Kmt5c (lysine methyltransferase 5C) - Rat Genome Database

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Gene: Kmt5c (lysine methyltransferase 5C) Rattus norvegicus
Analyze
Symbol: Kmt5c
Name: lysine methyltransferase 5C
RGD ID: 1305226
Description: Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; histone H4K20 methyltransferase activity; and histone binding activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in condensed chromosome, centromeric region and nucleoplasm. Predicted to be part of pericentric heterochromatin. Predicted to be active in nucleus. Biomarker of liver benign neoplasm. Orthologous to human KMT5C (lysine methyltransferase 5C); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [histone H4]-lysine20 N-methyltransferase KMT5B; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; LOC308345; lysine (K)-specific methyltransferase 5C; lysine-specific methyltransferase 5C; su(var)4-20 homolog 2; suppressor of variegation 4-20 homolog 2; suppressor of variegation 4-20 homolog 2 (Drosophila); suv4-20h2; Suv420h2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,128,325 - 78,135,931 (-)NCBIGRCr8
mRatBN7.2169,099,531 - 69,107,145 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,099,539 - 69,107,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,444,576 - 74,452,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,008,879 - 83,016,485 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,157,538 - 76,165,177 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,666,662 - 72,674,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,666,665 - 72,674,271 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,861,337 - 75,868,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,815,981 - 67,823,611 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,894,088 - 67,899,997 (-)NCBI
Celera168,017,407 - 68,024,973 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Pogribny IP, etal., Carcinogenesis. 2006 Jun;27(6):1180-6. Epub 2006 Feb 23.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Zhong Q and Kowluru RA, Diabetes. 2011 Apr;60(4):1304-13. doi: 10.2337/db10-0133. Epub 2011 Feb 25.
Additional References at PubMed
PMID:15145825   PMID:17182829   PMID:19486527   PMID:24049080   PMID:24396869   PMID:25335925   PMID:28114273  


Genomics

Comparative Map Data
Kmt5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,128,325 - 78,135,931 (-)NCBIGRCr8
mRatBN7.2169,099,531 - 69,107,145 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,099,539 - 69,107,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,444,576 - 74,452,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,008,879 - 83,016,485 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,157,538 - 76,165,177 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,666,662 - 72,674,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,666,665 - 72,674,271 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,861,337 - 75,868,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,815,981 - 67,823,611 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,894,088 - 67,899,997 (-)NCBI
Celera168,017,407 - 68,024,973 (+)NCBICelera
Cytogenetic Map1q12NCBI
KMT5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,339,876 - 55,348,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,339,853 - 55,348,121 (+)EnsemblGRCh38hg38GRCh38
GRCh371955,851,244 - 55,859,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,543,076 - 60,551,301 (+)NCBINCBI36Build 36hg18NCBI36
Build 341960,543,075 - 60,551,300NCBI
Celera1952,892,173 - 52,900,453 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,173,507 - 52,181,789 (+)NCBIHuRef
CHM1_11955,845,041 - 55,853,309 (+)NCBICHM1_1
T2T-CHM13v2.01958,435,095 - 58,443,627 (+)NCBIT2T-CHM13v2.0
Kmt5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,743,091 - 4,750,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,743,114 - 4,750,513 (+)EnsemblGRCm39 Ensembl
GRCm3874,740,092 - 4,747,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,740,115 - 4,747,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv3774,691,729 - 4,699,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,343,275 - 4,350,574 (+)NCBIMGSCv36mm8
Celera74,470,199 - 4,477,587 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.74NCBI
Kmt5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955567894,608 - 900,578 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955567895,334 - 901,240 (-)NCBIChiLan1.0ChiLan1.0
KMT5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,476,795 - 61,485,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,205,884 - 63,214,838 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,381,963 - 52,390,507 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11961,073,185 - 61,079,389 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,073,396 - 61,078,717 (+)Ensemblpanpan1.1panPan2
KMT5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,334,687 - 102,342,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,333,543 - 102,342,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,391,254 - 102,398,667 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01102,987,756 - 102,995,170 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,986,612 - 102,995,188 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,625,010 - 102,632,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,337,091 - 102,344,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,100,299 - 103,107,712 (-)NCBIUU_Cfam_GSD_1.0
Kmt5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,956,266 - 1,963,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886595,782 - 604,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886596,949 - 602,959 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,517,098 - 59,524,550 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,517,058 - 59,524,551 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KMT5C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,942,100 - 47,950,364 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,944,197 - 47,949,693 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045576,523 - 584,848 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt5c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,945,193 - 1,951,247 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248321,945,194 - 1,951,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmt5c
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:73
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000023744
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat

