Axl (Axl receptor tyrosine kinase) - Rat Genome Database

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Gene: Axl (Axl receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Axl
Name: Axl receptor tyrosine kinase
RGD ID: 620028
Description: Enables myosin heavy chain binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including animal organ regeneration; cellular response to hydrogen peroxide; and response to axon injury. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and extracellular space. Predicted to be part of receptor complex. Used to study glomerulonephritis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase); PARTICIPATES IN Gas6 - Axl signaling axis; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308444; tyrosine-protein kinase receptor UFO
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Axlem1Mcwi   Axlem2Mcwi  
Genetic Models: SS-Axlem1Mcwi SS-Axlem2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,265,656 - 81,296,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,658,736 - 86,688,215 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0195,209,987 - 95,239,417 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0188,414,540 - 88,444,021 (-)NCBIRnor_WKY
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gemcitabine  (ISO)
hydrogen peroxide  (EXP,ISO)
ifosfamide  (ISO)
Lasiocarpine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menaquinone  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mithramycin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nimesulide  (EXP)
nitric oxide  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phylloquinone  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (ISO)
warfarin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
apoptotic cell clearance  (ISO)
apoptotic process  (ISO)
blood vessel remodeling  (ISO)
cell differentiation  (IMP)
cell maturation  (ISO)
cell migration  (IBA)
cellular response to extracellular stimulus  (ISO)
cellular response to hydrogen peroxide  (IDA)
cellular response to interferon-alpha  (ISO)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
erythrocyte homeostasis  (ISO)
establishment of localization in cell  (ISO)
forebrain cell migration  (ISO)
inflammatory response  (ISO)
lymphocyte activation  (ISO)
natural killer cell differentiation  (IBA,ISO)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cytokine production  (ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of lymphocyte activation  (ISO)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type II interferon production  (ISO)
nervous system development  (IBA)
neuron apoptotic process  (ISO)
neuron migration  (ISO)
neutrophil clearance  (ISO)
ovulation cycle  (ISO)
phagocytosis  (IBA,ISO)
platelet activation  (IBA,ISO)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of protein kinase B signaling  (IBA,ISO)
positive regulation of viral life cycle  (ISO)
protein kinase B signaling  (ISO)
protein phosphorylation  (IEA)
response to axon injury  (IEP)
secretion by cell  (ISO)
spermatogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
tissue regeneration  (TAS)
tissue remodeling  (TAS)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vagina development  (ISO)
viral entry into host cell  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Noninsulin-dependent diabetes mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor. Augustine KA, etal., J Cell Physiol. 1999 Dec;181(3):433-47.
2. Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Cavet ME, etal., Arterioscler Thromb Vasc Biol. 2008 May;28(5):886-91. Epub 2008 Feb 21.
3. Gas6-Axl Pathway. The Role of Redox-Dependent Association of Axl With Nonmuscle Myosin IIB. Cavet ME, etal., Hypertension. 2010 May 17.
4. Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat. Couchie D, etal., Gastroenterology. 2005 Nov;129(5):1633-42.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target. Koorstra JB, etal., Cancer Biol Ther. 2009 Apr;8(7):618-26. Epub 2009 Apr 22.
7. Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction. Lindqvist N, etal., Ups J Med Sci. 2010 Feb;115(1):65-80. doi: 10.3109/03009731003597119.
8. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Melaragno MG, etal., Circ Res 1998 Oct 5;83(7):697-704.
9. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Melaragno MG, etal., J Mol Cell Cardiol. 2004 Oct;37(4):881-7.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Structural basis for Gas6-Axl signalling. Sasaki T, etal., EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15.
15. Identification of hypertension-related genes through an integrated genomic-transcriptomic approach. Yagil C, etal., Circ Res. 2005 Apr 1;96(6):617-25. Epub 2005 Feb 24.
16. Gas6, warfarin, and kidney diseases. Yanagita M Clin Exp Nephrol. 2004 Dec;8(4):304-9.
17. Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. Yanagita M, etal., Am J Pathol. 2001 Apr;158(4):1423-32.
Additional References at PubMed
PMID:9395235   PMID:10227296   PMID:10322635   PMID:11452127   PMID:15650770   PMID:16627783   PMID:16723520   PMID:16751775   PMID:16831897   PMID:17442946   PMID:18159085   PMID:18188450  
PMID:18393392   PMID:18787040   PMID:18804096   PMID:18840707   PMID:19027714   PMID:19463168   PMID:19581412   PMID:19602523   PMID:19657094   PMID:20088931   PMID:21047970   PMID:21270900  
PMID:21501828   PMID:21529875   PMID:22327215   PMID:22606290   PMID:23376485   PMID:23533145   PMID:23878224   PMID:27927649   PMID:28386842   PMID:29196212   PMID:31181097   PMID:31884887  
PMID:34678434  


