Bbc3 (Bcl-2 binding component 3) - Rat Genome Database

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Gene: Bbc3 (Bcl-2 binding component 3) Rattus norvegicus
Analyze
Symbol: Bbc3
Name: Bcl-2 binding component 3
RGD ID: 631434
Description: Predicted to enable ATPase binding activity. Involved in positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Predicted to colocalize with lysosome. Biomarker of intermittent claudication and transient cerebral ischemia. Orthologous to human BBC3 (BCL2 binding component 3); PARTICIPATES IN intrinsic apoptotic pathway; Huntington's disease pathway; measles pathway; INTERACTS WITH 1,3-dinitrobenzene; 4-hydroxynon-2-enal; 4-phenylbutylamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; Puma
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,141,450 - 86,150,666 (+)NCBIGRCr8
mRatBN7.2177,013,281 - 77,022,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,388,489 - 82,396,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0190,952,521 - 90,960,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,143,587 - 84,151,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutylamine  (EXP)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carboxin  (ISO)
celecoxib  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
erdosteine  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fostriecin  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glucose  (ISO)
glyphosate  (ISO)
gossypol  (ISO)
GSK690693  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
iron(III) nitrilotriacetate  (EXP)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lipoic acid  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
melatonin  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
metiram  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
morphine  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nonidet P-40  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pemetrexed  (ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
phosphoramide mustard  (EXP)
pinostrobin  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
potassium dichromate  (EXP)
propylparaben  (ISO)
resveratrol  (ISO)
rutin  (EXP)
ruxolitinib  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
Tiron  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
venetoclax  (ISO)
vorinostat  (ISO)
xanthohumol  (ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
lysosome  (ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
5. Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection. Ji X, etal., Front Biosci. 2007 Jan 1;12:1737-47.
6. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Li YZ, etal., Mol Cell Biol. 2008 Jan;28(2):564-74. Epub 2007 Nov 12.
7. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
8. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
9. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Niizuma K, etal., Stroke. 2009 Feb;40(2):618-25. Epub 2008 Dec 18.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz C, etal., J Cell Biol 2003 Aug 18;162(4):587-97.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
15. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
16. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
Additional References at PubMed
PMID:11463391   PMID:11463392   PMID:14500851   PMID:16151013   PMID:16286009   PMID:16399862   PMID:16407291   PMID:16705087   PMID:16832056   PMID:17024184   PMID:17289999   PMID:20421300  
PMID:20810912   PMID:20818388   PMID:21041309   PMID:21159964   PMID:21570442   PMID:22021910   PMID:22761832   PMID:23716698   PMID:24567336   PMID:25891762   PMID:26043893   PMID:26212789  
PMID:27117005   PMID:31878844   PMID:37088760  


Genomics

Comparative Map Data
Bbc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,141,450 - 86,150,666 (+)NCBIGRCr8
mRatBN7.2177,013,281 - 77,022,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,388,489 - 82,396,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0190,952,521 - 90,960,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,143,587 - 84,151,585 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
BBC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,220,824 - 47,232,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1947,220,822 - 47,232,766 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,724,081 - 47,735,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,415,924 - 52,426,291 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,415,923 - 52,426,291NCBI
Celera1944,527,934 - 44,539,878 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1944,148,994 - 44,171,276 (-)NCBIHuRef
CHM1_11947,726,482 - 47,738,433 (-)NCBICHM1_1
T2T-CHM13v2.01950,046,144 - 50,058,334 (-)NCBIT2T-CHM13v2.0
Bbc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,042,307 - 16,052,130 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,042,318 - 16,052,130 (+)EnsemblGRCm39 Ensembl
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,308,393 - 16,318,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBIMGSCv36mm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.85NCBI
Bbc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,167,242 - 1,174,966 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555741,167,790 - 1,174,966 (-)NCBIChiLan1.0ChiLan1.0
BBC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,361,167 - 53,374,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11955,232,535 - 55,245,609 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01944,203,517 - 44,215,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,727,826 - 52,738,535 (-)NCBIpanpan1.1PanPan1.1panPan2
BBC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,742,793 - 108,750,832 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,741,713 - 108,749,946 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,222,131 - 108,231,165 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,267,089 - 109,276,129 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,271,046 - 109,275,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,934,859 - 108,943,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,578,770 - 108,587,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,447,382 - 109,456,419 (+)NCBIUU_Cfam_GSD_1.0
Bbc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,343,021 - 19,354,349 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936664962,115 - 966,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,037,104 - 53,046,887 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,037,103 - 53,046,902 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,411,044 - 48,420,848 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BBC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,560,550 - 40,572,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,561,274 - 40,567,853 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607320,284,513 - 20,296,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,470,475 - 6,476,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,467,716 - 6,476,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bbc3
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000071296
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat

Markers in Region
RH70710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,022,115 - 77,022,240 (+)MAPPERmRatBN7.2
Rnor_6.0178,267,409 - 78,267,533NCBIRnor6.0
Rnor_5.0179,521,436 - 79,521,560UniSTSRnor5.0
Celera171,510,787 - 71,510,911UniSTS
BBC3_3813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,021,640 - 77,022,501 (+)MAPPERmRatBN7.2
Rnor_6.0178,266,934 - 78,267,794NCBIRnor6.0
Rnor_5.0179,520,961 - 79,521,821UniSTSRnor5.0
Celera171,510,312 - 71,511,172UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000096062   ⟹   ENSRNOP00000092134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,015,350 - 77,022,509 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101734   ⟹   ENSRNOP00000076660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)Ensembl
RefSeq Acc Id: NM_173837   ⟹   NP_776209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,142,701 - 86,150,666 (+)NCBI
mRatBN7.2177,014,543 - 77,022,509 (+)NCBI
Rnor_6.0178,261,491 - 78,267,802 (+)NCBI
Rnor_5.0179,520,749 - 79,521,829 (+)NCBI
Celera171,503,438 - 71,511,180 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080914   ⟹   XP_038936842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,141,450 - 86,146,901 (+)NCBI
mRatBN7.2177,013,281 - 77,018,740 (+)NCBI
RefSeq Acc Id: XM_039080919   ⟹   XP_038936847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,143,492 - 86,150,666 (+)NCBI
mRatBN7.2177,015,343 - 77,022,509 (+)NCBI
RefSeq Acc Id: XM_039080925   ⟹   XP_038936853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,143,491 - 86,150,666 (+)NCBI
mRatBN7.2177,015,344 - 77,022,509 (+)NCBI
RefSeq Acc Id: NP_776209   ⟸   NM_173837
- UniProtKB: Q80ZG6 (UniProtKB/Swiss-Prot),   A6J8A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936842   ⟸   XM_039080914
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936847   ⟸   XM_039080919
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936853   ⟸   XM_039080925
- Peptide Label: isoform X3
- UniProtKB: Q80ZG6 (UniProtKB/Swiss-Prot),   A6J8A5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092134   ⟸   ENSRNOT00000096062
RefSeq Acc Id: ENSRNOP00000076660   ⟸   ENSRNOT00000101734

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80ZG6-F1-model_v2 AlphaFold Q80ZG6 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631434 AgrOrtholog
BioCyc Gene G2FUF-60613 BioCyc
Ensembl Genes ENSRNOG00000062473 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016979 UniProtKB/Swiss-Prot
  ENSRNOG00060021083 UniProtKB/Swiss-Prot
  ENSRNOG00065033956 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000096062.1 UniProtKB/TrEMBL
  ENSRNOT00000101734 ENTREZGENE
  ENSRNOT00000101734.1 UniProtKB/Swiss-Prot
  ENSRNOT00055028859 UniProtKB/Swiss-Prot
  ENSRNOT00060036532 UniProtKB/Swiss-Prot
  ENSRNOT00065058321 UniProtKB/Swiss-Prot
InterPro Bbc3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:317673 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 317673 ENTREZGENE
PANTHER BCL-2-BINDING COMPONENT 3, ISOFORMS 3/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PUMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bbc3 PhenoGen
RatGTEx ENSRNOG00000062473 RatGTEx
  ENSRNOG00055016979 RatGTEx
  ENSRNOG00060021083 RatGTEx
  ENSRNOG00065033956 RatGTEx
UniProt A0A8I6AHA0 ENTREZGENE, UniProtKB/TrEMBL
  A6J8A5 ENTREZGENE, UniProtKB/TrEMBL
  BBC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Bbc3  Bcl-2 binding component 3      Symbol and Name status set to approved 625702 APPROVED