Zfp27 (zinc finger protein 27) - Rat Genome Database

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Gene: Zfp27 (zinc finger protein 27) Rattus norvegicus
Analyze
Symbol: Zfp27
Name: zinc finger protein 27
RGD ID: 2318958
Description: Predicted to enable metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription; INTERACTS WITH 2-methylcholine (ortholog); benzo[a]pyrene (ortholog); butanal (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100362022; LOC102550277; rCG53711-like; zinc finger protein 27-like
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,243,836 - 94,258,193 (-)NCBIGRCr8
mRatBN7.2185,117,455 - 85,130,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,117,483 - 85,130,178 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0187,771,238 - 87,788,554 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0188,951,948 - 88,965,355 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,910,957 - 84,914,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,493,401 - 79,505,791 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,243,836 - 94,258,193 (-)NCBIGRCr8
mRatBN7.2185,117,455 - 85,130,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,117,483 - 85,130,178 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0187,771,238 - 87,788,554 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0188,951,948 - 88,965,355 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,910,957 - 84,914,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,493,401 - 79,505,791 (-)NCBICelera
Cytogenetic Map1q21NCBI
ZNF585A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381937,145,540 - 37,172,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1937,106,734 - 37,172,741 (-)EnsemblGRCh38hg38GRCh38
GRCh371937,636,442 - 37,663,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361942,332,830 - 42,355,455 (-)NCBINCBI36Build 36hg18NCBI36
Celera1934,425,229 - 34,447,853 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1934,110,155 - 34,132,779 (-)NCBIHuRef
CHM1_11937,641,464 - 37,664,088 (-)NCBICHM1_1
T2T-CHM13v2.01939,820,506 - 39,847,661 (-)NCBIT2T-CHM13v2.0
Znf585a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554681,802,467 - 1,817,642 (-)NCBIChiLan1.0ChiLan1.0
ZNF585A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22043,251,874 - 43,317,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11945,135,966 - 45,201,897 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01934,074,766 - 34,136,220 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC484540
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11115,185,864 - 115,205,871 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1114,585,639 - 114,610,275 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01115,784,778 - 115,809,427 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11115,356,776 - 115,381,390 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,975,587 - 115,000,208 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01116,024,954 - 116,049,597 (-)NCBIUU_Cfam_GSD_1.0
Znf585a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934912,111,815 - 12,163,869 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936801277,205 - 315,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Znf585a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479411,140,664 - 11,156,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp27
67 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat

Markers in Region
BE108025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,122,596 - 85,122,780 (+)MAPPERmRatBN7.2
Rnor_6.0188,561,249 - 88,561,432NCBIRnor6.0
Rnor_6.0187,780,221 - 87,780,404NCBIRnor6.0
Rnor_5.0189,722,172 - 89,722,355UniSTSRnor5.0
Rnor_5.0188,957,090 - 88,957,273UniSTSRnor5.0
RGSC_v3.4184,915,279 - 84,915,462UniSTSRGSC3.4
Celera179,498,543 - 79,498,726UniSTS
RH 3.4 Map1852.3UniSTS
Cytogenetic Map1q21UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000093978   ⟹   ENSRNOP00000080440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl185,117,483 - 85,130,178 (-)Ensembl
RefSeq Acc Id: XM_008759225   ⟹   XP_008757447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,243,836 - 94,258,193 (-)NCBI
mRatBN7.2185,117,455 - 85,130,286 (-)NCBI
Rnor_6.0187,775,079 - 87,787,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759226   ⟹   XP_008757448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,243,836 - 94,258,193 (-)NCBI
mRatBN7.2185,117,455 - 85,130,250 (-)NCBI
Rnor_6.0187,775,079 - 87,787,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590507   ⟹   XP_017445996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,243,836 - 94,257,448 (-)NCBI
mRatBN7.2185,117,455 - 85,130,578 (-)NCBI
Rnor_6.0187,775,079 - 87,788,554 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008757447 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757448 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07814 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080440
  ENSRNOP00000080440.1
Reference Protein Sequences
RefSeq Acc Id: XP_008757447   ⟸   XM_008759225
- UniProtKB: A0A8I5ZQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757448   ⟸   XM_008759226
- UniProtKB: A0A8I5ZQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445996   ⟸   XM_017590507
- UniProtKB: A0A8I5ZQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000080440   ⟸   ENSRNOT00000093978
Protein Domains
C2H2-type   KRAB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-60167 BioCyc
Ensembl Genes ENSRNOG00000070848 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093978.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:100362022 UniProtKB/TrEMBL
NCBI Gene 100362022 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 484 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp27 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070848 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZQ59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zfp27  zinc finger protein 27  Zfp27  zinc finger protein 27  Data merged from RGD:149736110 737654 PROVISIONAL
2021-08-09 Zfp27  zinc finger protein 27      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Zfp27  zinc finger protein 27  LOC102550277  zinc finger protein 27-like  Data merged from RGD:7530922 737654 PROVISIONAL
2013-12-17 LOC102550277  zinc finger protein 27-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-08-24 Zfp27  zinc finger protein 27  LOC100362022  rCG53711-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100362022  rCG53711-like      Symbol and Name status set to provisional 70820 PROVISIONAL