Enables several functions, including G-protein alpha-subunit binding activity; heat shock protein binding activity; and microtubule binding activity. Involved in several processes, including negative regulation of cell death; positive regulation of glucocorticoid receptor signaling pathway; and response to arachidonic acid. Located in perikaryon and proximal dendrite. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
[bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of PPP5C gene, [bisphenol A co-treated with Fulvestrant] results in increased methylation of PPP5C gene
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPP5C protein], Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C protein]
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5.
The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant.
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.
