(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FGF21 mRNA] CTD PMID:31150632 (1->4)-beta-D-glucan multiple interactions ISO Fgf21 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FGF21 mRNA CTD PMID:36331819 1,2-dichloroethane decreases expression ISO Fgf21 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of FGF21 mRNA CTD PMID:28960355 1,4-dithiothreitol multiple interactions ISO Fgf21 (Mus musculus) 6480464 indolo(3 and 2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA] CTD PMID:27226639 1,4-dithiothreitol increases expression EXP 6480464 Dithiothreitol results in increased expression of FGF21 mRNA CTD PMID:23123503 1,4-dithiothreitol increases secretion EXP 6480464 Dithiothreitol results in increased secretion of FGF21 protein CTD PMID:23123503 1,4-dithiothreitol multiple interactions ISO FGF21 (Homo sapiens) 6480464 indolo(3 and 2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA] CTD PMID:27226639 1,4-dithiothreitol increases expression ISO FGF21 (Homo sapiens) 6480464 Dithiothreitol results in increased expression of FGF21 mRNA CTD PMID:23123503 and PMID:27226639 1,4-dithiothreitol increases expression ISO Fgf21 (Mus musculus) 6480464 Dithiothreitol results in increased expression of FGF21 mRNA CTD PMID:27226639 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of FGF21 mRNA CTD PMID:32145629 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Fgf21 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Fgf21 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of FGF21 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Fgf21 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA and Tetrachlorodibenzodioxin results in increased expression of FGF21 protein CTD PMID:21846477 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Fgf21 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of FGF21 mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases response to substance ISO Fgf21 (Mus musculus) 6480464 FGF21 protein results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:24769090 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO FGF21 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA CTD PMID:24769090 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO FGF21 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased expression of FGF21 mRNA] CTD PMID:27226639 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Fgf21 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of FGF21 mRNA CTD PMID:19770486 and PMID:27226639 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of FGF21 mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Fgf21 (Mus musculus) 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of FGF21 mRNA more ... CTD PMID:21846477 more ... 2,4-dinitrophenol multiple interactions ISO Fgf21 (Mus musculus) 6480464 [2 and 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of FGF21 mRNA CTD PMID:24872412 2-chloroethanol multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA and Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] CTD PMID:31499194 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO Fgf21 (Mus musculus) 6480464 3 more ... CTD PMID:28163111 and PMID:30312631 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:29474705 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO Fgf21 (Mus musculus) 6480464 3 more ... CTD PMID:28163111 and PMID:30312631 3,3',5,5'-tetrabromobisphenol A increases expression ISO Fgf21 (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of FGF21 mRNA CTD PMID:25172293 3,3',5,5'-tetrabromobisphenol A increases expression ISO FGF21 (Homo sapiens) 6480464 tetrabromobisphenol A results in increased expression of FGF21 mRNA CTD PMID:33476716 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Fgf21 (Mus musculus) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FGF21 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased secretion of FGF21 protein CTD PMID:31009676 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of FGF21 mRNA CTD PMID:24780913 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of FGF21 mRNA CTD PMID:28959563 aflatoxin B1 decreases expression ISO Fgf21 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of FGF21 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO FGF21 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of FGF21 gene CTD PMID:28458013 aflatoxin B1 decreases expression ISO FGF21 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of FGF21 mRNA CTD PMID:27153756 aldehydo-D-glucose affects uptake ISO FGF21 (Homo