Gpi (glucose-6-phosphate isomerase) - Rat Genome Database

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Gene: Gpi (glucose-6-phosphate isomerase) Rattus norvegicus
Analyze
Symbol: Gpi
Name: glucose-6-phosphate isomerase
RGD ID: 2727
Description: Enables glucose-6-phosphate isomerase activity and monosaccharide binding activity. Involved in several processes, including response to estradiol; response to progesterone; and response to testosterone. Predicted to be located in ciliary membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Amf; autocrine motility factor; glucose phosphate isomerase; Gpi1; neuroleukin; Nlk; Pgi; Phi; phosphoglucose isomerase; phosphohexose isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,965,389 - 95,996,932 (-)NCBIGRCr8
mRatBN7.2186,828,211 - 86,856,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx192,231,564 - 92,259,517 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,697,568 - 100,725,522 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,989,860 - 94,017,813 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,063,411 - 90,091,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0191,207,014 - 91,234,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,658,836 - 86,686,712 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,736,946 - 86,764,823 (-)NCBI
Celera181,194,482 - 81,222,306 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
prostaglandin A1  (ISO)
puerarin  (EXP)
quercetin  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thiram  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cumene peroxide and Fe(2+)-ascorbate-induced lipid peroxidation and effect of phosphoglucose isomerase. Agadjanyan ZS, etal., Mol Cell Biochem. 2006 Sep;289(1-2):49-53. Epub 2006 Apr 1.
2. Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). Beutler E, etal., Blood Cells Mol Dis. 1997 Dec;23(3):402-9.
3. Time course of chronic oral cadmium nephrotoxicity in Wistar rats: excretion of urinary enzymes. Bomhard EM, etal., Drug Chem Toxicol. 1999 Nov;22(4):679-703.
4. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
5. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
6. Alterations in the mRNA levels of two metabolic enzymes in rat skeletal muscle during stretch-induced hypertrophy and disuse atrophy. Brownson C and Loughna P, Pflugers Arch. 1996 Apr;431(6):990-2.
7. Evidence for the participation of opioids in the regulation of carbohydrate metabolism in rat mammary glands. Deshpande N and Mitchell I, J Endocrinol. 1980 Jun;85(3):415-21.
8. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. Gaitonde MK, etal., J Neurochem. 1989 May;52(5):1348-52.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Plasma and intracellular levels of lactate dehydrogenase, phosphohexose isomerase and lysozyme activity in acute leukemia. Ho AD, etal., Blut. 1984 Jul;49(1):19-28.
11. Glycolytic enzyme levels in synaptosomes. Knull HR and Fillmore SJ, Comp Biochem Physiol B. 1985;81(2):349-51.
12. Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency. Kugler W, etal., Hum Genet. 1998 Oct;103(4):450-4.
13. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. Luo Y, etal., J Neurochem. 2002 Jan;80(2):354-61.
14. Comparative study of the effects of beta-sitosterol, estradiol and progesterone on selected biochemical parameters of the uterus of ovariectomised rats. Malini T and Vanithakumari G, J Ethnopharmacol. 1992 Feb;36(1):51-5.
15. Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease. Merkle S and Pretsch W, Blood. 1993 Jan 1;81(1):206-13.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. Niinaka Y, etal., Cancer Res. 2010 Nov 15;70(22):9483-93. doi: 10.1158/0008-5472.CAN-09-3880. Epub 2010 Oct 26.
18. [Androgen regulation of aldolase and phosphohexose isomerase in the liver and seminal vesicles of white rats]. Nikulin AA, Vopr Med Khim. 1985 Mar-Apr;31(2):51-5.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Pizzolla A, etal., Am J Pathol. 2013 Oct;183(4):1144-55. doi: 10.1016/j.ajpath.2013.06.019. Epub 2013 Jul 30.
23. Red cell glucose phosphate isomerase (GPI): a molecular study of three novel mutations associated with hereditary nonspherocytic hemolytic anemia. Repiso A, etal., Hum Mutat. 2006 Nov;27(11):1159.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Neuroleukin inhibition sensitises neuronal cells to caspase-dependent apoptosis. Romagnoli A, etal., Biochem Biophys Res Commun. 2003 Mar 14;302(3):448-53.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia. Walker JA, etal., Eur J Immunol. 2012 Dec;42(12):3212-22. doi: 10.1002/eji.201242633. Epub 2012 Oct 16.
30. DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency. Walker JI, etal., Hum Mol Genet. 1993 Mar;2(3):327-9.
Additional References at PubMed
PMID:204065   PMID:1180875   PMID:1235912   PMID:1582174   PMID:1649192   PMID:2344351   PMID:3020690   PMID:3796661   PMID:7277315   PMID:7323947   PMID:7444718   PMID:8922529  
PMID:12054583   PMID:15155459   PMID:15665293   PMID:16229142   PMID:17634366   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20458337   PMID:22179047   PMID:22206666   PMID:22871113  
PMID:23376485   PMID:23533145   PMID:24006456   PMID:24810856   PMID:26459914   PMID:27103217   PMID:28803808  


Genomics

Comparative Map Data
Gpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,965,389 - 95,996,932 (-)NCBIGRCr8
mRatBN7.2186,828,211 - 86,856,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx192,231,564 - 92,259,517 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,697,568 - 100,725,522 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,989,860 - 94,017,813 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,063,411 - 90,091,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0191,207,014 - 91,234,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,658,836 - 86,686,712 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,736,946 - 86,764,823 (-)NCBI
Celera181,194,482 - 81,222,306 (-)NCBICelera
Cytogenetic Map1q21NCBI
GPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381934,359,718 - 34,402,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1934,359,480 - 34,402,413 (+)EnsemblGRCh38hg38GRCh38
GRCh371934,855,645 - 34,893,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361939,547,909 - 39,583,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 341939,547,908 - 39,583,076NCBI
Celera1931,557,376 - 31,605,748 (+)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1931,360,777 - 31,377,222 (+)NCBIHuRef
HuRef1931,390,807 - 31,399,974 (+)NCBIHuRef
CHM1_11934,857,156 - 34,895,165 (+)NCBICHM1_1
T2T-CHM13v2.01936,886,877 - 36,946,977 (+)NCBIT2T-CHM13v2.0
Gpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39733,900,752 - 33,929,761 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl733,900,755 - 33,929,761 (-)EnsemblGRCm39 Ensembl
GRCm38734,201,327 - 34,230,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl734,201,330 - 34,230,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv37734,986,346 - 35,015,324 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36733,910,918 - 33,939,022 (-)NCBIMGSCv36mm8
MGSCv36724,688,418 - 24,717,214 (-)NCBIMGSCv36mm8
Celera729,335,681 - 29,371,931 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.46NCBI
Gpi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554683,980,999 - 4,008,652 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554683,980,999 - 4,007,553 (+)NCBIChiLan1.0ChiLan1.0
GPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22040,351,367 - 40,402,743 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11942,351,411 - 42,404,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01931,301,469 - 31,355,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,024,584 - 40,080,598 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,024,584 - 40,080,598 (+)Ensemblpanpan1.1panPan2
GPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,922,380 - 117,948,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,922,635 - 117,948,316 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1117,320,830 - 117,346,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01118,518,230 - 118,543,889 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,497,395 - 118,544,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11118,079,121 - 118,105,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,705,505 - 117,731,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,763,883 - 118,789,615 (-)NCBIUU_Cfam_GSD_1.0
Gpi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,037,338 - 10,063,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,579,372 - 1,608,788 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,582,120 - 1,608,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,038,357 - 44,069,328 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,038,374 - 44,069,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2639,516,820 - 39,547,963 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q12NCBI
GPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1629,404,067 - 29,451,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl629,403,500 - 29,453,162 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,177,821 - 7,221,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,823,449 - 8,851,625 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,826,281 - 8,851,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpi
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:48
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000032613
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

Markers in Region
