Atp4a (ATPase H+/K+ transporting subunit alpha)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Atp4a (ATPase H+/K+ transporting subunit alpha) Rattus norvegicus

Analyze

Symbol:

Atp4a

Name:

ATPase H+/K+ transporting subunit alpha

RGD ID:

2177

Description:

Predicted to enable P-type potassium:proton transporter activity; magnesium ion binding activity; and potassium ion binding activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within pH reduction; regulation of proton transport; and response to xenobiotic stimulus. Located in apical plasma membrane. Orthologous to human ATP4A (ATPase H+/K+ transporting subunit alpha); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esomeprazole pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ATPase H+/K+ transporting alpha subunit; ATPase H+K+-transporting alpha / (gastric HK-ATPase catalytic subunit); ATPase, H+,K+-transporting, alpha / (gastric H,K-ATPase catalytic subunit); ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; gastric H(+)/K(+) ATPase subunit alpha; gastric H,K-ATPase catalytic subunit; H+,K+-ATPase alpha subunit; Hka; HKATPC; hydrogen/potassium-exchanging ATPase 4A; potassium-transporting ATPase alpha chain 1; proton pump; RATHKATPC

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	85,961,607 - 85,974,972 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,961,708 - 85,974,844 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	91,377,251 - 91,390,049 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,843,427 - 99,856,225 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,135,546 - 93,148,344 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,162,700 - 89,175,504 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,162,639 - 89,175,811 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,317,629 - 90,330,433 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,756,388 - 85,769,192 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	2,286,438 - 2,286,714 (+)	NCBI
Celera	1	80,333,302 - 80,346,109 (+)	NCBI		Celera
RH 2.0 Map	1	561.1	RGD
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 5 (ISO)

dystonia (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 75 (ISO)

stomach cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

copper atom (EXP)

copper(0) (EXP)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

graphite (EXP)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

sodium arsenite (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment or maintenance of transmembrane electrochemical gradient (IEA)

gastric acid secretion (TAS)

intracellular potassium ion homeostasis (IBA)

intracellular sodium ion homeostasis (IBA)

pH reduction (IEA,ISO)

potassium ion import across plasma membrane (IBA)

potassium ion transmembrane transport (IEA,ISO)

proton transmembrane transport (IBA,IEA)

regulation of proton transport (IEA,ISO)

response to xenobiotic stimulus (IEA,ISO)

sodium ion export across plasma membrane (IBA)

Cellular Component

apical plasma membrane (IDA,IEA)

plasma membrane (IBA,ISO)

potassium:proton exchanging ATPase complex (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

magnesium ion binding (IEA,ISO,ISS)

P-type potassium:proton transporter activity (IBA,IEA,ISO,TAS)

P-type sodium:potassium-exchanging transporter activity (IBA)

potassium ion binding (ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cimetidine pharmacodynamics pathway (ISO)

esomeprazole pharmacodynamics pathway (ISO)

esomeprazole pharmacokinetics pathway (ISO)

famotidine pharmacodynamics pathway (ISO)

lansoprazole pharmacodynamics pathway (ISO)

lansoprazole pharmacokinetics pathway (ISO)

nizatidine pharmacodynamics pathway (ISO)

omeprazole pharmacodynamics pathway (ISO)

omeprazole pharmacokinetics pathway (ISO)

oxidative phosphorylation pathway (IEA)

pantoprazole pharmacodynamics pathway (ISO)

pantoprazole pharmacokinetics pathway (ISO)

pirenzepine pharmacodynamics pathway (ISO)

rabeprazole pharmacodynamics pathway (ISO)

rabeprazole pharmacokinetics pathway (ISO)

ranitidine pharmacodynamics pathway (ISO)

roxatidine acetate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion.	Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Identification and Analysis of Key Genes Driving Gastric Cancer Through Bioinformatics.	Liu Z, etal., Genet Test Mol Biomarkers. 2021 Jan;25(1):1-11. doi: 10.1089/gtmb.2020.0126.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes.	Newman PR, etal., DNA Cell Biol 1990 Dec;9(10):749-62.
8.	Control region and gastric specific transcription of the rat H+,K(+)-ATPase alpha subunit gene.	Oshiman K, etal., FEBS Lett 1991 Apr 9;281(1-2):250-4.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Molecular cloning of the rat stomach (H+ + K+)-ATPase.	Shull GE and Lingrel JB, J Biol Chem 1986 Dec 25;261(36):16788-91.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:1324928	PMID:7762614	PMID:7840253	PMID:15743908	PMID:22664934