sapiens) 6480464 FGF21 protein affects the uptake of Glucose CTD PMID:15902306 aldehydo-D-glucose increases expression ISO FGF21 (Homo sapiens) 6480464 Glucose results in increased expression of FGF21 mRNA CTD PMID:27226639 aldehydo-D-glucose multiple interactions ISO Fgf21 (Mus musculus) 6480464 indolo(3 more ... CTD PMID:27226639 aldehydo-D-glucose increases secretion ISO Fgf21 (Mus musculus) 6480464 Glucose results in increased secretion of FGF21 protein CTD PMID:28123933 aldehydo-D-glucose increases expression ISO Fgf21 (Mus musculus) 6480464 Glucose deficiency results in increased expression of FGF21 mRNA CTD PMID:27226639 aldehydo-D-glucose multiple interactions ISO FGF21 (Homo sapiens) 6480464 indolo(3 more ... CTD PMID:27226639 aldehydo-D-glucose affects uptake ISO Fgf21 (Mus musculus) 6480464 FGF21 protein affects the uptake of Glucose CTD PMID:15902306 alpha-cyano-4-hydroxycinnamic acid multiple interactions ISO Fgf21 (Mus musculus) 6480464 alpha-cyano-4-hydroxycinnamate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA] CTD PMID:31009676 amino acid increases expression ISO Fgf21 (Mus musculus) 6480464 Amino Acids deficiency results in increased expression of FGF21 mRNA CTD PMID:29449374 amino acid multiple interactions ISO Fgf21 (Mus musculus) 6480464 EIF2AK4 gene mutant form inhibits the reaction [Amino Acids deficiency results in increased expression of FGF21 mRNA] CTD PMID:29449374 amiodarone increases expression ISO Fgf21 (Mus musculus) 6480464 Amiodarone results in increased expression of FGF21 mRNA CTD PMID:24489787 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of FGF21 mRNA CTD PMID:16483693 arachidonyl-2'-chloroethylamide increases expression ISO FGF21 (Homo sapiens) 6480464 arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA CTD PMID:27455076 arachidonyl-2'-chloroethylamide increases secretion EXP 6480464 arachidonyl-2-chloroethylamide results in increased secretion of FGF21 protein CTD PMID:27455076 arachidonyl-2'-chloroethylamide increases expression ISO Fgf21 (Mus musculus) 6480464 arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA and arachidonyl-2-chloroethylamide results in increased expression of FGF21 protein CTD PMID:27455076 arachidonyl-2'-chloroethylamide multiple interactions ISO Fgf21 (Mus musculus) 6480464 arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to FGF21 promoter] more ... CTD PMID:27455076 arachidonyl-2'-chloroethylamide multiple interactions ISO FGF21 (Homo sapiens) 6480464 ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA] and GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA] CTD PMID:27455076 arachidonyl-2'-chloroethylamide increases expression EXP 6480464 arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA CTD PMID:27455076 arachidonyl-2'-chloroethylamide increases secretion ISO Fgf21 (Mus musculus) 6480464 arachidonyl-2-chloroethylamide results in increased secretion of FGF21 protein CTD PMID:27455076 Aroclor 1254 decreases expression ISO Fgf21 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of FGF21 mRNA CTD PMID:25270620 arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of FGF21 mRNA CTD PMID:23123503 benzo[a]pyrene multiple interactions ISO Fgf21 (Mus musculus) 6480464 [corannulene co-treated with Benzo(a)pyrene] results in decreased expression of FGF21 mRNA CTD PMID:32417428 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FGF21 mRNA CTD PMID:18164116 bezafibrate multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein more ... CTD PMID:20854792 and PMID:22338096 bezafibrate increases expression ISO Fgf21 (Mus musculus) 6480464 Bezafibrate results in increased expression of FGF21 mRNA and Bezafibrate results in increased expression of FGF21 protein CTD PMID:18787029 more ... bezafibrate multiple interactions ISO FGF21 (Homo sapiens) 6480464 Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein] CTD PMID:22338096 bezafibrate increases expression ISO FGF21 (Homo sapiens) 6480464 Bezafibrate results in increased expression of FGF21 mRNA and Bezafibrate results in increased expression of FGF21 protein CTD PMID:22338096 bis(2-chloroethyl) sulfide increases expression ISO Fgf21 (Mus musculus) 6480464 Mustard Gas results in increased expression of FGF21 mRNA CTD PMID:15674844 bis(2-ethylhexyl) phthalate increases expression ISO Fgf21 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of FGF21 mRNA and Diethylhexyl Phthalate results in increased expression of FGF21 protein CTD PMID:20123618 and PMID:32522588 bis(2-ethylhexyl) phthalate multiple interactions