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Gene: KCNN1 (potassium calcium-activated channel subfamily N member 1) Homo sapiens
Symbol: KCNN1
Name: potassium calcium-activated channel subfamily N member 1
Description: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hSK1; KCa2.1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; SK1; SKCa 1; SKCA1; small conductance calcium-activated potassium channel 1; small conductance calcium-activated potassium channel protein 1; small-conductance calcium-activated potassium channel
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381917,951,302 - 17,999,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,062,111 - 18,110,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,923,111 - 17,970,930 (+)NCBINCBI36hg18NCBI36
Build 341917,923,110 - 17,970,930NCBI
Celera1917,963,835 - 18,011,634 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,627,350 - 17,675,149 (+)NCBIHuRef
CHM1_11918,061,819 - 18,109,567 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731634
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.