Genomics

Comparative Map Data

Atp4a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	85,961,607 - 85,974,972 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,961,708 - 85,974,844 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	91,377,251 - 91,390,049 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,843,427 - 99,856,225 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,135,546 - 93,148,344 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,162,700 - 89,175,504 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,162,639 - 89,175,811 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,317,629 - 90,330,433 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,756,388 - 85,769,192 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	2,286,438 - 2,286,714 (+)	NCBI
Celera	1	80,333,302 - 80,346,109 (+)	NCBI		Celera
RH 2.0 Map	1	561.1	RGD
Cytogenetic Map	1	q21	NCBI

ATP4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,550,031 - 35,563,658 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,550,031 - 35,563,658 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	36,040,933 - 36,054,560 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,732,935 - 40,746,400 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	40,732,934 - 40,746,400	NCBI
Celera	19	32,754,548 - 32,768,023 (-)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,546,540 - 32,560,013 (-)	NCBI		HuRef
CHM1_1	19	36,042,661 - 36,056,126 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,094,977 - 38,108,614 (-)	NCBI		T2T-CHM13v2.0

Atp4a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,411,634 - 30,424,959 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,411,634 - 30,424,959 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	30,712,209 - 30,725,534 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,712,209 - 30,725,534 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,497,251 - 31,510,553 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,421,112 - 30,433,944 (+)	NCBI		MGSCv36	mm8
Celera	7	25,294,279 - 25,307,645 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	19.2	NCBI

Atp4a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,778,295 - 4,842,366 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	4,778,327 - 4,844,498 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATP4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	43,546,280 - 43,560,837 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,496,614 - 32,510,649 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,233,630 - 41,246,893 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,234,052 - 41,248,628 (-)	Ensembl	panpan1.1		panPan2

ATP4A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	117,103,937 - 117,116,779 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	117,103,620 - 117,116,778 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,507,704 - 116,519,874 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,705,000 - 117,716,940 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,604,904 - 117,716,954 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,267,860 - 117,280,034 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,893,656 - 116,905,826 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,949,139 - 117,961,076 (+)	NCBI		UU_Cfam_GSD_1.0

Atp4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,831,472 - 10,843,738 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	802,170 - 814,056 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	802,170 - 815,023 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP4A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	44,984,233 - 44,997,552 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	44,984,014 - 45,057,796 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,444,521 - 40,454,205 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP4A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,475,352 - 30,489,500 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,475,764 - 30,489,080 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	8,269,571 - 8,283,253 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp4a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	8,033,020 - 8,060,292 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	8,046,638 - 8,059,359 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Atp4a
70 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	42
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000028508
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	72197680	90508767	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	78430754	91209302	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat
4889494	Scort2	Serum corticosterone level QTL 2	4.2		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	80592172	125592172	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	82174743	118944897	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)	1	83547917	128547917	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	85424647	100358001	Rat

Markers in Region

D1Bda8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,974,512 - 85,974,817 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	89,175,480 - 89,175,784	NCBI	Rnor6.0
Rnor_5.0	1	90,330,409 - 90,330,713	UniSTS	Rnor5.0
RGSC_v3.4	1	85,769,168 - 85,769,472	UniSTS	RGSC3.4
Celera	1	80,346,085 - 80,346,389	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low		14	8		7				10	2	23
Below cutoff	3	29	28	20	12	20	7	9	44	28	17	11	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L11569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M63963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000028508 ⟹ ENSRNOP00000028508

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	85,961,733 - 85,974,844 (+)	Ensembl
Rnor_6.0 Ensembl	1	89,162,639 - 89,175,811 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107494 ⟹ ENSRNOP00000083096

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	85,961,708 - 85,974,844 (+)	Ensembl

RefSeq Acc Id:

