Kcnn4 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4) - Rat Genome Database

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Gene: Kcnn4 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4) Mus musculus
Analyze
Symbol: Kcnn4
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
RGD ID: 732699
MGI Page MGI
Description: Enables intermediate conductance calcium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Acts upstream of or within several processes, including cell volume homeostasis; phospholipid translocation; and saliva secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytosol. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and skeleton. Human ortholog(s) of this gene implicated in angiosarcoma; cerebral infarction; dehydrated hereditary stomatocytosis 2; hypertension; and myocardial infarction. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IK; IK1; IKC; IKCA1; intermediate conductance calcium-activated potassium channel protein 4; KCa3.; KCa3.1; KCA4; mIK1; mIKC; mIKCa1; mKCa4; SK; SK4; SKCa 4; SKCa4; SKCas
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,069,750 - 24,084,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,069,688 - 24,086,115 (+)EnsemblGRCm39 Ensembl
GRCm38724,369,826 - 24,385,212 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,370,263 - 24,386,690 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,155,282 - 25,170,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,079,023 - 24,093,969 (+)NCBIMGSCv36mm8
Celera718,994,758 - 19,009,501 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetohydrazide  (EXP)
acetylcysteine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
aurantio-obtusin  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
calciol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chlorzoxazone  (ISO)
choline  (EXP)
cisplatin  (ISO)
clotrimazole  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
flavonoids  (ISO)
flurbiprofen  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
insulin  (ISO)
inulin  (EXP)
ionomycin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lidocaine  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
monocrotaline  (ISO)
N,N-diethyl-m-toluamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
pirinixic acid  (EXP)
potassium atom  (ISO)
progesterone  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-allylcysteine  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
tamoxifen  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraethylammonium  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
topotecan  (ISO)
TRAM-34  (ISO)
trichloroethene  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (IEA,ISO)
cardiac muscle hypertrophy  (ISO)
cell volume homeostasis  (IMP)
cellular response to hypoxia  (ISO)
establishment of localization in cell  (IMP)
hepatocyte apoptotic process  (ISO)
immune system process  (IEA)
macropinocytosis  (IEA)
monoatomic anion transport  (ISO)
mononuclear cell migration  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell volume  (ISO)
negative regulation of hepatic stellate cell proliferation  (ISO)
phospholipid translocation  (IMP)
positive regulation of G0 to G1 transition  (ISO)
positive regulation of microglial cell activation  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of protein secretion  (IDA)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
potassium ion export across plasma membrane  (ISO)
potassium ion transmembrane transport  (IBA,IDA)
potassium ion transport  (ISO)
protein homotetramerization  (IEA)
regulation of angiotensin levels in blood  (ISO)
regulation of calcium ion import across plasma membrane  (IEA)
regulation of monocyte chemotactic protein-1 production  (ISO)
regulation of renin secretion into blood stream  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to tetrachloromethane  (ISO)
saliva secretion  (IGI)
stabilization of membrane potential  (IEA,ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal colon morphology  (IEA)
abnormal digestive system physiology  (IAGP)
abnormal digit morphology  (IEA)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal joint morphology  (IEA)
abnormal liver morphology  (IEA)
abnormal rectum morphology  (IEA)
abnormal red blood cell deformability  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal skin morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal systemic arterial blood pressure  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal testis morphology  (IEA)
abnormal thymus morphology  (IEA)
abnormal tooth morphology  (IEA)
decreased exploration in new environment  (IEA)
decreased susceptibility to injury  (IAGP)
decreased vasodilation  (IAGP)
enlarged cecum  (IEA)
enlarged spleen  (IAGP)
enlarged testis  (IEA)
enlarged thymus  (IEA)
hydrometra  (IEA)
increased erythrocyte osmotic fragility  (IAGP)
increased fasting circulating glucose level  (IEA)
increased freezing behavior  (IEA)
increased heart weight  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin concentration distribution width  (IAGP)
increased mean corpuscular volume  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased parotid gland size  (IAGP)
increased red blood cell distribution width  (IEA)
increased spleen iron level  (IAGP)
increased spleen weight  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
macrocytosis  (IAGP)
renal interstitial fibrosis  (IAGP)
small heart  (IEA)
small liver  (IEA)
small seminal vesicle  (IEA)
small thymus  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Small-conductance Ca2+-activated K+ channels: form and function. Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
2. miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma. Chen Y, etal., Oncotarget. 2016 Sep 6;7(36):58148-58161. doi: 10.18632/oncotarget.11252.
3. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. Chen YJ, etal., J Cereb Blood Flow Metab. 2011 Dec;31(12):2363-74. doi: 10.1038/jcbfm.2011.101. Epub 2011 Jul 13.
4. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. Chen YJ, etal., J Cereb Blood Flow Metab. 2016 Dec;36(12):2146-2161. doi: 10.1177/0271678X15611434. Epub 2015 Nov 2.
5. The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. Chen YJ, etal., PLoS One. 2013 Nov 29;8(11):e81006. doi: 10.1371/journal.pone.0081006. eCollection 2013.
6. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Chen YJ, etal., Stroke. 2015 Jan;46(1):237-44. doi: 10.1161/STROKEAHA.114.007445. Epub 2014 Dec 4.
7. NADPH oxidase 2-derived superoxide downregulates endothelial KCa3.1 in preeclampsia. Choi S, etal., Free Radic Biol Med. 2013 Apr;57:10-21. doi: 10.1016/j.freeradbiomed.2012.12.009. Epub 2012 Dec 20.
8. Exenatide Inhibits the KCa3.1 Channels of Aortic Vascular Smooth Muscle in Diabetic Rats. Dong P, etal., Acta Cardiol Sin. 2017 Nov;33(6):648-655. doi: 10.6515/ACS20170612B.
9. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
10. Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1. Fei YD, etal., Theranostics. 2019 Aug 14;9(22):6396-6411. doi: 10.7150/thno.34801. eCollection 2019.
11. Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain. Glaser N, etal., Pediatr Diabetes. 2017 Aug;18(5):356-366. doi: 10.1111/pedi.12396. Epub 2016 May 13.
12. Involvement of Ca2+-activated K+ channel 3.1 in hypoxia-induced pulmonary arterial hypertension and therapeutic effects of TRAM-34 in rats. Guo S, etal., Biosci Rep. 2017 Jul 27;37(4):BSR20170763. doi: 10.1042/BSR20170763. Print 2017 Aug 31.
13. High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel. Huang C, etal., PLoS One. 2014 Apr 14;9(4):e95173. doi: 10.1371/journal.pone.0095173. eCollection 2014.
14. The KCa3.1 blocker TRAM34 reverses renal damage in a mouse model of established diabetic nephropathy. Huang C, etal., PLoS One. 2018 Feb 9;13(2):e0192800. doi: 10.1371/journal.pone.0192800. eCollection 2018.
15. Targeting the KCa3.1 channel suppresses diabetes-associated atherosclerosis via the STAT3/CD36 axis. Jiang XX, etal., Diabetes Res Clin Pract. 2022 Mar;185:109776. doi: 10.1016/j.diabres.2022.109776. Epub 2022 Feb 9.
16. Blockade of KCa3.1 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction. Ju CH, etal., Cell Physiol Biochem. 2015;36(4):1305-15. doi: 10.1159/000430298.
17. Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Kang H, etal., Cell Rep. 2014 Aug 21;8(4):1210-24. doi: 10.1016/j.celrep.2014.07.032. Epub 2014 Aug 14.
18. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
19. Modafinil improves monocrotaline-induced pulmonary hypertension rat model. Lee H, etal., Pediatr Res. 2016 Jul;80(1):119-27. doi: 10.1038/pr.2016.38. Epub 2016 Mar 9.
20. Inhibitory effects of candesartan on KCa3.1 potassium channel expression and cell culture and proliferation in peripheral blood CD4+T lymphocytes in Kazakh patients with hypertension from the Xinjiang region. Li H, etal., Clin Exp Hypertens. 2018;40(4):303-311. doi: 10.1080/10641963.2017.1377212. Epub 2018 Feb 1.
21. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. Mauler F, etal., Eur J Neurosci. 2004 Oct;20(7):1761-8. doi: 10.1111/j.1460-9568.2004.03615.x.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
26. Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models. Ongerth T, etal., Eur J Pharmacol. 2014 Oct 5;740:72-80. doi: 10.1016/j.ejphar.2014.06.061. Epub 2014 Jul 10.
