Bbc3 (BCL2 binding component 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Bbc3 (BCL2 binding component 3) Mus musculus
Analyze
Symbol: Bbc3
Name: BCL2 binding component 3
RGD ID: 1552484
MGI Page MGI
Description: Predicted to enable ATPase binding activity. Involved in several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of apoptotic process. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of apoptotic process; and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. Predicted to be located in mitochondrial envelope. Predicted to be part of PUMA-BCL-xl complex. Predicted to be active in mitochondrion. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Orthologous to human BBC3 (BCL2 binding component 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bcl-2 binding component 3; bcl-2-binding component 3; BH3-only; p53 up-regulated modulator of apoptosis; PU; PUMA; PUMA/JFY1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,042,307 - 16,052,259 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,042,318 - 16,052,130 (+)EnsemblGRCm39 Ensembl
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,308,393 - 16,318,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBIMGSCv36mm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(R)-mevalonic acid  (ISO)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
9,10-phenanthroquinone  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
carboxin  (ISO)
celecoxib  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cytarabine  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
erdosteine  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (EXP,ISO)
fenthion  (EXP)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
fostriecin  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyphosate  (ISO)
gossypol  (ISO)
GSK690693  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP)
indometacin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
iron(III) nitrilotriacetate  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lipoic acid  (EXP)
LY294002  (ISO)
maneb  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
metiram  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
morphine  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nonidet P-40  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pemetrexed  (ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
phosphoramide mustard  (ISO)
potassium dichromate  (ISO)
propylparaben  (ISO)
resveratrol  (EXP,ISO)
rutin  (ISO)
ruxolitinib  (ISO)
sanguinarine  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP,ISO)
Tiron  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
valsartan  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
xanthohumol  (ISO)
zinc acetate  (ISO)
zinc dichloride  (EXP)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IBA,ISO,ISS)
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
brain development  (ISO)
cellular response to DNA damage stimulus  (IGI)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (IGI)
determination of adult lifespan  (IGI)
execution phase of apoptosis  (IBA,ISO,ISS)
fibroblast apoptotic process  (IMP)
intrinsic apoptotic signaling pathway  (IEA)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IMP)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IMP,ISO)
lymphocyte apoptotic process  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of growth  (ISO,ISS)
positive regulation of apoptotic process  (IEA)
positive regulation of cysteine-type endopeptidase activity  (IMP)
positive regulation of fibroblast apoptotic process  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of lymphocyte apoptotic process  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein homooligomerization  (ISO)
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (IBA,IMP,ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of release of cytochrome c from mitochondria  (IBA,ISO)
positive regulation of T cell apoptotic process  (IMP)
positive regulation of thymocyte apoptotic process  (IGI)
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (IMP)
release of cytochrome c from mitochondria  (IBA,ISO,ISS)
release of sequestered calcium ion into cytosol  (ISO)
response to endoplasmic reticulum stress  (IDA,ISO)
T cell apoptotic process  (IMP)
toxin transport  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
2. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Niizuma K, etal., Stroke. 2009 Feb;40(2):618-25. Epub 2008 Dec 18.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz C, etal., J Cell Biol 2003 Aug 18;162(4):587-97.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
11. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
12. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Villunger A, etal., Science 2003 Nov 7;302(5647):1036-8. Epub 2003 Sep 18.