NM_012509 ⟹ NP_036641

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	85,961,702 - 85,974,857 (+)	NCBI
Rnor_6.0	1	89,162,700 - 89,175,504 (+)	NCBI
Rnor_5.0	1	90,317,629 - 90,330,433 (+)	NCBI
RGSC_v3.4	1	85,756,388 - 85,769,192 (+)	RGD
Celera	1	80,333,302 - 80,346,109 (+)	RGD

Sequence:

show sequence

ATGGGGAAGGCAGAGAATTATGAATTGTACTCAGTGGAACTGGGGACTGGCCCTGGTGGGAACA
TGGCTGCCAAGATGAGCAAGAAGAAGGCGGGAGGCGGGGGAGGCAAGAAGAAGGAGAAGCTAGA
GAACATGAAGAAGGAGATGGAGATGAACGACCACCAGTTGTCAGTGTCTGAGCTGGAGCAGAAG
TACCAGACCAGTGCCACCAAGGGCCTGAAGGCGAGTCTGGCAGCTGAGCTGCTGCTGAGGGATG
GGCCCAATGCACTCCGGCCACCTCGGGGCACCCCTGAGTACGTGAAGTTCGCCCGGCAGCTGGC
AGGCGGTCTGCAGTGCCTCATGTGGGTGGCTGCAGCCATCTGCCTCATTGCCTTTGCGATTCAG
GCCAGCGAGGGAGACCTGACCACTGATGACAATTTGTACCTGGCGTTGGCACTCATTGCTGTGG
TTGTGGTCACTGGCTGTTTTGGCTACTACCAGGAGTTCAAGAGCACAAATATCATCGCCAGCTT
CAAGAATCTTGTACCCCAGCAAGCCACAGTGATCCGAGACGGGGATAAGTTCCAGATCAACGCG
GATCAGCTTGTGGTGGGCGACCTGGTAGAGATGAAAGGCGGGGACCGCGTCCCAGCAGACATCC
GAATTCTGTCAGCCCAGGGCTGCAAGGTGGACAACTCCTCGCTTACTGGAGAGTCTGAACCGCA
GACCCGCTCACCTGAGTGTACACACGAGAGTCCCCTTGAGACCCGCAACATCGCCTTCTTCTCC
ACCATGTGTCTGGAGGGCACGGCGCAGGGCTTGGTGGTGAGCACCGGTGATCGCACCATCATTG
GACGCATCGCCTCTCTGGCTTCGGGTGTGGAAAACGAGAAGACTCCTATCGCGATCGAGATCGA
ACATTTTGTGGACATCATTGCTGGCCTGGCCATCCTCTTCGGTGCCACATTCTTTGTGGTGGCC
ATGTGTATCGGCTATACCTTCCTTCGGGCCATGGTCTTCTTCATGGCCATTGTGGTAGCCTATG
TGCCTGAGGGGCTGCTGGCTACTGTCACGGTCTGCCTGTCACTGACAGCAAAGAGGCTGGCCAG
TAAAAACTGTGTGGTCAAAAATCTGGAAGCAGTGGAGACCCTGGGTTCCACGTCAGTCATCTGC
TCAGACAAGACAGGAACTCTTACTCAGAACCGCATGACGGTGTCTCATCTATGGTTTGACAACC
ATATCCACACGGCGGACACCACAGAAGACCAGTCAGGGCAAACGTTCGACCAATCGTCGGAGAC
CTGGCGGGCGCTGTGCCGCGTGCTCACCCTGTGCAACCGCGCTGCCTTCAAGTCTGGCCAGGAC
GCCGTGCCAGTGCCCAAGCGCATCGTGATCGGAGACGCATCTGAGACTGCGCTGCTCAAGTTCT
