Nlrp5 (NLR family, pyrin domain containing 5) - Rat Genome Database

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Gene: Nlrp5 (NLR family, pyrin domain containing 5) Rattus norvegicus
Analyze
Symbol: Nlrp5
Name: NLR family, pyrin domain containing 5
RGD ID: 1307446
Description: Predicted to enable tubulin binding activity. Predicted to be involved in several processes, including cortical granule exocytosis; cytoskeleton organization; and positive regulation of embryonic development. Predicted to act upstream of or within several processes, including embryo implantation; regulation of RNA stability; and regulation of protein stability. Predicted to be located in several cellular components, including apical cortex; cortical granule; and ooplasm. Predicted to be part of subcortical maternal complex. Predicted to be active in several cellular components, including cell cortex; cytosol; and mitochondrion. Orthologous to human NLRP5 (NLR family pyrin domain containing 5); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; DDT.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC308325; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; Nalp5
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,811,044 - 76,872,964 (-)NCBIGRCr8
mRatBN7.2167,778,037 - 67,810,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,777,948 - 68,023,736 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0171,452,184 - 71,490,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,453,798 - 71,486,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0172,846,717 - 72,878,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,212,857 - 66,246,286 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,296,338 - 66,584,794 (-)NCBI
Celera165,519,807 - 65,552,240 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nlrp5RatEmbryo Loss  ISORGD:13483618554872ClinVar Annotator: match by term: Preimplantation embryonic lethalityClinVar 
Nlrp5Ratoculoectodermal syndrome  ISORGD:13483618554872ClinVar Annotator: match by term: Toriello-Lacassie-Droste syndromeClinVarPMID:20738330|PMID:26323243
Nlrp5RatOocyte/Zygote/Embryo Maturation Arrest 19  ISORGD:13483618554872ClinVar Annotator: match by term: NLRP5-related condition | ClinVar Annotator: match by term: Oocyte/zygote/embryo maturation more ...ClinVarPMID:25741868|PMID:28492532|PMID:30877238|PMID:35946397
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nlrp5RatOocyte/Zygote/Embryo Maturation Arrest 19  ISORGD:13483617240710 OMIM 

1 to 20 of 29 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nlrp5Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:13166426480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Nlrp5Rat1,2-dimethylhydrazine increases expressionEXP 64804641,2-Dimethylhydrazine results in increased expression of NLRP5 mRNACTDPMID:27840820
Nlrp5Rat17beta-estradiol multiple interactionsISORGD:13483616480464[Estradiol co-treated with Progesterone] results in increased expression of NLRP5 mRNACTDPMID:20660070
Nlrp5Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORGD:13166426480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Nlrp5Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORGD:13166426480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Nlrp5Rat2,4,4'-trichlorobiphenyl multiple interactionsISORGD:13166426480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Nlrp5Rat7,12-dimethyltetraphene affects expressionISORGD:131664264804649,10-Dimethyl-1,2-benzanthracene affects the expression of NLRP5 mRNACTDPMID:21785161
Nlrp5Ratacrylamide increases expressionISORGD:13166426480464Acrylamide results in increased expression of NLRP5 mRNACTDPMID:36599426|PMID:36997053
Nlrp5Ratbenzo[a]pyrene decreases methylationISORGD:13483616480464Benzo(a)pyrene results in decreased methylation of NLRP5 promoterCTDPMID:27901495
Nlrp5Ratbenzo[a]pyrene affects methylationISORGD:13483616480464Benzo(a)pyrene affects the methylation of NLRP5 intronCTDPMID:30157460
Nlrp5Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Testosterone] results in decreased expression of NLRP5 mRNACTDPMID:26496021
Nlrp5Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of NLRP5 mRNACTDPMID:25181051
Nlrp5Ratcalcitriol increases expressionISORGD:13483616480464Calcitriol results in increased expression of NLRP5 mRNACTDPMID:21592394
Nlrp5Ratcalcitriol multiple interactionsISORGD:13483616480464[Testosterone co-treated with Calcitriol] results in increased expression of NLRP5 mRNACTDPMID:21592394
Nlrp5RatCGP 52608 multiple interactionsISORGD:13483616480464CGP 52608 promotes the reaction [RORA protein binds to NLRP5 gene]CTDPMID:28238834
Nlrp5RatDDT decreases expressionEXP 6480464DDT results in decreased expression of NLRP5 mRNACTDPMID:30207508
Nlrp5Ratfolic acid decreases expressionISORGD:13483616480464Folic Acid results in decreased expression of NLRP5 mRNACTDPMID:21867686
Nlrp5Ratlead diacetate increases expressionISORGD:13166426480464lead acetate results in increased expression of NLRP5 mRNACTDPMID:22613225
Nlrp5Ratmethotrexate affects expressionISORGD:13166426480464Methotrexate affects the expression of NLRP5 mRNACTDPMID:18502557
Nlrp5RatPCB138 multiple interactionsISORGD:13166426480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870

