Sult2a1 (sulfotransferase family 2A member 1) - Rat Genome Database

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Gene: Sult2a1 (sulfotransferase family 2A member 1) Rattus norvegicus
Analyze
Symbol: Sult2a1 (Ensembl: Sult2a2)
Name: sulfotransferase family 2A member 1 (Ensembl:sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6)
RGD ID: 621337
Description: Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and alcohol sulfotransferase activity. Involved in several processes, including aging; cellular response to vitamin D; and response to activity. Located in cytosol. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1); PARTICIPATES IN tamoxifen pharmacokinetics pathway; estradiol biosynthetic pathway; paracetamol pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alcohol sulfotransferase; bile salt sulfotransferase; bile-salt sulfotransferase 2A1; hydroxysteroid sulfotransferase a; hydroxysteroid sulfotransferase-like; Smp-2; ST; ST-20; St2; St2a1; STa; Sth2; sulfotransferase 2A1; sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1; Sulfotransferase hydroxysteroid gene 2; sulfotransferase, hydroxysteroid preferring 2
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2175,451,178 - 75,508,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl174,911,100 - 75,508,134 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx180,831,011 - 80,887,885 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0189,395,069 - 89,451,949 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0182,586,085 - 82,642,962 (-)NCBIRnor_WKY
Rnor_6.0176,558,721 - 76,614,315 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,252,329 - 76,780,230 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,849,696 - 77,903,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,632,632 - 75,708,022 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RH 3.4 Map1767.8RGD
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(5alpha)-cholestan-3beta-ol  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4'-dichlorobiphenyl  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-dichlorobiphenyl  (ISO)
2,5-dihydroxybenzoic acid  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,5-dichlorobiphenyl  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-acetylaminofluorene  (EXP)
4-chlorobiphenyl  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
adenosine 3',5'-bismonophosphate  (ISO)
aflatoxin B1  (EXP,ISO)
alcohol  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
angelicin  (EXP)
antalarmin  (ISO)
astressin  (ISO)
atazanavir sulfate  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoquinones  (ISO)
beta-naphthoflavone  (EXP)
betulin  (ISO)
bexarotene  (EXP)
biochanin A  (EXP)
bisphenol A  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
cholic acid  (ISO)
ciprofibrate  (ISO)
clofibrate  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
endosulfan  (ISO)
entacapone  (EXP)
estrone  (ISO)
ethanol  (ISO)
etofenprox  (EXP)
ferulic acid  (EXP)
fipronil  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (ISO)
ginsenoside Rg1  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
Heliotrine  (ISO)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lithocholic acid  (EXP,ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-dimethylformamide  (ISO)
N-hydroxy-2-acetamidofluorene  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
parathion  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
psoralen  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinolin-8-ol  (ISO)
rifampicin  (EXP,ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulfluramid  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tolcapone  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
Yangonin  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa. Apak TI and Duffel MW, Drug Metab Dispos. 2004 Dec;32(12):1501-8. Epub 2004 Sep 15.
2. Changes in hepatic androgen sensitivity and gene expression during aging. Chatterjee B and Roy AK, J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):437-45.
3. Calorie restriction delays age-dependent loss in androgen responsiveness of the rat liver. Chatterjee B, etal., FASEB J. 1989 Feb;3(2):169-73.
4. Molecular cloning and characterization of cDNA for androgen-repressible rat liver protein, SMP-2. Chatterjee B, etal., J Biol Chem 1987 Jan 15;262(2):822-5.
5. Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Echchgadda I, etal., Mol Pharmacol. 2004 Mar;65(3):720-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers. Kim SY, etal., Drug Metab Dispos. 2005 Nov;33(11):1673-8. Epub 2005 Aug 11.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk. Kwon EM, etal., Cancer Epidemiol. 2012 Aug;36(4):347-53. Epub 2012 Apr 26.
10. Stress regulation of sulfotransferases in male rat liver. Maiti S, etal., Biochem Biophys Res Commun. 2004 Oct 8;323(1):235-41.
11. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers. Ogura K, etal., Biochem Biophys Res Commun 1990 Feb 14;166(3):1494-500.
14. Cloning and sequence analysis of a rat liver cDNA encoding hydroxysteroid sulfotransferase. Ogura K, etal., Biochem Biophys Res Commun. 1989 Nov 30;165(1):168-74. doi: 10.1016/0006-291x(89)91050-4.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Immunochemical characterisation of a dehydroepiandrosterone sulfotransferase in rats and humans. Sharp S, etal., Eur J Biochem. 1993 Feb 1;211(3):539-48.
20. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. Song CS, etal., J Biol Chem 2001 Nov 9;276(45):42549-56.
21. Molecular cloning and functions of rat liver hydroxysteroid sulfotransferases catalysing covalent binding of carcinogenic polycyclic arylmethanols to DNA. Watabe T, etal., Chem Biol Interact 1994 Jun;92(1-3):87-105.
22. Association of SULT2A1 allelic variants with plasma adrenal androgens and prostate cancer in African American men. Wilborn TW, etal., J Steroid Biochem Mol Biol. 2006 Jun;99(4-5):209-14. Epub 2006 Apr 17.
Additional References at PubMed
PMID:1588921   PMID:8033248   PMID:16469813   PMID:19548878   PMID:20056724   PMID:21721019   PMID:23026138   PMID:23207770  


Genomics

Comparative Map Data
Sult2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2175,451,178 - 75,508,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl174,911,100 - 75,508,134 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx180,831,011 - 80,887,885 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0189,395,069 - 89,451,949 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0182,586,085 - 82,642,962 (-)NCBIRnor_WKY
Rnor_6.0176,558,721 - 76,614,315 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,252,329 - 76,780,230 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,849,696 - 77,903,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,632,632 - 75,708,022 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RH 3.4 Map1767.8RGD
Cytogenetic Map1q21NCBI
SULT2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,870,467 - 47,886,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1947,870,467 - 47,886,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371948,373,724 - 48,389,572 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,065,682 - 53,081,405 (-)NCBINCBI36Build 36hg18NCBI36
Build 341953,065,681 - 53,081,405NCBI
Celera1945,179,460 - 45,195,376 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1944,800,492 - 44,816,411 (-)NCBIHuRef
CHM1_11948,375,906 - 48,391,802 (-)NCBICHM1_1
T2T-CHM13v2.01950,701,399 - 50,717,233 (-)NCBIT2T-CHM13v2.0
Sult2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39713,530,171 - 13,571,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl713,530,171 - 13,571,334 (-)EnsemblGRCm39 Ensembl
GRCm38713,796,246 - 13,837,410 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl713,796,246 - 13,837,409 (-)EnsemblGRCm38mm10GRCm38
MGSCv37714,381,595 - 14,422,759 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36714,381,602 - 14,422,724 (-)NCBIMGSCv36mm8
Celera711,427,949 - 11,449,279 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map78.02NCBI
SULT2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11953,517,248 - 53,532,573 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1953,517,248 - 53,532,573 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01944,864,747 - 44,880,688 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SULT2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,524,787 - 53,536,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,525,496 - 53,536,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,108,567 - 49,120,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SULT2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,160,707 - 41,175,382 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,159,978 - 41,175,300 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607320,926,980 - 20,942,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Sult2a1
386 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:84
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000041367
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat

Markers in Region
D1Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,505,449 - 75,505,830 (+)MAPPERmRatBN7.2
Rnor_6.0176,720,186 - 76,720,553NCBIRnor6.0
Rnor_6.0176,609,202 - 76,609,589NCBIRnor6.0
Rnor_5.0178,009,693 - 78,010,060UniSTSRnor5.0
Rnor_5.0177,900,170 - 77,900,557UniSTSRnor5.0
RGSC_v3.4175,705,355 - 75,705,739UniSTSRGSC3.4
RGSC_v3.4174,602,467 - 74,602,835RGDRGSC3.4
RGSC_v3.4174,602,468 - 74,602,835UniSTSRGSC3.4
RGSC_v3.4175,705,354 - 75,705,739RGDRGSC3.4