Additional References at PubMed
PMID:11463391   PMID:11572983   PMID:12477932   PMID:14585359   PMID:14610273   PMID:15192153   PMID:15489334   PMID:15525786   PMID:15750633   PMID:16118324   PMID:16151013   PMID:16286009  
PMID:16399862   PMID:16407291   PMID:16602821   PMID:16705087   PMID:16822983   PMID:16832056   PMID:17024184   PMID:17127703   PMID:17178918   PMID:17283183   PMID:17307841   PMID:17476283  
PMID:17634411   PMID:17879164   PMID:17893884   PMID:17967808   PMID:17968660   PMID:17989286   PMID:17992194   PMID:17996028   PMID:18032672   PMID:18048346   PMID:18077368   PMID:18088354  
PMID:18259198   PMID:18287039   PMID:18299399   PMID:18462686   PMID:18522850   PMID:18573879   PMID:18589438   PMID:18786355   PMID:18799693   PMID:18806761   PMID:18990690   PMID:19033888  
PMID:19064725   PMID:19064728   PMID:19079139   PMID:19144853   PMID:19148184   PMID:19159665   PMID:19237507   PMID:19285955   PMID:19300452   PMID:19339988   PMID:19364921   PMID:19417777  
PMID:19444283   PMID:19454543   PMID:19491259   PMID:19535997   PMID:19638343   PMID:19890018   PMID:19917256   PMID:19943111   PMID:19959756   PMID:19965665   PMID:19966290   PMID:20177048  
PMID:20351066   PMID:20360471   PMID:20362645   PMID:20413175   PMID:20477944   PMID:20498273   PMID:20664053   PMID:20679396   PMID:20711434   PMID:20818388   PMID:20829369   PMID:20921277  
PMID:21040902   PMID:21083429   PMID:21127253   PMID:21159778   PMID:21159964   PMID:21198986   PMID:21203486   PMID:21267068   PMID:21350561   PMID:21364616   PMID:21364664   PMID:21490394  
PMID:21660046   PMID:21670227   PMID:21677750   PMID:21690328   PMID:21699775   PMID:21725994   PMID:21742968   PMID:21762490   PMID:21855805   PMID:21868573   PMID:21873635   PMID:21945433  
PMID:21949016   PMID:21997190   PMID:22015606   PMID:22138576   PMID:22212482   PMID:22311782   PMID:22402282   PMID:22510886   PMID:22538851   PMID:22761832   PMID:22773666   PMID:22955282  
PMID:22960223   PMID:22967998   PMID:22996683   PMID:23000175   PMID:23056511   PMID:23122957   PMID:23238565   PMID:23243310   PMID:23261451   PMID:23365256   PMID:23377280   PMID:23492769  
PMID:23532334   PMID:23558951   PMID:23589895   PMID:23665218   PMID:23666531   PMID:23678004   PMID:23716698   PMID:23873265   PMID:23922240   PMID:23973961   PMID:24013501   PMID:24265320  
PMID:24553927   PMID:24566851   PMID:24625983   PMID:24625987   PMID:24637717   PMID:24658302   PMID:24769730   PMID:24830722   PMID:24859845   PMID:25012505   PMID:25124553   PMID:25144937  
PMID:25176652   PMID:25301392   PMID:25354317   PMID:25356864   PMID:25425107   PMID:25451294   PMID:25501596   PMID:25556649   PMID:25565426   PMID:25698446   PMID:25732191   PMID:25799988  
PMID:25847014   PMID:25858503   PMID:25940086   PMID:26030884   PMID:26159997   PMID:26179069   PMID:26334721   PMID:26344567   PMID:26410627   PMID:26640149   PMID:26742432   PMID:26768662  
PMID:26904937   PMID:26947081   PMID:26966181   PMID:27033313   PMID:27064265   PMID:27065327   PMID:27117005   PMID:27130031   PMID:27221652   PMID:27464000   PMID:27626385   PMID:27701148  
PMID:27797453   PMID:27889097   PMID:28277537   PMID:28408317   PMID:28409774   PMID:28682312   PMID:28777373   PMID:28918507   PMID:29244083   PMID:29358667   PMID:29581256   PMID:29795269  
PMID:29892060   PMID:30348983   PMID:30377227   PMID:30394308   PMID:30503207   PMID:30552702   PMID:30655546   PMID:30712844   PMID:30718289   PMID:30858352   PMID:30971184   PMID:31178404  
PMID:31197172   PMID:31276534   PMID:31296963   PMID:31409715   PMID:31582729   PMID:31749402   PMID:32080167   PMID:32451402   PMID:32641579   PMID:33086063   PMID:33147210   PMID:33236795  
PMID:33323382   PMID:33334825   PMID:33462115   PMID:33482083   PMID:33574585   PMID:33586242   PMID:33864208   PMID:34616039   PMID:35517788   PMID:35694536   PMID:35864088  


Genomics

Comparative Map Data
Bbc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,042,307 - 16,052,259 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,042,318 - 16,052,130 (+)EnsemblGRCm39 Ensembl
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,308,393 - 16,318,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBIMGSCv36mm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
BBC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,220,824 - 47,232,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1947,220,822 - 47,232,766 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,724,081 - 47,735,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,415,924 - 52,426,291 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,415,923 - 52,426,291NCBI
Celera1944,527,934 - 44,539,878 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1944,148,994 - 44,171,276 (-)NCBIHuRef
CHM1_11947,726,482 - 47,738,433 (-)NCBICHM1_1
T2T-CHM13v2.01950,046,144 - 50,057,991 (-)NCBIT2T-CHM13v2.0
Bbc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,013,281 - 77,022,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,388,489 - 82,396,486 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0190,952,521 - 90,960,521 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0184,143,587 - 84,151,585 (+)NCBIRnor_WKY