ISO Fgf21 (Mus musculus) 6480464 Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA] and Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 protein] CTD PMID:24769090 bisphenol A affects expression ISO FGF21 (Homo sapiens) 6480464 bisphenol A affects the expression of FGF21 mRNA CTD PMID:20170705 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of FGF21 mRNA CTD PMID:32145629 and PMID:34947998 bisphenol A decreases expression ISO Fgf21 (Mus musculus) 6480464 bisphenol A results in decreased expression of FGF21 mRNA CTD PMID:29161229 bisphenol A increases expression ISO Fgf21 (Mus musculus) 6480464 bisphenol A results in increased expression of FGF21 mRNA CTD PMID:30790712 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of FGF21 mRNA CTD PMID:25181051 more ... bisphenol F increases expression ISO Fgf21 (Mus musculus) 6480464 bisphenol F results in increased expression of FGF21 mRNA CTD PMID:30951980 bleomycin A2 multiple interactions ISO Fgf21 (Mus musculus) 6480464 Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of FGF21 protein] CTD PMID:30825431 bleomycin A2 decreases expression ISO Fgf21 (Mus musculus) 6480464 Bleomycin results in decreased expression of FGF21 protein CTD PMID:30825431 bortezomib multiple interactions ISO FGF21 (Homo sapiens) 6480464 [BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of FGF21 mRNA CTD PMID:25522274 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of FGF21 mRNA CTD PMID:32479839 camostat multiple interactions ISO Fgf21 (Mus musculus) 6480464 camostat results in increased expression of and results in increased secretion of FGF21 protein CTD PMID:30920846 cannabidiol increases expression ISO Fgf21 (Mus musculus) 6480464 Cannabidiol analog results in increased expression of FGF21 mRNA CTD PMID:30382123 cannabidiol multiple interactions ISO Fgf21 (Mus musculus) 6480464 Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of FGF21 protein] and Cannabidiol analog inhibits the reaction [Dietary Fats results in increased expression of FGF21 mRNA] CTD PMID:30382123 and PMID:30825431 carbon nanotube increases expression ISO Fgf21 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 chlorohydrocarbon multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of FGF21 mRNA CTD PMID:30744511 chlorpyrifos increases expression ISO Fgf21 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of FGF21 mRNA CTD PMID:34289071 choline multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA more ... CTD PMID:20350562 more ... ciguatoxin CTX1B affects expression ISO Fgf21 (Mus musculus) 6480464 Ciguatoxins affects the expression of FGF21 mRNA CTD PMID:18353800 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of FGF21 mRNA CTD PMID:22023808 Citreoviridin decreases expression ISO Fgf21 (Mus musculus) 6480464 citreoviridin results in decreased expression of FGF21 mRNA CTD PMID:28645467 Citreoviridin decreases expression ISO FGF21 (Homo sapiens) 6480464 citreoviridin results in decreased expression of FGF21 mRNA CTD PMID:28645467 cobalt dichloride multiple interactions ISO FGF21 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA] more ... CTD PMID:22917661 cobalt dichloride decreases secretion ISO FGF21 (Homo sapiens) 6480464 cobaltous chloride results in decreased secretion of FGF21 protein CTD PMID:22917661 corn oil affects expression EXP 6480464 Corn Oil affects the expression of FGF21 mRNA CTD PMID:16360708 cyclosporin A increases expression ISO FGF21 (Homo sapiens) 6480464 Cyclosporine results in increased expression of FGF21 mRNA CTD PMID:20106945 and PMID:27989131 cyhalothrin decreases expression ISO Fgf21 (Mus musculus) 6480464 cyhalothrin results in decreased expression of FGF21 mRNA and cyhalothrin results in decreased expression of FGF21 protein CTD PMID:36529352 D-glucose affects uptake ISO FGF21 (Homo sapiens) 6480464 FGF21 protein affects the uptake of Glucose CTD PMID:15902306 D-glucose multiple interactions ISO Fgf21 (Mus musculus) 6480464 indolo(3 more ... CTD PMID:27226639 D-glucose increases secretion ISO Fgf21 (Mus musculus) 6480464 Glucose results in increased secretion of FGF21 protein CTD PMID:28123933 D-glucose increases expression ISO Fgf21 (Mus musculus) 6480464 Glucose deficiency results in increased expression of FGF21 mRNA CTD PMID:27226639 D-glucose multiple interactions ISO FGF21 (Homo sapiens) 6480464 indolo(3 more ... CTD PMID:27226639 D-glucose increases expression ISO FGF21 (Homo sapiens) 6480464 Glucose results in increased expression of FGF21 mRNA CTD PMID:27226639 D-glucose affects