Ceacam6 (CEA cell adhesion molecule 6) - Rat Genome Database

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Gene: Ceacam6 (CEA cell adhesion molecule 6) Rattus norvegicus
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Symbol: Ceacam6
Name: CEA cell adhesion molecule 6
RGD ID: 1642421
Description: Predicted to enable identical protein binding activity; protein heterodimerization activity; and protein tyrosine kinase binding activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of cell adhesion. Predicted to be located in apical plasma membrane and extracellular space. Predicted to be active in cell surface and plasma membrane. Orthologous to several human genes including CEACAM6 (CEA cell adhesion molecule 6); PSG4 (pregnancy specific beta-1-glycoprotein 4); and PSG6 (pregnancy specific beta-1-glycoprotein 6); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; copper atom.
Type: ncrna (Ensembl: protein-coding)
RefSeq Status: VALIDATED
Previously known as: carcinoembryonic antigen-related cell adhesion molecule 1-like; carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6-like; LOC103689938; MGC93832
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,544,415 - 89,562,552 (+)NCBIGRCr8
mRatBN7.2180,416,531 - 80,434,668 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,416,531 - 80,434,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,809,061 - 85,827,197 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,359,932 - 94,378,069 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,564,825 - 87,582,957 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,683,500 - 81,701,230 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,683,463 - 81,701,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,300,780 - 84,318,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0182,940,564 - 82,958,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,110,384 - 80,129,016 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera175,527,118 - 75,528,059 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2317824   PMID:2803308   PMID:8776764   PMID:10436421   PMID:10910050   PMID:11590190   PMID:12477932   PMID:16204051   PMID:18685128   PMID:21982860   PMID:23106565   PMID:25171863  
PMID:25645918   PMID:26483485  


Genomics

Comparative Map Data
Ceacam6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,544,415 - 89,562,552 (+)NCBIGRCr8
mRatBN7.2180,416,531 - 80,434,668 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,416,531 - 80,434,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,809,061 - 85,827,197 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,359,932 - 94,378,069 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,564,825 - 87,582,957 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,683,500 - 81,701,230 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,683,463 - 81,701,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,300,780 - 84,318,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0182,940,564 - 82,958,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,110,384 - 80,129,016 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera175,527,118 - 75,528,059 (-)NCBICelera
Cytogenetic Map1q21NCBI
CEACAM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,755,530 - 41,772,211 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,750,977 - 41,772,211 (+)EnsemblGRCh38hg38GRCh38
GRCh371942,259,438 - 42,276,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,951,341 - 46,967,953 (+)NCBINCBI36Build 36hg18NCBI36
Build 341946,951,340 - 46,967,953NCBI
Celera1939,059,109 - 39,075,821 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,691,297 - 38,708,013 (+)NCBIHuRef
CHM1_11942,261,025 - 42,277,743 (+)NCBICHM1_1
T2T-CHM13v2.01944,574,887 - 44,591,561 (+)NCBIT2T-CHM13v2.0
LOC100976543
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,865,319 - 48,776,239 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,734,247 - 50,644,888 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,648,451 - 39,559,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,154,101 - 47,169,691 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,154,101 - 47,169,691 (+)Ensemblpanpan1.1panPan2
CEACAM6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,986,767 - 36,003,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,987,271 - 35,998,212 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,225,690 - 14,241,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ceacam6
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:127
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000034553, ENSRNOT00000057600
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
RH134089  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8190,216,382 - 90,216,639 (+)Marker Load Pipeline
mRatBN7.2181,088,586 - 81,088,843 (+)MAPPERmRatBN7.2
Rnor_6.0182,372,935 - 82,373,191NCBIRnor6.0
Rnor_5.0183,634,435 - 83,634,691UniSTSRnor5.0
RGSC_v3.4180,787,690 - 80,787,946UniSTSRGSC3.4
Celera175,529,124 - 75,529,380UniSTS
RH 3.4 Map1826.7UniSTS
BF390792  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0184,319,030 - 84,319,188NCBIRnor5.0
Rnor_5.0183,631,977 - 83,632,135NCBIRnor5.0
Rnor_5.0182,958,784 - 82,958,942NCBIRnor5.0
RGSC_v3.4180,785,077 - 80,785,234UniSTSRGSC3.4
RGSC_v3.4180,129,322 - 80,129,479UniSTSRGSC3.4
Celera174,883,686 - 74,883,843UniSTS
Celera175,526,656 - 75,526,813UniSTS
RH 3.4 Map1823.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 28 21 19 8 13 8 5 45 25 18 3 24 11