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury. Sevelsted Møller L, etal., Sci Rep. 2016 Jun 29;6:28770. doi: 10.1038/srep28770.
30. KCa3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats. She G, etal., J Am Heart Assoc. 2019 Jan 8;8(1):e010418. doi: 10.1161/JAHA.118.010418.
31. Insulin-mediated upregulation of K(Ca)3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle. Su XL, etal., J Mol Cell Cardiol. 2011 Jul;51(1):51-7. doi: 10.1016/j.yjmcc.2011.03.014. Epub 2011 Apr 2.
32. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. Toyama K, etal., J Clin Invest. 2008 Sep;118(9):3025-37. doi: 10.1172/JCI30836.
33. Oxidative stress promotes myocardial fibrosis by upregulating KCa3.1 channel expression in AGT-REN double transgenic hypertensive mice. Wang LP, etal., Pflugers Arch. 2017 Sep;469(9):1061-1071. doi: 10.1007/s00424-017-1984-0. Epub 2017 Apr 28.
34. [Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats]. Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.
35. Molecular and functional characterization of the small Ca(2+)-regulated K+ channel (rSK4) of colonic crypts. Warth R, etal., Pflugers Arch 1999 Sep;438(4):437-44.
36. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
37. Relationship between haplotypes of KCNN4 gene and susceptibility to human vascular diseases in Japanese. Yamaguchi M, etal., Med Sci Monit. 2009 Aug;15(8):CR389-97.
38. The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke. Yi M, etal., J Neuroinflammation. 2017 Oct 16;14(1):203. doi: 10.1186/s12974-017-0973-8.
39. Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathway. Yu Z, etal., J Neurochem. 2014 Jul;130(1):41-49. doi: 10.1111/jnc.12710. Epub 2014 Mar 27.
40. Potassium channel changes of peripheral blood T-lymphocytes from Kazakh hypertensive patients in Northwest China and the inhibition effect towards potassium channels by telmisartan. Zhang Q, etal., Kardiol Pol. 2016;74(5):476-488. doi: 10.5603/KP.a2015.0210. Epub 2015 Oct 27.
41. [Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh]. Zhang QB, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1020-4.
42. The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Zhao LM, etal., Pflugers Arch. 2015 Nov;467(11):2275-85. doi: 10.1007/s00424-015-1694-4. Epub 2015 Feb 27.
Additional References at PubMed
PMID:9705284   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11724775   PMID:12388098   PMID:12477932   PMID:12882916   PMID:14681479   PMID:15347667   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16418402   PMID:16571783   PMID:16873365   PMID:16873714   PMID:16985003   PMID:17070838   PMID:17379640   PMID:17498734   PMID:17584847   PMID:17699636  
PMID:18097031   PMID:18188587   PMID:18195387   PMID:18216162   PMID:18523267   PMID:18815226   PMID:19037656   PMID:19176762   PMID:19218287   PMID:19380617   PMID:19401418   PMID:19523941  
PMID:19574736   PMID:19706538   PMID:19715983   PMID:20080610   PMID:20090940   PMID:20427707   PMID:20696915   PMID:20857305   PMID:20884616   PMID:20956206   PMID:20971723   PMID:21099262  
PMID:21267068   PMID:21308776   PMID:21345794   PMID:21493782   PMID:21691077   PMID:21732368   PMID:21873635   PMID:22005466   PMID:22041182   PMID:22414869   PMID:22621787   PMID:23077667  
PMID:23110108   PMID:23325003   PMID:23492185   PMID:23585521   PMID:23594188   PMID:23656889   PMID:24158513   PMID:24166472   PMID:24177326   PMID:24344200   PMID:24591580   PMID:24674776  
PMID:24858807   PMID:25372486   PMID:25545736   PMID:25704182   PMID:25774850   PMID:25798587   PMID:25865881   PMID:26088577   PMID:26138196   PMID:26418566   PMID:26438401   PMID:26481309  
PMID:26592662   PMID:26627722   PMID:26765773   PMID:26795234   PMID:26820527   PMID:27029904   PMID:27054329   PMID:27163196   PMID:27363720   PMID:27567685   PMID:27696527   PMID:27884747  
PMID:28274924   PMID:28557306   PMID:28705898   PMID:28823609   PMID:28857417   PMID:29143340   PMID:29554088   PMID:29576450   PMID:29915289   PMID:29944670   PMID:29981425   PMID:30207167  
PMID:30808854   PMID:30857243   PMID:31352162   PMID:31470105   PMID:31638180   PMID:31838908   PMID:32150577   PMID:32520608   PMID:32554809   PMID:32814712   PMID:34400625   PMID:34623632  
PMID:34924112   PMID:35658672   PMID:36927341   PMID:36951065   PMID:38134241   PMID:38334149   PMID:38355793  


Genomics

Comparative Map Data
Kcnn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,069,750 - 24,084,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,069,688 - 24,086,115 (+)EnsemblGRCm39 Ensembl