uptake ISO Fgf21 (Mus musculus) 6480464 FGF21 protein affects the uptake of Glucose CTD PMID:15902306 dexamethasone increases expression EXP 15045603 dexamethasone increases Fgf21 mRNA expression in liver in rat RGD dexamethasone increases expression ISO Fgf21 (Mus musculus) 6480464 Dexamethasone results in increased expression of FGF21 mRNA and Dexamethasone results in increased expression of FGF21 protein CTD PMID:28088388 dexamethasone multiple interactions ISO FGF21 (Homo sapiens) 6480464 Dexamethasone promotes the reaction [NR1I2 protein binds to FGF21 promoter] more ... CTD PMID:28088388 dexamethasone increases expression ISO FGF21 (Homo sapiens) 6480464 Dexamethasone results in increased expression of FGF21 mRNA and Dexamethasone results in increased expression of FGF21 protein CTD PMID:28088388 dexamethasone multiple interactions ISO Fgf21 (Mus musculus) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FGF21 mRNA more ... CTD PMID:28088388 and PMID:31009676 dexamethasone decreases expression ISO Fgf21 (Mus musculus) 6480464 Dexamethasone results in decreased expression of FGF21 mRNA CTD PMID:22733784 diazinon affects expression EXP 6480464 Diazinon affects the expression of FGF21 mRNA CTD PMID:19130878 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of FGF21 mRNA CTD PMID:21266533 dichloroacetic acid increases expression ISO Fgf21 (Mus musculus) 6480464 Dichloroacetic Acid results in increased expression of FGF21 mRNA CTD PMID:28962523 dieldrin decreases expression EXP 6480464 Dieldrin results in decreased expression of FGF21 mRNA CTD PMID:19130878 dioxygen decreases expression ISO FGF21 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of FGF21 mRNA CTD PMID:22917661 dioxygen decreases secretion ISO FGF21 (Homo sapiens) 6480464 Oxygen deficiency results in decreased secretion of FGF21 protein CTD PMID:22917661 diquat increases expression ISO Fgf21 (Mus musculus) 6480464 Diquat results in increased expression of FGF21 mRNA CTD PMID:36851058 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of FGF21 mRNA CTD PMID:29391264 epalrestat increases expression ISO Fgf21 (Mus musculus) 6480464 epalrestat results in increased expression of FGF21 mRNA CTD PMID:28204799 epoxiconazole decreases expression ISO Fgf21 (Mus musculus) 6480464 epoxiconazole results in decreased expression of FGF21 mRNA CTD PMID:35436446 ethanol increases response to substance ISO Fgf21 (Mus musculus) 6480464 FGF21 gene mutant form results in increased susceptibility to Ethanol CTD PMID:28131861 ethanol multiple interactions ISO Fgf21 (Mus musculus) 6480464 [[PPARA protein co-treated with CYP2A5 protein] affects the susceptibility to Ethanol] which affects the expression of FGF21 protein more ... CTD PMID:27455076 more ... ethanol increases expression ISO Fgf21 (Mus musculus) 6480464 Ethanol results in increased expression of FGF21 mRNA and Ethanol results in increased expression of FGF21 protein CTD PMID:27455076 and PMID:28131861 famotidine increases expression ISO FGF21 (Homo sapiens) 6480464 Famotidine results in increased expression of FGF21 protein CTD PMID:8774986 fenofibrate increases expression ISO FGF21 (Homo sapiens) 6480464 Fenofibrate results in increased expression of FGF21 mRNA and Fenofibrate results in increased expression of FGF21 protein CTD PMID:22338096 fluoranthene multiple interactions ISO Fgf21 (Mus musculus) 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of FGF21 mRNA CTD PMID:28329830 flutamide increases expression EXP 6480464 Flutamide results in increased expression of FGF21 mRNA CTD PMID:24136188 folic acid multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF21 mRNA CTD PMID:20938992 and PMID:29127188 fructose increases response to substance ISO Fgf21 (Mus musculus) 6480464 FGF21 gene mutant form results in increased susceptibility to Fructose CTD PMID:28123933 fructose increases secretion ISO Fgf21 (Mus musculus) 6480464 Fructose results in increased secretion of FGF21 protein CTD PMID:28123933 fructose multiple interactions ISO Fgf21 (Mus musculus) 6480464 [FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose more ... CTD PMID:28123933 fructose increases expression ISO Fgf21 (Mus musculus) 6480464 Fructose results in increased expression of FGF21 mRNA CTD PMID:28123933 furan increases expression ISO Fgf21 (Mus musculus) 6480464 furan results in increased expression of FGF21 mRNA CTD PMID:24183702 and PMID:37517673 furan increases expression EXP 6480464 furan results in increased expression of FGF21 mRNA CTD PMID:26194646 glucagon multiple