Kcnn3 (potassium calcium-activated channel subfamily N member 3) - Rat Genome Database

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Gene: Kcnn3 (potassium calcium-activated channel subfamily N member 3) Rattus norvegicus
Analyze
Symbol: Kcnn3
Name: potassium calcium-activated channel subfamily N member 3
RGD ID: 2964
Description: Enables small conductance calcium-activated potassium channel activity. Involved in potassium ion transport. Located in filopodium; neuromuscular junction; and neuronal cell body. Human ortholog(s) of this gene implicated in paranoid schizophrenia and schizophrenia. Orthologous to human KCNN3 (potassium calcium-activated channel subfamily N member 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; schizophrenia pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; SKCa3; small conductance calcium-activated potassium channel protein 3; small-conductance Ca2+-activated K+ channel 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,929,846 - 175,088,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,936,629 - 175,081,145 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2182,082,045 - 182,226,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,104,430 - 180,248,869 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,705,175 - 174,849,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,837,280 - 188,991,794 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,844,073 - 188,988,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,267,083 - 208,411,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,715,888 - 181,860,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,665,999 - 181,810,563 (+)NCBI
Celera2168,877,193 - 169,021,955 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small-conductance Ca2+-activated K+ channels: form and function. Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
2. Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3. Barfod ET, etal., Am J Physiol Cell Physiol 2001 Apr;280(4):C836-42.
3. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Bowen T, etal., Mol Psychiatry 1998 May;3(3):266-9.
4. Expression of Ca(2+)-activated K(+) channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract. Fujita A, etal., Am J Physiol Cell Physiol 2001 Nov;281(5):C1727-33.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. Hosseini R, etal., J Physiol 2001 Sep 1;535(Pt 2):323-34.
7. Small-conductance, calcium-activated potassium channels from mammalian brain. Kohler M, etal., Science 1996 Sep 20;273(5282):1709-14.
8. Formation of cellular projections in neural progenitor cells depends on SK3 channel activity. Liebau S, etal., J Neurochem. 2007 Jun;101(5):1338-1350.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. Monaghan AS, etal., J Biol Chem 2004 Jan 9;279(2):1003-9. Epub 2003 Oct 14.
11. The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system. Mongan LC, etal., Neuroscience. 2005;131(1):161-75.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Noble K, etal., Cell Calcium. 2010 Jan;47(1):47-54. doi: 10.1016/j.ceca.2009.11.004. Epub 2009 Dec 6.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia. Ritsner M, etal., Biol Psychiatry 2002 May 15;51(10):788-94.
18. Presynaptic localization of the small conductance calcium-activated potassium channel SK3 at the neuromuscular junction. Roncarati R, etal., Neuroscience. 2001;104(1):253-62.
Additional References at PubMed
PMID:14638680   PMID:15170822   PMID:16055520   PMID:16134141   PMID:16627563   PMID:17167222   PMID:18703580   PMID:19254702   PMID:20364152   PMID:20369552   PMID:20662937   PMID:21464958  
PMID:23129791   PMID:23966325   PMID:24096910   PMID:24270810   PMID:24505302   PMID:25096234   PMID:25148577   PMID:28342809   PMID:29038048   PMID:29952429   PMID:30361965   PMID:31155282  
PMID:34233598  


