GPI (glucose-6-phosphate isomerase) - Rat Genome Database

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Gene: GPI (glucose-6-phosphate isomerase) Canis lupus familiaris
Analyze
Symbol: GPI
Name: glucose-6-phosphate isomerase
RGD ID: 12089693
Description: ENCODES a protein that exhibits glucose-6-phosphate isomerase activity (ortholog); monosaccharide binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN erythrocyte homeostasis (ortholog); fructose 6-phosphate metabolic process (ortholog); glucose 6-phosphate metabolic process (ortholog); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); Animal Disease Models (ortholog); FOUND IN ciliary membrane (ortholog); cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glucose phosphate isomerase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,922,380 - 117,948,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,922,635 - 117,948,316 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1117,320,830 - 117,346,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01118,518,230 - 118,543,889 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,497,395 - 118,544,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11118,079,121 - 118,105,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,705,505 - 117,731,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,763,883 - 118,789,615 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,922,380 - 117,948,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,922,635 - 117,948,316 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1117,320,830 - 117,346,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01118,518,230 - 118,543,889 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,497,395 - 118,544,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11118,079,121 - 118,105,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,705,505 - 117,731,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,763,883 - 118,789,615 (-)NCBIUU_Cfam_GSD_1.0
GPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381934,359,718 - 34,402,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1934,359,480 - 34,402,413 (+)EnsemblGRCh38hg38GRCh38
GRCh371934,855,645 - 34,893,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361939,547,909 - 39,583,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 341939,547,908 - 39,583,076NCBI
Celera1931,557,376 - 31,605,748 (+)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1931,360,777 - 31,377,222 (+)NCBIHuRef
HuRef1931,390,807 - 31,399,974 (+)NCBIHuRef
CHM1_11934,857,156 - 34,895,165 (+)NCBICHM1_1
T2T-CHM13v2.01936,886,877 - 36,946,977 (+)NCBIT2T-CHM13v2.0
Gpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39733,900,752 - 33,929,761 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl733,900,755 - 33,929,761 (-)EnsemblGRCm39 Ensembl
GRCm38734,201,327 - 34,230,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl734,201,330 - 34,230,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv37734,986,346 - 35,015,324 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36733,910,918 - 33,939,022 (-)NCBIMGSCv36mm8
MGSCv36724,688,418 - 24,717,214 (-)NCBIMGSCv36mm8
Celera729,335,681 - 29,371,931 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.46NCBI
Gpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,965,389 - 95,996,932 (-)NCBIGRCr8
mRatBN7.2186,828,211 - 86,856,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx192,231,564 - 92,259,517 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,697,568 - 100,725,522 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,989,860 - 94,017,813 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,063,411 - 90,091,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0191,207,014 - 91,234,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,658,836 - 86,686,712 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,736,946 - 86,764,823 (-)NCBI
Celera181,194,482 - 81,222,306 (-)NCBICelera
Cytogenetic Map1q21NCBI
Gpi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554683,980,999 - 4,008,652 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554683,980,999 - 4,007,553 (+)NCBIChiLan1.0ChiLan1.0
GPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22040,351,367 - 40,402,743 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11942,351,411 - 42,404,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01931,301,469 - 31,355,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,024,584 - 40,080,598 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,024,584 - 40,080,598 (+)Ensemblpanpan1.1panPan2
Gpi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,037,338 - 10,063,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,579,372 - 1,608,788 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,582,120 - 1,608,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,038,357 - 44,069,328 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,038,374 - 44,069,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2639,516,820 - 39,547,963 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q12NCBI
GPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1629,404,067 - 29,451,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl629,403,500 - 29,453,162 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,177,821 - 7,221,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,823,449 - 8,851,625 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,826,281 - 8,851,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPI
385 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000011733   ⟹   ENSCAFP00000010874
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1117,922,635 - 117,948,292 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070424   ⟹   ENSCAFP00000055680
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1117,922,635 - 117,948,316 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845007474   ⟹   ENSCAFP00845005906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1118,497,395 - 118,543,889 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845007489   ⟹   ENSCAFP00845005919
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1118,517,618 - 118,544,065 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845007493   ⟹   ENSCAFP00845005923
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1118,517,618 - 118,544,065 (-)Ensembl
RefSeq Acc Id: XM_038468627   ⟹   XP_038324555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11118,079,121 - 118,105,067 (-)NCBI
RefSeq Acc Id: XM_038529417   ⟹   XP_038385345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01118,763,883 - 118,789,615 (-)NCBI
RefSeq Acc Id: XM_038593678   ⟹   XP_038449606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01117,705,505 - 117,731,413 (-)NCBI
RefSeq Acc Id: XM_038657539   ⟹   XP_038513467
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01118,518,230 - 118,543,889 (-)NCBI
RefSeq Acc Id: XM_848765   ⟹   XP_853858
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11117,922,380 - 117,948,325 (-)NCBI
Dog10K_Boxer_Tasha1117,320,830 - 117,346,503 (-)NCBI
Sequence:
RefSeq Acc Id: XP_853858   ⟸   XM_848765
- UniProtKB: A0A8C0M159 (UniProtKB/TrEMBL),   A0A8I3RTC4 (UniProtKB/TrEMBL),   A0A8I3RRW0 (UniProtKB/TrEMBL),   A0A8P0TS87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010874   ⟸   ENSCAFT00000011733
RefSeq Acc Id: ENSCAFP00000055680   ⟸   ENSCAFT00000070424
RefSeq Acc Id: XP_038324555   ⟸   XM_038468627
RefSeq Acc Id: XP_038449606   ⟸   XM_038593678
RefSeq Acc Id: XP_038513467   ⟸   XM_038657539
- UniProtKB: A0A8C0M159 (UniProtKB/TrEMBL),   A0A8I3RTC4 (UniProtKB/TrEMBL),   A0A8I3RRW0 (UniProtKB/TrEMBL),   A0A8P0TS87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038385345   ⟸   XM_038529417
- UniProtKB: A0A8C0M159 (UniProtKB/TrEMBL),   A0A8I3RRW0 (UniProtKB/TrEMBL),   A0A8I3RTC4 (UniProtKB/TrEMBL),   A0A8P0TS87 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845005923   ⟸   ENSCAFT00845007493
RefSeq Acc Id: ENSCAFP00845005906   ⟸   ENSCAFT00845007474
RefSeq Acc Id: ENSCAFP00845005919   ⟸   ENSCAFT00845007489

Promoters
RGD ID:13682357
Promoter ID:EPDNEW_C424
Type:initiation region
Name:GPI_1
Description:glucose-6-phosphate isomerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11117,948,308 - 117,948,368EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007258 UniProtKB/TrEMBL
  ENSCAFG00000007303 Ensembl
  ENSCAFG00030001498 UniProtKB/TrEMBL
  ENSCAFG00040003200 UniProtKB/TrEMBL
  ENSCAFG00845004146 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011733.5 UniProtKB/TrEMBL
  ENSCAFT00000104534.1 UniProtKB/TrEMBL
  ENSCAFT00030002748.1 UniProtKB/TrEMBL
  ENSCAFT00040006091.1 UniProtKB/TrEMBL
  ENSCAFT00845007474 ENTREZGENE
  ENSCAFT00845007474.1 UniProtKB/TrEMBL
  ENSCAFT00845007489.1 UniProtKB/TrEMBL
  ENSCAFT00845007493.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1390.10 UniProtKB/TrEMBL
InterPro G6P_Isomerase UniProtKB/TrEMBL
  G6P_Isomerase_C UniProtKB/TrEMBL
  Phosphoglucose_isomerase_CS UniProtKB/TrEMBL
  SIS_dom_sf UniProtKB/TrEMBL
  SIS_PGI_1 UniProtKB/TrEMBL
  SIS_PGI_2 UniProtKB/TrEMBL
KEGG Report cfa:611942 UniProtKB/TrEMBL
NCBI Gene GPI ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATE ISOMERASE UniProtKB/TrEMBL
  PTHR11469 UniProtKB/TrEMBL
Pfam PGI UniProtKB/TrEMBL
PRINTS G6PISOMERASE UniProtKB/TrEMBL
PROSITE P_GLUCOSE_ISOMERASE_1 UniProtKB/TrEMBL
  P_GLUCOSE_ISOMERASE_2 UniProtKB/TrEMBL
  P_GLUCOSE_ISOMERASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF53697 UniProtKB/TrEMBL
UniProt A0A8C0M159 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MPB5_CANLF UniProtKB/TrEMBL
  A0A8I3RRW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TS87 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41381 ENTREZGENE