interactions ISO Fgf21 (Mus musculus) 6480464 Glucagon analog promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of FGF21 protein] and Glucagon analog promotes the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of FGF21 protein] CTD PMID:29988851 glucose affects uptake ISO FGF21 (Homo sapiens) 6480464 FGF21 protein affects the uptake of Glucose CTD PMID:15902306 glucose increases expression ISO Fgf21 (Mus musculus) 6480464 Glucose deficiency results in increased expression of FGF21 mRNA CTD PMID:27226639 glucose multiple interactions ISO Fgf21 (Mus musculus) 6480464 indolo(3 more ... CTD PMID:27226639 glucose increases secretion ISO Fgf21 (Mus musculus) 6480464 Glucose results in increased secretion of FGF21 protein CTD PMID:28123933 glucose multiple interactions ISO FGF21 (Homo sapiens) 6480464 indolo(3 more ... CTD PMID:27226639 glucose increases expression ISO FGF21 (Homo sapiens) 6480464 Glucose results in increased expression of FGF21 mRNA CTD PMID:27226639 glucose affects uptake ISO Fgf21 (Mus musculus) 6480464 FGF21 protein affects the uptake of Glucose CTD PMID:15902306 GW 4064 increases expression ISO Fgf21 (Mus musculus) 6480464 GW 4064 results in increased expression of FGF21 mRNA CTD PMID:26655953 GW 7647 multiple interactions ISO FGF21 (Homo sapiens) 6480464 indolo(3 and 2-b)carbazole inhibits the reaction [GW 7647 results in increased expression of FGF21 mRNA] CTD PMID:27226639 GW 7647 increases expression ISO FGF21 (Homo sapiens) 6480464 GW 7647 results in increased expression of FGF21 mRNA CTD PMID:27226639 Heptachlor epoxide decreases expression ISO Fgf21 (Mus musculus) 6480464 Heptachlor Epoxide results in decreased expression of FGF21 mRNA CTD PMID:25270620 hexadecanoic acid multiple interactions ISO FGF21 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] results in increased expression of FGF21 mRNA and [Palmitic Acid co-treated with Oleic Acid] results in increased expression of FGF21 mRNA CTD PMID:30547786 imidazopyrazole affects expression ISO FGF21 (Homo sapiens) 6480464 imidazopyrazole analog affects the expression of FGF21 mRNA CTD PMID:30388846 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA more ... CTD PMID:22129741 inulin multiple interactions ISO Fgf21 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of FGF21 mRNA CTD PMID:36331819 L-1,4-dithiothreitol increases expression EXP 6480464 Dithiothreitol results in increased expression of FGF21 mRNA CTD PMID:23123503 L-1,4-dithiothreitol increases secretion EXP 6480464 Dithiothreitol results in increased secretion of FGF21 protein CTD PMID:23123503 L-1,4-dithiothreitol multiple interactions ISO FGF21 (Homo sapiens) 6480464 indolo(3 and 2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA] CTD PMID:27226639 L-1,4-dithiothreitol increases expression ISO FGF21 (Homo sapiens) 6480464 Dithiothreitol results in increased expression of FGF21 mRNA CTD PMID:23123503 and PMID:27226639 L-1,4-dithiothreitol increases expression ISO Fgf21 (Mus musculus) 6480464 Dithiothreitol results in increased expression of FGF21 mRNA CTD PMID:27226639 L-1,4-dithiothreitol multiple interactions ISO Fgf21 (Mus musculus) 6480464 indolo(3 and 2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA] CTD PMID:27226639 L-glutamine increases expression EXP 6480464 Glutamine deficiency results in increased expression of FGF21 mRNA CTD PMID:23123503 L-methionine multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA more ... CTD PMID:20350562 more ... L-methionine increases expression ISO Fgf21 (Mus musculus) 6480464 Methionine deficiency results in increased expression of FGF21 mRNA and Methionine deficiency results in increased expression of FGF21 protein CTD PMID:25178843 lansoprazole increases expression ISO FGF21 (Homo sapiens) 6480464 Lansoprazole results in increased expression of FGF21 protein CTD PMID:8774986 lead diacetate increases expression ISO Fgf21 (Mus musculus) 6480464 lead acetate results in increased expression of FGF21 mRNA CTD PMID:22609695 lipopolysaccharide multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA and Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] CTD PMID:31499194 lithium chloride increases expression EXP 10401923 Lithium increases expression of Fgf21 mRNA in cerebellar granular cells and hippocampal and cortical neurons RGD metformin multiple interactions ISO FGF21 (Homo sapiens) 6480464 Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein] CTD PMID:36764371 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of FGF21 mRNA CTD PMID:22484513 