Markers in Region
BE107946  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,099,441 - 69,099,656 (+)MAPPERmRatBN7.2
Rnor_6.0172,666,568 - 72,666,782NCBIRnor6.0
Rnor_5.0175,868,826 - 75,869,040UniSTSRnor5.0
RGSC_v3.4167,815,884 - 67,816,098UniSTSRGSC3.4
Celera168,024,856 - 68,025,070UniSTS
Cytogenetic Map1q12UniSTS
BF396701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,103,071 - 69,103,271 (+)MAPPERmRatBN7.2
Rnor_6.0172,670,198 - 72,670,397NCBIRnor6.0
Rnor_5.0175,865,211 - 75,865,410UniSTSRnor5.0
RGSC_v3.4167,819,514 - 67,819,713UniSTSRGSC3.4
Celera168,021,244 - 68,021,443UniSTS
Cytogenetic Map1q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 27 27 6 27 66 26 35 3
Low 9 30 14 13 14 8 11 8 9 6 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023744   ⟹   ENSRNOP00000023744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,099,539 - 69,107,145 (-)Ensembl
Rnor_6.0 Ensembl172,666,665 - 72,674,271 (-)Ensembl
RefSeq Acc Id: NM_001107475   ⟹   NP_001100945
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,128,325 - 78,135,931 (-)NCBI
mRatBN7.2169,099,539 - 69,107,145 (-)NCBI
Rnor_6.0172,666,665 - 72,674,271 (-)NCBI
Rnor_5.0175,861,337 - 75,868,946 (+)NCBI
RGSC_v3.4167,815,981 - 67,823,611 (-)RGD
Celera168,017,407 - 68,024,973 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100945 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023744
  ENSRNOP00000023744.5
  ENSRNOP00055020174
  ENSRNOP00060038235
  ENSRNOP00065045786
GenBank Protein P0C2N6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100945   ⟸   NM_001107475
- UniProtKB: P0C2N6 (UniProtKB/Swiss-Prot),   A6KNN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023744   ⟸   ENSRNOT00000023744
Protein Domains
SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C2N6-F1-model_v2 AlphaFold P0C2N6 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689699
Promoter ID:EPDNEW_R224
Type:single initiation site
Name:Kmt5c_1
Description:lysine methyltransferase 5C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,674,227 - 72,674,287EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305226 AgrOrtholog
BioCyc Gene G2FUF-60856 BioCyc
Ensembl Genes ENSRNOG00000017508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055014386 UniProtKB/Swiss-Prot
  ENSRNOG00060026588 UniProtKB/Swiss-Prot
  ENSRNOG00065032308 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023744 ENTREZGENE
  ENSRNOT00000023744.6 UniProtKB/Swiss-Prot
  ENSRNOT00055024693 UniProtKB/Swiss-Prot
  ENSRNOT00060046045 UniProtKB/Swiss-Prot
  ENSRNOT00065055620 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1700 UniProtKB/Swiss-Prot
  2.170.270.10 UniProtKB/Swiss-Prot
  Histone-lysine N-methyltransferase UniProtKB/TrEMBL
  SET domain UniProtKB/TrEMBL
InterPro Hist-Lys_N-MTase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hist-Lys_N-MTase_Suvar4-20 UniProtKB/Swiss-Prot
  KMT5B/KMT5C/SET9 UniProtKB/Swiss-Prot
  KMT5C_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Suv4-20/Set9 UniProtKB/TrEMBL
  Suv4-20_animal UniProtKB/TrEMBL
KEGG Report rno:308345 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 308345 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE KMT5C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kmt5c PhenoGen
PROSITE SAM_MT43_SUVAR420_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017508 RatGTEx
  ENSRNOG00055014386 RatGTEx
  ENSRNOG00060026588 RatGTEx
  ENSRNOG00065032308 RatGTEx
SMART SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SET domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KNN2 ENTREZGENE, UniProtKB/TrEMBL
  KMT5C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kmt5c  lysine methyltransferase 5C  Kmt5c  lysine (K)-specific methyltransferase 5C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Kmt5c  lysine (K)-specific methyltransferase 5C  Suv420h2  suppressor of variegation 4-20 homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Suv420h2  suppressor of variegation 4-20 homolog 2 (Drosophila)   Suv420h2_predicted  suppressor of variegation 4-20 homolog 2 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Suv420h2_predicted  suppressor of variegation 4-20 homolog 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED