Gene: Kcnn4 (potassium calcium-activated channel subfamily N member 4) Rattus norvegicus
Analyze
Symbol: Kcnn4
Name: potassium calcium-activated channel subfamily N member 4
Description: ENCODES a protein that exhibits Intermediate conductance calcium-activated potassium channel activity; calcium-activated potassium channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN anion transport; potassium ion export across plasma membrane; potassium ion transport; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; Dehydrated Hereditary Stomatocytosis (ortholog); Dehydrated Hereditary Stomatocytosis 2 (ortholog); FOUND IN apical plasma membrane; basolateral plasma membrane; membrane raft; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil
AGR Description: Exhibits Intermediate conductance calcium-activated potassium channel activity; involved in anion transport and potassium ion export across plasma membrane; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and membrane raft; orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4).
Merged Description: Exhibits Intermediate conductance calcium-activated potassium channel activity; involved in anion transport and potassium ion export across plasma membrane; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and membrane raft; orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IK1; intermediate conductance calcium-activated potassium channel; intermediate conductance calcium-activated potassium channel protein 4; intermediate conductance K channel; intermediate-conductance Ca-activated K channel; KCa3.1; KCa4; MGC156636; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; rKCNN4c; rSK4; SK4; SKCa 4; SKCa4
Orthologs:
Homo sapiens (human) : KCNN4 (potassium calcium-activated channel subfamily N member 4)  HGNC  Alliance
Mus musculus (house mouse) : Kcnn4 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kcnn4 (potassium calcium-activated channel subfamily N member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : KCNN4 (potassium calcium-activated channel subfamily N member 4)
Canis lupus familiaris (dog) : KCNN4 (potassium calcium-activated channel subfamily N member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kcnn4 (potassium calcium-activated channel subfamily N member 4)
Sus scrofa (pig) : KCNN4 (potassium calcium-activated channel subfamily N member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0181,227,855 - 81,245,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,490,768 - 82,508,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,613,736 - 79,628,887 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,691,846 - 79,706,998 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Kcnn4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621476
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.