Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


RGD ID: 62052
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnni3
Name: troponin I3, cardiac type
Acc ID: CHEBI:75725
Term: (R,R)-tramadol
Definition: A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnni3increases expressionEXP 6480464CTDTramadol results in increased expression of TNNI3 proteinPMID:33645892
Tnni3multiple interactionsEXP 6480464CTDEthanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]PMID:33645892
Go Back to source page   Continue to Ontology report