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
Bbc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,167,242 - 1,174,966 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555741,167,790 - 1,174,966 (-)NCBIChiLan1.0ChiLan1.0
BBC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,727,826 - 52,738,535 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01944,203,517 - 44,215,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BBC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,742,793 - 108,750,832 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,741,713 - 108,749,946 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,222,131 - 108,231,165 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,267,089 - 109,276,129 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,271,046 - 109,275,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,934,859 - 108,943,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,578,770 - 108,587,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,447,382 - 109,456,419 (+)NCBIUU_Cfam_GSD_1.0
Bbc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,343,021 - 19,354,349 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936664962,115 - 966,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,037,104 - 53,046,887 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,037,103 - 53,046,902 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,411,044 - 48,420,848 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BBC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,560,550 - 40,572,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,561,274 - 40,567,853 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607320,284,513 - 20,296,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,470,475 - 6,476,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,467,716 - 6,476,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir222mmu-miR-222-3pOncomiRDBexternal_infoNANA21042732
Mir222mmu-miR-222-3pOncomiRDBexternal_infoNANA20813046
Mir483mmu-miR-483-3pOncomiRDBexternal_infoNANA20388800
Mir221mmu-miR-221-3pOncomiRDBexternal_infoNANA21042732
Mir221mmu-miR-221-3pOncomiRDBexternal_infoNANA20813046

Predicted Target Of
Summary Value
Count of predictions:904
Count of miRNA genes:499
Interacting mature miRNAs:601
Transcripts:ENSMUST00000002152, ENSMUST00000136781, ENSMUST00000147267
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25394569Skmw57_mskeletal muscle weight 57, gastroc (mouse)7458046916687861Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse

Markers in Region
RH70710  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38716,317,804 - 16,317,934UniSTSGRCm38
MGSCv37716,903,153 - 16,903,283UniSTSGRCm37
Celera713,512,858 - 13,512,987UniSTS
Cytogenetic Map7A2UniSTS
BBC3_3813  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38716,317,328 - 16,318,195UniSTSGRCm38
MGSCv37716,902,677 - 16,903,544UniSTSGRCm37
Celera713,512,382 - 13,513,248UniSTS
Cytogenetic Map7A2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001382549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF332561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002152   ⟹   ENSMUSP00000002152
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl716,043,541 - 16,052,130 (+)Ensembl
GRCm38.p6 Ensembl716,309,616 - 16,318,205 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136781   ⟹   ENSMUSP00000119225
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl716,044,380 - 16,047,663 (+)Ensembl
GRCm38.p6 Ensembl716,310,455 - 16,313,738 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147267
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl716,047,442 - 16,051,622 (+)Ensembl
GRCm38.p6 Ensembl716,313,517 - 16,317,697 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209688   ⟹   ENSMUSP00000147422
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl716,042,318 - 16,046,339 (+)Ensembl
GRCm38.p6 Ensembl716,308,393 - 16,312,414 (+)Ensembl
RefSeq Acc Id: NM_001382549   ⟹   NP_001369478
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,044,356 - 16,052,130 (+)NCBI
GRCm38716,310,431 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382550   ⟹   NP_001369479
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,044,356 - 16,052,130 (+)NCBI
GRCm38716,310,431 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382551   ⟹   NP_001369480
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,044,186 - 16,052,130 (+)NCBI
GRCm38716,310,261 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382552   ⟹   NP_001369481
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,044,356 - 16,052,130 (+)NCBI
GRCm38716,310,431 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382553   ⟹   NP_001369482
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,044,356 - 16,052,130 (+)NCBI
GRCm38716,310,431 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133234   ⟹   NP_573497
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,043,508 - 16,052,259 (+)NCBI
GRCm38716,309,583 - 16,318,334 (+)NCBI
MGSCv37716,894,932 - 16,903,683 (+)RGD
Celera713,504,637 - 13,513,389 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539575   ⟹   XP_006539638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,044,186 - 16,052,130 (+)NCBI
GRCm38716,310,259 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539578   ⟹   XP_006539641
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,042,307 - 16,052,130 (+)NCBI
GRCm38716,308,398 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539579   ⟹   XP_006539642
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,042,837 - 16,052,130 (+)NCBI
GRCm38716,309,618 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539580   ⟹   XP_006539643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,045,794 - 16,052,130 (+)NCBI
GRCm38716,311,864 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539582   ⟹   XP_006539645
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,042,684 - 16,052,130 (+)NCBI
GRCm38716,308,838 - 16,318,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006539583   ⟹   XP_006539646
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39716,046,839 - 16,052,130 (+)NCBI
GRCm38716,312,941 - 16,318,205 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_573497   ⟸   NM_133234
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   B2RVL4 (UniProtKB/TrEMBL),   A0A6P5Q718 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539641   ⟸   XM_006539578
- Peptide Label: isoform X2
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   B2RVL4 (UniProtKB/TrEMBL),   A0A6P5Q718 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539645   ⟸   XM_006539582
- Peptide Label: isoform X2
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   B2RVL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539642   ⟸   XM_006539579
- Peptide Label: isoform X2
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   B2RVL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539638   ⟸   XM_006539575
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006539643   ⟸   XM_006539580
- Peptide Label: isoform X2
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   B2RVL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539646   ⟸   XM_006539583
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001369480   ⟸   NM_001382551
RefSeq Acc Id: NP_001369479   ⟸   NM_001382550
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   A0A6P5Q718 (UniProtKB/TrEMBL),   B2RVL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001369481   ⟸   NM_001382552
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   A0A6P5Q718 (UniProtKB/TrEMBL),   B2RVL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001369478   ⟸   NM_001382549
- UniProtKB: Q99ML1 (UniProtKB/Swiss-Prot),   A0A6P5Q718 (UniProtKB/TrEMBL),   B2RVL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001369482   ⟸   NM_001382553
RefSeq Acc Id: ENSMUSP00000002152   ⟸   ENSMUST00000002152
RefSeq Acc Id: ENSMUSP00000147422   ⟸   ENSMUST00000209688
RefSeq Acc Id: ENSMUSP00000119225   ⟸   ENSMUST00000136781

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99ML1-F1-model_v2 AlphaFold Q99ML1 1-193 view protein structure

Promoters
RGD ID:6891918
Promoter ID:EPDNEW_M9410
Type:initiation region
Name:Bbc3_1
Description:Mus musculus BCL2 binding component 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38716,309,618 - 16,309,678EPDNEW
RGD ID:6840695
Promoter ID:MM_KWN:48900
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:UC009FHO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,894,046 - 16,895,207 (+)MPROMDB
RGD ID:6840692
Promoter ID:MM_KWN:48901
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000053028
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,894,926 - 16,896,172 (+)MPROMDB
RGD ID:6840693
Promoter ID:MM_KWN:48902
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000053029
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,897,881 - 16,899,357 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2181667 AgrOrtholog
Ensembl Genes ENSMUSG00000002083 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002152 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000119225.2 UniProtKB/TrEMBL
  ENSMUSP00000147422.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002152 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000136781.2 UniProtKB/TrEMBL
  ENSMUST00000209688.2 UniProtKB/TrEMBL
InterPro Bbc3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:170770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2181667 ENTREZGENE
NCBI Gene 170770 ENTREZGENE
PANTHER PTHR28639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PUMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bbc3 PhenoGen
UniProt A0A1B0GR88_MOUSE UniProtKB/TrEMBL
  A0A6P5PV88 ENTREZGENE
  A0A6P5Q718 ENTREZGENE
  B2RVL4 ENTREZGENE, UniProtKB/TrEMBL
  BBC3_MOUSE UniProtKB/Swiss-Prot
  D3Z2M5_MOUSE UniProtKB/TrEMBL
  Q99ML1 ENTREZGENE