Gp6 (glycoprotein VI) - Rat Genome Database

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Gene: Gp6 (glycoprotein VI) Rattus norvegicus
Analyze
Symbol: Gp6
Name: glycoprotein VI
RGD ID: 1589130
Description: Predicted to enable collagen binding activity; collagen receptor activity; and protein tyrosine kinase binding activity. Involved in platelet aggregation. Predicted to be located in cell surface and tetraspanin-enriched microdomain. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in blood platelet disease (multiple); coronary artery disease (multiple); and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet); PARTICIPATES IN platelet aggregation pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycoprotein 6 (platelet); LOC684555; platelet glycoprotein VI; similar to glycoprotein VI (platelet); uncharacterized protein LOC684555
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,471,900 - 78,535,374 (+)NCBIGRCr8
mRatBN7.2169,429,232 - 69,492,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,465,789 - 69,491,326 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0172,994,977 - 73,064,639 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,040,901 - 73,064,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,481,966 - 75,549,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera167,640,031 - 67,699,932 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Elevated soluble platelet glycoprotein VI is a useful marker for DVT in postoperative patients treated with edoxaban. Aota T, etal., Int J Hematol. 2014 Nov;100(5):450-6. doi: 10.1007/s12185-014-1676-x. Epub 2014 Sep 25.
2. Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Bender M, etal., Arterioscler Thromb Vasc Biol. 2013 May;33(5):926-34. doi: 10.1161/ATVBAHA.112.300672. Epub 2013 Feb 28.
3. Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice. Bieber M, etal., Exp Neurol. 2021 Oct;344:113804. doi: 10.1016/j.expneurol.2021.113804. Epub 2021 Jul 6.
4. Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome. Bigalke B, etal., Am Heart J. 2008 Jul;156(1):193-200. doi: 10.1016/j.ahj.2008.02.010. Epub 2008 Apr 23.
5. Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS). Bigalke B, etal., Basic Res Cardiol. 2009 May;104(3):352-7. doi: 10.1007/s00395-009-0779-7. Epub 2009 Feb 3.
6. Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery disease. Bigalke B, etal., Clin Res Cardiol. 2010 Apr;99(4):227-33. doi: 10.1007/s00392-009-0109-y. Epub 2010 Jan 5.
7. Glycoprotein VI for diagnosis of acute coronary syndrome when ECG is ambiguous. Bigalke B, etal., Int J Cardiol. 2011 Jun 2;149(2):164-168. doi: 10.1016/j.ijcard.2009.12.026. Epub 2010 Jan 13.
8. Platelet glycoprotein VI: a novel marker for acute coronary syndrome. Bigalke B, etal., Semin Thromb Hemost. 2007 Mar;33(2):179-84. doi: 10.1055/s-2007-969032.
9. Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. Bray PF, etal., Blood. 2007 Mar 1;109(5):1862-9. doi: 10.1182/blood-2006-03-013151. Epub 2006 Nov 14.
10. Novel platelet membrane glycoprotein VI dimorphism is a risk factor for myocardial infarction. Croft SA, etal., Circulation. 2001 Sep 25;104(13):1459-63. doi: 10.1161/hc3801.096397.
11. Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Devi S, etal., Am J Pathol. 2010 Sep;177(3):1131-42. doi: 10.2353/ajpath.2010.091143. Epub 2010 Jul 22.
12. Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study. El-Galaly TC, etal., Br J Haematol. 2013 Mar;160(6):838-41. doi: 10.1111/bjh.12132. Epub 2012 Nov 15.
13. Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation. Engström K, etal., Environ Epigenet. 2015 Nov 27;1(1):dvv007. doi: 10.1093/eep/dvv007. eCollection 2015.
14. Epigenetic modulation of glycoprotein VI gene expression by DNA methylation. Gao S, etal., Life Sci. 2020 Jan 15;241:117103. doi: 10.1016/j.lfs.2019.117103. Epub 2019 Nov 26.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice. Grüner S, etal., Blood. 2005 Feb 15;105(4):1492-9. doi: 10.1182/blood-2004-06-2391. Epub 2004 Oct 26.
17. Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. Kotuličová D, etal., Blood Coagul Fibrinolysis. 2012 Sep;23(6):543-7. doi: 10.1097/MBC.0b013e328355a808.