GRCm38724,369,826 - 24,385,212 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,370,263 - 24,386,690 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,155,282 - 25,170,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,079,023 - 24,093,969 (+)NCBIMGSCv36mm8
Celera718,994,758 - 19,009,501 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.37NCBI
KCNN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,766,533 - 43,780,973 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,766,533 - 43,780,976 (-)EnsemblGRCh38hg38GRCh38
GRCh371944,270,685 - 44,285,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,962,525 - 48,977,249 (-)NCBINCBI36Build 36hg18NCBI36
Build 341948,962,524 - 48,977,249NCBI
Celera1941,074,253 - 41,088,976 (-)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,702,891 - 40,717,615 (-)NCBIHuRef
CHM1_11944,272,786 - 44,287,492 (-)NCBICHM1_1
T2T-CHM13v2.01946,589,266 - 46,619,926 (-)NCBIT2T-CHM13v2.0
Kcnn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,084,306 - 89,102,279 (+)NCBIGRCr8
mRatBN7.2179,956,380 - 79,974,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,959,322 - 79,974,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,353,007 - 85,367,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,902,801 - 93,917,830 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,108,816 - 87,123,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,227,855 - 81,245,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,230,612 - 81,245,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,490,768 - 82,508,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,613,736 - 79,628,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,691,846 - 79,706,998 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBICelera
Cytogenetic Map1q21NCBI
Kcnn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,490,052 - 1,509,113 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,493,600 - 1,509,113 (-)NCBIChiLan1.0ChiLan1.0
KCNN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22049,929,192 - 49,945,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11951,801,737 - 51,819,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01940,715,621 - 40,735,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11949,321,403 - 49,335,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,321,403 - 49,335,900 (-)Ensemblpanpan1.1panPan2
KCNN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,391,464 - 111,407,612 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,391,159 - 111,407,701 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,871,521 - 110,887,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,964,804 - 111,980,983 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,968,172 - 111,980,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,590,240 - 111,606,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,224,067 - 111,240,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,107,905 - 112,124,068 (+)NCBIUU_Cfam_GSD_1.0
Kcnn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,593,227 - 16,605,448 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936706940,585 - 952,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,580,022 - 50,593,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,580,016 - 50,593,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,440,884 - 46,454,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,289,088 - 37,316,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607316,833,196 - 16,851,561 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,266,348 - 1,278,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,266,348 - 1,279,258 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnn4
1060 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:166
Interacting mature miRNAs:183
Transcripts:ENSMUST00000171904
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
Kcnn4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS
AF042487  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38724,384,736 - 24,384,860UniSTSGRCm38
MGSCv37725,169,755 - 25,169,879UniSTSGRCm37
Celera719,009,025 - 19,009,149UniSTS
Cytogenetic Map7A3UniSTS
Whitehead/MRC_RH7308.8UniSTS
Kcnn4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB128930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX639773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY197732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC874395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000171904   ⟹   ENSMUSP00000133065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,069,724 - 24,084,626 (+)Ensembl
GRCm38.p6 Ensembl724,370,299 - 24,385,201 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205428   ⟹   ENSMUSP00000146012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,069,688 - 24,084,630 (+)Ensembl
