BBC3 (BCL2 binding component 3) - Rat Genome Database

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Gene: BBC3 (BCL2 binding component 3) Homo sapiens
Analyze
Symbol: BBC3
Name: BCL2 binding component 3
RGD ID: 735389
HGNC Page HGNC:17868
Description: Enables ATPase binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and positive regulation of cellular component organization. Located in PUMA-BCL-xl complex and mitochondrion. Colocalizes with lysosome. Biomarker of lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: bcl-2-binding component 3; FLJ42994; JFY-1; JFY1; p53 up-regulated modulator of apoptosis; p53-upregulated modulator of apoptosis; PUMA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,220,824 - 47,232,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1947,220,822 - 47,232,766 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,724,081 - 47,735,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,415,924 - 52,426,291 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,415,923 - 52,426,291NCBI
Celera1944,527,934 - 44,539,878 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1944,148,994 - 44,171,276 (-)NCBIHuRef
CHM1_11947,726,482 - 47,738,433 (-)NCBICHM1_1
T2T-CHM13v2.01950,046,144 - 50,057,991 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP)
(S)-amphetamine  (EXP)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-methoxypsoralen  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-O-methylguanine  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9,10-phenanthroquinone  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
atrazine  (EXP)
azoxystrobin  (EXP)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
camptothecin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carboxin  (EXP)
celecoxib  (EXP)
chlorambucil  (EXP)
chloroacetaldehyde  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
cidofovir anhydrous  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
crystal violet  (EXP)
CU-O LINKAGE  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
diepoxybutane  (EXP)
diethyl maleate  (EXP)
dioscin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (EXP)
epichlorohydrin  (EXP)
erdosteine  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP,ISO)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fostriecin  (EXP)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyphosate  (EXP)
gossypol  (EXP)
GSK690693  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxyurea  (ISO)
indometacin  (EXP)
iohexol  (EXP)
iopamidol  (EXP)
iron(III) nitrilotriacetate  (ISO)
ivermectin  (EXP)
juglone  (EXP)
kaempferol  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
Licochalcone A  (EXP)
Licochalcone B  (EXP)
lipoic acid  (ISO)
LY294002  (EXP,ISO)
maneb  (EXP)
melatonin  (EXP,ISO)
menadione  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylseleninic acid  (EXP)
metiram  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotophos  (ISO)
morphine  (EXP)
motexafin gadolinium  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
niclosamide  (EXP)
nicotinamide  (EXP)
nitric oxide  (EXP)
nitrogen dioxide  (EXP)
Nonidet P-40  (EXP)
Nutlin-3  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pemetrexed  (EXP)
perfluorooctanoic acid  (EXP)
pevonedistat  (EXP)
phenobarbital  (EXP)
phosphoramide mustard  (ISO)
potassium dichromate  (ISO)
propylparaben  (EXP)
resveratrol  (EXP,ISO)
rutin  (ISO)
ruxolitinib  (EXP)
sanguinarine  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (EXP)
testosterone  (EXP)
thapsigargin  (EXP,ISO)
Tiron  (ISO)
topotecan  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
Tungsten carbide  (EXP)
tunicamycin  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vemurafenib  (EXP)
vorinostat  (EXP)
xanthohumol  (EXP)
zinc acetate  (EXP)
zinc dichloride  (ISO)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,IDA)
apoptotic process  (IEA,IMP)
apoptotic signaling pathway  (IDA)
brain development  (ISO)
cellular response to DNA damage stimulus  (IEA,ISS)
cellular response to hypoxia  (IEP)
