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Gene: Tmem147 (transmembrane protein 147) Rattus norvegicus
Analyze
Symbol:
Tmem147
Name:
transmembrane protein 147
RGD ID:
1304706
Description:
Predicted to localize to endoplasmic reticulum membrane; plasma membrane; and protein-containing complex. Orthologous to human TMEM147 (transmembrane protein 147); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC292792; MGC125231; RGD1304706; seven transmembrane domain protein; similar to seven transmembrane domain protein
RGD Orthologs
Alliance Genes
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TMEM147 (transmembrane protein 147)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Tmem147 (transmembrane protein 147)
HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tmem147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TMEM147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TMEM147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tmem147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TMEM147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
TMEM147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Tmem147 (transmembrane protein 147)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Tmem147 (transmembrane protein 147)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Homo sapiens (human):
TMEM147 (transmembrane protein 147)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
tmem147 (transmembrane protein 147)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
ZK418.5
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
CG5861
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 1 85,977,028 - 85,978,848 (-) NCBI Rnor_6.0 Ensembl 1 89,177,992 - 89,179,825 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 1 89,177,995 - 89,179,815 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 1 90,332,924 - 90,334,744 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 85,771,683 - 85,773,503 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 1 85,849,790 - 85,851,609 (-) NCBI Celera 1 80,348,600 - 80,350,420 (-) NCBI Celera Cytogenetic Map 1 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
1,2-dimethylhydrazine multiple interactions ISO RGD:1312308 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TMEM147 mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO RGD:1312308 6480464 1, 2-Dimethylhydrazine results in decreased expression of TMEM147 mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of TMEM147 mRNA CTD PMID:17351261 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1312308 6480464 Tetrachlorodibenzodioxin results in decreased expression of TMEM147 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312308 6480464 Tetrachlorodibenzodioxin affects the expression of TMEM147 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TMEM147 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TMEM147 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of TMEM147 mRNA] CTD PMID:21215274 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of TMEM147 mRNA CTD PMID:21346803 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of TMEM147 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of TMEM147 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1607077 6480464 Lactic Acid results in decreased expression of TMEM147 mRNA CTD PMID:30851411 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1312308 6480464 [bis4-hydroxyphenylsulfone co-treated with Tretinoin] results in decreased expression of TMEM147 mRNA CTD PMID:30951980 aflatoxin B1 increases methylation ISO RGD:1607077 6480464 Aflatoxin B1 results in increased methylation of TMEM147 gene CTD PMID:27153756 all-trans-retinoic acid multiple interactions ISO RGD:1312308 6480464 [bis4-hydroxyphenylsulfone co-treated with Tretinoin] results in decreased expression of TMEM147 mRNA CTD PMID:30951980 Aroclor 1254 increases expression ISO RGD:1312308 6480464 Chlorodiphenyl 54% Chlorine results in increased expression of TMEM147 mRNA CTD PMID:23650126 benzo[a]pyrene increases expression EXP 6480464 Benzoapyrene results in increased expression of TMEM147 mRNA CTD PMID:21839799 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TMEM147 mRNA CTD PMID:18164116 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TMEM147 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:1607077 6480464 bisphenol A affects the expression of TMEM147 mRNA CTD PMID:30903817 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of TMEM147 mRNA CTD PMID:19167457 carbon nanotube increases expression ISO RGD:1312308 6480464 Nanotubes, Carbon results in increased expression of TMEM147 mRNA CTD PMID:25554681 chromium(6+) affects expression ISO RGD:1312308 6480464 chromium hexavalent ion affects the expression of TMEM147 mRNA CTD PMID:28472532 clofibrate multiple interactions ISO RGD:1312308 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of TMEM147 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TMEM147 mRNA] CTD PMID:17585979 copper(II) sulfate decreases expression ISO RGD:1607077 6480464 Copper Sulfate results in decreased expression of TMEM147 mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:1607077 6480464 Cyclosporine results in increased expression of TMEM147 mRNA CTD PMID:20106945 diazinon increases methylation ISO RGD:1607077 6480464 Diazinon results in increased methylation of TMEM147 gene CTD PMID:22964155 doxorubicin increases expression ISO RGD:1607077 6480464 Doxorubicin results in increased expression of TMEM147 mRNA CTD PMID:29803840 ethyl methanesulfonate decreases expression ISO RGD:1607077 6480464 Ethyl Methanesulfonate results in decreased expression of TMEM147 mRNA CTD PMID:23649840 flutamide increases expression EXP 6480464 Flutamide results in increased expression of TMEM147 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1312308 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TMEM147 mRNA CTD PMID:22206623 hydrogen peroxide affects expression ISO RGD:1607077 6480464 Hydrogen Peroxide affects the expression of TMEM147 mRNA CTD PMID:20044591 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of TMEM147 mRNA CTD PMID:30467583 methyl methanesulfonate