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Biological Process
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nlrp5Ratactin filament organization involved_inISORGD:13166421624291 PMID:25208553RGDPMID:25208553
Nlrp5Ratanimal organ morphogenesis acts_upstream_of_or_withinISORGD:13166421624291 PMID:10754103RGDPMID:10754103
Nlrp5Ratcortical granule exocytosis involved_inISORGD:13166421624291 PMID:31118423RGDPMID:31118423
Nlrp5Ratembryo implantation acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:18804437RGDPMID:18804437
Nlrp5Ratestablishment of organelle localization involved_inISORGD:13166421624291 PMID:24374158, PMID:31118423RGDPMID:24374158|PMID:31118423
Nlrp5Ratestablishment of spindle localization involved_inISORGD:13166421624291 PMID:25208553RGDPMID:25208553
Nlrp5Ratexocytosis involved_inISORGD:13166421624291 PMID:24374158RGDPMID:24374158
Nlrp5Ratfertilization acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:11062459, PMID:18804437RGDPMID:11062459|PMID:18804437
Nlrp5Ratin utero embryonic development acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:11062459, PMID:18804437RGDPMID:11062459|PMID:18804437
Nlrp5Ratinflammatory response involved_inIEAUniProtKB-KW:KW-03951600115GO_REF:0000043UniProtGO_REF:0000043
Nlrp5Ratpositive regulation of embryonic development involved_inISORGD:13166421624291 PMID:22357545RGDPMID:22357545
Nlrp5Ratprotein localization acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:20830304RGDPMID:20830304
Nlrp5Ratprotein-containing complex assembly acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:18804437RGDPMID:18804437
Nlrp5Ratregulation of cell division involved_inISORGD:13166421624291 PMID:25208553RGDPMID:25208553
Nlrp5Ratregulation of inflammatory response involved_inIBAMGI:2141990|MGI:2444084|MGI:2653833|MGI:2676630|PANTHER:PTN000647852|UniProtKB:P59044|UniProtKB:P59046|UniProtKB:Q96P201600115GO_REF:0000033GO_CentralGO_REF:0000033
Nlrp5Ratregulation of protein localization involved_inISORGD:13166421624291 PMID:22357545RGDPMID:22357545
Nlrp5Ratregulation of protein stability acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:18057100RGDPMID:18057100
Nlrp5Ratregulation of RNA stability acts_upstream_of_or_withinISORGD:13166421624291MGI:2178449 PMID:11062459RGDPMID:11062459
1 to 18 of 18 rows