18. The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. Kubisz P, etal., Hematology. 2012 Nov;17(6):355-62. doi: 10.1179/1024533212Z.000000000142.
19. The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats. Li H, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1199-205. doi: 10.1161/ATVBAHA.107.140590. Epub 2007 Feb 22.
20. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Liu J, etal., Nat Med. 2011 Feb;17(2):206-10. doi: 10.1038/nm.2295. Epub 2011 Jan 23.
21. Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI. Lukito P, etal., J Thromb Haemost. 2016 Nov;14(11):2253-2260. doi: 10.1111/jth.13497. Epub 2016 Oct 20.
22. An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families. Matus V, etal., J Thromb Haemost. 2013 Sep;11(9):1751-9. doi: 10.1111/jth.12334.
23. Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes. Moin ASM, etal., Front Endocrinol (Lausanne). 2021 Mar 30;12:651009. doi: 10.3389/fendo.2021.651009. eCollection 2021.
24. The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. Munnix IC, etal., Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2673-8. doi: 10.1161/01.ATV.0000193568.71980.4a. Epub 2005 Oct 27.
25. Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. Navarro S, etal., Int J Mol Sci. 2021 Dec 29;23(1):358. doi: 10.3390/ijms23010358.
26. Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. Ollikainen E, etal., Atherosclerosis. 2004 Sep;176(1):95-9. doi: 10.1016/j.atherosclerosis.2004.03.021.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Polymorphisms in GP6, PEAR1A, MRVI1, PIK3CG, JMJD1C, and SHH Genes in Patients with Unstable Angina. Rudzik R, etal., Int J Environ Res Public Health. 2020 Oct 15;17(20):7506. doi: 10.3390/ijerph17207506.
32. The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. Schönberger T, etal., Am J Physiol Cell Physiol. 2012 Oct 1;303(7):C757-66. doi: 10.1152/ajpcell.00060.2012. Epub 2012 Jul 18.
33. The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- mice. Schönberger T, etal., Cardiovasc Res. 2008 Oct 1;80(1):131-7. doi: 10.1093/cvr/cvn169. Epub 2008 Jun 19.
34. Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. Shaffer JR, etal., Nutr Metab Cardiovasc Dis. 2011 Aug;21(8):546-52. doi: 10.1016/j.numecd.2009.12.002. Epub 2010 Mar 15.
35. Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation. Shida Y, etal., Blood. 2014 Sep 11;124(11):1799-807. doi: 10.1182/blood-2013-09-521484. Epub 2014 Jul 22.
36. The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE-Platelets project. Snoep JD, etal., J Thromb Haemost. 2010 Nov;8(11):2377-84. doi: 10.1111/j.1538-7836.2010.04018.x.
37. Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. Sokol J, etal., Expert Rev Hematol. 2015 Dec;8(6):863-8. doi: 10.1586/17474086.2015.1083417. Epub 2015 Aug 25.
38. Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism. Sokol J, etal., Fertil Steril. 2012 Nov;98(5):1170-4. doi: 10.1016/j.fertnstert.2012.07.1108. Epub 2012 Aug 14.
39. A GPVI polymorphism is a risk factor for myocardial infarction in Japanese. Takagi S, etal., Atherosclerosis. 2002 Dec;165(2):397-8. doi: 10.1016/s0021-9150(02)00241-1.
40. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Trégouët DA, etal., Blood. 2009 May 21;113(21):5298-303. doi: 10.1182/blood-2008-11-190389. Epub 2009 Mar 10.
41. Inhibition of plasma kallikrein mitigates experimental hypertension-enhanced cerebral hematoma expansion. Wang J, etal., Brain Res Bull. 2021 May;170:49-57. doi: 10.1016/j.brainresbull.2021.02.004. Epub 2021 Feb 5.
42. Elevated plasma levels of soluble platelet glycoprotein VI (GPVI) in patients with thrombotic microangiopathy. Yamashita Y, etal., Thromb Res. 2014 Mar;133(3):440-4. doi: 10.1016/j.thromres.2013.11.023. Epub 2013 Dec 1.
43. GP6 Haplotype of Missense Variants is Associated with Sticky Platelet Syndrome Manifested by Fetal Loss. Škereňová M, etal., Clin Appl Thromb Hemost. 2018 Jan;24(1):63-69. doi: 10.1177/1076029616685428. Epub 2017 Jan 2.
Additional References at PubMed
PMID:10961879   PMID:18795891   PMID:23376485   PMID:23382103   PMID:23533145   PMID:27609517  


