Brsk1 (BR serine/threonine kinase 1) - Rat Genome Database

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Gene: Brsk1 (BR serine/threonine kinase 1) Rattus norvegicus
Analyze
Symbol: Brsk1
Name: BR serine/threonine kinase 1
RGD ID: 1563268
Description: Enables protein serine/threonine kinase activity. Involved in neurotransmitter secretion and regulation of synaptic vesicle priming. Located in distal axon. Is active in cholinergic synapse; postsynaptic density; and synaptic vesicle. Orthologous to human BRSK1 (BR serine/threonine kinase 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BR serine/threonine-protein kinase 1; brain-specific serine/threonine-protein kinase 1; LOC499073; RGD1563268; Sad-b; serine/threonine-protein kinase BRSK1; serine/threonine-protein kinase SAD-B; similar to Probable serine/threonine-protein kinase KIAA1811
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,162,944 - 78,193,598 (-)NCBIGRCr8
mRatBN7.2169,134,166 - 69,159,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,134,565 - 69,160,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,479,595 - 74,504,981 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,043,896 - 83,069,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,196,377 - 76,221,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,701,281 - 72,727,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,701,610 - 72,727,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,808,536 - 75,834,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,851,020 - 67,876,360 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,964,521 - 67,990,006 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (ISO)
centrosome  (IBA,ISO,ISS)
cholinergic synapse  (IDA,IEP,IMP)
cytoplasm  (ISO)
distal axon  (IMP)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
postsynaptic density  (IDA,IEP)
presynaptic active zone  (IEA)
synaptic vesicle  (IDA,IEP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Inoue E, etal., Neuron. 2006 Apr 20;50(2):261-75.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Polarized activities of AMPK and BRSK in primary hippocampal neurons. Sample V, etal., Mol Biol Cell. 2015 May 15;26(10):1935-46. doi: 10.1091/mbc.E14-02-0764. Epub 2015 Mar 18.
Additional References at PubMed
PMID:14976552   PMID:15150265   PMID:15705853   PMID:17482548   PMID:18268107   PMID:18324781   PMID:19648910   PMID:20026642   PMID:21985311   PMID:26444684   PMID:26514267   PMID:30053369  


Genomics

Comparative Map Data
Brsk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,162,944 - 78,193,598 (-)NCBIGRCr8
mRatBN7.2169,134,166 - 69,159,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,134,565 - 69,160,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,479,595 - 74,504,981 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,043,896 - 83,069,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,196,377 - 76,221,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,701,281 - 72,727,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,701,610 - 72,727,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,808,536 - 75,834,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,851,020 - 67,876,360 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,964,521 - 67,990,006 (+)NCBICelera
Cytogenetic Map1q12NCBI
BRSK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,283,997 - 55,312,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,282,072 - 55,312,562 (+)EnsemblGRCh38hg38GRCh38
GRCh371955,795,365 - 55,823,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,487,346 - 60,515,742 (+)NCBINCBI36Build 36hg18NCBI36
Build 341960,487,345 - 60,515,713NCBI
Celera1952,836,546 - 52,864,920 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,118,294 - 52,145,956 (+)NCBIHuRef
CHM1_11955,789,481 - 55,817,759 (+)NCBICHM1_1
T2T-CHM13v2.01958,379,535 - 58,408,087 (+)NCBIT2T-CHM13v2.0
Brsk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,693,635 - 4,718,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,693,603 - 4,718,996 (+)EnsemblGRCm39 Ensembl
GRCm3874,690,636 - 4,715,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,690,604 - 4,715,997 (+)EnsemblGRCm38mm10GRCm38
MGSCv3774,642,530 - 4,667,599 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,294,015 - 4,319,084 (+)NCBIMGSCv36mm8
MGSCv3674,044,979 - 4,071,504 (+)NCBIMGSCv36mm8
Celera74,421,153 - 4,445,975 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.71NCBI
Brsk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955567924,734 - 943,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955567924,728 - 943,092 (-)NCBIChiLan1.0ChiLan1.0
BRSK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,421,716 - 61,450,169 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,150,814 - 63,179,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,326,538 - 52,355,060 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11961,021,479 - 61,046,190 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,021,493 - 61,045,659 (+)Ensemblpanpan1.1panPan2
BRSK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,367,050 - 102,384,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,367,581 - 102,385,466 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,423,618 - 102,441,538 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,020,112 - 103,038,041 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,020,112 - 103,038,435 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,657,351 - 102,675,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,369,126 - 102,386,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,132,673 - 103,150,595 (-)NCBIUU_Cfam_GSD_1.0
Brsk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,992,067 - 2,013,003 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886546,222 - 570,521 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886541,831 - 567,197 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRSK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,468,733 - 59,499,059 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,468,289 - 59,499,062 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,372,199 - 54,377,541 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRSK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,888,813 - 47,915,019 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,888,920 - 47,917,920 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045520,043 - 548,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brsk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,975,314 - 1,995,056 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248321,975,448 - 1,995,102 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brsk1
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:77
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000031172
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat

Markers in Region
RH137446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,134,168 - 69,134,377 (+)MAPPERmRatBN7.2
Rnor_6.0172,701,284 - 72,701,492NCBIRnor6.0
Rnor_5.0175,834,116 - 75,834,324UniSTSRnor5.0
RGSC_v3.4167,850,624 - 67,850,832UniSTSRGSC3.4
Celera167,990,194 - 67,990,402UniSTS
Cytogenetic Map1q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 2 2 2 74 18 37
Low 3 25 48 33 18 33 7 10 17 4 11 7
Below cutoff 7 6 1 6 1 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000031172   ⟹   ENSRNOP00000033679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,134,565 - 69,158,684 (-)Ensembl
Rnor_6.0 Ensembl172,701,610 - 72,727,112 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097053   ⟹   ENSRNOP00000087514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,134,565 - 69,160,365 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116072   ⟹   ENSRNOP00000096545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,145,138 - 69,158,516 (-)Ensembl
RefSeq Acc Id: NM_001127337   ⟹   NP_001120809
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,163,341 - 78,188,723 (-)NCBI
mRatBN7.2169,134,565 - 69,159,947 (-)NCBI
Rnor_6.0172,701,680 - 72,727,061 (-)NCBI
Rnor_5.0175,808,536 - 75,834,327 (+)NCBI
RGSC_v3.4167,851,020 - 67,876,360 (-)RGD
Celera167,964,521 - 67,990,006 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228283   ⟹   XP_006228345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,162,944 - 78,187,175 (-)NCBI
mRatBN7.2169,134,166 - 69,158,405 (-)NCBI
Rnor_6.0172,701,281 - 72,725,511 (-)NCBI
Rnor_5.0175,808,536 - 75,834,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270832   ⟹   XP_063126902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,162,944 - 78,193,598 (-)NCBI
RefSeq Acc Id: NP_001120809   ⟸   NM_001127337
- UniProtKB: F1M6Y8 (UniProtKB/Swiss-Prot),   B2DD29 (UniProtKB/Swiss-Prot),   A0A8L2QIE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228345   ⟸   XM_006228283
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QIE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033679   ⟸   ENSRNOT00000031172
RefSeq Acc Id: ENSRNOP00000096545   ⟸   ENSRNOT00000116072
RefSeq Acc Id: ENSRNOP00000087514   ⟸   ENSRNOT00000097053
RefSeq Acc Id: XP_063126902   ⟸   XM_063270832
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QIE9 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2DD29-F1-model_v2 AlphaFold B2DD29 1-778 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563268 AgrOrtholog
BioCyc Gene G2FUF-60851 BioCyc
Ensembl Genes ENSRNOG00000017673 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014409 UniProtKB/Swiss-Prot
  ENSRNOG00060026686 UniProtKB/Swiss-Prot
  ENSRNOG00065032331 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000031172.7 UniProtKB/TrEMBL
  ENSRNOT00000097053 ENTREZGENE
  ENSRNOT00000097053.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116072.1 UniProtKB/TrEMBL
  ENSRNOT00055024792 UniProtKB/Swiss-Prot
  ENSRNOT00060046487 UniProtKB/Swiss-Prot
  ENSRNOT00065055718 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRSK1_2-like_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:499073 UniProtKB/Swiss-Prot
NCBI Gene 499073 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KA1_BRSK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA_BRSK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Brsk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017673 RatGTEx
  ENSRNOG00055014409 RatGTEx
  ENSRNOG00060026686 RatGTEx
  ENSRNOG00065032331 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AQZ1_RAT UniProtKB/TrEMBL
  A0A8L2QIE9 ENTREZGENE, UniProtKB/TrEMBL
  B2DD29 ENTREZGENE, UniProtKB/Swiss-Prot
  F1M6Y8 ENTREZGENE
UniProt Secondary F1M6Y8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Brsk1  BR serine/threonine kinase 1  RGD1563268_predicted  similar to Probable serine/threonine-protein kinase KIAA1811 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563268_predicted  similar to Probable serine/threonine-protein kinase KIAA1811 (predicted)  LOC499073  similar to Probable serine/threonine-protein kinase KIAA1811  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499073  similar to Probable serine/threonine-protein kinase KIAA1811      Symbol and Name status set to provisional 70820 PROVISIONAL