cellular response to ionizing radiation  (IEA,ISO)
determination of adult lifespan  (IEA,ISS)
execution phase of apoptosis  (IBA,IDA)
fibroblast apoptotic process  (IEA,ISO)
intrinsic apoptotic signaling pathway  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IDA,IEA,ISS)
lymphocyte apoptotic process  (IEA,ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (IDA)
negative regulation of growth  (IMP)
positive regulation of apoptotic process  (IEA)
positive regulation of cysteine-type endopeptidase activity  (IEA,ISS)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (TAS)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IMP,ISS)
positive regulation of IRE1-mediated unfolded protein response  (TAS)
positive regulation of lymphocyte apoptotic process  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISS)
positive regulation of protein homooligomerization  (IDA)
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (IBA,IDA,IEA,ISO)
positive regulation of protein-containing complex assembly  (IDA)
positive regulation of release of cytochrome c from mitochondria  (IBA,IEA,IGI)
positive regulation of T cell apoptotic process  (IEA,ISO)
positive regulation of thymocyte apoptotic process  (IEA,ISS)
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (IEA,ISO)
release of cytochrome c from mitochondria  (IBA,IDA)
release of sequestered calcium ion into cytosol  (IDA)
response to endoplasmic reticulum stress  (IDA,IEA)
T cell apoptotic process  (IEA,ISO)
toxin transport  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
3. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
4. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Niizuma K, etal., Stroke. 2009 Feb;40(2):618-25. Epub 2008 Dec 18.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz C, etal., J Cell Biol 2003 Aug 18;162(4):587-97.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
9. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
Additional References at PubMed
PMID:11463391   PMID:11463392   PMID:11572983   PMID:12477932   PMID:12574499   PMID:12963126   PMID:14550297   PMID:14585351   PMID:14634023   PMID:14702039   PMID:14993250   PMID:15143349  
PMID:15174051   PMID:15547745   PMID:15574335   PMID:15595728   PMID:15694340   PMID:15721256   PMID:15731037   PMID:15731089   PMID:15905879   PMID:16007132   PMID:16091745   PMID:16151013  
PMID:16407291   PMID:16462759   PMID:16608847   PMID:16697956   PMID:16983338   PMID:17011204   PMID:17024184   PMID:17267315   PMID:17289999   PMID:17360476   PMID:17368424   PMID:17388661  
PMID:17393317   PMID:17616685   PMID:17698840   PMID:17934815   PMID:17996028   PMID:18215742   PMID:18324703   PMID:18354037   PMID:18367875   PMID:18573879   PMID:18579560   PMID:18811981  
PMID:18835564   PMID:18941118   PMID:19028473   PMID:19050264   PMID:19064725   PMID:19074266   PMID:19380879   PMID:19421143   PMID:19439449   PMID:19444283   PMID:19587239   PMID:19638343  
PMID:19641508   PMID:19652530   PMID:19660860   PMID:19679565   PMID:19737931   PMID:19815839   PMID:19851330   PMID:19966853   PMID:20075864   PMID:20153921   PMID:20206402   PMID:20413175  
PMID:20418652   PMID:20419447   PMID:20421300   PMID:20430872   PMID:20478995   PMID:20627101   PMID:20723285   PMID:20810912   PMID:20813046   PMID:20978166   PMID:21041309   PMID:21042732  
PMID:21044367   PMID:21048031   PMID:21120639   PMID:21151175   PMID:21153863   PMID:21159778   PMID:21364604   PMID:21364664   PMID:21486225   PMID:21490394   PMID:21613222   PMID:21633093  
PMID:21699775   PMID:21730980   PMID:21863213   PMID:21868573   PMID:21873635   PMID:21887277   PMID:21997190   PMID:22013210   PMID:22021910   PMID:22086558   PMID:22130069   PMID:22159712  
PMID:22174832   PMID:22178394   PMID:22283740   PMID:22286758   PMID:22359675   PMID:22394200   PMID:22446329   PMID:22516262   PMID:22714709   PMID:22761832   PMID:22763818   PMID:22773666  
PMID:22997714   PMID:23001513   PMID:23220852   PMID:23243310   PMID:23321162   PMID:23340338   PMID:23475628   PMID:23517560   PMID:23532334   PMID:23805223   PMID:23873935   PMID:23916609  
