Csrp3 (cysteine and glycine rich protein 3) - Rat Genome Database

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Gene: Csrp3 (cysteine and glycine rich protein 3) Rattus norvegicus
Analyze
Symbol: Csrp3
Name: cysteine and glycine rich protein 3
RGD ID: 71092
Description: Enables MRF binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in blood vessel remodeling. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of myotube differentiation. Located in Z disc and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3); INTERACTS WITH 1-benzylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CRP3; cysteine and glycine rich protein 3 c-terminal HA-tagged; cysteine and glycine rich protein 3 lacking the LIM1-domain; cysteine and glycine rich protein 3 N-terminal nuclear localization sequence; cysteine and glycine-rich protein 3; cysteine and glycine-rich protein 3 (cardiac LIM protein); cysteine-rich protein 3; LIM domain protein, cardiac; MLP; muscle LIM protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,664,338 - 107,682,916 (-)NCBIGRCr8
mRatBN7.2198,528,067 - 98,546,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,528,068 - 98,546,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,881,687 - 103,900,350 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01112,353,629 - 112,372,274 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,676,355 - 105,694,925 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01104,147,205 - 104,166,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,147,206 - 104,166,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,206,459 - 105,225,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,601,681 - 98,611,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,679,791 - 98,689,858 (-)NCBI
Celera192,735,902 - 92,745,962 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-benzylpiperazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Botulinum toxin type A  (EXP)
cantharidin  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
Echimidine  (EXP)
genistein  (EXP)
Heliotrine  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalenes  (EXP)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
progesterone  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
verapamil  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA)
Z disc  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Arber S, etal., Cell 1994 Oct 21;79(2):221-31.
2. Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload. Ecarnot-Laubriet A, etal., J Mol Cell Cardiol. 2000 Dec;32(12):2385-95.
3. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin. Flick MJ and Konieczny SF, J Cell Sci. 2000 May;113 ( Pt 9):1553-64.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Geier C, etal., Circulation. 2003 Mar 18;107(10):1390-5.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Knoll R, etal., Cell 2002 Dec 27;111(7):943-55.
8. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Kong Y, etal., Mol Cell Biol. 1997 Aug;17(8):4750-60.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. Rajavashisth T, etal., J Clin Invest 1998 Jun 15;101(12):2702-10.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. A role for muscle LIM protein (MLP) in vascular remodeling. Wang X, etal., J Mol Cell Cardiol. 2006 Apr;40(4):503-9. Epub 2006 Mar 6.
Additional References at PubMed
PMID:10555147   PMID:12127981   PMID:12477932   PMID:15582318   PMID:15665106   PMID:16322914   PMID:19351738   PMID:19376126   PMID:22421737   PMID:24860983   PMID:24945278   PMID:27353086  
PMID:28706255   PMID:29634311   PMID:30673598   PMID:32914385  


Genomics

Comparative Map Data
Csrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,664,338 - 107,682,916 (-)NCBIGRCr8
mRatBN7.2198,528,067 - 98,546,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,528,068 - 98,546,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,881,687 - 103,900,350 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01112,353,629 - 112,372,274 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,676,355 - 105,694,925 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01104,147,205 - 104,166,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,147,206 - 104,166,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,206,459 - 105,225,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,601,681 - 98,611,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,679,791 - 98,689,858 (-)NCBI
Celera192,735,902 - 92,745,962 (-)NCBICelera
Cytogenetic Map1q22NCBI
CSRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,182,030 - 19,201,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,182,030 - 19,210,571 (-)EnsemblGRCh38hg38GRCh38
GRCh371119,203,577 - 19,223,530 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,160,154 - 19,180,177 (-)NCBINCBI36Build 36hg18NCBI36
Build 341119,160,153 - 19,180,177NCBI
Celera1119,336,055 - 19,356,021 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,887,548 - 18,916,047 (-)NCBIHuRef
CHM1_11119,202,919 - 19,231,414 (-)NCBICHM1_1
T2T-CHM13v2.01119,302,167 - 19,322,081 (-)NCBIT2T-CHM13v2.0
Csrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39748,480,146 - 48,497,799 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl748,480,146 - 48,497,781 (-)EnsemblGRCm39 Ensembl
GRCm38748,830,398 - 48,848,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl748,830,398 - 48,848,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv37756,085,768 - 56,099,021 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36748,698,419 - 48,711,672 (-)NCBIMGSCv36mm8
Celera744,274,422 - 44,287,671 (-)NCBICelera
Cytogenetic Map7B4NCBI
cM Map731.11NCBI
Csrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955476154,917 - 176,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955476155,913 - 176,122 (-)NCBIChiLan1.0ChiLan1.0
CSRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,487,369 - 21,507,272 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11121,447,665 - 21,467,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01119,208,025 - 19,228,000 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11119,121,234 - 19,149,374 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1119,121,234 - 19,140,820 (-)Ensemblpanpan1.1panPan2
CSRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,300,277 - 41,318,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2141,300,425 - 41,318,738 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,778,804 - 40,797,354 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02142,423,567 - 42,442,117 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,423,567 - 42,442,039 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,425,878 - 41,444,425 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,603,282 - 41,621,845 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,980,467 - 41,999,019 (-)NCBIUU_Cfam_GSD_1.0
Csrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494743,636,738 - 43,655,378 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936654271,067 - 289,823 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936654271,067 - 313,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,215,353 - 40,240,616 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,219,288 - 40,240,614 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,258,339 - 43,279,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSRP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,792,106 - 45,813,715 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,803,243 - 45,813,800 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,137,913 - 143,148,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csrp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476610,611,804 - 10,631,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476610,611,798 - 10,631,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csrp3
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:58
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000019311
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
RH128977  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2198,528,076 - 98,528,263 (+)MAPPERmRatBN7.2
Rnor_6.01104,147,215 - 104,147,401NCBIRnor6.0
Rnor_5.01105,206,469 - 105,206,655UniSTSRnor5.0
RGSC_v3.4198,601,691 - 98,601,877UniSTSRGSC3.4
Celera192,735,912 - 92,736,098UniSTS
RH 3.4 Map1923.19UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 49 55 62 66 35 21 35 6 178 88 40 41 48 31

