KCNN4 (potassium calcium-activated channel subfamily N member 4) - Rat Genome Database

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Gene: KCNN4 (potassium calcium-activated channel subfamily N member 4) Sus scrofa
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Symbol: KCNN4
Name: potassium calcium-activated channel subfamily N member 4
RGD ID: 14211762
Description: ENCODES a protein that exhibits intermediate conductance calcium-activated potassium channel activity (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cardiac muscle hypertrophy (ortholog); cellular response to hypoxia (ortholog); hepatocyte apoptotic process (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Acute Subdural Hematoma (ortholog); angiosarcoma (ortholog); atherosclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); neuronal cell body (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: intermediate conductance calcium-activated potassium channel protein 4; intermediate-conductance calcium-activated potassium channel; KCa3.1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,580,022 - 50,593,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,580,016 - 50,593,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,440,884 - 46,454,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (IEA)
cardiac muscle hypertrophy  (ISO)
cell volume homeostasis  (IEA)
cellular response to hypoxia  (ISO)
establishment of localization in cell  (IEA)
hepatocyte apoptotic process  (ISO)
macropinocytosis  (IEA)
monoatomic anion transport  (ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
mononuclear cell migration  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell volume  (ISO)
negative regulation of hepatic stellate cell proliferation  (ISO)
phospholipid translocation  (IEA)
positive regulation of G0 to G1 transition  (ISO)
positive regulation of microglial cell activation  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of protein secretion  (IEA)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell receptor signaling pathway  (IEA)
potassium ion export across plasma membrane  (ISO)
potassium ion transmembrane transport  (IBA,IEA)
potassium ion transport  (IEA,ISO)
protein homotetramerization  (IEA)
regulation of angiotensin levels in blood  (ISO)
regulation of calcium ion import across plasma membrane  (IEA)
regulation of monocyte chemotactic protein-1 production  (ISO)
regulation of renin secretion into blood stream  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to tetrachloromethane  (ISO)
saliva secretion  (IEA)
stabilization of membrane potential  (IEA)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12466245   PMID:18309114   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,580,022 - 50,593,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,580,016 - 50,593,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,440,884 - 46,454,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,766,533 - 43,780,973 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,766,533 - 43,780,976 (-)EnsemblGRCh38hg38GRCh38
GRCh371944,270,685 - 44,285,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,962,525 - 48,977,249 (-)NCBINCBI36Build 36hg18NCBI36
Build 341948,962,524 - 48,977,249NCBI
Celera1941,074,253 - 41,088,976 (-)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,702,891 - 40,717,615 (-)NCBIHuRef
CHM1_11944,272,786 - 44,287,492 (-)NCBICHM1_1
T2T-CHM13v2.01946,589,266 - 46,619,926 (-)NCBIT2T-CHM13v2.0
Kcnn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,069,750 - 24,084,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,069,688 - 24,086,115 (+)EnsemblGRCm39 Ensembl
GRCm38724,369,826 - 24,385,212 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,370,263 - 24,386,690 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,155,282 - 25,170,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,079,023 - 24,093,969 (+)NCBIMGSCv36mm8
Celera718,994,758 - 19,009,501 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.37NCBI
Kcnn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,084,306 - 89,102,279 (+)NCBIGRCr8
mRatBN7.2179,956,380 - 79,974,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,959,322 - 79,974,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,353,007 - 85,367,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,902,801 - 93,917,830 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,108,816 - 87,123,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,227,855 - 81,245,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,230,612 - 81,245,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,490,768 - 82,508,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,613,736 - 79,628,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,691,846 - 79,706,998 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBICelera
Cytogenetic Map1q21NCBI
Kcnn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,490,052 - 1,509,113 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,493,600 - 1,509,113 (-)NCBIChiLan1.0ChiLan1.0
KCNN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22049,929,192 - 49,945,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11951,801,737 - 51,819,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01940,715,621 - 40,735,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11949,321,403 - 49,335,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,321,403 - 49,335,900 (-)Ensemblpanpan1.1panPan2
KCNN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,391,464 - 111,407,612 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,391,159 - 111,407,701 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,871,521 - 110,887,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,964,804 - 111,980,983 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,968,172 - 111,980,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,590,240 - 111,606,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,224,067 - 111,240,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,107,905 - 112,124,068 (+)NCBIUU_Cfam_GSD_1.0
Kcnn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,593,227 - 16,605,448 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936706940,585 - 952,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,289,088 - 37,316,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607316,833,196 - 16,851,561 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,266,348 - 1,278,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,266,348 - 1,279,258 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNN4
212 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 5 1 2 6 2 5 1 3 2

