Kcnn1 (potassium calcium-activated channel subfamily N member 1) - Rat Genome Database

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Gene: Kcnn1 (potassium calcium-activated channel subfamily N member 1) Rattus norvegicus
Analyze
Symbol: Kcnn1
Name: potassium calcium-activated channel subfamily N member 1
RGD ID: 2962
Description: Enables small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KCa2.1; LOC100360811; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like; SK1; SKCa 1; SKCa1; small conductance calcium-activated potassium channel protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,608,782 - 18,632,571 (+)NCBIGRCr8
mRatBN7.21618,574,858 - 18,598,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,585,992 - 18,597,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,628,268 - 18,639,511 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,760,948 - 19,772,191 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,681,212 - 18,692,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,325,270 - 20,349,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,336,638 - 20,348,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,194,340 - 20,206,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11619,093,437 - 19,103,818 (+)NCBI
Celera1618,778,700 - 18,789,456 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small-conductance Ca2+-activated K+ channels: form and function. Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Joiner WJ, etal., Proc Natl Acad Sci U S A 1997 Sep 30;94(20):11013-8.
5. Small-conductance, calcium-activated potassium channels from mammalian brain. Kohler M, etal., Science 1996 Sep 20;273(5282):1709-14.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. Monaghan AS, etal., J Biol Chem 2004 Jan 9;279(2):1003-9. Epub 2003 Oct 14.
8. The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system. Mongan LC, etal., Neuroscience. 2005;131(1):161-75.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Noble K, etal., Cell Calcium. 2010 Jan;47(1):47-54. doi: 10.1016/j.ceca.2009.11.004. Epub 2009 Dec 6.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11267657   PMID:14761961   PMID:16055520   PMID:16641100   PMID:19101546   PMID:19254702   PMID:22647293   PMID:24096910   PMID:24841382   PMID:31001092   PMID:31276786  


Genomics

Comparative Map Data
Kcnn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,608,782 - 18,632,571 (+)NCBIGRCr8
mRatBN7.21618,574,858 - 18,598,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,585,992 - 18,597,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,628,268 - 18,639,511 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,760,948 - 19,772,191 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,681,212 - 18,692,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,325,270 - 20,349,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,336,638 - 20,348,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,194,340 - 20,206,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11619,093,437 - 19,103,818 (+)NCBI
Celera1618,778,700 - 18,789,456 (+)NCBICelera
Cytogenetic Map16p14NCBI
KCNN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,951,290 - 18,000,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,951,293 - 18,000,085 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,062,099 - 18,110,894 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,923,111 - 17,970,930 (+)NCBINCBI36Build 36hg18NCBI36
Build 341917,923,110 - 17,970,930NCBI
Celera1917,963,835 - 18,011,634 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,627,350 - 17,675,149 (+)NCBIHuRef
CHM1_11918,061,819 - 18,109,567 (+)NCBICHM1_1
T2T-CHM13v2.01918,085,382 - 18,134,163 (+)NCBIT2T-CHM13v2.0
Kcnn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,295,802 - 71,318,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,294,693 - 71,315,902 (-)EnsemblGRCm39 Ensembl
GRCm38870,843,158 - 70,865,691 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,842,049 - 70,863,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,365,948 - 73,380,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,772,147 - 73,784,574 (-)NCBIMGSCv36mm8
Celera873,403,345 - 73,418,311 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.27NCBI
Kcnn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,322,551 - 3,344,346 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,323,188 - 3,344,321 (-)NCBIChiLan1.0ChiLan1.0
KCNN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,813,690 - 22,859,843 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,820,499 - 21,868,525 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,430,795 - 17,478,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,405,077 - 18,455,686 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,422,231 - 18,458,630 (+)Ensemblpanpan1.1panPan2
KCNN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,939,619 - 44,971,923 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,939,603 - 44,969,020 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,852,263 - 44,883,423 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,424,541 - 45,455,928 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,424,773 - 45,454,118 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,661,785 - 44,685,096 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,071,928 - 45,103,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,347,879 - 45,379,261 (-)NCBIUU_Cfam_GSD_1.0
Kcnn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,558,492 - 203,574,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,107,925 - 3,123,942 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,107,631 - 3,123,433 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,780,013 - 59,817,059 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,780,010 - 59,814,815 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,348,738 - 59,385,538 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,440,908 - 16,470,613 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,448,038 - 16,472,319 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,908,764 - 2,956,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,442,553 - 1,451,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,438,592 - 1,451,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnn1
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:78
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000044291
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH141952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,597,417 - 18,597,604 (+)MAPPERmRatBN7.2
Rnor_6.01620,348,001 - 20,348,187NCBIRnor6.0
Rnor_5.01620,205,099 - 20,205,285UniSTSRnor5.0
RGSC_v3.41619,103,865 - 19,104,051UniSTSRGSC3.4
Celera1618,789,501 - 18,789,687UniSTS
RH 3.4 Map16182.5UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001841544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001841545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF000973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ137426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044291   ⟹   ENSRNOP00000042517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,586,118 - 18,597,482 (+)Ensembl
Rnor_6.0 Ensembl1620,336,817 - 20,347,956 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080467   ⟹   ENSRNOP00000073862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,585,992 - 18,597,482 (+)Ensembl
Rnor_6.0 Ensembl1620,336,638 - 20,348,804 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112622   ⟹   ENSRNOP00000084680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,586,118 - 18,597,482 (+)Ensembl
RefSeq Acc Id: NM_019313   ⟹   NP_062186
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,610,769 - 18,632,571 (+)NCBI
mRatBN7.21618,576,779 - 18,598,585 (+)NCBI
Rnor_6.01620,336,817 - 20,347,956 (+)NCBI
Rnor_5.01620,194,340 - 20,206,261 (+)NCBI
Celera1618,778,700 - 18,789,456 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094789   ⟹   XP_038950717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,632,566 (+)NCBI
mRatBN7.21618,574,862 - 18,597,780 (+)NCBI
RefSeq Acc Id: XM_063275658   ⟹   XP_063131728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,618,284 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275659   ⟹   XP_063131729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275660   ⟹   XP_063131730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275661   ⟹   XP_063131731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275662   ⟹   XP_063131732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275663   ⟹   XP_063131733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275664   ⟹   XP_063131734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,611,590 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275665   ⟹   XP_063131735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,611,590 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275666   ⟹   XP_063131736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,618,277 - 18,632,566 (+)NCBI
RefSeq Acc Id: XM_063275667   ⟹   XP_063131737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,784 - 18,632,566 (+)NCBI
RefSeq Acc Id: XR_005494662
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,790 - 18,631,183 (+)NCBI
mRatBN7.21618,574,862 - 18,597,265 (+)NCBI
RefSeq Acc Id: XR_005494664
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,782 - 18,631,183 (+)NCBI
mRatBN7.21618,574,858 - 18,597,265 (+)NCBI
RefSeq Acc Id: XR_010058309
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,610,757 - 18,631,184 (+)NCBI
RefSeq Acc Id: XR_010058310
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,608,782 - 18,631,184 (+)NCBI
RefSeq Acc Id: NP_062186   ⟸   NM_019313
- UniProtKB: P70606 (UniProtKB/Swiss-Prot),   A0A8I6A039 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073862   ⟸   ENSRNOT00000080467
Ensembl Acc Id: ENSRNOP00000042517   ⟸   ENSRNOT00000044291
RefSeq Acc Id: XP_038950717   ⟸   XM_039094789
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QL77 (UniProtKB/TrEMBL),   A0A8I6A039 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084680   ⟸   ENSRNOT00000112622
RefSeq Acc Id: XP_063131737   ⟸   XM_063275667
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131730   ⟸   XM_063275660
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131729   ⟸   XM_063275659
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131733   ⟸   XM_063275663
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131731   ⟸   XM_063275661
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131732   ⟸   XM_063275662
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131735   ⟸   XM_063275665
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131734   ⟸   XM_063275664
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131736   ⟸   XM_063275666
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131728   ⟸   XM_063275658
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A039 (UniProtKB/TrEMBL),   A0A8L2QL77 (UniProtKB/TrEMBL)
Protein Domains
Calmodulin-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70606-F1-model_v2 AlphaFold P70606 1-536 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2962 AgrOrtholog
BioCyc Gene G2FUF-11812 BioCyc
Ensembl Genes ENSRNOG00000029264 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055010288 UniProtKB/Swiss-Prot
  ENSRNOG00060010593 UniProtKB/Swiss-Prot
  ENSRNOG00065023871 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044291.4 UniProtKB/TrEMBL
  ENSRNOT00000080467.2 UniProtKB/TrEMBL
  ENSRNOT00000112622.1 UniProtKB/TrEMBL
  ENSRNOT00055017398 UniProtKB/Swiss-Prot
  ENSRNOT00060017942 UniProtKB/Swiss-Prot
  ENSRNOT00065041005 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CaM-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CaM-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Ca-activ_SK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54261 UniProtKB/Swiss-Prot
NCBI Gene 54261 ENTREZGENE
PANTHER PTHR10153 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CaMBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SK_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnn1 PhenoGen
PRINTS SKCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029264 RatGTEx
  ENSRNOG00055010288 RatGTEx
  ENSRNOG00060010593 RatGTEx
  ENSRNOG00065023871 RatGTEx
SMART CaMBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208895
UniProt A0A0G2K6L7_RAT UniProtKB/TrEMBL
  A0A8I6A039 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QL77 ENTREZGENE, UniProtKB/TrEMBL
  A6K9Z3_RAT UniProtKB/TrEMBL
  A6K9Z4_RAT UniProtKB/TrEMBL
  KCNN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnn1  potassium calcium-activated channel subfamily N member 1  Kcnn1  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnn1  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1  Kcnn1  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Kcnn1  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1  LOC100360811  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like  Data merged from RGD:2321347 737654 PROVISIONAL
2010-05-05 LOC100360811  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Kcnn1  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a leucine zipper-like domain 729207
gene_process may contribute to the afterhyperpolarization in central neurons 69872