RGD Reference Report - [Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh]. - Rat Genome Database

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[Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh].

Authors: Zhang, Qiu-bing  Zhang, Yuan-ming  Cheng, Lu-feng  Yuan, Qing-yan  Zhang, Gui-ming  Liang, Ping  Gou, Fang 
Citation: Zhang QB, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1020-4.
RGD ID: 401794566
Pubmed: PMID:24524604   (View Abstract at PubMed)


OBJECTIVE: To observe the current changes of voltage-dependent potassium channel (Kv1.3 potassium channel) and calcium-activated potassium channel (IKCa1 potassium channel) in peripheral blood T-lymphocyte derived from hypertensive patients of Xinjiang Kazakh.
METHODS: Twenty randomly selected untreated Kazakh hypertensive patients and 20 Kazakh healthy subjects from Xinjiang were included in this study. T-lymphocytes were isolated from peripheral blood with magnetic cell sorting, the whole-cell currents of Kv1.3 and IKCa1 potassium channels were recorded with patch-clamp technique.
RESULTS: (1) The current density of Kv1.3 potassium channel was significantly higher in the hypertensive group [(280 ± 74) pA/pF (n = 39)] than that in the control group [(179 ± 51) pA/pF (n = 38), P < 0.01], while the membrane capacitance was similar between the two groups. (2) The current density of IKCa1 potassium channel was also significantly higher in the hypertensive group [(198 ± 44) pA/pF (n = 28)] than that in the control group [(124 ± 43) pA/pF (n = 26), P < 0.01], while the membrane capacitance was also similar between the two groups.
CONCLUSIONS: The T-lymphocytes Kv1.3 potassium channel and IKCa1 potassium channel current densities are higher in hypertensive patients in Xinjiang Kazakh suggesting a potential role of Kv1.3 and IKCa1 potassium channels activation in the pathophysiology of hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KCNA3Humanhypertension  IEP protein:increased activity:T cell (human)RGD 
KCNN4Humanhypertension  IEP protein:increased activity:T cell (human)RGD 
Kcna3Rathypertension  ISOKCNA3 (Homo sapiens)protein:increased activity:T cell (human)RGD 
Kcna3Mousehypertension  ISOKCNA3 (Homo sapiens)protein:increased activity:T cell (human)RGD 
Kcnn4Rathypertension  ISOKCNN4 (Homo sapiens)protein:increased activity:T cell (human)RGD 
Kcnn4Mousehypertension  ISOKCNN4 (Homo sapiens)protein:increased activity:T cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcna3  (potassium voltage-gated channel subfamily A member 3)
Kcnn4  (potassium calcium-activated channel subfamily N member 4)

Genes (Mus musculus)
Kcna3  (potassium voltage-gated channel, shaker-related subfamily, member 3)
Kcnn4  (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4)

Genes (Homo sapiens)
KCNA3  (potassium voltage-gated channel subfamily A member 3)
KCNN4  (potassium calcium-activated channel subfamily N member 4)


Additional Information