Sequence


Ensembl Acc Id: ENSRNOT00000019311   ⟹   ENSRNOP00000019310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl198,528,068 - 98,538,135 (-)Ensembl
Rnor_6.0 Ensembl1104,147,206 - 104,157,855 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092211   ⟹   ENSRNOP00000071918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl198,530,215 - 98,546,653 (-)Ensembl
Rnor_6.0 Ensembl1104,149,705 - 104,166,367 (-)Ensembl
RefSeq Acc Id: NM_057144   ⟹   NP_476485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81107,664,338 - 107,682,916 (-)NCBI
mRatBN7.2198,528,067 - 98,546,647 (-)NCBI
Rnor_6.01104,147,205 - 104,157,855 (-)NCBI
Rnor_5.01105,206,459 - 105,225,635 (-)NCBI
RGSC_v3.4198,601,681 - 98,611,747 (-)RGD
Celera192,735,902 - 92,745,962 (-)RGD
Sequence:
RefSeq Acc Id: NP_476485   ⟸   NM_057144
- UniProtKB: P50463 (UniProtKB/Swiss-Prot),   G3V7U0 (UniProtKB/TrEMBL),   A6JBF3 (UniProtKB/TrEMBL),   A0A3S4B5A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071918   ⟸   ENSRNOT00000092211
Ensembl Acc Id: ENSRNOP00000019310   ⟸   ENSRNOT00000019311
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50463-F1-model_v2 AlphaFold P50463 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690080
Promoter ID:EPDNEW_R600
Type:single initiation site
Name:Csrp3_1
Description:cysteine and glycine rich protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01104,166,306 - 104,166,366EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71092 AgrOrtholog
BioCyc Gene G2FUF-59572 BioCyc
Ensembl Genes ENSRNOG00000014327 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019311.6 UniProtKB/TrEMBL
  ENSRNOT00000092211.2 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117505 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117505 ENTREZGENE
PANTHER CYSTEINE AND GLYCINE-RICH PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO-GTPASE-ACTIVATING PROTEIN LRG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csrp3 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014327 RatGTEx
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1N8_RAT UniProtKB/TrEMBL
  A0A3S4B5A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A3S4CLA1_RAT UniProtKB/TrEMBL
  A0A3S4FDI0_RAT UniProtKB/TrEMBL
  A0A447DUT9_RAT UniProtKB/TrEMBL
  A6JBF3 ENTREZGENE, UniProtKB/TrEMBL
  CSRP3_RAT UniProtKB/Swiss-Prot
  G3V7U0 ENTREZGENE, UniProtKB/TrEMBL
  P50463 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Csrp3  cysteine and glycine rich protein 3  Csrp3  cysteine and glycine-rich protein 3 (cardiac LIM protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Csrp3  cysteine and glycine-rich protein 3 (cardiac LIM protein)  Csrp3  cysteine and glycine-rich protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Csrp3  cysteine and glycine-rich protein 3    cysteine-rich protein 3  Name updated 1299863 APPROVED
2002-07-09 Csrp3  cysteine-rich protein 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference