RGD Reference Report - Small-conductance Ca2+-activated K+ channels: form and function. - Rat Genome Database

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Small-conductance Ca2+-activated K+ channels: form and function.

Authors: Adelman, JP  Maylie, J  Sah, P 
Citation: Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
RGD ID: 7204683
Pubmed: PMID:21942705   (View Abstract at PubMed)
DOI: DOI:10.1146/annurev-physiol-020911-153336   (Journal Full-text)

Small-conductance Ca(2+)-activated K(+) channels (SK channels) are widely expressed throughout the central nervous system. These channels are activated solely by increases in intracellular Ca(2+). SK channels are stable macromolecular complexes of the ion pore-forming subunits with calmodulin, which serves as the intrinsic Ca(2+) gating subunit, as well as with protein kinase CK2 and protein phosphatase 2A, which modulate Ca(2+) sensitivity. Well-known for their roles in regulating somatic excitability in central neurons, SK channels are also expressed in the postsynaptic membrane of glutamatergic synapses, where their activation and regulated trafficking modulate synaptic transmission and the induction and expression of synaptic plasticity, thereby affecting learning and memory. In this review we discuss the molecular and functional properties of SK channels and their physiological roles in central neurons.



Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Kcnn1  (potassium calcium-activated channel subfamily N member 1)
Kcnn2  (potassium calcium-activated channel subfamily N member 2)
Kcnn3  (potassium calcium-activated channel subfamily N member 3)
Kcnn4  (potassium calcium-activated channel subfamily N member 4)

Genes (Mus musculus)
Kcnn1  (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1)
Kcnn2  (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2)
Kcnn3  (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3)
Kcnn4  (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4)

Genes (Homo sapiens)
KCNN1  (potassium calcium-activated channel subfamily N member 1)
KCNN2  (potassium calcium-activated channel subfamily N member 2)
KCNN3  (potassium calcium-activated channel subfamily N member 3)
KCNN4  (potassium calcium-activated channel subfamily N member 4)


Additional Information