMID:15489334   PMID:15673614   PMID:15695173   PMID:15782199   PMID:15791206   PMID:15961082   PMID:16051150   PMID:16176184   PMID:16537926   PMID:16543145   PMID:16602821   PMID:16941690  
PMID:17052453   PMID:17178402   PMID:17274640   PMID:17371841   PMID:17391670   PMID:17510631   PMID:17543867   PMID:17548347   PMID:17569662   PMID:17682063   PMID:17908561   PMID:17986005  
PMID:18003720   PMID:18052755   PMID:18195042   PMID:18285345   PMID:18327788   PMID:18550525   PMID:18551195   PMID:18583716   PMID:18671898   PMID:18851840   PMID:18978355   PMID:18987114  
PMID:19064989   PMID:19106302   PMID:19214430   PMID:19258035   PMID:19389373   PMID:19520363   PMID:19706605   PMID:19801986   PMID:19850877   PMID:19858210   PMID:19925672   PMID:20061376  
PMID:20194497   PMID:20299330   PMID:20300527   PMID:20357757   PMID:20368287   PMID:20371704   PMID:20516643   PMID:20541704   PMID:20552232   PMID:20553816   PMID:20576936   PMID:20696171  
PMID:20729907   PMID:20818428   PMID:20981831   PMID:21035757   PMID:21047779   PMID:21062867   PMID:21084607   PMID:21130869   PMID:21191064   PMID:21233250   PMID:21253590   PMID:21267068  
PMID:21295277   PMID:21325041   PMID:21421818   PMID:21498050   PMID:21502951   PMID:21658600   PMID:21677750   PMID:21685889   PMID:21873635   PMID:21937714   PMID:22022450   PMID:22065737  
PMID:22086876   PMID:22384031   PMID:22539723   PMID:22665058   PMID:22674256   PMID:22761446   PMID:22814108   PMID:22872236   PMID:22904158   PMID:22986169   PMID:23015435   PMID:23142783  
PMID:23167932   PMID:23174342   PMID:23185619   PMID:23239877   PMID:23470087   PMID:23549082   PMID:23583239   PMID:23606540   PMID:23705847   PMID:23798682   PMID:23817039   PMID:23823480  
PMID:24094580   PMID:24138923   PMID:24142875   PMID:24333443   PMID:24397546   PMID:24523925   PMID:24803542   PMID:24952961   PMID:25073924   PMID:25078444   PMID:25125302   PMID:25183803  
PMID:25195860   PMID:25208523   PMID:25224226   PMID:25273085   PMID:25299332   PMID:25451156   PMID:25568307   PMID:25608967   PMID:25724980   PMID:25788881   PMID:25808536   PMID:25833158  
PMID:25833708   PMID:26100021   PMID:26179612   PMID:26240067   PMID:26526197   PMID:26633882   PMID:26749572   PMID:26766591   PMID:26974342   PMID:26976650   PMID:27026523   PMID:27053198  
PMID:27140617   PMID:27170189   PMID:27215380   PMID:27284979   PMID:27807348   PMID:27841351   PMID:28114292   PMID:28244152   PMID:28352664   PMID:28556462   PMID:28630333   PMID:28916722  
PMID:29109121   PMID:29385396   PMID:29472592   PMID:29555900   PMID:29574946   PMID:29642012   PMID:30119888   PMID:30679422   PMID:30688489   PMID:30745182   PMID:30814515   PMID:30898653  
PMID:30928428   PMID:31453382   PMID:31540917   PMID:31581792   PMID:31900153   PMID:31914663   PMID:32087280   PMID:32325033   PMID:32581704   PMID:32680958   PMID:32798765   PMID:32859995  
PMID:33023073   PMID:34394077   PMID:34400288   PMID:34518365   PMID:34638997   PMID:35159367   PMID:35528516  


