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Gene: Ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit) Rattus norvegicus
Symbol: Ercc2
Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Description: Predicted to contribute to DNA-dependent ATPase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. Involved in aging; embryonic organ development; and response to hypoxia. Localizes to the transcription factor TFIIH core complex. Biomarker of asphyxia neonatorum. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); eye disease (multiple); hematologic cancer (multiple); skin disease (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH aflatoxin B1; cyclophosphamide; cypermethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: excision repair cross-complementation group 2; excision repair cross-complementing rodent repair deficiency, complementation group 2; LOC308415; rCG54110-like; TFIIH basal transcription factor complex helicase XPD subunit
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0180,293,574 - 80,307,334 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0181,559,883 - 81,573,643 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera173,495,273 - 73,509,033 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ercc2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309109
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.