Sequence


Ensembl Acc Id: ENSSSCT00000003406   ⟹   ENSSSCP00000003323
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl650,580,022 - 50,593,544 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000082543   ⟹   ENSSSCP00000067661
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl650,580,022 - 50,593,544 (-)Ensembl
RefSeq Acc Id: NM_214018   ⟹   NP_999183
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1650,580,016 - 50,593,518 (-)NCBI
Sequence:
RefSeq Acc Id: NP_999183   ⟸   NM_214018
- UniProtKB: A0A4X1W2T9 (UniProtKB/TrEMBL),   A0A5G2R0D5 (UniProtKB/TrEMBL),   Q8WMG4 (UniProtKB/TrEMBL),   A0A4X1W3A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000003323   ⟸   ENSSSCT00000003406
Ensembl Acc Id: ENSSSCP00000067661   ⟸   ENSSSCT00000082543
Protein Domains
Calmodulin-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003069 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015039897 UniProtKB/TrEMBL
  ENSSSCG00025048652 UniProtKB/TrEMBL
  ENSSSCG00030073373 UniProtKB/TrEMBL
  ENSSSCG00035003833 UniProtKB/TrEMBL
  ENSSSCG00040027715 UniProtKB/TrEMBL
  ENSSSCG00045023678 UniProtKB/TrEMBL
  ENSSSCG00050014408 UniProtKB/TrEMBL
  ENSSSCG00055026551 UniProtKB/TrEMBL
  ENSSSCG00060042350 UniProtKB/TrEMBL
  ENSSSCG00065050251 UniProtKB/TrEMBL
  ENSSSCG00070028440 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003406 ENTREZGENE
  ENSSSCT00000003406.3 UniProtKB/TrEMBL
  ENSSSCT00000082543.1 UniProtKB/TrEMBL
  ENSSSCT00015053465.1 UniProtKB/TrEMBL
  ENSSSCT00015053589.1 UniProtKB/TrEMBL
  ENSSSCT00025066294.1 UniProtKB/TrEMBL
  ENSSSCT00025066458.1 UniProtKB/TrEMBL
  ENSSSCT00030102768.1 UniProtKB/TrEMBL
  ENSSSCT00030102775.1 UniProtKB/TrEMBL
  ENSSSCT00035004774.1 UniProtKB/TrEMBL
  ENSSSCT00035004787.1 UniProtKB/TrEMBL
  ENSSSCT00040037203.1 UniProtKB/TrEMBL
  ENSSSCT00040037297.1 UniProtKB/TrEMBL
  ENSSSCT00045040494.1 UniProtKB/TrEMBL
  ENSSSCT00045040627.1 UniProtKB/TrEMBL
  ENSSSCT00050019473.1 UniProtKB/TrEMBL
  ENSSSCT00050019481.1 UniProtKB/TrEMBL
  ENSSSCT00055052561.1 UniProtKB/TrEMBL
  ENSSSCT00055052634.1 UniProtKB/TrEMBL
  ENSSSCT00060057424.1 UniProtKB/TrEMBL
  ENSSSCT00060057436.1 UniProtKB/TrEMBL
  ENSSSCT00065068854.1 UniProtKB/TrEMBL
  ENSSSCT00065068862.1 UniProtKB/TrEMBL
  ENSSSCT00070057024.1 UniProtKB/TrEMBL
  ENSSSCT00070057025.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro CaM-bd_dom UniProtKB/TrEMBL
  CaM-bd_dom_sf UniProtKB/TrEMBL
  K_chnl_Ca-activ_SK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
KEGG Report ssc:397081 UniProtKB/TrEMBL
NCBI Gene KCNN4 ENTREZGENE
PANTHER PTHR10153 UniProtKB/TrEMBL
Pfam CaMBD UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
  SK_channel UniProtKB/TrEMBL
SMART CaMBD UniProtKB/TrEMBL
Superfamily-SCOP SSF81327 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A4X1W2T9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W3A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2R0D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YD16_PIG UniProtKB/TrEMBL
  Q8WMG4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89381 ENTREZGENE