Fgf21 (fibroblast growth factor 21) - Rat Genome Database

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Gene: Fgf21 (fibroblast growth factor 21) Rattus norvegicus
Analyze
Symbol: Fgf21
Name: fibroblast growth factor 21
RGD ID: 620175
Description: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including cellular response to glucagon stimulus; endothelial cell apoptotic process; and negative regulation of cell death. Located in extracellular space. Orthologous to human FGF21 (fibroblast growth factor 21); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fgf8c; fibroblast growth factor 8c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,083,495 - 96,084,738 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,083,441 - 96,090,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,468,930 - 101,470,173 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01109,941,627 - 109,942,870 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01103,232,004 - 103,233,247 (-)NCBIRnor_WKY
Rnor_6.01101,595,579 - 101,596,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,595,579 - 101,596,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,674,359 - 102,675,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,082,475 - 96,083,718 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,160,585 - 96,161,829 (-)NCBI
Celera190,337,152 - 90,338,395 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,4-dithiothreitol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-chloroethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arachidonyl-2'-chloroethylamide  (EXP,ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
camostat  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
Citreoviridin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
endosulfan  (EXP)
epalrestat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP,ISO)
glucagon  (ISO)
glucose  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (EXP)
L-1,4-dithiothreitol  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
Octicizer  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
streptozocin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
extracellular space  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk. Al-Aqil FA, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2927-2937. doi: 10.1016/j.bbadis.2018.06.003. Epub 2018 Jun 6.
2. Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? Arafat AM, etal., Diabetologia. 2013 Mar;56(3):588-97. doi: 10.1007/s00125-012-2803-y. Epub 2012 Dec 22.
3. Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Chow WS, etal., Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2454-9. doi: 10.1161/ATVBAHA.113.301599. Epub 2013 Jul 25.
4. Serum fibroblast growth factor 21 is associated with renal function and chronic kidney disease in community-dwelling adults. Crasto C, etal., J Am Geriatr Soc. 2012 Apr;60(4):792-3. doi: 10.1111/j.1532-5415.2011.03879.x.
5. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Fisher FM, etal., Genes Dev. 2012 Feb 1;26(3):271-81. doi: 10.1101/gad.177857.111.
6. Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction. Fletcher JA, etal., Appl Physiol Nutr Metab. 2012 Dec;37(6):1054-62. doi: 10.1139/h2012-091. Epub 2012 Aug 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction. Hu Y, etal., JHEP Rep. 2020 Feb 18;2(2):100093. doi: 10.1016/j.jhepr.2020.100093. eCollection 2020 Apr.
9. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. Iizuka K, etal., FEBS Lett. 2009 Sep 3;583(17):2882-6. doi: 10.1016/j.febslet.2009.07.053. Epub 2009 Aug 4.
10. Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Johnson CL, etal., Gastroenterology. 2009 Nov;137(5):1795-804. doi: 10.1053/j.gastro.2009.07.064. Epub 2009 Aug 5.
11. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Kamimura N, etal., Obesity (Silver Spring). 2011 Jul;19(7):1396-403. doi: 10.1038/oby.2011.6. Epub 2011 Feb 3.
12. Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function. Kim JH, etal., Diabetes Obes Metab. 2015 Feb;17(2):161-9. doi: 10.1111/dom.12408. Epub 2014 Nov 28.
13. FGF21 is an endocrine signal of protein restriction. Laeger T, etal., J Clin Invest. 2014 Sep;124(9):3913-22. doi: 10.1172/JCI74915. Epub 2014 Aug 18.
14. Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. Lee CH, etal., J Clin Endocrinol Metab. 2015 Apr;100(4):1368-75. doi: 10.1210/jc.2014-3465. Epub 2015 Jan 27.
15. FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers. Leng Y, etal., Mol Psychiatry. 2015 Feb;20(2):215-23. doi: 10.1038/mp.2013.192. Epub 2014 Jan 28.
16. Fibroblast growth factor 21 as a possible endogenous factor inhibits apoptosis in cardiac endothelial cells. Lu Y, etal., Chin Med J (Engl). 2010 Dec;123(23):3417-21.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Nishimura T, etal., Biochim Biophys Acta 2000 Jun 21;1492(1):203-6.
20. Metformin stimulates FGF21 expression in primary hepatocytes. Nygaard EB, etal., Exp Diabetes Res. 2012;2012:465282. doi: 10.1155/2012/465282. Epub 2012 Oct 15.
21. Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle. Perrone CE, etal., J Nutrigenet Nutrigenomics. 2012;5(3):132-57. doi: 10.1159/000339347. Epub 2012 Oct 9.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Planavila A, etal., Nat Commun. 2013;4:2019. doi: 10.1038/ncomms3019.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Schaap FG, etal., Biochimie. 2013 Apr;95(4):692-9. doi: 10.1016/j.biochi.2012.10.019. Epub 2012 Nov 2.
28. Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats. Wang WF, etal., Endocrine. 2015 May;49(1):119-29. doi: 10.1007/s12020-014-0433-5. Epub 2014 Oct 12.
29. Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes. Xiao Y, etal., Cardiovasc Diabetol. 2015 Jun 6;14:72. doi: 10.1186/s12933-015-0229-9.
Additional References at PubMed
PMID:17623664   PMID:18187602   PMID:19837871   PMID:21215149   PMID:21317437   PMID:21392510   PMID:22661717   PMID:23305840   PMID:24498293   PMID:24733293   PMID:25176985   PMID:26329882  
PMID:26982498   PMID:27248050   PMID:27387420   PMID:27445299   PMID:27574977   PMID:28188284   PMID:28559436   PMID:28774557   PMID:28889722   PMID:28890831   PMID:29077838   PMID:29273504  
PMID:30059270   PMID:30197006   PMID:30322116   PMID:30620889   PMID:31740658   PMID:32657446   PMID:33830241   PMID:34127689   PMID:34233693   PMID:34453661   PMID:35159376   PMID:35513524  
PMID:35531910   PMID:35634669   PMID:35879461   PMID:36213282  