CGGAGTTGACGTTGGGCAACGCCATGGGTTATCGGGACCGCTTCCCCAAAGTTTGCGAGATCCC
CTTCAACTCCACCAACAAGTTTCAGCTGTCCATTCACACTCTGGAGGATCCGCGCGACCCCCGG
CACTTGCTGGTGATGAAGGGCGCCCCAGAGCGCGTGCTGGAGCGTTGCAGCTCCATCCTCATCA
AGGGCCAGGAGCTGCCCCTGGACGAGCAATGGCGTGAGGCCTTCCAGACAGCCTACCTTAGCCT
GGGAGGCCTAGGCGAACGCGTTCTTGGTTTCTGCCAGCTCTACCTGAATGAGAAGGACTACCCG
CCTGGCTACACCTTTGATGTGGAGGCCATGAACTTTCCAAGTAGTGGCCTCTGCTTTGCGGGAC
TTGTATCCATGATTGACCCTCCCCGGGCCACCGTTCCAGATGCTGTGCTCAAATGCCGTACGGC
AGGCATCCGGGTGATCATGGTGACTGGTGACCATCCCATCACAGCCAAGGCCATTGCAGCCAGT
GTGGGGATCATCTCGGAAGGCAGCGAGACAGTGGAAGACATCGCCGCCCGCCTCCGAATGCCTG
TAGACCAGGTTAATAAGAAGGATGCCCGGGCCTGTGTGATCAATGGCATGCAGTTGAAGGACAT
GGACCCATCTGAGCTGGTGGAGGCGCTGCGCACCCACCCTGAGATGGTGTTTGCTCGAACCAGT
CCTCAGCAGAAGCTGGTGATTGTGGAGAGCTGTCAGCGACTGGGTGCCATTGTGGCTGTAACAG
GGGATGGTGTGAATGACTCCCCAGCCCTGAAGAAGGCTGACATTGGTGTAGCCATGGGCATTGC
TGGCTCCGATGCTGCTAAAAATGCTGCTGACATGATCTTGCTGGATGACAACTTCGCTTCCATT
GTGACGGGCGTGGAGCAGGGCCGACTGATCTTTGACAACCTGAAGAAATCCATCGCCTATACAC
TGACCAAGAACATTCCAGAACTGACACCCTACCTTATCTATATCACTGTCAGTGTGCCCCTACC
CCTTGGGTGTATCACCATTCTCTTCATAGAACTCTGCACAGATATCTTTCCATCTGTGTCCCTG
GCATATGAAAAGGCCGAGAGTGACATCATGCACCTGCGCCCACGGAACCCCAGGCGGGACCGGT
TGGTCAATGAACCCCTGGCTGCTTATTCCTATTTTCAGATTGGTGCCATTCAGTCATTTGCCGG
CTTTGCTGACTACTTCACGGCCATGGCCCAGGAGGGCTGGTTCCCTCTGCTGTGTGTGGGGCTG
CGACCACAATGGGAGGACCACCATCTACAAGATCTTCAAGACAGCTACGGCCAGGAATGGACAT
TTGGTCAGCGTCTGTACCAGCAGTACACCTGTTACACCGTGTTCTTCATCAGCATCGAGATGTG
CCAGATCGCTGATGTCCTCATCCGCAAGACACGCCGCCTCTCCGCTTTCCAGCAGGGATTCTTC
AGGAACAGGATCCTGGTGATCGCCATCGTGTTTCAGGTCTGCATTGGCTGCTTCCTGTGCTACT
GCCCAGGGATGCCCAACATCTTCAACTTCATGCCCATCCGGTTCCAGTGGTGGCTGGTCCCCAT
GCCCTTTGGCCTTCTCATCTTTGTCTATGATGAGATCCGGAAACTTGGAGTTCGCTGTTGCCCA
GGGAGCTGGTGGGACCAGGAACTCTACTATTAG

