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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3multiple interactionsEXP 6480464CTD[SERPINF1 protein co-treated with sodium arsenite] results in increased expression of BBC3 mRNAPMID:30408888
Bbc3decreases expressionISOBBC3 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of BBC3 mRNAPMID:34032870
Bbc3increases expressionISOBbc3 (Mus musculus)6480464CTDsodium arsenite results in increased expression of BBC3 mRNAPMID:16166651 PMID:20477944 PMID:30357543
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of BBC3 mRNA; sodium arsenite results in increased expression of BBC3 proteinPMID:34798143 PMID:36586010
Bbc3increases response to substanceISOBbc3 (Mus musculus)6480464CTDBBC3 results in increased susceptibility to sodium arsenitePMID:16166651
Bbc3multiple interactionsISOBbc3 (Mus musculus)6480464CTDsodium arsenite results in increased expression of and affects the localization of BBC3 protein; sodium arsenite results in increased expression of and results in increased activity of BBC3 protein; TRP53 gene mutant form affects the reaction [sodium arsenite results in increased expression of BBC3 mRNA]; TRP53 gene mutant form affects the reaction [sodium arsenite results in increased expression of BBC3 protein]; TRP73 protein affects the reaction [sodium arsenite results in increased activity of BBC3 protein]; TRP73 protein affects the reaction [sodium arsenite results in increased expression of BBC3 mRNA]PMID:16166651 PMID:20477944
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in decreased expression of BBC3 protein; MCL1 protein promotes the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in decreased expression of BBC3 protein]; sodium arsenite promotes the reaction [BBC3 protein binds to BCL2L1 protein]PMID:32802178 PMID:34798143
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