decreases expression ISO RGD:1607077 6480464 Methyl Methanesulfonate results in decreased expression of TMEM147 mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TMEM147 mRNA CTD PMID:18164116 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of TMEM147 mRNA CTD PMID:24136188 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of TMEM147 mRNA CTD PMID:24136188 paracetamol affects expression ISO RGD:1312308 6480464 Acetaminophen affects the expression of TMEM147 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:1312308 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of TMEM147 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TMEM147 mRNA] CTD PMID:17585979 pirinixic acid increases expression ISO RGD:1312308 6480464 pirinixic acid results in increased expression of TMEM147 mRNA CTD PMID:15302862 , PMID:20813756 rac-lactic acid decreases expression ISO RGD:1607077 6480464 Lactic Acid results in decreased expression of TMEM147 mRNA CTD PMID:30851411 sodium arsenite decreases expression ISO RGD:1607077 6480464 sodium arsenite results in decreased expression of TMEM147 mRNA CTD PMID:25879800 tetrachloromethane decreases expression ISO RGD:1312308 6480464 Carbon Tetrachloride results in decreased expression of TMEM147 mRNA CTD PMID:31919559 valproic acid increases methylation ISO RGD:1607077 6480464 Valproic Acid results in increased methylation of TMEM147 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1607077 6480464 Valproic Acid results in increased expression of TMEM147 mRNA CTD PMID:23179753 , PMID:27188386 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of TMEM147 mRNA CTD PMID:22570695 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of TMEM147 mRNA CTD PMID:23034163
1,2-dimethylhydrazine (ISO) 17alpha-ethynylestradiol (EXP) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4,6-trinitrotoluene (EXP) 2,4-dinitrotoluene (EXP) 2,6-dinitrotoluene (EXP) 2-hydroxypropanoic acid (ISO) 4,4'-sulfonyldiphenol (ISO) aflatoxin B1 (ISO) all-trans-retinoic acid (ISO) Aroclor 1254 (ISO) benzo[a]pyrene (EXP) beta-naphthoflavone (EXP)
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
2313402 Anxrr24 Anxiety related response QTL 24 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 1 49147799 156446783 Rat 631688 Hcas2 Hepatocarcinoma susceptibility QTL 2 3 0.0001 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) 1 5655769 122614963 Rat 4889494 Scort2 Serum corticosterone level QTL 2 4.2 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 1 86776571 131776571 Rat 6903308 Scl36 Serum cholesterol QTL 36 2 0.0125 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 50522714 94225616 Rat 631495 Bp96 Blood pressure QTL 96 4.52 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 23406428 108057505 Rat 631512 Scl6 Serum cholesterol level QTL 6 9.6 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 1 67227683 94201552 Rat 7411712 Strs4 Sensitivity to stroke QTL 4 8.7 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) 1 79689548 124689548 Rat 7421628 Bp361 Blood pressure QTL 361 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 64588516 125875986 Rat 1300121 Hrtrt1 Heart rate QTL 1 3.7 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 1 66113339 122614963 Rat 1300172 Bp172 Blood pressure QTL 172 3.56 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 1 35377508 94364229 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 25951907 130917265 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 35377692 217372257 Rat 1549903 Bp267 Blood pressure QTL 267 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 79134941 113593716 Rat 1582234 Gluco18 Glucose level QTL 18 3.4 0.0003 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 85917265 130917265 Rat 1578649 Bmd8 Bone mineral density QTL 8 4.9 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 1 49578577 94578577 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 1 49578577 169852184 Rat 61342 Bp27 Blood pressure QTL 27 3.4 0.0006 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 57761301 104391981 Rat 61344 Bp29 Blood pressure QTL 29 7.5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 85779320 130779320 Rat 61433 Cia2 Collagen induced arthritis QTL 2 5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 1 79689765 94909507 Rat 70225 Bp58 Blood pressure QTL 58 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34993530 173445086 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 4.6 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 1 58354072 161711996 Rat 2313059 Bss55 Bone structure and strength QTL 55 3.2 0.0001 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) 1 43579208 126240667 Rat 2313083 Bmd74 Bone mineral density QTL 74 4 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 83656882 126240667 Rat 2313072 Bss53 Bone structure and strength QTL 53 4.3 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 43579208 126240667 Rat 2313094 Bss58 Bone structure and strength QTL 58 3.7 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 43579208 126240667 Rat 10054135 Gmadr2 Adrenal mass QTL 2 1.97 0.0129 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 83502376 128502376 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 1 58209327 103209327 Rat 2313051 Bss57 Bone structure and strength QTL 57 3.7 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 43579208 126240667 Rat 1578780 Cm52 Cardiac mass QTL 52 3.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 1 82788437 239853971 Rat 2313098 Bmd70 Bone mineral density QTL 70 3.6 0.0001 tibia mineral mass (VT:1000283) cortical volumetric bone mineral density (CMO:0001730) 1 43579208 126240667 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 49578693 217054291 Rat 2313099 Bss56 Bone structure and strength QTL 56 2.4 0.0001 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) 1 43579208 126240667 Rat 2313078 Bss54 Bone structure and strength QTL 54 3.5 0.0001 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) 1 43579208 126240667 Rat 2300324 Fetw1 Fetal weight QTL 1 12.1 0.005 fetal growth trait (VT:0004201) fetal body weight (CMO:0002080) 1 88634585 106002500 Rat