Sequence


Ensembl Acc Id: ENSRNOT00000034553   ⟹   ENSRNOP00000034872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl180,416,531 - 80,434,668 (+)Ensembl
Rnor_6.0 Ensembl181,683,500 - 81,701,230 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057600   ⟹   ENSRNOP00000054410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl180,416,531 - 80,434,668 (+)Ensembl
Rnor_6.0 Ensembl181,683,463 - 81,701,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071029   ⟹   ENSRNOP00000066253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,043,490 - 83,061,477 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074720   ⟹   ENSRNOP00000064263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,043,760 - 83,049,924 (+)Ensembl
RefSeq Acc Id: NR_045097
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,544,415 - 89,562,552 (+)NCBI
mRatBN7.2180,416,531 - 80,434,668 (+)NCBI
Rnor_6.0181,683,500 - 81,701,230 (+)NCBI
Celera175,527,118 - 75,528,059 (-)NCBI
Sequence:
Protein Sequences
GenBank Protein AAH78962 (Get FASTA)   NCBI Sequence Viewer  
  BAG55210 (Get FASTA)   NCBI Sequence Viewer  
  EDM08072 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034872.2
  ENSRNOP00000054410.5
Ensembl Acc Id: ENSRNOP00000054410   ⟸   ENSRNOT00000057600
Ensembl Acc Id: ENSRNOP00000034872   ⟸   ENSRNOT00000034553
Ensembl Acc Id: ENSRNOP00000064263   ⟸   ENSRNOT00000074720
Ensembl Acc Id: ENSRNOP00000066253   ⟸   ENSRNOT00000071029
Protein Domains
Ig-like   Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R9S3-F1-model_v2 AlphaFold M0R9S3 1-455 view protein structure
AF-F7FIX1-F1-model_v2 AlphaFold F7FIX1 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1642421 AgrOrtholog
BioCyc Gene G2FUF-60415 BioCyc
Ensembl Genes ENSRNOG00000030331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000045673 Ensembl
Ensembl Transcript ENSRNOT00000034553.6 UniProtKB/TrEMBL
  ENSRNOT00000057600 ENTREZGENE
  ENSRNOT00000057600.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111028 IMAGE-MGC_LOAD
InterPro CEA_cell_adhesion UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
MGC_CLONE MGC:93832 IMAGE-MGC_LOAD
NCBI Gene 100125369 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1 UniProtKB/TrEMBL
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Ceacam6 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030331 RatGTEx
  ENSRNOG00000045673 RatGTEx
RNAcentral URS000075E042 RNACentral
  URS0000CD074B RNACentral
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt B3Y574_RAT UniProtKB/TrEMBL
  F7EZA6_RAT UniProtKB/TrEMBL
  Q6AYP8_RAT UniProtKB/TrEMBL
UniProt Secondary F7FIX1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ceacam6  CEA cell adhesion molecule 6  LOC103689938  carcinoembryonic antigen-related cell adhesion molecule 1-like  Data merged from RGD:9070653 737654 PROVISIONAL
2019-09-03 Ceacam6  CEA cell adhesion molecule 6  Ceacam6  carcinoembryonic antigen-related cell adhesion molecule 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103689938  carcinoembryonic antigen-related cell adhesion molecule 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-09-15 Ceacam6  carcinoembryonic antigen-related cell adhesion molecule 6      Symbol and Name status set to provisional 70820 PROVISIONAL