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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3decreases expressionISOBBC3 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of BBC3 proteinPMID:20723298
Bbc3increases expressionISOBbc3 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of BBC3 mRNAPMID:23892647
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of BBC3 mRNA; Arsenic Trioxide results in increased expression of BBC3 proteinPMID:17374990 PMID:21454520 PMID:24345465 PMID:29266867 PMID:30472098
Bbc3multiple interactionsISOBbc3 (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of BBC3 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of BBC3 mRNA]PMID:23892647
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with VS-5584] results in increased expression of BBC3 mRNA; [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA; [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA; [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA; Dasatinib promotes the reaction [Arsenic Trioxide results in increased expression of BBC3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of BBC3 protein]PMID:24345465 PMID:29266867 PMID:29274334 PMID:29574283 PMID:30012499 PMID:30472098
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