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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62052
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnni3
Name: troponin I3, cardiac type
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDIsoproterenol results in increased expression of TNNI3 protein

PMID:17654401, PMID:19854236, PMID:22878004, PMID:24286936, PMID:27491814
increases secretionEXP 6480464CTDIsoproterenol results in increased secretion of TNNI3 protein

PMID:27527349
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Isoproterenol results in increased secretion of TNNI3 protein]

PMID:27527349
increases expressionISORGD:623446480464CTDIsoproterenol results in increased expression of TNNI3 protein

PMID:19549929
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.