Axl (Axl receptor tyrosine kinase) - Rat Genome Database
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Gene: Axl (Axl receptor tyrosine kinase) Rattus norvegicus
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Symbol: Axl
Name: Axl receptor tyrosine kinase
RGD ID: 620028
Description: Exhibits myosin heavy chain binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including animal organ regeneration; cellular response to hydrogen peroxide; and negative regulation of apoptotic process. Predicted to localize to several cellular components, including actin cytoskeleton; cell surface; and extracellular space. Used to study glomerulonephritis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase); PARTICIPATES IN Gas6 - Axl signaling axis; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC308444; tyrosine-protein kinase receptor UFO
Orthologs:
Homo sapiens (human) : AXL (AXL receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Axl (AXL receptor tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Axl (AXL receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : AXL (AXL receptor tyrosine kinase)
Canis lupus familiaris (dog) : AXL (AXL receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Axl (AXL receptor tyrosine kinase)
Sus scrofa (pig) : AXL (AXL receptor tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : AXL (AXL receptor tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Axl (AXL receptor tyrosine kinase)
more info ...
Allele / Splice: Axlem1Mcwi   Axlem2Mcwi  
Genetic Models: SS-Axlem1Mcwi SS-Axlem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gemcitabine  (ISO)
hydrogen peroxide  (EXP,ISO)
ifosfamide  (ISO)
Lasiocarpine  (EXP)
leflunomide  (ISO)
menaquinone  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mithramycin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nimesulide  (EXP)
nitric oxide  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
phenethyl caffeate  (EXP)
phylloquinone  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (ISO)
warfarin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
apoptotic cell clearance  (ISO)
blood vessel remodeling  (ISO)
cell differentiation  (IMP)
cell maturation  (ISO)
cell migration  (IBA)
cellular response to extracellular stimulus  (ISO)
cellular response to hydrogen peroxide  (IDA)
cellular response to interferon-alpha  (ISO)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (ISO)
enzyme linked receptor protein signaling pathway  (ISO)
erythrocyte homeostasis  (ISO)
forebrain cell migration  (ISO)
inflammatory response  (ISO)
multicellular organism development  (IBA)
natural killer cell differentiation  (IBA,ISO)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cytokine production  (ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of lymphocyte activation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
nervous system development  (IBA)
neuron migration  (ISO)
neutrophil clearance  (ISO)
ovulation cycle  (ISO)
peptidyl-tyrosine phosphorylation  (IEA)
phagocytosis  (IBA,ISO)
platelet activation  (IBA,ISO)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of protein kinase B signaling  (IBA,ISO)
protein kinase B signaling  (ISO)
secretion by cell  (ISO)
spermatogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
tissue regeneration  (TAS)
tissue remodeling  (TAS)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vagina development  (ISO)
viral entry into host cell  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9395235   PMID:10227296   PMID:10322635   PMID:11452127   PMID:15650770   PMID:16627783   PMID:16723520   PMID:16751775   PMID:16831897   PMID:17442946   PMID:18159085   PMID:18188450  
PMID:18393392   PMID:18787040   PMID:18804096   PMID:18840707   PMID:19027714   PMID:19463168   PMID:19581412   PMID:19602523   PMID:19657094   PMID:20088931   PMID:21047970   PMID:21270900  
PMID:21501828   PMID:21529875   PMID:22327215   PMID:22606290   PMID:23376485   PMID:23533145   PMID:23878224   PMID:27927649   PMID:28386842   PMID:29196212   PMID:31181097  


Genomics

Comparative Map Data
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1941,219,223 - 41,261,766 (+)EnsemblGRCh38hg38GRCh38
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,725,104 - 41,767,672 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBINCBI36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBI
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBImm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11946,719,615 - 46,761,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0panPan3
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)Ensembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBI
Axl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBI

Position Markers
Axl  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0182,553,005 - 82,553,665NCBIRnor6.0
Rnor_5.0183,814,231 - 83,814,891UniSTSRnor5.0
RGSC_v3.4180,966,864 - 80,967,524UniSTSRGSC3.4
Celera175,707,940 - 75,708,600UniSTS
Cytogenetic Map1q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14190724986907249Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14954732883657083Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14957857794578577Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15052271494225616Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15385134883657083Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15385134883657083Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)16722768394201552Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17968976594909507Rat


Genetic Models
This gene Axl is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:74
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000028131, ENSRNOT00000028132
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 50 34 19 34 7 10 70 34 40 11 7
Low 6 7 7 7 1 1 4 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07002708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07002709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07002710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01004317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01004318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01004319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01004320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01004321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01156502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB067526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB067527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF046886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI464138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028131   ⟹   ENSRNOP00000028131
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl182,550,892 - 82,580,761 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000028132   ⟹   ENSRNOP00000028132
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl182,550,892 - 82,580,761 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078668   ⟹   ENSRNOP00000072240
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl182,549,420 - 82,580,007 (-)Ensembl
RefSeq Acc Id: NM_001013147   ⟹   NP_001013165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,550,892 - 82,580,761 (-)NCBI
Rnor_5.0183,812,118 - 83,840,542 (-)NCBI
RGSC_v3.4180,964,751 - 80,994,300 (-)RGD
Celera175,705,827 - 75,734,332 (-)RGD
Sequence:
RefSeq Acc Id: NM_031794   ⟹   NP_113982
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,550,892 - 82,580,761 (-)NCBI
Rnor_5.0183,812,118 - 83,840,542 (-)NCBI
RGSC_v3.4180,964,751 - 80,994,300 (-)RGD
Celera175,705,827 - 75,734,332 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001013165   ⟸   NM_001013147
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8VI99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_113982   ⟸   NM_031794
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8VIA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028132   ⟸   ENSRNOT00000028132
RefSeq Acc Id: ENSRNOP00000028131   ⟸   ENSRNOT00000028131
RefSeq Acc Id: ENSRNOP00000072240   ⟸   ENSRNOT00000078668
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689826
Promoter ID:EPDNEW_R351
Type:initiation region
Name:Axl_2
Description:Axl receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R352  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,579,868 - 82,579,928EPDNEW
RGD ID:13689828
Promoter ID:EPDNEW_R352
Type:initiation region
Name:Axl_1
Description:Axl receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R351  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,580,785 - 82,580,845EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620028 AgrOrtholog
Ensembl Genes ENSRNOG00000020716 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028131 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000028132 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072240 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028131 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000028132 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000078668 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:308444 UniProtKB/TrEMBL
NCBI Gene 308444 ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Axl PhenoGen
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniGene Rn.161805 ENTREZGENE
UniProt A0A0G2K2H0_RAT UniProtKB/TrEMBL
  E9PSX9_RAT UniProtKB/TrEMBL
  E9PSY0_RAT UniProtKB/TrEMBL
  Q8VI99 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIA0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Axl  Axl receptor tyrosine kinase  LOC687188  similar to AXL receptor tyrosine kinase  Data Merged 1643240 APPROVED
2006-11-19 LOC687188  similar to AXL receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-04-27 Axl  Axl receptor tyrosine kinase  Axl_predicted  AXL receptor tyrosine kinase (predicted)  Data Merged 1299863 APPROVED
2005-01-20 Axl  Axl receptor tyrosine kinase      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Axl_predicted  AXL receptor tyrosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Axl  Axl receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease identified as a possible hypertension gene 1559295
gene_regulation expression increases in response to vascular injury 631894