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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of BBC3 mRNA; cobaltous chloride results in increased expression of BBC3 proteinPMID:19376846 PMID:21687937 PMID:23380477
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTD[cobaltous chloride co-treated with TP53 gene mutant form] results in decreased expression of BBC3 protein; cobaltous chloride inhibits the reaction [[Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 mRNA]PMID:19714248 PMID:21687937
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