hide sequence

RefSeq Acc Id:

XM_039094282 ⟹ XP_038950210

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	85,961,607 - 85,974,972 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_036641	(Get FASTA)	NCBI Sequence Viewer
	XP_038950210	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41331	(Get FASTA)	NCBI Sequence Viewer
	AAA72354	(Get FASTA)	NCBI Sequence Viewer
	CAA43937	(Get FASTA)	NCBI Sequence Viewer
	CAA43938	(Get FASTA)	NCBI Sequence Viewer
	CAA43939	(Get FASTA)	NCBI Sequence Viewer
	EDM07724	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028508
	ENSRNOP00000028508.5
	ENSRNOP00000083096.1
GenBank Protein	P09626	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036641 ⟸ NM_012509

- UniProtKB:

F1LRK1 (UniProtKB/TrEMBL), A6JA10 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGKAENYELYSVELGTGPGGNMAAKMSKKKAGGGGGKKKEKLENMKKEMEMNDHQLSVSELEQK
YQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQ
ASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINA
DQLVVGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFS
TMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVA
MCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVIC
SDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQD
AVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPR
HLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYP
PGYTFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAAS
VGIISEGSETVEDIAARLRMPVDQVNKKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTS
PQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASI
VTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSL
AYEKAESDIMHLRPRNPRRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGL
RPQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFF
RNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCP
GSWWDQELYY

hide sequence

RefSeq Acc Id:

ENSRNOP00000028508 ⟸ ENSRNOT00000028508

RefSeq Acc Id:	XP_038950210 ⟸ XM_039094282
- Peptide Label:	isoform X1
- UniProtKB:	Q6LD86 (UniProtKB/Swiss-Prot), Q63253 (UniProtKB/Swiss-Prot), P97892 (UniProtKB/Swiss-Prot), P70511 (UniProtKB/Swiss-Prot), P09626 (UniProtKB/Swiss-Prot), A6JA10 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000083096 ⟸ ENSRNOT00000107494

Protein Domains

Cation-transporting P-type ATPase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P09626-F1-model_v2	AlphaFold	P09626	1-1033	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689928

Promoter ID:

EPDNEW_R452

Type:

single initiation site

Name:

Atp4a_1

Description:

ATPase H+/K+ transporting alpha subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	89,162,669 - 89,162,729	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2177	AgrOrtholog
BioCyc Gene	G2FUF-60082	BioCyc
Ensembl Genes	ENSRNOG00000020985	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028508	ENTREZGENE
	ENSRNOT00000028508.8	UniProtKB/TrEMBL
	ENSRNOT00000107494.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.1000	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Calcium-transporting ATPase, cytoplasmic transduction domain A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Calcium-transporting ATPase, transmembrane domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ATPase_P-typ_cation-transptr_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_P-typ_cation-transptr_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_P-typ_cyto_dom_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_P-typ_H/K-transp_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_P-typ_P_site	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_P-typ_transduc_dom_A_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HAD_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-type_ATPase_IIC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_typ_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P_typ_ATPase_HD_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24216	UniProtKB/TrEMBL
NCBI Gene	24216	ENTREZGENE
PANTHER	POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cation_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cation_ATPase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cation_ATPase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	E1-E2_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	H-K_ATPase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hydrolase_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Atp4a	PhenoGen
PRINTS	CATATPASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAKATPASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ATPASE_E1_E2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020985	RatGTEx
SMART	Cation_ATPase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81653	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81660	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81665	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC233041
UniProt	A0A8I5ZYI7_RAT	UniProtKB/TrEMBL
	A6JA10	ENTREZGENE, UniProtKB/TrEMBL
	ATP4A_RAT	UniProtKB/Swiss-Prot
	F1LRK1	ENTREZGENE, UniProtKB/TrEMBL
	P09626	ENTREZGENE
	P70511	ENTREZGENE
	P97892	ENTREZGENE
	Q63253	ENTREZGENE
	Q6LD86	ENTREZGENE
UniProt Secondary	P70511	UniProtKB/Swiss-Prot
	P97892	UniProtKB/Swiss-Prot
	Q63253	UniProtKB/Swiss-Prot
	Q6LD86	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-03	Atp4a	ATPase H+/K+ transporting subunit alpha	Atp4a	ATPase H+/K+ transporting alpha subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-17	Atp4a	ATPase H+/K+ transporting alpha subunit	Atp4a	ATPase, H+/K+ exchanging, alpha polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Atp4a	ATPase, H+/K+ exchanging, alpha polypeptide		ATPase, H+/K+ transporting, alpha polypeptide	Name updated	1299863	APPROVED
2002-11-06	Atp4a	ATPase, H+/K+ transporting, alpha polypeptide		ATPase, H+,K+-transporting, alpha / (gastric H,K-ATPase catalytic subunit)	Name updated	625702	APPROVED
2002-06-10	Atp4a	ATPase, H+,K+-transporting, alpha / (gastric H,K-ATPase catalytic subunit)			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	gene was transcribed only in gastric mucosa	631780
gene_function	subunit of ATP dependent pump that catalyzes the exchange of H+ and K+	631722
gene_process	involved in secretion of acid into the stomach	631722
gene_transcript	may have response elements for Ca2+ and cAMP	631781

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)