Leng8 (leukocyte receptor cluster member 8) - Rat Genome Database

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Gene: Leng8 (leukocyte receptor cluster member 8) Rattus norvegicus
Analyze
Symbol: Leng8
Name: leukocyte receptor cluster member 8
RGD ID: 1306180
Description: Predicted to be active in nucleus. Orthologous to human LENG8 (leukocyte receptor cluster member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukocyte receptor cluster (LRC) member 8; LOC361506; MGC112858
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2170,040,785 - 70,052,662 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl170,040,785 - 70,052,488 (-)Ensembl
Rnor_6.0173,722,088 - 73,734,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,722,088 - 73,733,788 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0174,814,175 - 74,826,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,452,495 - 69,464,195 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1169,531,183 - 69,542,295 (-)NCBI
Celera167,069,280 - 67,080,980 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Leng8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2170,040,785 - 70,052,662 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl170,040,785 - 70,052,488 (-)Ensembl
Rnor_6.0173,722,088 - 73,734,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,722,088 - 73,733,788 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0174,814,175 - 74,826,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,452,495 - 69,464,195 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1169,531,183 - 69,542,295 (-)NCBI
Celera167,069,280 - 67,080,980 (+)NCBICelera
Cytogenetic Map1q21NCBI
LENG8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,449,199 - 54,462,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1954,448,887 - 54,462,016 (+)EnsemblGRCh38hg38GRCh38
GRCh371954,960,377 - 54,973,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,652,213 - 59,665,008 (+)NCBINCBI36hg18NCBI36
Build 341959,652,211 - 59,665,008NCBI
Celera1952,000,644 - 52,013,775 (+)NCBI
Cytogenetic Map19q13.42NCBI
HuRef1951,284,107 - 51,297,238 (+)NCBIHuRef
CHM1_11954,953,906 - 54,967,035 (+)NCBICHM1_1
T2T-CHM13v2.01957,542,477 - 57,555,296 (+)NCBI
Leng8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,139,998 - 4,151,176 (+)NCBIGRCm39mm39
GRCm39 Ensembl74,140,038 - 4,151,176 (+)Ensembl
GRCm3874,137,013 - 4,148,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,137,039 - 4,148,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv3774,088,658 - 4,099,775 (+)NCBIGRCm37mm9NCBIm37
MGSCv3673,740,143 - 3,751,260 (+)NCBImm8
Celera73,887,839 - 3,898,963 (+)NCBICelera
Cytogenetic Map7A1NCBI
Leng8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,539,537 - 1,553,285 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,539,537 - 1,552,170 (+)NCBIChiLan1.0ChiLan1.0
LENG8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11960,236,200 - 60,249,767 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,238,383 - 60,249,584 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01951,395,432 - 51,408,875 (+)NCBIMhudiblu_PPA_v0panPan3
LENG8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,844,842 - 102,856,642 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,844,961 - 102,857,341 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,906,685 - 102,918,478 (-)NCBI
ROS_Cfam_1.01103,490,545 - 103,502,329 (-)NCBI
ROS_Cfam_1.0 Ensembl1103,490,544 - 103,502,303 (-)Ensembl
UMICH_Zoey_3.11103,132,608 - 103,144,381 (-)NCBI
UNSW_CanFamBas_1.01102,888,274 - 102,900,068 (-)NCBI
UU_Cfam_GSD_1.01103,602,267 - 103,614,056 (-)NCBI
Leng8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,385,376 - 2,396,745 (-)NCBI
SpeTri2.0NW_004936886162,509 - 173,849 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LENG8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl658,860,184 - 58,870,907 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1658,860,193 - 58,871,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,412,023 - 53,422,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LENG8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,152,925 - 47,165,342 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl647,154,960 - 47,167,942 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607327,371,699 - 27,384,044 (+)NCBIVero_WHO_p1.0
Leng8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,276,433 - 2,287,684 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248322,278,115 - 2,289,179 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BF386243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2170,041,141 - 70,041,340 (+)MAPPERmRatBN7.2
Rnor_6.0173,722,445 - 73,722,643NCBIRnor6.0
Rnor_5.0174,825,494 - 74,825,692UniSTSRnor5.0
RGSC_v3.4169,452,852 - 69,453,050UniSTSRGSC3.4
Celera167,080,425 - 67,080,623UniSTS
Cytogenetic Map1q12UniSTS
RH138743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2170,041,500 - 70,041,690 (+)MAPPERmRatBN7.2
Rnor_6.0173,722,804 - 73,722,990NCBIRnor6.0
Rnor_5.0174,825,147 - 74,825,333UniSTSRnor5.0
RGSC_v3.4169,453,211 - 69,453,397UniSTSRGSC3.4
Celera167,080,078 - 67,080,264UniSTS
Cytogenetic Map1q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:418
Count of miRNA genes:206
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000025338
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 51 35 19 35 3 6 74 35 41 11 3
