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Gene: Spint2 (serine peptidase inhibitor, Kunitz type, 2) Rattus norvegicus
Symbol: Spint2
Name: serine peptidase inhibitor, Kunitz type, 2
RGD ID: 735123
Description: Predicted to have serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus and negative regulation of neural precursor cell proliferation. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HAI-2; hepatocyte growth factor activator inhibitor type 2; kunitz-type protease inhibitor 2; MGC72638; Pb; placental bikunin; serine protease inhibitor, Kunitz type 2; Unknown (protein for MGC:72638)
Homo sapiens (human) : SPINT2 (serine peptidase inhibitor, Kunitz type 2)  HGNC  Alliance
Mus musculus (house mouse) : Spint2 (serine protease inhibitor, Kunitz type 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spint2 (serine peptidase inhibitor, Kunitz type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SPINT2 (serine peptidase inhibitor, Kunitz type 2)
Canis lupus familiaris (dog) : SPINT2 (serine peptidase inhibitor, Kunitz type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spint2 (serine peptidase inhibitor, Kunitz type 2)
Sus scrofa (pig) : SPINT2 (serine peptidase inhibitor, Kunitz type 2)
Chlorocebus sabaeus (African green monkey) : SPINT2 (serine peptidase inhibitor, Kunitz type 2)
Heterocephalus glaber (naked mole-rat) : Spint2 (serine peptidase inhibitor, Kunitz type 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0187,199,373 - 87,221,826 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,199,313 - 87,221,892 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,379,991 - 88,402,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,393,845 - 84,416,299 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1184,471,959 - 84,494,410 (-)NCBI
Celera178,945,340 - 78,967,783 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Spint2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735123
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.