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of FGF21 mRNA CTD PMID:30467583 methylmercury chloride multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of FGF21 mRNA CTD PMID:30744511 microcystin-LR increases expression ISO Fgf21 (Mus musculus) 6480464 cyanoginosin LR results in increased expression of FGF21 mRNA CTD PMID:25497113 and PMID:37342990 mifepristone multiple interactions ISO Fgf21 (Mus musculus) 6480464 Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FGF21 mRNA] CTD PMID:28088388 mifepristone multiple interactions ISO FGF21 (Homo sapiens) 6480464 Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FGF21 mRNA] CTD PMID:28088388 mono(2-ethylhexyl) phthalate increases expression ISO Fgf21 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA CTD PMID:20123618 more ... mono(2-ethylhexyl) phthalate increases secretion ISO Fgf21 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased secretion of FGF21 protein CTD PMID:31009676 mono(2-ethylhexyl) phthalate multiple interactions ISO Fgf21 (Mus musculus) 6480464 alpha-cyano-4-hydroxycinnamate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA] more ... CTD PMID:20123618 and PMID:31009676 monosodium L-glutamate multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Sodium Glutamate co-treated with Trans Fatty Acids] results in increased expression of FGF21 mRNA CTD PMID:19001666 Muraglitazar increases expression EXP 6480464 muraglitazar results in increased expression of FGF21 mRNA CTD PMID:21515302 N-acetyl-L-cysteine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA and Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA] CTD PMID:22129741 N-acetyl-L-cysteine multiple interactions ISO FGF21 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA] and Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased secretion of FGF21 protein] CTD PMID:22917661 N-methyl-4-phenylpyridinium increases methylation EXP 6480464 1-Methyl-4-phenylpyridinium results in increased methylation of FGF21 gene CTD PMID:28801915 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of FGF21 mRNA CTD PMID:28801915 N-methylformamide increases expression ISO Fgf21 (Mus musculus) 6480464 methylformamide analog results in increased expression of FGF21 mRNA and methylformamide results in increased expression of FGF21 mRNA CTD PMID:17040096 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FGF21 mRNA more ... CTD PMID:18164116 and PMID:22129741 N-nitrosodiethylamine multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FGF21 mRNA CTD PMID:24535843 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of FGF21 mRNA CTD PMID:24136188 nickel atom affects expression EXP 6480464 Nickel affects the expression of FGF21 mRNA CTD PMID:19130878 Nor-9-carboxy-delta9-THC multiple interactions ISO FGF21 (Homo sapiens) 6480464 [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of FGF21 gene CTD PMID:30521419 Octicizer multiple interactions ISO Fgf21 (Mus musculus) 6480464 [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1 and 3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FGF21 mRNA CTD PMID:33367866 oleic acid multiple interactions ISO FGF21 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] results in increased expression of FGF21 mRNA and [Palmitic Acid co-treated with Oleic Acid] results in increased expression of FGF21 mRNA CTD PMID:30547786 paracetamol affects expression ISO Fgf21 (Mus musculus) 6480464 Acetaminophen affects the expression of FGF21 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of FGF21 mRNA CTD PMID:32479839 paracetamol multiple interactions ISO Fgf21 (Mus musculus) 6480464 Acetaminophen promotes the reaction [Dexamethasone results in increased expression of FGF21 mRNA] more ... CTD PMID:28088388 paracetamol increases expression ISO Fgf21 (Mus musculus) 6480464 Acetaminophen results in increased expression of FGF21 mRNA CTD PMID:28088388 paracetamol decreases expression ISO FGF21 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of FGF21 mRNA CTD PMID:22230336 paracetamol increases expression ISO FGF21 (Homo sapiens) 6480464 Acetaminophen results in increased expression of FGF21 mRNA CTD PMID:21420995 PCB138 multiple interactions ISO Fgf21 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 perfluorononanoic acid increases expression ISO FGF21 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in increased expression of FGF21 mRNA CTD PMID:32588087 perfluorooctane-1-sulfonic acid multiple interactions ISO Fgf21 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FGF21 