PMID:24077289   PMID:24127039   PMID:24236056   PMID:24265320   PMID:24452416   PMID:24566851   PMID:24625983   PMID:24625987   PMID:24685133   PMID:24769730   PMID:24824714   PMID:24830722  
PMID:25012639   PMID:25354317   PMID:25356864   PMID:25457551   PMID:25474084   PMID:25499216   PMID:25544752   PMID:25585941   PMID:25647720   PMID:25684518   PMID:25812964   PMID:25831048  
PMID:25846496   PMID:25893985   PMID:25895606   PMID:26030884   PMID:26043078   PMID:26125773   PMID:26186194   PMID:26212789   PMID:26397041   PMID:26397233   PMID:26431330   PMID:26576741  
PMID:26904937   PMID:26917778   PMID:27117005   PMID:27235693   PMID:27277529   PMID:27339788   PMID:27472460   PMID:27609421   PMID:27626385   PMID:27684187   PMID:27718035   PMID:27737950  
PMID:27780918   PMID:27786352   PMID:27924057   PMID:28012060   PMID:28128736   PMID:28202514   PMID:28277537   PMID:28287251   PMID:28409774   PMID:28423513   PMID:28423586   PMID:28445976  
PMID:28489680   PMID:28514442   PMID:28692117   PMID:28747638   PMID:28893313   PMID:28905491   PMID:28921546   PMID:29030732   PMID:29227280   PMID:29229477   PMID:29307600   PMID:29352138  
PMID:29533771   PMID:29581256   PMID:29686375   PMID:29693134   PMID:29755130   PMID:29991800   PMID:30185800   PMID:30556447   PMID:30712844   PMID:31202167   PMID:31881122   PMID:32080167  
PMID:32173531   PMID:32296183   PMID:32588752   PMID:32694731   PMID:33034274   PMID:33218295   PMID:33631672   PMID:33785736   PMID:33961781   PMID:34239363   PMID:34461288   PMID:34587475  
PMID:34636989   PMID:34874225   PMID:34903507   PMID:36122664  


Genomics

Comparative Map Data
BBC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,220,824 - 47,232,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1947,220,822 - 47,232,766 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,724,081 - 47,735,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,415,924 - 52,426,291 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,415,923 - 52,426,291NCBI
Celera1944,527,934 - 44,539,878 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1944,148,994 - 44,171,276 (-)NCBIHuRef
CHM1_11947,726,482 - 47,738,433 (-)NCBICHM1_1
T2T-CHM13v2.01950,046,144 - 50,057,991 (-)NCBIT2T-CHM13v2.0
Bbc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,042,307 - 16,052,259 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,042,318 - 16,052,130 (+)EnsemblGRCm39 Ensembl
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,308,393 - 16,318,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBIMGSCv36mm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
Bbc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,013,281 - 77,022,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,388,489 - 82,396,486 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0190,952,521 - 90,960,521 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0184,143,587 - 84,151,585 (+)NCBIRnor_WKY
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
Bbc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,167,242 - 1,174,966 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555741,167,790 - 1,174,966 (-)NCBIChiLan1.0ChiLan1.0
BBC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,727,826 - 52,738,535 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01944,203,517 - 44,215,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BBC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,742,793 - 108,750,832 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,741,713 - 108,749,946 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,222,131 - 108,231,165 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,267,089 - 109,276,129 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,271,046 - 109,275,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,934,859 - 108,943,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,578,770 - 108,587,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,447,382 - 109,456,419 (+)NCBIUU_Cfam_GSD_1.0
