Meiosin (meiosis initiator) - Rat Genome Database

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Gene: Meiosin (meiosis initiator) Rattus norvegicus
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Symbol: Meiosin
Name: meiosis initiator
RGD ID: 7528935
Description: Predicted to enable DNA binding activity and protein dimerization activity. Predicted to be involved in several processes, including activation of meiosis; cellular response to retinoic acid; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human MEIOSIN (meiosis initiator); INTERACTS WITH aflatoxin B1 (ortholog); Aflatoxin B2 alpha (ortholog); benzo[e]pyrene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: basic helix-loop-helix and HMG box domain-containing protein 1; basic helix-loop-helix and HMG-box containing 1; Bhmg1; LOC102553424; uncharacterized LOC102553424
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,873,020 - 87,896,092 (-)NCBIGRCr8
GRCr8 Ensembl187,872,760 - 87,906,314 (-)EnsemblGRCr8 Ensembl
mRatBN7.2178,744,504 - 78,768,104 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,744,983 - 78,764,977 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0180,004,481 - 80,028,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0181,272,252 - 81,296,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera173,211,377 - 73,235,744 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA,ISO)

Molecular Function

References

Genomics

Comparative Map Data
Meiosin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,873,020 - 87,896,092 (-)NCBIGRCr8
GRCr8 Ensembl187,872,760 - 87,906,314 (-)EnsemblGRCr8 Ensembl
mRatBN7.2178,744,504 - 78,768,104 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,744,983 - 78,764,977 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0180,004,481 - 80,028,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0181,272,252 - 81,296,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera173,211,377 - 73,235,744 (-)NCBICelera
Cytogenetic Map1q21NCBI
MEIOSIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,733,439 - 45,764,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,733,439 - 45,764,541 (+)EnsemblGRCh38hg38GRCh38
GRCh371946,236,697 - 46,267,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,934,794 - 50,967,602 (+)NCBINCBI36Build 36hg18NCBI36
Celera1943,049,081 - 43,073,496 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,672,001 - 42,691,753 (+)NCBIHuRef
CHM1_11946,246,380 - 46,266,252 (+)NCBICHM1_1
T2T-CHM13v2.01948,560,985 - 48,592,076 (+)NCBIT2T-CHM13v2.0
Meiosin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,832,196 - 18,852,456 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,832,971 - 18,852,293 (-)EnsemblGRCm39 Ensembl
GRCm38719,098,271 - 19,118,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,099,046 - 19,118,368 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,684,395 - 19,703,717 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,257,568 - 18,276,890 (-)NCBIMGSCv36mm8
Celera716,509,661 - 16,529,873 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.46NCBI
Meiosin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574193,972 - 221,497 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574194,108 - 221,395 (+)NCBIChiLan1.0ChiLan1.0
MEIOSIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,894,298 - 51,930,127 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,765,764 - 53,801,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,740,226 - 42,773,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,275,766 - 51,311,428 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,277,884 - 51,311,007 (+)Ensemblpanpan1.1panPan2
MEIOSIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,840,667 - 109,865,886 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,840,173 - 109,861,205 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,325,208 - 109,351,048 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,373,740 - 110,399,132 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,373,291 - 110,394,314 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,048,898 - 110,074,750 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,683,556 - 109,709,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,552,815 - 110,578,212 (-)NCBIUU_Cfam_GSD_1.0
Meiosin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,750,883 - 17,772,787 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367062,105,135 - 2,119,707 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEIOSIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,079,224 - 52,095,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,079,726 - 52,094,663 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MEIOSIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,178,855 - 39,214,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,190,614 - 39,214,065 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,797,140 - 18,847,397 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Meiosin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,435,090 - 7,460,171 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248327,434,741 - 7,460,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Meiosin
180 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
sensory system
visual system
1 1 17 5 14 10 6 20 3 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000109913   ⟹   ENSRNOP00000091260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,873,031 - 87,904,077 (-)Ensembl
mRatBN7.2 Ensembl178,744,983 - 78,764,977 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155535   ⟹   ENSRNOP00000099655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,872,760 - 87,906,314 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166028   ⟹   ENSRNOP00000107621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,873,014 - 87,898,923 (-)Ensembl
RefSeq Acc Id: XM_039093370   ⟹   XP_038949298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,873,020 - 87,879,695 (-)NCBI
mRatBN7.2178,744,504 - 78,751,654 (-)NCBI
RefSeq Acc Id: XM_063277530   ⟹   XP_063133600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,873,020 - 87,896,092 (-)NCBI
RefSeq Acc Id: XM_063277536   ⟹   XP_063133606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,873,020 - 87,896,089 (-)NCBI
RefSeq Acc Id: XM_063277543   ⟹   XP_063133613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,873,020 - 87,896,091 (-)NCBI
RefSeq Acc Id: XM_063277546   ⟹   XP_063133616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,873,020 - 87,896,089 (-)NCBI
RefSeq Acc Id: XM_063277554   ⟹   XP_063133624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,873,020 - 87,879,672 (-)NCBI
RefSeq Acc Id: XP_038949298   ⟸   XM_039093370
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000091260   ⟸   ENSRNOT00000109913
RefSeq Acc Id: XP_063133600   ⟸   XM_063277530
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AB99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133613   ⟸   XM_063277543
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AB99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133616   ⟸   XM_063277546
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AB99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133606   ⟸   XM_063277536
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AB99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133624   ⟸   XM_063277554
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000107621   ⟸   ENSRNOT00000166028
Ensembl Acc Id: ENSRNOP00000099655   ⟸   ENSRNOT00000155535
Protein Domains
bHLH   HMG box

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7528935 AgrOrtholog
BioCyc Gene G2FUF-60531 BioCyc
Ensembl Genes ENSRNOG00000067421 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000109913 ENTREZGENE
  ENSRNOT00000109913.1 UniProtKB/TrEMBL
  ENSRNOT00000166028 ENTREZGENE
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC102553424 ENTREZGENE
PANTHER HIGH MOBILITY GROUP B PROTEIN 12-RELATED UniProtKB/TrEMBL
  MEIOSIS INITIATOR PROTEIN UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
PhenoGen Meiosin PhenoGen
PROSITE BHLH UniProtKB/TrEMBL
  HMG_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000067421 RatGTEx
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
  SSF47459 UniProtKB/TrEMBL
UniProt A0A8I6AB99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Meiosin  meiosis initiator  Meiosin  meiosis initiator  Data merged from RGD:149736123 737654 PROVISIONAL
2021-08-09 Meiosin  meiosis initiator      Symbol and Name status set to provisional 45752 PROVISIONAL
2020-06-22 Meiosin  meiosis initiator  Bhmg1  basic helix-loop-helix and HMG-box containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-05-18 Bhmg1  basic helix-loop-helix and HMG-box containing 1  LOC102553424  uncharacterized LOC102553424  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102553424  uncharacterized LOC102553424      Symbol and Name status set to provisional 70820 PROVISIONAL