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Gene: Cyp2a2 (cytochrome P450, family 2, subfamily a, polypeptide 2) Rattus norvegicus
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Symbol: Cyp2a2
Name: cytochrome P450, family 2, subfamily a, polypeptide 2
RGD ID: 2464
Description: Exhibits steroid hydroxylase activity. Predicted to be involved in several processes, including coumarin metabolic process; epoxygenase P450 pathway; and exogenous drug catabolic process. Predicted to localize to cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7); PARTICIPATES IN caffeine metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CYP2A21; CYPIIA2; cytochrome P450 2A2; Cytochrome P450 IIA2; cytochrome P450, subfamily 2A, polypeptide 1; cytochrome P450, subfamily 2A, polypeptide 2; cytochrome P450-UT-4; hepatic steroid hydroxylase IIA2 (CYP2A2); P450-UT-4; RATCYP2A21; testosterone 15-alpha-hydroxylase
Orthologs:
No known orthologs. homologs ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0183,744,229 - 83,766,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,957,716 - 84,980,712 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,039,229 - 82,064,293 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,117,339 - 82,142,404 (+)NCBI
Celera176,681,056 - 76,706,240 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Position Markers
QTLs in Region (Rnor_6.0)

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Cyp2a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2464
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.