Bbc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,343,021 - 19,354,349 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936664962,115 - 966,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,037,104 - 53,046,887 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,037,103 - 53,046,902 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,411,044 - 48,420,848 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BBC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,560,550 - 40,572,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,561,274 - 40,567,853 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607320,284,513 - 20,296,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,470,475 - 6,476,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,467,716 - 6,476,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BBC3
6 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR483hsa-miR-483-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20388800
MIR483hsa-miR-483-3pOncomiRDBexternal_infoNANA20388800
MIR222hsa-miR-222-3pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//LucifFunctional MTI20813046
MIR222hsa-miR-222-3pOncomiRDBexternal_infoNANA21042732
MIR222hsa-miR-222-3pOncomiRDBexternal_infoNANA20813046
MIR221hsa-miR-221-3pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//LucifFunctional MTI20813046
MIR221hsa-miR-221-3pOncomiRDBexternal_infoNANA21042732
MIR221hsa-miR-221-3pOncomiRDBexternal_infoNANA20813046
MIR296hsa-miR-296-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21633093

Predicted Target Of
Summary Value
Count of predictions:3115
Count of miRNA genes:694
Interacting mature miRNAs:821
Transcripts:ENST00000300880, ENST00000341983, ENST00000439096, ENST00000449228, ENST00000598636, ENST00000601438
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH70710  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,724,349 - 47,724,470UniSTSGRCh37
Build 361952,416,189 - 52,416,310RGDNCBI36
Celera1944,528,204 - 44,528,325RGD
Cytogenetic Map19q13.3-q13.4UniSTS
GeneMap99-GB4 RH Map19265.62UniSTS
NCBI RH Map19524.0UniSTS
BBC3_3813  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,724,090 - 47,724,966UniSTSGRCh37
Build 361952,415,930 - 52,416,806RGDNCBI36
Celera1944,527,945 - 44,528,821RGD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 650 820 214 130 1176 59 1561 487 593 111 298 661 76 53 876 2
Low 1782 2158 1505 489 764 403 2792 1698 3093 299 1147 946 95 1151 1910 2
Below cutoff 2 6 4 3 4 3 2 8 23 9 7 3 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_031991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006723141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA887822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF354654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF354655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF354656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG258126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK670947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK670948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U82987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000300880   ⟹   ENSP00000300880
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1947,220,824 - 47,232,766 (-)Ensembl
RefSeq Acc Id: ENST00000341983   ⟹   ENSP00000341155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1947,220,824 - 47,232,766 (-)Ensembl
RefSeq Acc Id: ENST00000439096   ⟹   ENSP00000395862
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1947,220,824 - 47,231,199 (-)Ensembl
RefSeq Acc Id: ENST00000449228   ⟹   ENSP00000404503
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1947,220,824 - 47,232,766 (-)Ensembl
RefSeq Acc Id: ENST00000598636
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1947,221,645 - 47,227,189 (-)Ensembl
RefSeq Acc Id: ENST00000601438
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1947,220,822 - 47,222,568 (-)Ensembl
RefSeq Acc Id: NM_001127240   ⟹   NP_001120712
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,232,667 (-)NCBI
