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Molecular cloning and developmental expression of the rat cardiac-specific isoform of troponin I.

Authors: Martin, AF  Orlowski, J 
Citation: Martin AF and Orlowski J, J Mol Cell Cardiol 1991 May;23(5):583-8.
Pubmed: (View Article at PubMed) PMID:1886137

Troponin I is the subunit of the troponin complex in striated muscle which inhibits actomyosin ATPase activity. We have isolated a full-length cDNA clone for rat cardiac troponin I and determined its nucleic acid sequence. The amino acid sequence deduced from this clone shows 88%-92% similarity with previously reported amino acid sequences for rabbit (Wilkinson and Grand, 1978) and bovine (Leszyk et al.) cardiac troponin I. Examination of cardiac troponin I mRNA abundance during development revealed a 15-fold induction in its expression in the adult heart compared to that in embryonic (14 day) heart muscle. Furthermore, expression of cardiac troponin I mRNA was restricted to heart muscle and was not detected in skeletal muscle at any developmental stage.


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RGD Object Information
RGD ID: 730167
Created: 2003-12-01
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.