Genomics

Comparative Map Data
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,265,656 - 81,296,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,658,736 - 86,688,215 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0195,209,987 - 95,239,417 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0188,414,540 - 88,444,021 (-)NCBIRnor_WKY
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1941,219,223 - 41,261,766 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,725,128 - 41,767,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
T2T-CHM13v2.01944,040,107 - 44,082,625 (+)NCBIT2T-CHM13v2.0
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)EnsemblGRCm39 Ensembl
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBIMGSCv36mm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11949,297,139 - 49,340,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,719,615 - 46,761,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)Ensemblpanpan1.1panPan2
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,297,567 - 113,324,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBIUU_Cfam_GSD_1.0
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,657,831 - 3,687,816 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607313,772,922 - 13,815,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Axl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462490777,806 - 106,228 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Axl
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:74
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000028131, ENSRNOT00000028132
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat

Markers in Region
Axl  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,268,663 - 81,269,324 (+)MAPPERmRatBN7.2
Rnor_6.0182,553,005 - 82,553,665NCBIRnor6.0
Rnor_5.0183,814,231 - 83,814,891UniSTSRnor5.0
RGSC_v3.4180,966,864 - 80,967,524UniSTSRGSC3.4
Celera175,707,940 - 75,708,600UniSTS
Cytogenetic Map1q21UniSTS


Genetic Models
This gene Axl is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 50 34 19 34 7 10 70 34 40 11 7
Low 6 7 7 7 1 1 4 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028131   ⟹   ENSRNOP00000028131
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,265,088 - 81,296,193 (-)Ensembl
Rnor_6.0 Ensembl182,550,892 - 82,580,761 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000028132   ⟹   ENSRNOP00000028132
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)Ensembl
Rnor_6.0 Ensembl182,550,892 - 82,580,761 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078668   ⟹   ENSRNOP00000072240
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)Ensembl
Rnor_6.0 Ensembl182,549,420 - 82,580,007 (-)Ensembl
RefSeq Acc Id: NM_001013147   ⟹   NP_001013165
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,266,551 - 81,296,043 (-)NCBI
Rnor_6.0182,550,892 - 82,580,761 (-)NCBI
Rnor_5.0183,812,118 - 83,840,542 (-)NCBI
RGSC_v3.4180,964,751 - 80,994,300 (-)RGD
Celera175,705,827 - 75,734,332 (-)RGD
Sequence:
RefSeq Acc Id: NM_031794   ⟹   NP_113982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,266,551 - 81,296,043 (-)NCBI
Rnor_6.0182,550,892 - 82,580,761 (-)NCBI
Rnor_5.0183,812,118 - 83,840,542 (-)NCBI
RGSC_v3.4180,964,751 - 80,994,300 (-)RGD
Celera175,705,827 - 75,734,332 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111487   ⟹   XP_038967415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,265,656 - 81,296,278 (-)NCBI
RefSeq Acc Id: XM_039111490   ⟹   XP_038967418
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,265,656 - 81,296,278 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001013165   ⟸   NM_001013147
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0G2K2H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_113982   ⟸   NM_031794
- Peptide Label: isoform 1 precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000028132   ⟸   ENSRNOT00000028132
RefSeq Acc Id: ENSRNOP00000028131   ⟸   ENSRNOT00000028131
RefSeq Acc Id: ENSRNOP00000072240   ⟸   ENSRNOT00000078668
RefSeq Acc Id: XP_038967418   ⟸   XM_039111490
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038967415   ⟸   XM_039111487
- Peptide Label: isoform X1
Protein Domains
Fibronectin type-III   Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSY0-F1-model_v2 AlphaFold E9PSY0 1-888 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689826
Promoter ID:EPDNEW_R351
Type:initiation region
Name:Axl_2
Description:Axl receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R352  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,579,868 - 82,579,928EPDNEW
RGD ID:13689828
Promoter ID:EPDNEW_R352
Type:initiation region
Name:Axl_1
Description:Axl receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R351  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,580,785 - 82,580,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620028 AgrOrtholog
BioCyc Gene G2FUF-60366 BioCyc
Ensembl Genes ENSRNOG00000020716 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028131 ENTREZGENE
  ENSRNOP00000028131.4 UniProtKB/TrEMBL
  ENSRNOP00000028132.2 UniProtKB/TrEMBL
  ENSRNOP00000072240 ENTREZGENE
  ENSRNOP00000072240.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028131 ENTREZGENE
  ENSRNOT00000028131.7 UniProtKB/TrEMBL
  ENSRNOT00000028132.3 UniProtKB/TrEMBL
  ENSRNOT00000078668 ENTREZGENE
  ENSRNOT00000078668.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:308444 UniProtKB/TrEMBL
NCBI Gene 308444 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UFO UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Axl PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K2H0 ENTREZGENE, UniProtKB/TrEMBL
  E9PSX9_RAT UniProtKB/TrEMBL
  E9PSY0_RAT UniProtKB/TrEMBL
  Q8VI99_RAT UniProtKB/TrEMBL
  Q8VIA0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Axl  Axl receptor tyrosine kinase  LOC687188  similar to AXL receptor tyrosine kinase  Data Merged 1643240 APPROVED
2006-11-19 LOC687188  similar to AXL receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-04-27 Axl  Axl receptor tyrosine kinase  Axl_predicted  AXL receptor tyrosine kinase (predicted)  Data Merged 1299863 APPROVED
2005-01-20 Axl  Axl receptor tyrosine kinase      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Axl_predicted  AXL receptor tyrosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Axl  Axl receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease identified as a possible hypertension gene 1559295
gene_regulation expression increases in response to vascular injury 631894