GRCh371947,724,079 - 47,736,023 (-)ENTREZGENE
HuRef1944,148,994 - 44,171,276 (-)ENTREZGENE
CHM1_11947,726,482 - 47,738,433 (-)NCBI
T2T-CHM13v2.01950,046,144 - 50,057,991 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001127241   ⟹   NP_001120713
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,232,667 (-)NCBI
GRCh371947,724,079 - 47,736,023 (-)ENTREZGENE
HuRef1944,148,994 - 44,171,276 (-)ENTREZGENE
CHM1_11947,726,482 - 47,738,433 (-)NCBI
T2T-CHM13v2.01950,046,144 - 50,057,991 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001127242   ⟹   NP_001120714
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,232,667 (-)NCBI
GRCh371947,724,079 - 47,736,023 (-)ENTREZGENE
HuRef1944,148,994 - 44,171,276 (-)ENTREZGENE
CHM1_11947,726,482 - 47,738,433 (-)NCBI
T2T-CHM13v2.01950,046,144 - 50,057,991 (-)NCBI
Sequence:
RefSeq Acc Id: NM_014417   ⟹   NP_055232
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,231,199 (-)NCBI
GRCh371947,724,079 - 47,736,023 (-)ENTREZGENE
Build 361952,415,924 - 52,426,291 (-)NCBI Archive
HuRef1944,148,994 - 44,171,276 (-)ENTREZGENE
CHM1_11947,726,482 - 47,736,853 (-)NCBI
T2T-CHM13v2.01950,046,144 - 50,056,523 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006723141   ⟹   XP_006723204
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,232,860 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011526722   ⟹   XP_011525024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,230,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047438606   ⟹   XP_047294562
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,220,824 - 47,232,461 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_055232   ⟸   NM_014417
- Peptide Label: isoform 4
- UniProtKB: Q96PG9 (UniProtKB/Swiss-Prot),   Q9BXH1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120714   ⟸   NM_001127242
- Peptide Label: isoform 3
- UniProtKB: Q9BXH1 (UniProtKB/Swiss-Prot),   Q96PG8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120713   ⟸   NM_001127241
- Peptide Label: isoform 2
- UniProtKB: Q9BXH1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120712   ⟸   NM_001127240
- Peptide Label: isoform 1
- UniProtKB: Q9BXH1 (UniProtKB/Swiss-Prot),   Q96PG8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006723204   ⟸   XM_006723141
- Peptide Label: isoform X1
- UniProtKB: Q96PG9 (UniProtKB/Swiss-Prot),   Q9BXH1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525024   ⟸   XM_011526722
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000395862   ⟸   ENST00000439096
RefSeq Acc Id: ENSP00000300880   ⟸   ENST00000300880
RefSeq Acc Id: ENSP00000341155   ⟸   ENST00000341983
RefSeq Acc Id: ENSP00000404503   ⟸   ENST00000449228
RefSeq Acc Id: XP_047294562   ⟸   XM_047438606
- Peptide Label: isoform X1
- UniProtKB: Q96PG9 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96PG8-F1-model_v2 AlphaFold Q96PG8 1-261 view protein structure

Promoters
RGD ID:13204870
Promoter ID:EPDNEW_H26018
Type:multiple initiation site
Name:BBC3_5
Description:BCL2 binding component 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26019  EPDNEW_H26021  EPDNEW_H26020  EPDNEW_H26022  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,230,560 - 47,230,620EPDNEW
RGD ID:13204872
Promoter ID:EPDNEW_H26019
Type:initiation region
Name:BBC3_1
Description:BCL2 binding component 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26018  EPDNEW_H26021  EPDNEW_H26020  EPDNEW_H26022  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,231,199 - 47,231,259EPDNEW
RGD ID:13204876
Promoter ID:EPDNEW_H26020
Type:initiation region
Name:BBC3_3
Description:BCL2 binding component 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26018  EPDNEW_H26019  EPDNEW_H26021  EPDNEW_H26022  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,232,747 - 47,232,807EPDNEW
RGD ID:13204874
Promoter ID:EPDNEW_H26021
Type:initiation region
Name:BBC3_4
Description:BCL2 binding component 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26018  EPDNEW_H26019  EPDNEW_H26020  EPDNEW_H26022  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381947,232,956 - 47,233,016EPDNEW