Genomics

Comparative Map Data
Gp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,471,900 - 78,535,374 (+)NCBIGRCr8
mRatBN7.2169,429,232 - 69,492,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,465,789 - 69,491,326 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0172,994,977 - 73,064,639 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,040,901 - 73,064,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,481,966 - 75,549,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera167,640,031 - 67,699,932 (-)NCBICelera
Cytogenetic Map1q12NCBI
GP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,013,705 - 55,038,264 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,013,705 - 55,038,264 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,525,073 - 55,549,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,216,885 - 60,241,444 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,216,888 - 60,241,444NCBI
Celera1952,564,628 - 52,589,432 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,846,650 - 51,873,103 (-)NCBIHuRef
CHM1_11955,518,809 - 55,543,457 (-)NCBICHM1_1
T2T-CHM13v2.01958,107,037 - 58,139,153 (-)NCBIT2T-CHM13v2.0
Gp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,365,852 - 4,400,849 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,366,964 - 4,400,743 (-)EnsemblGRCm39 Ensembl
GRCm3874,362,853 - 4,397,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,363,965 - 4,397,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,320,315 - 4,349,346 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,971,800 - 4,000,831 (-)NCBIMGSCv36mm8
MGSCv3673,710,704 - 3,739,082 (-)NCBIMGSCv36mm8
Celera74,122,265 - 4,147,420 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.52NCBI
GP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,146,176 - 61,164,299 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,875,491 - 62,894,718 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,051,138 - 52,071,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,746,578 - 60,770,643 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,746,578 - 60,770,643 (-)Ensemblpanpan1.1panPan2
GP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,586,229 - 102,612,067 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,585,544 - 102,613,905 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,642,923 - 102,670,979 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,252,299 - 103,280,340 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,252,324 - 103,280,350 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,872,144 - 102,900,106 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,587,387 - 102,615,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,348,282 - 103,376,061 (+)NCBIUU_Cfam_GSD_1.0
Gp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,248,412 - 2,263,666 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886296,025 - 310,614 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886295,950 - 310,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,215,600 - 59,237,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,214,227 - 59,237,860 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,086,654 - 54,109,771 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,614,221 - 47,630,020 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,614,384 - 47,624,160 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045166,206 - 184,102 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248322,197,897 - 2,208,019 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gp6
345 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000071927, ENSRNOT00000075537
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 2 41 73 72 75 51 18 51 161 70 63 34 38 24

Sequence


Ensembl Acc Id: ENSRNOT00000071927   ⟹   ENSRNOP00000065697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,465,789 - 69,491,326 (+)Ensembl
Rnor_6.0 Ensembl173,040,901 - 73,064,641 (+)Ensembl
RefSeq Acc Id: NM_001427838   ⟹   NP_001414767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,508,508 - 78,535,374 (+)NCBI
RefSeq Acc Id: XM_039097279   ⟹   XP_038953207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,471,900 - 78,535,371 (+)NCBI
mRatBN7.2169,429,232 - 69,492,709 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414767 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953207 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75830 (Get FASTA)   NCBI Sequence Viewer  
  EDL75831 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065697.1
  ENSRNOP00000102047
Ensembl Acc Id: ENSRNOP00000065697   ⟸   ENSRNOT00000071927
RefSeq Acc Id: XP_038953207   ⟸   XM_039097279
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001414767   ⟸   NM_001427838
- Peptide Label: precursor
- UniProtKB: A6KNL2 (UniProtKB/TrEMBL),   M0R8A3 (UniProtKB/TrEMBL),   A6KNL1 (UniProtKB/TrEMBL)
Protein Domains
Immunoglobulin   Immunoglobulin subtype

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8A3-F1-model_v2 AlphaFold M0R8A3 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589130 AgrOrtholog
BioCyc Gene G2FUF-60834 BioCyc
Ensembl Genes ENSRNOG00000047204 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071927.4 UniProtKB/TrEMBL
  ENSRNOT00000123610 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig-like_Receptors_ImmuneReg UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
NCBI Gene 684555 ENTREZGENE
PANTHER MHC CLASS I NK CELL RECEPTOR UniProtKB/TrEMBL
  PLATELET GLYCOPROTEIN VI UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
PhenoGen Gp6 PhenoGen
RatGTEx ENSRNOG00000047204 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6KNL1 ENTREZGENE, UniProtKB/TrEMBL
  A6KNL2 ENTREZGENE, UniProtKB/TrEMBL
  M0R8A3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 Gp6  glycoprotein VI  Gp6  glycoprotein 6 (platelet)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-16 Gp6  glycoprotein 6 (platelet)  LOC684555  similar to glycoprotein VI (platelet)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC684555  similar to glycoprotein VI (platelet)      Symbol and Name status set to provisional 70820 PROVISIONAL