Tnni3 (troponin I3, cardiac type) - Rat Genome Database

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Gene: Tnni3 (troponin I3, cardiac type) Rattus norvegicus
Analyze
Symbol: Tnni3
Name: troponin I3, cardiac type
RGD ID: 62052
Description: Predicted to enable several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Involved in cardiac muscle contraction and regulation of smooth muscle contraction. Located in sarcomere. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; (R,R)-tramadol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiac troponin I; cTNI; TnI; troponin 1, type 3; Troponin I; troponin I cardiac; troponin I type 3 (cardiac); troponin I, cardiac; troponin I, cardiac muscle
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2169,299,900 - 69,303,582 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,658,817 - 74,662,501 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0183,223,130 - 83,226,814 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0176,372,704 - 76,376,399 (+)NCBIRnor_WKY
Rnor_6.0172,882,806 - 72,886,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,665,119 - 75,668,803 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,028,198 - 68,031,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,106,308 - 68,109,991 (+)NCBI
Celera167,824,338 - 67,828,022 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(R)-lipoic acid  (EXP)
(R,R)-tramadol  (EXP)
(S)-colchicine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-methoxypsoralen  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
Allylamine  (EXP)
aluminium phosphide  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anethole  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
celastrol  (EXP)
chelerythrine  (ISO)
chlordecone  (ISO)
cisplatin  (EXP,ISO)
cocaine  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
Cyanoginosin  (EXP)
cyclophosphamide  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dibromine  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP)
ferric oxide  (ISO)
ferruginol  (EXP)
flavonoids  (EXP)
gefitinib  (EXP)
glyburide  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (EXP)
loperamide  (EXP)
melphalan  (ISO)
metaproterenol  (EXP)
methamphetamine  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrofen  (EXP)
O-acetyl-L-carnitine  (EXP)
orciprenaline  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentanal  (ISO)
perphenazine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
plumbagin  (EXP)
ponatinib  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrvinium  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rosuvastatin calcium  (EXP)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
taurine  (EXP)
tetrathiomolybdate(2-)  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tramadol  (EXP)
trans-anethole  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Developmental expression of rat cardiac troponin I mRNA. Ausoni S, etal., Development 1991 Aug;112(4):1041-51.
2. Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Doolan A, etal., J Mol Cell Cardiol. 2005 Feb;38(2):387-93. Epub 2005 Jan 27.
3. Cardiac troponins and N-terminal pro-brain natriuretic peptide in acute ischemic stroke do not relate to clinical prognosis. Etgen T, etal., Stroke. 2005 Feb;36(2):270-5. Epub 2004 Dec 16.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Kedar V, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18135-40. Epub 2004 Dec 15.
7. Molecular cloning and developmental expression of the rat cardiac-specific isoform of troponin I. Martin AF and Orlowski J, J Mol Cell Cardiol 1991 May;23(5):583-8.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Murphy AM, etal., Biochem J 1997 Mar 1;322 ( Pt 2):393-401.
10. Molecular cloning of rat cardiac troponin I and analysis of troponin I isoform expression in developing rat heart. Murphy AM, etal., Biochemistry 1991 Jan 22;30(3):707-12.
11. Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Murphy RT, etal., Lancet. 2004 Jan 31;363(9406):371-2.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Titin isoform switch in ischemic human heart disease. Neagoe C, etal., Circulation. 2002 Sep 10;106(11):1333-41.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Medium perfusion enables engineering of compact and contractile cardiac tissue. Radisic M, etal., Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H507-16. Epub 2003 Oct 9.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation. Rossmanith GH, etal., J Physiol. 1997 Nov 15;505 ( Pt 1):217-27.
22. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, etal., BMC Cell Biol. 2011 May 10;12:18. doi: 10.1186/1471-2121-12-18.
23. Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response. Westfall MV, etal., J Biol Chem. 2005 Dec 16;280(50):41324-31. Epub 2005 Oct 18.
24. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Wu LL, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R408-16.
25. Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy. Yumoto F, etal., Biochem Biophys Res Commun. 2005 Dec 23;338(3):1519-26. Epub 2005 Nov 2.
Additional References at PubMed
PMID:7957210   PMID:10642551   PMID:10806205   PMID:10850966   PMID:11158984   PMID:11356618   PMID:11735257   PMID:11815426   PMID:11984006   PMID:12093807   PMID:12531876   PMID:12551921  
PMID:12721663   PMID:12809519   PMID:15142843   PMID:15542288   PMID:15611140   PMID:16481394   PMID:16754800   PMID:17875210   PMID:18397962   PMID:18548271   PMID:18721805   PMID:18986304  
PMID:19278978   PMID:19801490   PMID:20161772   PMID:20594472   PMID:20945043   PMID:21613513   PMID:21876643   PMID:22052912   PMID:22207765   PMID:22364878   PMID:22500757   PMID:22684024  
PMID:22808244   PMID:23246786   PMID:23454346   PMID:23764111   PMID:23904327   PMID:24853739   PMID:24932661   PMID:25089838   PMID:25185555   PMID:25481661   PMID:25771144   PMID:26290107  
PMID:26869200   PMID:26944554   PMID:27150586   PMID:27974300   PMID:28587770   PMID:28864299   PMID:28958680   PMID:29544221   PMID:29642034   PMID:29704484   PMID:32066368   PMID:33080242  
PMID:33378032   PMID:34957754  


Genomics

Comparative Map Data
Tnni3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2169,299,900 - 69,303,582 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,658,817 - 74,662,501 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0183,223,130 - 83,226,814 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0176,372,704 - 76,376,399 (+)NCBIRnor_WKY
Rnor_6.0172,882,806 - 72,886,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,665,119 - 75,668,803 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,028,198 - 68,031,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,106,308 - 68,109,991 (+)NCBI
Celera167,824,338 - 67,828,022 (-)NCBICelera
Cytogenetic Map1q12NCBI
TNNI3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,151,767 - 55,157,732 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1955,151,767 - 55,157,773 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,663,135 - 55,669,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,354,947 - 60,360,912 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,354,949 - 60,360,858NCBI
Celera1952,704,329 - 52,710,294 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,986,278 - 51,992,090 (-)NCBIHuRef
CHM1_11955,656,700 - 55,662,665 (-)NCBICHM1_1
T2T-CHM13v2.01958,245,731 - 58,251,791 (-)NCBIT2T-CHM13v2.0
Tnni3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,521,304 - 4,526,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,521,304 - 4,527,228 (-)EnsemblGRCm39 Ensembl
GRCm3874,518,305 - 4,522,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,518,305 - 4,524,229 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,469,910 - 4,474,045 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,121,395 - 4,125,530 (-)NCBIMGSCv36mm8
Celera74,262,821 - 4,266,956 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.61NCBI
Tnni3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,037,462 - 1,042,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,037,325 - 1,042,102 (+)NCBIChiLan1.0ChiLan1.0
TNNI3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11960,887,630 - 60,892,875 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,887,630 - 60,894,219 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01952,193,061 - 52,198,782 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TNNI3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,475,146 - 102,478,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,475,146 - 102,478,318 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,532,199 - 102,535,372 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,128,720 - 103,131,893 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11102,765,644 - 102,768,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,477,237 - 102,480,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,241,266 - 103,244,439 (+)NCBIUU_Cfam_GSD_1.0
Tnni3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,117,982 - 2,121,466 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886437,754 - 440,458 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936886437,754 - 440,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNI3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,366,829 - 59,371,160 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1 Ensembl659,371,080 - 59,377,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,366,828 - 59,377,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,294,993 - 54,298,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235292
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,746,293 - 47,752,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,745,386 - 47,752,204 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666523445 - 2,272 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnni3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,088,589 - 2,092,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,088,455 - 2,092,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnni3
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000024640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat

Markers in Region
D1Wox56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,301,051 - 69,301,153 (+)MAPPERmRatBN7.2
Rnor_6.0172,883,958 - 72,884,061NCBIRnor6.0
Rnor_5.0175,667,548 - 75,667,651UniSTSRnor5.0
RGSC_v3.4168,029,350 - 68,029,453UniSTSRGSC3.4
Celera167,826,767 - 67,826,870UniSTS
Cytogenetic Map1q12UniSTS
RH139764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,299,103 - 69,299,322 (+)MAPPERmRatBN7.2
Rnor_6.0172,882,010 - 72,882,228NCBIRnor6.0
Rnor_5.0175,669,381 - 75,669,599UniSTSRnor5.0
RGSC_v3.4168,027,402 - 68,027,620UniSTSRGSC3.4
Celera167,828,600 - 67,828,818UniSTS
Cytogenetic Map1q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 43
Medium 6 2 2 30 11
Low 54 40 14 40 8 9 74 32 11 8
Below cutoff 3 1 1 3 1 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024640   ⟹   ENSRNOP00000024640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)Ensembl
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110513   ⟹   ENSRNOP00000090895
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)Ensembl
RefSeq Acc Id: NM_017144   ⟹   NP_058840
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2169,299,900 - 69,303,582 (+)NCBI
Rnor_6.0172,882,806 - 72,886,490 (+)NCBI
Rnor_5.0175,665,119 - 75,668,803 (-)NCBI
RGSC_v3.4168,028,198 - 68,031,882 (+)RGD
Celera167,824,338 - 67,828,022 (-)RGD
Sequence:
RefSeq Acc Id: XM_039103599   ⟹   XP_038959527
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2169,300,635 - 69,303,582 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058840   ⟸   NM_017144
- UniProtKB: Q4PP23 (UniProtKB/Swiss-Prot),   P23693 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024640   ⟸   ENSRNOT00000024640
RefSeq Acc Id: XP_038959527   ⟸   XM_039103599
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000090895   ⟸   ENSRNOT00000110513

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23693-F1-model_v2 AlphaFold P23693 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689705
Promoter ID:EPDNEW_R230
Type:single initiation site
Name:Tnni3_1
Description:troponin I3, cardiac type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,882,791 - 72,882,851EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62052 AgrOrtholog
BioCyc Gene G2FUF-60839 BioCyc
Ensembl Genes ENSRNOG00000018250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024640 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000090895.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024640 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000110513.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Troponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Troponin-I_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Troponin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29248 UniProtKB/Swiss-Prot
NCBI Gene 29248 ENTREZGENE
Pfam Troponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Troponin-I_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnni3 PhenoGen
Superfamily-SCOP SSF90250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ADH6_RAT UniProtKB/TrEMBL
  P23693 ENTREZGENE
  Q4PP23 ENTREZGENE
  TNNI3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4PP23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Tnni3  troponin I3, cardiac type  Tnni3  troponin I type 3 (cardiac)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tnni3  troponin I type 3 (cardiac)    troponin I, cardiac  Name updated 1299863 APPROVED
2004-09-10 Tnni3  troponin I, cardiac    troponin 1, type 3  Name updated 1299863 APPROVED
2002-06-10 Tnni3  troponin 1, type 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the myocardium throughout development 730032
gene_regulation transcription is induced by transcription factor GATA-4 730167