mRNA more ... CTD PMID:36331819 perfluorooctanoic acid increases expression ISO FGF21 (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of FGF21 mRNA CTD PMID:32588087 phenobarbital multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FGF21 mRNA more ... CTD PMID:19482888 and PMID:24535843 phenobarbital decreases expression ISO Fgf21 (Mus musculus) 6480464 Phenobarbital results in decreased expression of FGF21 mRNA CTD PMID:19482888 and PMID:23091169 phenobarbital affects expression ISO Fgf21 (Mus musculus) 6480464 Phenobarbital affects the expression of FGF21 mRNA CTD PMID:19482888 pioglitazone increases expression ISO FGF21 (Homo sapiens) 6480464 pioglitazone results in increased expression of FGF21 mRNA CTD PMID:21720023 pioglitazone increases expression ISO Fgf21 (Mus musculus) 6480464 pioglitazone results in increased expression of FGF21 mRNA CTD PMID:21720023 pirinixic acid multiple interactions ISO Fgf21 (Mus musculus) 6480464 [pirinixic acid results in increased activity of PPARA protein] which results in increased expression of FGF21 mRNA CTD PMID:20032461 pirinixic acid increases expression ISO Fgf21 (Mus musculus) 6480464 pirinixic acid results in increased expression of FGF21 mRNA CTD PMID:18301758 more ... pregnenolone 16alpha-carbonitrile decreases expression ISO Fgf21 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of FGF21 mRNA CTD PMID:22698814 and PMID:28903501 resveratrol increases expression ISO FGF21 (Homo sapiens) 6480464 resveratrol results in increased expression of FGF21 mRNA and resveratrol results in increased expression of FGF21 protein CTD PMID:24184811 resveratrol multiple interactions ISO Fgf21 (Mus musculus) 6480464 Resveratrol inhibits the reaction [titanium dioxide results in increased expression of FGF21 mRNA] CTD PMID:31298478 sirolimus multiple interactions ISO Fgf21 (Mus musculus) 6480464 Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] CTD PMID:31499194 sodium arsenite decreases expression ISO Fgf21 (Mus musculus) 6480464 sodium arsenite results in decreased expression of FGF21 mRNA CTD PMID:25270620 sodium arsenite increases expression ISO Fgf21 (Mus musculus) 6480464 sodium arsenite results in increased expression of FGF21 mRNA CTD PMID:16014739 sodium dichromate increases expression ISO Fgf21 (Mus musculus) 6480464 sodium bichromate results in increased expression of FGF21 mRNA CTD PMID:22155349 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of FGF21 mRNA CTD PMID:25993096 streptozocin multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of FGF21 protein more ... CTD PMID:23499715 more ... streptozocin affects response to substance ISO Fgf21 (Mus musculus) 6480464 FGF21 protein affects the susceptibility to Streptozocin CTD PMID:23499715 tacrolimus hydrate decreases expression ISO Fgf21 (Mus musculus) 6480464 Tacrolimus results in decreased expression of FGF21 mRNA CTD PMID:25270620 tamoxifen affects expression ISO Fgf21 (Mus musculus) 6480464 Tamoxifen affects the expression of FGF21 mRNA CTD PMID:20937368 Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of FGF21 mRNA CTD PMID:21515302 tetrachloroethene increases expression ISO Fgf21 (Mus musculus) 6480464 Tetrachloroethylene results in increased expression of FGF21 mRNA CTD PMID:28973375 tetrachloromethane increases expression ISO Fgf21 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of FGF21 mRNA CTD PMID:16929488 more ... tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of FGF21 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FGF21 mRNA] CTD PMID:31150632 tetrachloromethane multiple interactions ISO Fgf21 (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of FGF21 mRNA CTD PMID:30517762 thapsigargin increases expression ISO FGF21 (Homo sapiens) 6480464 Thapsigargin results in increased expression of FGF21 mRNA CTD PMID:23123503 thapsigargin increases secretion EXP 6480464 Thapsigargin results in increased secretion of FGF21 protein CTD PMID:23123503 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of FGF21 mRNA CTD PMID:23123503 thapsigargin multiple interactions ISO Fgf21 (Mus musculus) 6480464 indolo(3 more ... CTD PMID:27226639 thapsigargin increases expression ISO Fgf21 (Mus musculus) 6480464 Thapsigargin results in increased expression of FGF21 mRNA CTD PMID:27226639 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of FGF21 mRNA CTD PMID:34492290 titanium dioxide multiple interactions ISO Fgf21 (Mus musculus) 6480464 Resveratrol inhibits the reaction [titanium dioxide results in increased expression of