GRCm38.p6 Ensembl724,370,263 - 24,385,205 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205626   ⟹   ENSMUSP00000145873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,069,763 - 24,084,184 (+)Ensembl
GRCm38.p6 Ensembl724,370,338 - 24,384,759 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205881
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,081,595 - 24,084,214 (+)Ensembl
GRCm38.p6 Ensembl724,382,170 - 24,384,789 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,082,479 - 24,086,115 (+)Ensembl
GRCm38.p6 Ensembl724,383,054 - 24,386,690 (+)Ensembl
RefSeq Acc Id: NM_001163510   ⟹   NP_001156982
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
GRCm38724,370,263 - 24,385,212 (+)NCBI
MGSCv37725,155,282 - 25,170,231 (+)RGD
Celera718,994,758 - 19,009,501 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001412606   ⟹   NP_001399535
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NM_001412607   ⟹   NP_001399536
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NM_001412608   ⟹   NP_001399537
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NM_001412609   ⟹   NP_001399538
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NM_008433   ⟹   NP_032459
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
GRCm38724,370,263 - 24,385,212 (+)NCBI
MGSCv37725,155,282 - 25,170,231 (+)RGD
Celera718,994,758 - 19,009,501 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_182004
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NR_182005
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NR_182006
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NR_182007
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,069,750 - 24,084,635 (+)NCBI
RefSeq Acc Id: NP_032459   ⟸   NM_008433
- Peptide Label: isoform a
- UniProtKB: Q3U1J8 (UniProtKB/Swiss-Prot),   Q9CY39 (UniProtKB/Swiss-Prot),   O89109 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156982   ⟸   NM_001163510
- Peptide Label: isoform a
- UniProtKB: Q3U1J8 (UniProtKB/Swiss-Prot),   Q9CY39 (UniProtKB/Swiss-Prot),   O89109 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000133065   ⟸   ENSMUST00000171904
Ensembl Acc Id: ENSMUSP00000146012   ⟸   ENSMUST00000205428
Ensembl Acc Id: ENSMUSP00000145873   ⟸   ENSMUST00000205626
RefSeq Acc Id: NP_001399535   ⟸   NM_001412606
- Peptide Label: isoform a
- UniProtKB: Q3U1J8 (UniProtKB/Swiss-Prot),   O89109 (UniProtKB/Swiss-Prot),   Q9CY39 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001399538   ⟸   NM_001412609
- Peptide Label: isoform b
RefSeq Acc Id: NP_001399536   ⟸   NM_001412607
- Peptide Label: isoform b
RefSeq Acc Id: NP_001399537   ⟸   NM_001412608
- Peptide Label: isoform c
Protein Domains
Calmodulin-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89109-F1-model_v2 AlphaFold O89109 1-425 view protein structure

Promoters
RGD ID:6892176
Promoter ID:EPDNEW_M9539
Type:initiation region
Name:Kcnn4_1
Description:Mus musculus potassium intermediate/small conductance calcium-activatedchannel, subfamily N, member 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38724,370,325 - 24,370,385EPDNEW
RGD ID:6841382
Promoter ID:MM_KWN:49363
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_001163510,   NM_008433
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,154,939 - 25,155,439 (+)MPROMDB
RGD ID:6848158
Promoter ID:MM_ACW:43837
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:KCNN4.ESEP07,   KCNN4.GSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,167,111 - 25,167,611 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277957 AgrOrtholog
Ensembl Genes ENSMUSG00000054342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000171904 ENTREZGENE
  ENSMUST00000171904.3 UniProtKB/Swiss-Prot
  ENSMUST00000205428 ENTREZGENE
  ENSMUST00000205428.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
InterPro CaM-bd_dom UniProtKB/Swiss-Prot
  CaM-bd_dom_sf UniProtKB/Swiss-Prot
  K_chnl_Ca-activ_SK UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot
KEGG Report mmu:16534 UniProtKB/Swiss-Prot
MGD MGI:1277957 ENTREZGENE
NCBI Gene 16534 ENTREZGENE
PANTHER PTHR10153 UniProtKB/Swiss-Prot
Pfam CaMBD UniProtKB/Swiss-Prot
  Ion_trans_2 UniProtKB/Swiss-Prot
  SK_channel UniProtKB/Swiss-Prot
PhenoGen Kcnn4 PhenoGen
SMART CaMBD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81327 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0U1RP82_MOUSE UniProtKB/TrEMBL
  D1MQ07_MOUSE UniProtKB/TrEMBL
  KCNN4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U1J8 ENTREZGENE
  Q8C2E0_MOUSE UniProtKB/TrEMBL
  Q9CY39 ENTREZGENE
UniProt Secondary Q3U1J8 UniProtKB/Swiss-Prot
  Q9CY39 UniProtKB/Swiss-Prot