RGSC_v3.1175,783,465 - 75,783,850RGD
Celera170,385,758 - 70,386,127UniSTS
RH 3.4 Map1781.9RGD
RH 3.4 Map1781.9UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map1q21.3-q22.1UniSTS
RH94657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,058,585 - 76,058,698 (+)MAPPERmRatBN7.2
mRatBN7.2174,911,126 - 74,911,239 (+)MAPPERmRatBN7.2
mRatBN7.2175,451,204 - 75,451,317 (+)MAPPERmRatBN7.2
Rnor_6.0176,558,755 - 76,558,867NCBIRnor6.0
Rnor_6.0176,529,148 - 76,529,260NCBIRnor6.0
Rnor_5.0177,823,892 - 77,824,004UniSTSRnor5.0
Rnor_5.0177,849,723 - 77,849,835UniSTSRnor5.0
RGSC_v3.4174,553,826 - 74,553,938UniSTSRGSC3.4
RGSC_v3.4175,632,659 - 75,632,771UniSTSRGSC3.4
Celera170,337,183 - 70,337,295UniSTS
RH 3.4 Map1767.8UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map1q21.3-q22.1UniSTS
BI301823  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2174,812,064 - 74,812,230 (+)MAPPERmRatBN7.2
Rnor_6.0176,144,306 - 76,144,471NCBIRnor6.0
Rnor_5.0177,448,413 - 77,448,578UniSTSRnor5.0
RGSC_v3.4174,453,133 - 74,453,298UniSTSRGSC3.4
Celera170,238,177 - 70,238,342UniSTS
RH 3.4 Map1766.59UniSTS
Cytogenetic Map1q21.3-q22.1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_131903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide D14987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_131903   ⟹   NP_571978
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,451,178 - 75,508,113 (-)NCBI
Rnor_6.0176,558,728 - 76,614,279 (-)NCBI
Rnor_5.0177,849,696 - 77,903,846 (-)NCBI
RGSC_v3.4175,632,632 - 75,708,022 (-)RGD
Sequence:
RefSeq Acc Id: XM_008758891   ⟹   XP_008757113
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,464,945 - 75,508,142 (-)NCBI
Rnor_6.0176,571,742 - 76,614,315 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_571978 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757113 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41356 (Get FASTA)   NCBI Sequence Viewer  
  BAA03632 (Get FASTA)   NCBI Sequence Viewer  
  BAA03633 (Get FASTA)   NCBI Sequence Viewer  
  P15709 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_571978   ⟸   NM_131903
- UniProtKB: P15709 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757113   ⟸   XM_008758891
- Peptide Label: isoform X1
- Sequence:
Protein Domains
Sulfotransfer_1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15709-F1-model_v2 AlphaFold P15709 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689717
Promoter ID:EPDNEW_R241
Type:initiation region
Name:Sult2a2_1
Description:sulfotransferase family 2A, dehydroepiandrosterone -preferring,member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R242  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0176,614,300 - 76,614,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621337 AgrOrtholog
BioCyc Gene G2FUF-60656 BioCyc
Ensembl Genes ENSRNOG00000047986 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043445.4 UniProtKB/TrEMBL
  ENSRNOP00000045076.4 UniProtKB/TrEMBL
  ENSRNOP00000070596 ENTREZGENE
  ENSRNOP00000070596.2 UniProtKB/TrEMBL
  ENSRNOP00000082704.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041367.5 UniProtKB/TrEMBL
  ENSRNOT00000052129.3 UniProtKB/TrEMBL
  ENSRNOT00000089371 ENTREZGENE
  ENSRNOT00000089371.2 UniProtKB/TrEMBL
  ENSRNOT00000094902.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24912 UniProtKB/Swiss-Prot
NCBI Gene 24912 ENTREZGENE
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SULT2A1 RGD
PhenoGen Sult2a1 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVR1_RAT UniProtKB/TrEMBL
  A0A8L2R491_RAT UniProtKB/TrEMBL
  F1M7G5_RAT UniProtKB/TrEMBL
  M3ZCQ0_RAT UniProtKB/TrEMBL
  P15709 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2JYC0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-12 Sult2a1  sulfotransferase family 2A member 1  Sult2a1  sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-01   sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1  Sult2a1  sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1  Name updated 1299863 APPROVED
2005-02-28 Sult2a1  sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1  Sth2  sulfotransferase, hydroxysteroid preferring 2  Data Merged 737654 APPROVED
2003-04-09 Sth2  sulfotransferase, hydroxysteroid preferring 2    Sulfotransferase hydroxysteroid gene 2  Name updated 629478 APPROVED
2002-08-07 Sult2a1  sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Sth2  Sulfotransferase hydroxysteroid gene 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression present in the rat liver cytosol 634136
gene_regulation mRNA expression is repressed by androgen 634135