FGF21 mRNA] CTD PMID:31298478 titanium dioxide increases expression ISO Fgf21 (Mus musculus) 6480464 titanium dioxide results in increased expression of FGF21 mRNA CTD PMID:31298478 tributyl phosphate multiple interactions ISO Fgf21 (Mus musculus) 6480464 [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1 and 3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FGF21 mRNA CTD PMID:33367866 trichloroethene increases expression ISO Fgf21 (Mus musculus) 6480464 Trichloroethylene results in increased expression of FGF21 mRNA CTD PMID:25549359 and PMID:28973375 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of FGF21 mRNA CTD PMID:33387578 trichostatin A increases expression ISO FGF21 (Homo sapiens) 6480464 trichostatin A results in increased expression of FGF21 mRNA and trichostatin A results in increased expression of FGF21 protein CTD PMID:22338096 trichostatin A increases expression ISO Fgf21 (Mus musculus) 6480464 trichostatin A results in increased expression of FGF21 protein CTD PMID:22338096 trimethyltin increases expression ISO Fgf21 (Mus musculus) 6480464 trimethyltin results in increased expression of FGF21 mRNA CTD PMID:24002884 triphenyl phosphate multiple interactions ISO Fgf21 (Mus musculus) 6480464 [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1 and 3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FGF21 mRNA CTD PMID:33367866 tris(2-butoxyethyl) phosphate multiple interactions ISO Fgf21 (Mus musculus) 6480464 [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1 and 3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FGF21 mRNA CTD PMID:33367866 tris(2-chloroethyl) phosphate multiple interactions ISO Fgf21 (Mus musculus) 6480464 [tris(2-butoxyethyl) phosphate co-treated with IMOL S-140 co-treated with tri-(2-chloroisopropyl)phosphate co-treated with tris(1 and 3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with santicizer 148 co-treated with tris(chloroethyl)phosphate co-treated with 2-ethylhexyldiphenylphosphate co-treated with tributyl phosphate] results in increased expression of FGF21 mRNA CTD PMID:33367866 tris(2-chloroethyl) phosphate decreases expression ISO Fgf21 (Mus musculus) 6480464 tris(chloroethyl)phosphate results in decreased expression of FGF21 mRNA CTD PMID:35780845 troglitazone increases expression EXP 6480464 troglitazone results in increased expression of FGF21 mRNA CTD PMID:21515302 troglitazone decreases expression ISO Fgf21 (Mus musculus) 6480464 troglitazone results in decreased expression of FGF21 mRNA CTD PMID:28973697 tunicamycin multiple interactions ISO FGF21 (Homo sapiens) 6480464 FGF21 protein inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA] more ... CTD PMID:29289645 tunicamycin increases expression ISO Fgf21 (Mus musculus) 6480464 Tunicamycin results in increased expression of FGF21 mRNA and Tunicamycin results in increased expression of FGF21 protein CTD PMID:23123503 tunicamycin multiple interactions ISO Fgf21 (Mus musculus) 6480464 FGF21 protein inhibits the reaction [Tunicamycin promotes the reaction [PPARD gene mutant form results in increased expression of VLDLR mRNA]] more ... CTD PMID:29289645 valproic acid affects expression ISO Fgf21 (Mus musculus) 6480464 Valproic Acid affects the expression of FGF21 mRNA CTD PMID:17963808 valproic acid increases expression EXP 10401923 [Valproic acid cotreated with lithium] increases expression of Fgf21 mRNA and protein in cerebellar granular cells RGD valproic acid increases methylation ISO FGF21 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of FGF21 gene CTD PMID:29154799 valproic acid decreases expression ISO Fgf21 (Mus musculus) 6480464 Valproic Acid results in decreased expression of FGF21 mRNA CTD PMID:17292431 valproic acid increases expression ISO FGF21 (Homo sapiens) 6480464 Valproic Acid results in increased expression of FGF21 mRNA CTD PMID:29154799 valproic acid increases expression ISO Fgf21 (Mus musculus) 6480464 Valproic Acid results in increased expression of FGF21 mRNA CTD PMID:24489787 vanillic acid multiple interactions ISO FGF21 (Homo sapiens) 6480464 Vanillic Acid inhibits the reaction [INS protein results in decreased expression of FGF21 protein] CTD PMID:36764371 very-low-density lipoprotein triglyceride multiple interactions ISO Fgf21 (Mus musculus) 6480464 FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride] CTD PMID:28123933 very-low-density lipoprotein triglyceride decreases secretion ISO Fgf21 (Mus musculus) 6480464 FGF21 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride CTD PMID:28123933