PMC164521P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,830,299 - 86,831,706 (+)MAPPERmRatBN7.2
Rnor_6.0190,065,500 - 90,066,906NCBIRnor6.0
Rnor_5.0191,209,103 - 91,210,509UniSTSRnor5.0
RGSC_v3.4186,660,925 - 86,662,331UniSTSRGSC3.4
Celera181,196,529 - 81,197,935UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 3 43 57 41 19 41 8 8 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000032613   ⟹   ENSRNOP00000029515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)Ensembl
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097410   ⟹   ENSRNOP00000087782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101765   ⟹   ENSRNOP00000085356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112795   ⟹   ENSRNOP00000080691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,828,216 - 86,855,568 (-)Ensembl
RefSeq Acc Id: NM_207592   ⟹   NP_997475
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,965,393 - 95,993,261 (-)NCBI
mRatBN7.2186,828,211 - 86,856,077 (-)NCBI
Rnor_6.0190,063,411 - 90,091,287 (-)NCBI
Rnor_5.0191,207,014 - 91,234,890 (-)NCBI
RGSC_v3.4186,658,836 - 86,686,712 (-)RGD
Celera181,194,482 - 81,222,306 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283685   ⟹   XP_063139755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,965,389 - 95,996,883 (-)NCBI
RefSeq Acc Id: XM_063283691   ⟹   XP_063139761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,965,389 - 95,996,932 (-)NCBI
RefSeq Acc Id: NP_997475   ⟸   NM_207592
- UniProtKB: Q6P6V0 (UniProtKB/Swiss-Prot),   A0A8I6A243 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029515   ⟸   ENSRNOT00000032613
RefSeq Acc Id: ENSRNOP00000080691   ⟸   ENSRNOT00000112795
RefSeq Acc Id: ENSRNOP00000085356   ⟸   ENSRNOT00000101765
RefSeq Acc Id: ENSRNOP00000087782   ⟸   ENSRNOT00000097410
RefSeq Acc Id: XP_063139761   ⟸   XM_063283691
- Peptide Label: isoform X1
- UniProtKB: Q6P6V0 (UniProtKB/Swiss-Prot),   A0A8I6A243 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139755   ⟸   XM_063283685
- Peptide Label: isoform X1
- UniProtKB: Q6P6V0 (UniProtKB/Swiss-Prot),   A0A8I6A243 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6V0-F1-model_v2 AlphaFold Q6P6V0 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689949
Promoter ID:EPDNEW_R473
Type:multiple initiation site
Name:Gpi_1
Description:glucose-6-phosphate isomerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0190,091,293 - 90,091,353EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2727 AgrOrtholog
BioCyc Gene G2FUF-60019 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY-5659 [GDP-mannose biosynthesis] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
  UDPNACETYLGALSYN-PWY [UDP-N-acetyl-D-glucosamine biosynthesis II] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY-5659 BioCyc
  PWY66-399 BioCyc
  UDPNACETYLGALSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000023150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033158 UniProtKB/Swiss-Prot
  ENSRNOG00060027113 UniProtKB/Swiss-Prot
  ENSRNOG00065031609 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032613 ENTREZGENE
  ENSRNOT00000032613.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097410.1 UniProtKB/Swiss-Prot
  ENSRNOT00000101765.1 UniProtKB/TrEMBL
  ENSRNOT00000112795.1 UniProtKB/TrEMBL
  ENSRNOT00055057309 UniProtKB/Swiss-Prot
  ENSRNOT00060047108 UniProtKB/Swiss-Prot
  ENSRNOT00065054503 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599776 IMAGE-MGC_LOAD
InterPro G6P_Isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G6P_Isomerase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphoglucose_isomerase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS_PGI_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS_PGI_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292804 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72563 IMAGE-MGC_LOAD
NCBI Gene Gpi ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATE ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11469 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PGI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpi PhenoGen
PRINTS G6PISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_GLUCOSE_ISOMERASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_GLUCOSE_ISOMERASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_GLUCOSE_ISOMERASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023150 RatGTEx
  ENSRNOG00055033158 RatGTEx
  ENSRNOG00060027113 RatGTEx
  ENSRNOG00065031609 RatGTEx
Superfamily-SCOP SSF53697 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A243 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G6Z4_RAT UniProtKB/TrEMBL
  A6JA88_RAT UniProtKB/TrEMBL
  G6PI_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Gpi  glucose-6-phosphate isomerase  Gpi  glucose phosphate isomerase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gpi  glucose phosphate isomerase    Glucose phosphate isomerase  Name updated 625702 APPROVED
2002-06-10 Gpi  Glucose phosphate isomerase      Symbol and Name status set to approved 70586 APPROVED