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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3decreases expressionISOBbc3 (Mus musculus)6480464CTDEstradiol results in decreased expression of BBC3 mRNAPMID:22467019
Bbc3decreases expressionISOBBC3 (Homo sapiens)6480464CTDEstradiol results in decreased expression of BBC3 mRNAPMID:25321415 PMID:31614463
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDEstradiol results in increased expression of BBC3 mRNAPMID:23373633
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTDEstradiol inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]; Estradiol inhibits the reaction [dibenzo(a,l)pyrene affects the expression of BBC3 protein]; Okadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]]PMID:24954032
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