RGD ID:6811500
Promoter ID:HG_ACW:42049
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:BBC3.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361952,422,261 - 52,423,122 (-)MPROMDB
RGD ID:6795170
Promoter ID:HG_KWN:30373
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_014417
Position:
Human AssemblyChrPosition (strand)Source
Build 361952,426,161 - 52,426,717 (-)MPROMDB
RGD ID:6795171
Promoter ID:HG_KWN:30374
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC002PGG.2,   UC010EKY.1,   UC010EKZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361952,427,421 - 52,427,921 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:46458122-47683579)x1 copy number loss See cases [RCV000053976] Chr19:46458122..47683579 [GRCh38]
Chr19:46961379..48186836 [GRCh37]
Chr19:51653219..52878648 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:44971420-48257402)x3 copy number gain See cases [RCV000136578] Chr19:44971420..48257402 [GRCh38]
Chr19:45474677..48760659 [GRCh37]
Chr19:50166517..53452471 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh37/hg19 19q13.32(chr19:47567615-47856225)x3 copy number gain See cases [RCV000447005] Chr19:47567615..47856225 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19q13.32(chr19:46918881-47782258)x3 copy number gain See cases [RCV000446734] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19q13.32(chr19:47450549-47880338)x3 copy number gain See cases [RCV000447405] Chr19:47450549..47880338 [GRCh37]
Chr19:19q13.32
likely pathogenic
GRCh37/hg19 19q13.32-13.33(chr19:46404248-48488721)x1 copy number loss See cases [RCV000511362] Chr19:46404248..48488721 [GRCh37]
Chr19:19q13.32-13.33
likely pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19q13.32(chr19:47228251-47867279)x3 copy number gain not provided [RCV000585171] Chr19:47228251..47867279 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_014417.5(BBC3):c.*23C>T single nucleotide variant not provided [RCV000949621] Chr19:47221779 [GRCh38]
Chr19:47725036 [GRCh37]
Chr19:19q13.32
benign
GRCh37/hg19 19q13.32-13.33(chr19:47036361-48525536) copy number gain not provided [RCV000767770] Chr19:47036361..48525536 [GRCh37]
Chr19:19q13.32-13.33
pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
GRCh37/hg19 19q13.32-13.33(chr19:45531056-48174177)x3 copy number gain not provided [RCV001007051] Chr19:45531056..48174177 [GRCh37]
Chr19:19q13.32-13.33
uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
GRCh37/hg19 19q13.32-13.33(chr19:47331662-48234260)x3 copy number gain not provided [RCV001007053] Chr19:47331662..48234260 [GRCh37]
Chr19:19q13.32-13.33
uncertain significance
GRCh37/hg19 19q13.32(chr19:46918881-47782258) copy number gain not specified [RCV002052687] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17868 AgrOrtholog
COSMIC BBC3 COSMIC
Ensembl Genes ENSG00000105327 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000300880 ENTREZGENE
  ENSP00000300880.7 UniProtKB/Swiss-Prot
  ENSP00000341155 ENTREZGENE
  ENSP00000341155.4 UniProtKB/Swiss-Prot
  ENSP00000395862 ENTREZGENE
  ENSP00000395862.2 UniProtKB/Swiss-Prot
  ENSP00000404503 ENTREZGENE
  ENSP00000404503.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000300880 ENTREZGENE
  ENST00000300880.11 UniProtKB/Swiss-Prot
  ENST00000341983 ENTREZGENE
  ENST00000341983.8 UniProtKB/Swiss-Prot
  ENST00000439096 ENTREZGENE
  ENST00000439096.3 UniProtKB/Swiss-Prot
  ENST00000449228 ENTREZGENE
  ENST00000449228.5 UniProtKB/Swiss-Prot
GTEx ENSG00000105327 GTEx
HGNC ID HGNC:17868 ENTREZGENE
Human Proteome Map BBC3 Human Proteome Map
InterPro Bbc3 UniProtKB/Swiss-Prot
KEGG Report hsa:27113 UniProtKB/Swiss-Prot
NCBI Gene 27113 ENTREZGENE
OMIM 605854 OMIM
PANTHER PTHR28639 UniProtKB/Swiss-Prot
Pfam PUMA UniProtKB/Swiss-Prot
PharmGKB PA38471 PharmGKB
UniProt BBC3_HUMAN UniProtKB/Swiss-Prot
  BBC3B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q96PG9 ENTREZGENE
  Q9BXH1 ENTREZGENE
UniProt Secondary B9EGI3 UniProtKB/Swiss-Prot
  O00171 UniProtKB/Swiss-Prot
  Q96PG9 UniProtKB/Swiss-Prot