Genomics

Comparative Map Data
Fgf21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,083,495 - 96,084,738 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,083,441 - 96,090,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,468,930 - 101,470,173 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01109,941,627 - 109,942,870 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01103,232,004 - 103,233,247 (-)NCBIRnor_WKY
Rnor_6.01101,595,579 - 101,596,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,595,579 - 101,596,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,674,359 - 102,675,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,082,475 - 96,083,718 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,160,585 - 96,161,829 (-)NCBI
Celera190,337,152 - 90,338,395 (-)NCBICelera
Cytogenetic Map1q22NCBI
FGF21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,755,524 - 48,758,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1948,755,524 - 48,758,333 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,258,781 - 49,261,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,951,156 - 53,953,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,951,305 - 53,953,289NCBI
Celera1946,125,436 - 46,127,638 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,638,191 - 45,640,357 (+)NCBIHuRef
CHM1_11949,261,115 - 49,263,353 (+)NCBICHM1_1
T2T-CHM13v2.01951,749,989 - 51,752,722 (+)NCBIT2T-CHM13v2.0
Fgf21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,263,314 - 45,264,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,263,310 - 45,264,914 (-)EnsemblGRCm39 Ensembl
GRCm38745,613,890 - 45,615,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,613,886 - 45,615,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,869,260 - 52,870,860 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36735,187,750 - 35,189,350 (-)NCBIMGSCv36mm8
MGSCv36745,481,932 - 45,483,532 (-)NCBIMGSCv36mm8
Celera741,070,177 - 41,081,186 (-)NCBICelera
Cytogenetic Map7B3NCBI
Fgf21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,817,110 - 1,820,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,818,400 - 1,821,423 (-)NCBIChiLan1.0ChiLan1.0
FGF21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,345,966 - 54,347,712 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01945,755,466 - 45,758,472 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FGF21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,571,449 - 107,576,630 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,571,446 - 107,573,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,093,881 - 107,096,319 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,096,091 - 108,098,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,096,198 - 108,097,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,762,951 - 107,765,389 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,409,841 - 107,412,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,245,446 - 108,247,884 (-)NCBIUU_Cfam_GSD_1.0
Fgf21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,208,545 - 21,210,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,826,823 - 2,828,330 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366642,826,823 - 2,828,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,080,739 - 54,084,601 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,082,653 - 54,084,532 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,828,972 - 49,831,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,006,125 - 42,008,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,006,064 - 42,008,736 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,876,517 - 21,879,217 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,164,856 - 5,167,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,165,195 - 5,166,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf21
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:111
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000028490
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 16 16 1
Low 2 26 24 13 12 13 58 19 34 10
Below cutoff 1 16 17 12 7 12 8 9 13 15 6 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028490   ⟹   ENSRNOP00000028490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,083,441 - 96,090,454 (-)Ensembl
Rnor_6.0 Ensembl1101,595,579 - 101,596,822 (-)Ensembl
RefSeq Acc Id: NM_130752   ⟹   NP_570108
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,083,495 - 96,084,738 (-)NCBI
Rnor_6.01101,595,579 - 101,596,822 (-)NCBI
Rnor_5.01102,674,359 - 102,675,602 (-)NCBI
RGSC_v3.4196,082,475 - 96,083,718 (-)RGD
Celera190,337,152 - 90,338,395 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_570108 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB84299 (Get FASTA)   NCBI Sequence Viewer  
  EDM07326 (Get FASTA)   NCBI Sequence Viewer  
  VDK10968 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_570108   ⟸   NM_130752
- Peptide Label: precursor
- UniProtKB: Q8VI80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028490   ⟸   ENSRNOT00000028490

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VI80-F1-model_v2 AlphaFold Q8VI80 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620175 AgrOrtholog
BioCyc Gene G2FUF-59666 BioCyc
Ensembl Genes ENSRNOG00000020990 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028490.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028490.3 UniProtKB/TrEMBL
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  FGF15/19/21 UniProtKB/TrEMBL
  FGF21 UniProtKB/TrEMBL
  GF_heparin_bd UniProtKB/TrEMBL
KEGG Report rno:170580 UniProtKB/TrEMBL
NCBI Gene 170580 ENTREZGENE
PANTHER IL1_HBGF UniProtKB/TrEMBL
  PTHR11486:SF81 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PhenoGen Fgf21 PhenoGen
PIRSF FGF-19_FGF-21 UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt F7FG05_RAT UniProtKB/TrEMBL
  Q8VI80 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fgf21  fibroblast growth factor 21      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgf21  fibroblast growth factor 21      Symbol and Name status set to provisional 70820 PROVISIONAL