Cellular Component
1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nlrp5Ratapical cortex located_inISORGD:13166421624291 PMID:18057100RGDPMID:18057100
Nlrp5Ratcanonical inflammasome complex part_ofIEAUniProtKB-KW:KW-12711600115GO_REF:0000043UniProtGO_REF:0000043
Nlrp5Ratcanonical inflammasome complex part_ofIEAUniProtKB-SubCell:SL-04881600115GO_REF:0000044UniProtGO_REF:0000044
Nlrp5Ratcell cortex located_inISORGD:13166421624291 PMID:18057100, PMID:18804437, PMID:19376971, PMID:25208553, PMID:31575650RGDPMID:18057100|PMID:18804437|PMID:19376971|PMID:25208553|PMID:31575650
Nlrp5Ratcell cortex is_active_inIBAMGI:1345193|PANTHER:PTN000647868|UniProtKB:F1MT67|UniProtKB:Q647I91600115GO_REF:0000033GO_CentralGO_REF:0000033
Nlrp5Ratcortical granule located_inISORGD:13483611624291 PMID:19192343RGDPMID:19192343
Nlrp5Ratcytoplasm located_inISORGD:13166421624291 PMID:20830304, PMID:28992324, PMID:31575650RGDPMID:20830304|PMID:28992324|PMID:31575650
Nlrp5Ratcytoplasm located_inISORGD:13483611624291 PMID:19192343, PMID:19542546, PMID:25542835RGDPMID:19192343|PMID:19542546|PMID:25542835
Nlrp5Ratcytoplasmic lattice is_active_inISORGD:13483611624291 PMID:37922900RGDPMID:37922900
Nlrp5Ratcytosol is_active_inIBAMGI:1345193|PANTHER:PTN000647868|UniProtKB:F1MT67|UniProtKB:Q647I91600115GO_REF:0000033GO_CentralGO_REF:0000033
Nlrp5Ratcytosol located_inISORGD:13166421624291 PMID:10433232RGDPMID:10433232
Nlrp5RatGolgi apparatus located_inISORGD:13483611624291 PMID:19192343RGDGO_REF:0000052|PMID:19192343
Nlrp5Ratmitochondrion located_inISORGD:13483611624291 PMID:19192343RGDPMID:19192343
Nlrp5Ratmitochondrion is_active_inIBAMGI:1345193|PANTHER:PTN000647868|UniProtKB:P590471600115GO_REF:0000033GO_CentralGO_REF:0000033
Nlrp5Ratmitochondrion located_inISORGD:13166421624291 PMID:14670992RGDPMID:14670992
Nlrp5Ratnucleolus located_inISORGD:13166421624291 PMID:14670992RGDPMID:14670992
Nlrp5Ratnucleus located_inISORGD:13483611624291 PMID:19192343, PMID:25542835RGDPMID:19192343|PMID:25542835
Nlrp5Ratnucleus is_active_inIBAMGI:1345193|PANTHER:PTN000647868|UniProtKB:F1MT67|UniProtKB:P59047|UniProtKB:Q647I91600115GO_REF:0000033GO_CentralGO_REF:0000033
Nlrp5Ratooplasm located_inISORGD:13166421624291 PMID:18057100RGDPMID:18057100
Nlrp5Ratprotein-containing complex part_ofISORGD:13166421624291 PMID:18057100, PMID:18804437RGDPMID:18057100|PMID:18804437
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Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nlrp5Ratprotein binding enablesISORGD:13483611624291UniProtKB:A6NGQ2|UniProtKB:Q02156|UniProtKB:Q587J8|UniProtKB:Q9H808-1 PMID:19542546, PMID:25542835RGDPMID:19542546|PMID:25542835
Nlrp5Ratprotein binding enablesISORGD:13166421624291PR:Q66X22|PR:Q9CWE6|PR:Q9CWU5|PR:Q9CWU5-2|PR:Q9WVB3|UniProtKB:P18760|UniProtKB:Q9CWE6|UniProtKB:Q9CWU5|UniProtKB:Q9D0L1|UniProtKB:Q9WVB3 PMID:18057100, PMID:18804437, PMID:25208553, PMID:28992324, PMID:31575650, PMID:32413845RGDPMID:18057100|PMID:18804437|PMID:25208553|PMID:28992324|PMID:31575650|PMID:32413845
Nlrp5Rattubulin binding enablesISORGD:13483611624291UniProtKB:Q13509 PMID:24374158RGDPMID:24374158


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10433232   PMID:10754103   PMID:11062459   PMID:14670992   PMID:18057100   PMID:18068672   PMID:18804437   PMID:19376971   PMID:20830304   PMID:22166940  



Nlrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,811,044 - 76,872,964 (-)NCBIGRCr8
mRatBN7.2167,778,037 - 67,810,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,777,948 - 68,023,736 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0171,452,184 - 71,490,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,453,798 - 71,486,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0172,846,717 - 72,878,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,212,857 - 66,246,286 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,296,338 - 66,584,794 (-)NCBI
Celera165,519,807 - 65,552,240 (-)NCBICelera
Cytogenetic Map1q12NCBI
NLRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,999,726 - 56,061,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,999,726 - 56,061,810 (+)EnsemblGRCh38hg38GRCh38
GRCh371956,511,092 - 56,573,176 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361961,202,904 - 61,264,988 (+)NCBINCBI36Build 36hg18NCBI36
Build 341961,202,903 - 61,264,984NCBI
Celera1953,555,479 - 53,617,543 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1952,821,949 - 52,884,428 (+)NCBIHuRef
CHM1_11956,504,661 - 56,566,808 (+)NCBICHM1_1
T2T-CHM13v2.01959,098,923 - 59,161,007 (+)NCBIT2T-CHM13v2.0
Nlrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39723,085,314 - 23,141,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl723,085,314 - 23,141,347 (+)EnsemblGRCm39 Ensembl
GRCm38723,385,889 - 23,441,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl723,385,889 - 23,441,922 (+)EnsemblGRCm38mm10GRCm38
MGSCv37724,170,916 - 24,226,940 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36723,094,657 - 23,150,681 (+)NCBIMGSCv36mm8
Celera718,067,211 - 18,125,836 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.22NCBI
NLRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22062,282,978 - 62,346,665 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11964,073,038 - 64,136,776 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01953,021,034 - 53,083,590 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11961,818,345 - 61,879,623 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,818,345 - 61,879,538 (+)Ensemblpanpan1.1panPan2
NLRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11101,813,449 - 101,842,643 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1101,813,449 - 101,842,633 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1101,999,948 - 102,029,018 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01102,460,071 - 102,498,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,459,949 - 102,489,156 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,098,621 - 102,137,465 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01101,816,356 - 101,855,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01102,573,033 - 102,611,882 (-)NCBIUU_Cfam_GSD_1.0
Nlrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494718,958,071 - 18,980,966 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365621,069,745 - 1,092,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl660,379,623 - 60,409,465 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1660,375,670 - 60,418,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2655,531,230 - 55,564,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1648,589,792 - 48,653,181 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl648,600,935 - 48,652,860 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660451,271,216 - 1,364,141 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Nlrp5
281 total Variants

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000041542
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat

1 to 10 of 46 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 3 12 34 35 27 8 17 8 4 70 43 16 8 47 19



Ensembl Acc Id: ENSRNOT00000041542   ⟹   ENSRNOP00000043888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,777,948 - 67,810,946 (-)Ensembl
Rnor_6.0 Ensembl171,453,798 - 71,486,790 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097841   ⟹   ENSRNOP00000089713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,777,948 - 68,023,736 (-)Ensembl
RefSeq Acc Id: XM_063280572   ⟹   XP_063136642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,811,044 - 76,872,964 (-)NCBI
Protein RefSeqs XP_063136642 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83172 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043888.3
  ENSRNOP00000089713.1
Ensembl Acc Id: ENSRNOP00000043888   ⟸   ENSRNOT00000041542
Ensembl Acc Id: ENSRNOP00000089713   ⟸   ENSRNOT00000097841
RefSeq Acc Id: XP_063136642   ⟸   XM_063280572
- UniProtKB: A0A8I6ALL1 (UniProtKB/TrEMBL)
NACHT

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDM5-F1-model_v2 AlphaFold D3ZDM5 1-880 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60917 BioCyc
Ensembl Genes ENSRNOG00000022994 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041542.5 UniProtKB/TrEMBL
  ENSRNOT00000097841.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/TrEMBL
  NLRP_innate_immun_reg UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 308325 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PhenoGen Nlrp5 PhenoGen
PROSITE NACHT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022994 RatGTEx
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6ALL1 ENTREZGENE, UniProtKB/TrEMBL
  A6KS81_RAT UniProtKB/TrEMBL
  D3ZDM5_RAT UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Nlrp5  NLR family, pyrin domain containing 5  Nalp5  NACHT, leucine rich repeat and PYD containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nalp5  NACHT, leucine rich repeat and PYD containing 5   Nalp5_predicted  NACHT, leucine rich repeat and PYD containing 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nalp5_predicted  NACHT, leucine rich repeat and PYD containing 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED