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Gene: Bbc3 (Bcl-2 binding component 3) Rattus norvegicus
Symbol: Bbc3
Name: Bcl-2 binding component 3
Description: Predicted to have ATPase binding activity. Involved in brain development and positive regulation of intrinsic apoptotic signaling pathway. Localizes to the mitochondrion. Predicted to colocalize with the lysosome. Biomarker of intermittent claudication and transient cerebral ischemia. Orthologous to human BBC3 (BCL2 binding component 3); PARTICIPATES IN intrinsic apoptotic pathway; Huntington's disease pathway; measles pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 4-hydroxynon-2-enal.
Type: protein-coding
Also known as: bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; Puma
Homo sapiens (human) : BBC3 (BCL2 binding component 3)  HGNC  Alliance
Mus musculus (house mouse) : Bbc3 (BCL2 binding component 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bbc3 (BCL2 binding component 3)
Pan paniscus (bonobo/pygmy chimpanzee) : BBC3 (BCL2 binding component 3)
Canis lupus familiaris (dog) : BBC3 (BCL2 binding component 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bbc3 (BCL2 binding component 3)
Sus scrofa (pig) : BBC3 (BCL2 binding component 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Bbc3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631434
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.