Low 4 6 6 6 5 5 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025338   ⟹   ENSRNOP00000025338
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl170,040,785 - 70,052,488 (-)Ensembl
Rnor_6.0 Ensembl173,722,088 - 73,733,788 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077964   ⟹   ENSRNOP00000071606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl170,041,360 - 70,052,471 (-)Ensembl
Rnor_6.0 Ensembl173,722,665 - 73,732,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106606   ⟹   ENSRNOP00000088396
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl170,049,500 - 70,052,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111838   ⟹   ENSRNOP00000093659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl170,040,785 - 70,052,488 (-)Ensembl
RefSeq Acc Id: NM_001037790   ⟹   NP_001032879
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2170,040,785 - 70,052,488 (-)NCBI
Rnor_6.0173,722,088 - 73,733,788 (-)NCBI
Rnor_5.0174,814,175 - 74,826,049 (+)NCBI
RGSC_v3.4169,452,495 - 69,464,195 (-)RGD
Celera167,069,280 - 67,080,980 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228218   ⟹   XP_006228280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2170,041,360 - 70,052,662 (-)NCBI
Rnor_6.0173,722,663 - 73,734,459 (-)NCBI
Rnor_5.0174,814,175 - 74,826,049 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228219   ⟹   XP_006228281
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2170,041,360 - 70,052,329 (-)NCBI
Rnor_6.0173,722,663 - 73,733,664 (-)NCBI
Rnor_5.0174,814,175 - 74,826,049 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228220   ⟹   XP_006228282
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2170,041,360 - 70,052,662 (-)NCBI
Rnor_6.0173,722,663 - 73,734,459 (-)NCBI
Rnor_5.0174,814,175 - 74,826,049 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008758946   ⟹   XP_008757168
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2170,041,360 - 70,052,662 (-)NCBI
Rnor_6.0173,722,663 - 73,734,459 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758948   ⟹   XP_008757170
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2170,041,360 - 70,052,662 (-)NCBI
Rnor_6.0173,722,663 - 73,734,459 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001032879   ⟸   NM_001037790
- UniProtKB: D3ZX52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228280   ⟸   XM_006228218
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006228282   ⟸   XM_006228220
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006228281   ⟸   XM_006228219
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757170   ⟸   XM_008758948
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008757168   ⟸   XM_008758946
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071606   ⟸   ENSRNOT00000077964
RefSeq Acc Id: ENSRNOP00000025338   ⟸   ENSRNOT00000025338
RefSeq Acc Id: ENSRNOP00000088396   ⟸   ENSRNOT00000106606
RefSeq Acc Id: ENSRNOP00000093659   ⟸   ENSRNOT00000111838
Protein Domains
PCI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX52-F1-model_v2 AlphaFold D3ZX52 1-846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689712
Promoter ID:EPDNEW_R237
Type:multiple initiation site
Name:Leng8_1
Description:leukocyte receptor cluster member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0173,733,777 - 73,733,837EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 73722347 73722348 G A snv CDR, GH/OmrMcwi (MCW), SBH/Ygl (MCW), LH/MavRrrcAek (2020), LH/MavRrrc (RGD), SBH/Ygl (RGD), WN/N (2020), WN/N (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 74825790 74825791 C T snv GH/OmrMcwi (MCW), SBH/Ygl (MCW), WN/N (KNAW), BUF/MNa (KyushuU), SBH/Ygl (KNAW), SDLEF7/Barth (UDEL), LH/MavRrrc (KNAW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 70041044 70041045 G A snv WN/N (2020), LH/MavRrrcAek (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306180 AgrOrtholog
BioCyc Gene G2FUF-60819 BioCyc
Ensembl Genes ENSRNOG00000018642 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025338 ENTREZGENE
  ENSRNOP00000025338.5 UniProtKB/TrEMBL
  ENSRNOP00000071606 ENTREZGENE
  ENSRNOP00000071606.1 UniProtKB/TrEMBL
  ENSRNOP00000088396.1 UniProtKB/TrEMBL
  ENSRNOP00000093659 ENTREZGENE
  ENSRNOP00000093659.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025338 ENTREZGENE
  ENSRNOT00000025338.8 UniProtKB/TrEMBL
  ENSRNOT00000077964 ENTREZGENE
  ENSRNOT00000077964.2 UniProtKB/TrEMBL
  ENSRNOT00000106606.1 UniProtKB/TrEMBL
  ENSRNOT00000111838 ENTREZGENE
  ENSRNOT00000111838.1 UniProtKB/TrEMBL
InterPro PCI_dom UniProtKB/TrEMBL
  SAC3/GANP/Nin1/mts3/eIF-3-p25 UniProtKB/TrEMBL
  SAC3/GANP/THP3 UniProtKB/TrEMBL
KEGG Report rno:361506 UniProtKB/TrEMBL
NCBI Gene 361506 ENTREZGENE
PANTHER PTHR12436 UniProtKB/TrEMBL
Pfam SAC3_GANP UniProtKB/TrEMBL
PhenoGen Leng8 PhenoGen
PROSITE PCI UniProtKB/TrEMBL
UniProt A0A0G2K0W4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A647_RAT UniProtKB/TrEMBL
  A0A8I6GKE0_RAT UniProtKB/TrEMBL
  D3ZX52 ENTREZGENE, UniProtKB/TrEMBL
  Q498R6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Leng8  leukocyte receptor cluster member 8  Leng8  leukocyte receptor cluster (LRC) member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Leng8  leukocyte receptor cluster (LRC) member 8  Leng8_predicted  leukocyte receptor cluster (LRC) member 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Leng8_predicted  leukocyte receptor cluster (LRC) member 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED