Gene: Kcnn4 (potassium calcium-activated channel subfamily N member 4) Rattus norvegicus
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Symbol: Kcnn4
Name: potassium calcium-activated channel subfamily N member 4
Description: ENCODES a protein that exhibits Intermediate conductance calcium-activated potassium channel activity; calcium-activated potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN anion transport; potassium ion export across plasma membrane; potassium ion transport; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; Dehydrated Hereditary Stomatocytosis (ortholog); Dehydrated Hereditary Stomatocytosis 2 (ortholog); FOUND IN apical plasma membrane; basolateral plasma membrane; membrane raft; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil
AGR Description: Exhibits Intermediate conductance calcium-activated potassium channel activity; involved in anion transport and potassium ion export across plasma membrane; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and membrane raft; orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4).
Merged Description: Exhibits Intermediate conductance calcium-activated potassium channel activity; involved in anion transport and potassium ion export across plasma membrane; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and membrane raft; orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IK1; intermediate conductance calcium-activated potassium channel; intermediate conductance calcium-activated potassium channel protein 4; intermediate conductance K channel; intermediate-conductance Ca-activated K channel; KCa3.1; KCa4; MGC156636; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; rKCNN4c; rSK4; SK4; SKCa 4; SKCa4
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0181,227,855 - 81,245,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,490,768 - 82,508,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,613,736 - 79,628,887 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,691,846 - 79,706,998 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kcnn4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621476
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.