Genomics

Comparative Map Data
Kcnn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,929,846 - 175,088,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,936,629 - 175,081,145 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2182,082,045 - 182,226,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,104,430 - 180,248,869 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,705,175 - 174,849,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,837,280 - 188,991,794 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,844,073 - 188,988,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,267,083 - 208,411,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,715,888 - 181,860,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,665,999 - 181,810,563 (+)NCBI
Celera2168,877,193 - 169,021,955 (+)NCBICelera
Cytogenetic Map2q34NCBI
KCNN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,697,455 - 154,870,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1154,697,455 - 154,870,281 (-)EnsemblGRCh38hg38GRCh38
GRCh371154,669,931 - 154,842,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361152,946,526 - 153,109,378 (-)NCBINCBI36Build 36hg18NCBI36
Build 341151,492,989 - 151,645,411NCBI
Celera1127,751,520 - 127,913,779 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1126,032,908 - 126,048,980 (-)NCBIHuRef
HuRef1126,060,322 - 126,204,704 (-)NCBIHuRef
CHM1_11156,066,361 - 156,239,140 (-)NCBICHM1_1
T2T-CHM13v2.01153,834,568 - 154,009,637 (-)NCBIT2T-CHM13v2.0
Kcnn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,427,471 - 89,579,801 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,427,471 - 89,582,439 (+)EnsemblGRCm39 Ensembl
GRCm38389,520,164 - 89,672,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,520,164 - 89,675,132 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,324,086 - 89,476,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,606,348 - 89,753,332 (+)NCBIMGSCv36mm8
Celera389,555,070 - 89,707,910 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.16NCBI
Kcnn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,216,650 - 1,374,270 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,212,240 - 1,374,189 (-)NCBIChiLan1.0ChiLan1.0
KCNN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1194,702,198 - 94,873,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,052,903 - 130,218,977 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,666,849 - 133,828,679 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,666,876 - 133,828,366 (-)Ensemblpanpan1.1panPan2
KCNN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,562,500 - 42,704,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,572,432 - 42,698,047 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,063,572 - 42,196,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,442,589 - 42,575,584 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,442,641 - 42,568,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,222,259 - 42,355,157 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,275,911 - 42,408,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,559,462 - 42,692,483 (+)NCBIUU_Cfam_GSD_1.0
Kcnn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,240,985 - 25,395,768 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,277,217 - 4,426,493 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365804,277,219 - 4,426,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,915,965 - 95,113,275 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,913,631 - 95,112,845 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,700,718 - 103,872,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,961,833 - 9,124,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,962,302 - 9,124,166 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,298,278 - 8,463,050 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,597,466 - 2,726,363 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,597,605 - 2,731,598 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnn3
738 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:28
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000028117
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
D2Wox58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,936,981 - 174,937,201 (+)MAPPERmRatBN7.2
Rnor_6.02188,844,457 - 188,844,676NCBIRnor6.0
Rnor_5.02208,267,436 - 208,267,655UniSTSRnor5.0
RGSC_v3.42181,716,241 - 181,716,460UniSTSRGSC3.4
Celera2168,877,546 - 168,877,765UniSTS
Cytogenetic Map2q34UniSTS
G16005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,937,074 - 174,937,326 (+)MAPPERmRatBN7.2
Rnor_6.02188,844,550 - 188,844,801NCBIRnor6.0
Rnor_5.02208,267,529 - 208,267,780UniSTSRnor5.0
RGSC_v3.42181,716,334 - 181,716,585UniSTSRGSC3.4
Celera2168,877,639 - 168,877,890UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 5
Low 3 35 16 4 15 4 8 11 58 28 34 11 8
Below cutoff 8 17 13 4 13 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF284345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF292389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ137428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028117   ⟹   ENSRNOP00000028117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,936,629 - 175,081,145 (+)Ensembl
Rnor_6.0 Ensembl2188,844,073 - 188,988,774 (+)Ensembl
RefSeq Acc Id: NM_019315   ⟹   NP_062188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,936,629 - 175,081,155 (+)NCBI
Rnor_6.02188,844,104 - 188,988,598 (+)NCBI
Rnor_5.02208,267,083 - 208,411,812 (+)NCBI
RGSC_v3.42181,715,888 - 181,860,459 (+)RGD
Celera2168,877,193 - 169,021,955 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591053   ⟹   XP_017446542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,929,846 - 175,088,910 (+)NCBI
Rnor_6.02188,837,280 - 188,991,794 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102982   ⟹   XP_038958910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,936,580 - 175,088,910 (+)NCBI
RefSeq Acc Id: XM_039102983   ⟹   XP_038958911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,938,338 - 175,088,910 (+)NCBI
RefSeq Acc Id: XM_039102985   ⟹   XP_038958913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,961,665 - 175,088,910 (+)NCBI
RefSeq Acc Id: XM_039102986   ⟹   XP_038958914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,938,340 - 175,088,910 (+)NCBI
RefSeq Acc Id: XM_039102987   ⟹   XP_038958915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,941,259 - 175,088,910 (+)NCBI
RefSeq Acc Id: XM_039102988   ⟹   XP_038958916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,939,706 - 175,088,910 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062188   ⟸   NM_019315
- UniProtKB: Q9ERQ4 (UniProtKB/Swiss-Prot),   Q9EQ81 (UniProtKB/Swiss-Prot),   P70605 (UniProtKB/Swiss-Prot),   G3V8S7 (UniProtKB/TrEMBL),   A6J6H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446542   ⟸   XM_017591053
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000028117   ⟸   ENSRNOT00000028117
RefSeq Acc Id: XP_038958910   ⟸   XM_039102982
- Peptide Label: isoform X1
- UniProtKB: Q9ERQ4 (UniProtKB/Swiss-Prot),   Q9EQ81 (UniProtKB/Swiss-Prot),   P70605 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038958911   ⟸   XM_039102983
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958914   ⟸   XM_039102986
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958916   ⟸   XM_039102988
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958915   ⟸   XM_039102987
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958913   ⟸   XM_039102985
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70605-F1-model_v2 AlphaFold P70605 1-732 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2964 AgrOrtholog
BioCyc Gene G2FUF-52401 BioCyc
Ensembl Genes ENSRNOG00000020706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028117 ENTREZGENE
  ENSRNOP00000028117.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028117 ENTREZGENE
  ENSRNOT00000028117.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CaM-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CaM-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Ca-activ_SK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54263 UniProtKB/Swiss-Prot
NCBI Gene 54263 ENTREZGENE
PANTHER PTHR10153 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CaMBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SK_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnn3 PhenoGen
PRINTS SKCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CaMBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP beta-sandwich domain of Sec23/24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J6H0 ENTREZGENE, UniProtKB/TrEMBL
  A6J6H1_RAT UniProtKB/TrEMBL
  G3V8S7 ENTREZGENE, UniProtKB/TrEMBL
  KCNN3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9EQ81 ENTREZGENE
  Q9ERQ4 ENTREZGENE
UniProt Secondary Q9EQ81 UniProtKB/Swiss-Prot
  Q9ERQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnn3  potassium calcium-activated channel subfamily N member 3  Kcnn3  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnn3  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3  Kcnn3  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnn3  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cell bodies and processes of neurons 727322
gene_expression protein expressed in the interstitial cells of Cajal (ICC), myenteric plexus and muscular layers of the stomach, ileum, and colon; mRNA expressed in the brain 628451
gene_process may mediate a rhythmic pacemaker current in the gastrointestinal (GI) tract 628451