Tnni3 (troponin I3, cardiac type) - Rat Genome Database

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Gene: Tnni3 (troponin I3, cardiac type) Chinchilla lanigera
Analyze
Symbol: Tnni3
Name: troponin I3, cardiac type
RGD ID: 8911864
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); heart contraction (ortholog); heart development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2L (ortholog); cardiac amyloidosis (ortholog); FOUND IN cardiac myofibril (ortholog); cardiac Troponin complex (ortholog); contractile muscle fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: troponin I type 3 (cardiac); troponin I, cardiac muscle
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,037,462 - 1,042,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,037,325 - 1,042,102 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnni3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,037,462 - 1,042,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,037,325 - 1,042,102 (+)NCBIChiLan1.0ChiLan1.0
TNNI3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,151,767 - 55,157,732 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,151,767 - 55,157,773 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,663,135 - 55,669,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,354,947 - 60,360,912 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,354,949 - 60,360,858NCBI
Celera1952,704,329 - 52,710,294 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,986,278 - 51,992,090 (-)NCBIHuRef
CHM1_11955,656,700 - 55,662,665 (-)NCBICHM1_1
T2T-CHM13v2.01958,245,731 - 58,251,791 (-)NCBIT2T-CHM13v2.0
Tnni3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,521,304 - 4,526,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,521,304 - 4,527,228 (-)EnsemblGRCm39 Ensembl
GRCm3874,518,305 - 4,522,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,518,305 - 4,524,229 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,469,910 - 4,474,045 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,121,395 - 4,125,530 (-)NCBIMGSCv36mm8
Celera74,262,821 - 4,266,956 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.61NCBI
Tnni3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,342,571 - 78,346,255 (+)NCBIGRCr8
mRatBN7.2169,299,900 - 69,303,582 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,299,900 - 69,303,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,658,817 - 74,662,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,223,130 - 83,226,814 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,372,704 - 76,376,399 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,882,806 - 72,886,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,882,806 - 72,886,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,665,119 - 75,668,803 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,028,198 - 68,031,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,106,308 - 68,109,991 (+)NCBI
Celera167,824,338 - 67,828,022 (-)NCBICelera
Cytogenetic Map1q12NCBI
TNNI3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,288,194 - 61,293,931 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,017,317 - 63,023,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,193,061 - 52,198,782 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,887,630 - 60,892,875 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,887,630 - 60,894,219 (-)Ensemblpanpan1.1panPan2
TNNI3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,475,146 - 102,478,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,475,146 - 102,478,318 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,532,199 - 102,535,372 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,128,720 - 103,131,893 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11102,765,644 - 102,768,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,477,237 - 102,480,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,241,266 - 103,244,439 (+)NCBIUU_Cfam_GSD_1.0
Tnni3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,117,982 - 2,121,466 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886437,754 - 440,458 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886437,754 - 440,925 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNI3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,366,829 - 59,371,160 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1 Ensembl659,371,080 - 59,377,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,366,828 - 59,377,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,294,993 - 54,298,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235292
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,746,293 - 47,752,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,745,386 - 47,752,204 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666523445 - 2,272 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnni3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,088,589 - 2,092,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,088,455 - 2,092,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000000682   ⟹   ENSCLAP00000000649
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555671,037,462 - 1,042,039 (+)Ensembl
RefSeq Acc Id: XM_005413355   ⟹   XP_005413412
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555671,037,325 - 1,042,102 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005413412 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000000649
  ENSCLAP00000000649.1
RefSeq Acc Id: XP_005413412   ⟸   XM_005413355
- UniProtKB: A0A8C2UHK7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000000649   ⟸   ENSCLAT00000000682


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000516 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000682 ENTREZGENE
  ENSCLAT00000000682.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/TrEMBL
  6.10.250.180 UniProtKB/TrEMBL
InterPro Troponin UniProtKB/TrEMBL
  Troponin-I_N UniProtKB/TrEMBL
  Troponin_I UniProtKB/TrEMBL
  Troponin_sf UniProtKB/TrEMBL
NCBI Gene Tnni3 ENTREZGENE
PANTHER TROPONIN I UniProtKB/TrEMBL
  TROPONIN I, CARDIAC MUSCLE UniProtKB/TrEMBL
Pfam Troponin UniProtKB/TrEMBL
  Troponin-I_N UniProtKB/TrEMBL
Superfamily-SCOP SSF90250 UniProtKB/TrEMBL
UniProt A0A8C2UHK7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tnni3  troponin I3, cardiac type    troponin I type 3 (cardiac)  Symbol and/or name change 5135510 APPROVED