RGD Reference Report - Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver. - Rat Genome Database

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Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver.

Authors: Rao, PV  Pugazhenthi, S  Khandelwal, RL 
Citation: Rao PV, etal., Biochem Biophys Res Commun. 1995 Dec 5;217(1):250-6.
RGD ID: 10401824
Pubmed: PMID:8526919   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1995.2771   (Journal Full-text)

The chronic effect of insulin on the expression of the glycogen synthase kinase-3 alpha gene in streptozotocin-induced diabetic rat liver is examined. The mRNA levels of glycogen synthase kinase-3 alpha were increased (143% of normal levels) in diabetic livers and these were normalized by insulin supplementation to the diabetic animals. Neither diabetes nor insulin supplementation to diabetic rats altered the transcription rate of glycogen synthase kinase-3 alpha. However, diabetes caused an increase in the half-life of glycogen synthase kinase-3 alpha mRNA from 5 h in normal hepatocytes to 8 h in diabetic ones. Insulin supplementation to the incubation medium of diabetic hepatocytes decreased the half-life of glycogen synthase kinase-3 alpha mRNA to a level comparable with normal values. This study suggests that the chronic effect of insulin decreases the levels of glycogen synthase kinase-3 alpha mRNA by altering its stability.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus treatmentISOGsk3a (Rattus norvegicus)10401824; 10401824 RGD 
Experimental Diabetes Mellitus treatmentIEP 10401824 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsk3a  (glycogen synthase kinase 3 alpha)

Genes (Mus musculus)
Gsk3a  (glycogen synthase kinase 3 alpha)

Genes (Homo sapiens)
GSK3A  (glycogen synthase kinase 3 alpha)


Additional Information