Genomics

Comparative Map Data
Gsk3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,927,683 - 24,937,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl724,927,683 - 24,937,276 (-)Ensembl
GRCm38725,228,258 - 25,237,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,013,278 - 26,022,870 (-)NCBIGRCm37mm9NCBIm37
MGSCv36724,937,019 - 24,946,611 (-)NCBImm8
Celera719,843,563 - 19,853,655 (-)NCBICelera
Cytogenetic Map7A3NCBI
GSK3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,230,190 - 42,242,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1942,226,225 - 42,242,625 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,734,342 - 42,746,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,426,178 - 47,438,576 (-)NCBINCBI36hg18NCBI36
Build 341947,426,177 - 47,438,576NCBI
Celera1939,535,133 - 39,547,532 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1939,164,764 - 39,177,148 (-)NCBIHuRef
CHM1_11942,736,013 - 42,748,418 (-)NCBICHM1_1
T2T-CHM13v2.01945,049,564 - 45,061,976 (-)NCBI
Gsk3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)Ensembl
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Celera175,259,483 - 75,269,362 (-)NCBICelera
Cytogenetic Map1q21NCBI
Gsk3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBIChiLan1.0ChiLan1.0
GSK3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11947,710,197 - 47,722,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,710,197 - 47,726,948 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBIMhudiblu_PPA_v0panPan3
GSK3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,129,116 - 112,138,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,103,825 - 112,138,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,555,288 - 111,565,002 (+)NCBI
ROS_Cfam_1.01112,741,760 - 112,751,476 (+)NCBI
ROS_Cfam_1.0 Ensembl1112,741,641 - 112,751,092 (+)Ensembl
UMICH_Zoey_3.11112,295,962 - 112,305,677 (+)NCBI
UNSW_CanFamBas_1.01111,931,910 - 111,941,621 (+)NCBI
UU_Cfam_GSD_1.01112,858,454 - 112,868,171 (+)NCBI
Gsk3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,919,119 - 15,929,912 (+)NCBI
SpeTri2.0NW_004936706266,462 - 277,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,690,370 - 49,701,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,690,319 - 49,700,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,607,906 - 45,618,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,434,966 - 36,447,676 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl636,435,578 - 36,447,633 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607314,679,200 - 14,692,630 (-)NCBIVero_WHO_p1.0
Gsk3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907511,889 - 522,168 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624907511,919 - 522,106 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AU016887  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,230,107 - 25,230,190UniSTSGRCm38
MGSCv37726,015,126 - 26,015,209UniSTSGRCm37
Celera719,845,910 - 19,845,993UniSTS
Cytogenetic Map7A3UniSTS
Whitehead/MRC_RH7365.05UniSTS
UniSTS:238085  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X136,930,699 - 136,930,902UniSTSGRCm38
GRCm38725,228,859 - 25,229,875UniSTSGRCm38
MGSCv37X133,465,238 - 133,465,441UniSTSGRCm37
MGSCv37726,013,878 - 26,014,894UniSTSGRCm37
CeleraX120,210,845 - 120,211,048UniSTS
Celera719,844,662 - 19,845,678UniSTS
Cytogenetic MapXF1UniSTS
Cytogenetic Map7A3UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir149mmu-miR-149-3pOncomiRDBexternal_infoNANA21896753

Predicted Target Of
Summary Value
Count of predictions:708
Count of miRNA genes:222
Interacting mature miRNAs:245
Transcripts:ENSMUST00000071739, ENSMUST00000108411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071739   ⟹   ENSMUSP00000071654
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,927,683 - 24,937,276 (-)Ensembl
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108411   ⟹   ENSMUSP00000104049
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,927,683 - 24,937,276 (-)Ensembl
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206654
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,928,890 - 24,930,669 (-)Ensembl
GRCm38.p6 Ensembl725,229,465 - 25,231,244 (-)Ensembl
RefSeq Acc Id: NM_001031667   ⟹   NP_001026837
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,927,684 - 24,937,276 (-)NCBI
GRCm38725,228,259 - 25,237,851 (-)NCBI
MGSCv37726,013,278 - 26,022,870 (-)RGD
Celera719,843,563 - 19,853,655 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540258   ⟹   XP_006540321
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,927,683 - 24,937,271 (-)NCBI
GRCm38725,228,258 - 25,237,846 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540259   ⟹   XP_006540322
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,927,683 - 24,937,245 (-)NCBI
GRCm38725,228,258 - 25,237,807 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153313   ⟹   XP_036009206
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,927,683 - 24,937,245 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001026837   ⟸   NM_001031667
- UniProtKB: Q2NL51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540321   ⟸   XM_006540258
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006540322   ⟸   XM_006540259
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000071654   ⟸   ENSMUST00000071739
RefSeq Acc Id: ENSMUSP00000104049   ⟸   ENSMUST00000108411
RefSeq Acc Id: XP_036009206   ⟸   XM_036153313
- Peptide Label: isoform X3
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2NL51-F1-model_v2 AlphaFold Q2NL51 1-490 view protein structure

Promoters
RGD ID:6892246
Promoter ID:EPDNEW_M9574
Type:initiation region
Name:Gsk3a_1
Description:Mus musculus glycogen synthase kinase 3 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,237,791 - 25,237,851EPDNEW
RGD ID:6848145
Promoter ID:MM_ACW:43884
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung,   MEF_B6
Transcripts:GSK3A.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,015,926 - 26,016,847 (-)MPROMDB
RGD ID:6848176
Promoter ID:MM_ACW:43885
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   MEF_B6
Transcripts:GSK3A.HSEP07,   SMACHAR.ASEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,016,699 - 26,017,199 (-)MPROMDB
RGD ID:6841265
Promoter ID:MM_KWN:49428
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000108411,   OTTMUST00000050005
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,022,621 - 26,023,807 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2152453 AgrOrtholog
Ensembl Genes ENSMUSG00000057177 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000071654 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000104049.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071739 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000108411.2 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_GSK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:606496 UniProtKB/Swiss-Prot
MGD MGI:2152453 ENTREZGENE
NCBI Gene 606496 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gsk3a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z7E5_MOUSE UniProtKB/TrEMBL
  GSK3A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-31 Gsk3a  glycogen synthase kinase 3 alpha  2700086H06Rik  RIKEN cDNA 2700086H06 gene  Data Merged 737654 PROVISIONAL