Bcat2 (branched chain amino acid transaminase 2) - Rat Genome Database

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Gene: Bcat2 (branched chain amino acid transaminase 2) Rattus norvegicus
Analyze
Symbol: Bcat2
Name: branched chain amino acid transaminase 2
RGD ID: 68948
Description: Enables branched-chain-amino-acid transaminase activity. Involved in isoleucine catabolic process; lactation; and leucine biosynthetic process. Located in mitochondrion and nucleus. Orthologous to human BCAT2 (branched chain amino acid transaminase 2); PARTICIPATES IN valine, leucine and isoleucine biosynthetic pathway; valine, leucine and isoleucine degradation pathway; pantothenic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCAT(m); Bcatm; BCT2; branched chain amino acid transaminase 2, mitochondrial; branched chain aminotransferase 2, mitochondrial; branched-chain-amino-acid aminotransferase, mitochondrial; heart branched chain aminotransferase precursor encoding mitochondrial protein; mBcat
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,040,407 - 96,060,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,042,625 - 96,060,007 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,428,109 - 101,445,450 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01109,900,801 - 109,918,146 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01103,191,189 - 103,208,524 (+)NCBIRnor_WKY
Rnor_6.01101,553,900 - 101,572,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,554,642 - 101,572,080 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,633,422 - 102,650,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,038,287 - 96,055,622 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,116,397 - 96,133,732 (+)NCBI
Celera190,298,174 - 90,315,510 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (EXP,ISO)
fenofibrate  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
haloperidol  (ISO)
ibuprofen  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
metformin  (EXP)
mifepristone  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
Nivalenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm). Bledsoe RK, etal., Biochim Biophys Acta 1997 Apr 25;1339(1):9-13.
2. Induction of expression of branched-chain aminotransferase and alpha-keto acid dehydrogenase in rat tissues during lactation. DeSantiago S, etal., Adv Exp Med Biol. 2001;501:93-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Ontogeny and subcellular localization of rat liver mitochondrial branched chain amino-acid aminotransferase. Torres N, etal., Eur J Biochem. 2001 Dec;268(23):6132-9.
15. Localization and expression of BCAT during pregnancy and lactation in the rat mammary gland. Tovar AR, etal., Am J Physiol Endocrinol Metab 2001 Mar;280(3):E480-8.
16. ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. Wu JY, etal., J Clin Invest 2004 Feb;113(3):434-40.
Additional References at PubMed
PMID:8428987   PMID:11264579   PMID:12269802   PMID:14651853   PMID:17767905   PMID:18614015   PMID:19858196   PMID:20237068   PMID:20439489   PMID:27488662   PMID:31833233  


Genomics

Comparative Map Data
Bcat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,040,407 - 96,060,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,042,625 - 96,060,007 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,428,109 - 101,445,450 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01109,900,801 - 109,918,146 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01103,191,189 - 103,208,524 (+)NCBIRnor_WKY
Rnor_6.01101,553,900 - 101,572,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,554,642 - 101,572,080 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,633,422 - 102,650,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,038,287 - 96,055,622 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,116,397 - 96,133,732 (+)NCBI
Celera190,298,174 - 90,315,510 (+)NCBICelera
Cytogenetic Map1q22NCBI
BCAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,795,064 - 48,811,029 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1948,795,062 - 48,811,029 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,298,321 - 49,314,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,990,131 - 54,006,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 341953,990,131 - 54,006,113NCBI
Celera1946,166,129 - 46,182,134 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,677,853 - 45,693,853 (-)NCBIHuRef
CHM1_11949,300,194 - 49,316,125 (-)NCBICHM1_1
T2T-CHM13v2.01951,790,087 - 51,806,051 (-)NCBIT2T-CHM13v2.0
Bcat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,218,391 - 45,239,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,219,577 - 45,239,135 (+)EnsemblGRCm39 Ensembl
GRCm38745,568,967 - 45,589,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,570,153 - 45,589,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,825,733 - 52,845,078 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,438,405 - 45,457,750 (+)NCBIMGSCv36mm8
Celera741,023,580 - 41,045,483 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.36NCBI
Bcat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,785,253 - 1,797,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,785,253 - 1,796,838 (+)NCBIChiLan1.0ChiLan1.0
BCAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,945,156 - 54,962,887 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,945,157 - 54,962,887 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,793,433 - 45,809,546 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BCAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,539,125 - 107,549,286 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,538,465 - 107,549,234 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,061,565 - 107,071,746 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,063,749 - 108,073,941 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,063,615 - 108,073,930 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,730,663 - 107,740,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,377,548 - 107,387,729 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,213,156 - 108,223,338 (+)NCBIUU_Cfam_GSD_1.0
Bcat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,247,666 - 21,259,021 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366642,865,804 - 2,890,038 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,107,684 - 54,142,790 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,107,682 - 54,123,595 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,855,038 - 49,870,815 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,031,003 - 42,051,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,030,984 - 42,049,050 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,910,508 - 21,927,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,134,590 - 5,147,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,132,667 - 5,147,099 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcat2
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:45
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000028474
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat

Markers in Region
RH127555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,059,638 - 96,059,820 (+)MAPPERmRatBN7.2
Rnor_6.01101,571,734 - 101,571,915NCBIRnor6.0
Rnor_5.01102,650,514 - 102,650,695UniSTSRnor5.0
RGSC_v3.4196,055,253 - 96,055,434UniSTSRGSC3.4
Celera190,315,141 - 90,315,322UniSTS
RH 3.4 Map1907.6UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 38 22 19 22 8 11 66 35 41 11 8
Low 19 19 19 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028474   ⟹   ENSRNOP00000028474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,042,625 - 96,060,007 (+)Ensembl
Rnor_6.0 Ensembl1101,554,642 - 101,572,080 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095787   ⟹   ENSRNOP00000095006
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,042,625 - 96,060,001 (+)Ensembl
RefSeq Acc Id: NM_022400   ⟹   NP_071795
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,042,671 - 96,060,008 (+)NCBI
Rnor_6.01101,554,642 - 101,572,103 (+)NCBI
Rnor_5.01102,633,422 - 102,650,883 (+)NCBI
RGSC_v3.4196,038,287 - 96,055,622 (+)RGD
Celera190,298,174 - 90,315,510 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229149   ⟹   XP_006229211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,042,769 - 96,060,008 (+)NCBI
Rnor_6.01101,554,679 - 101,572,103 (+)NCBI
Rnor_5.01102,633,422 - 102,650,883 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759413   ⟹   XP_008757635
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,041,948 - 96,060,008 (+)NCBI
Rnor_6.01101,553,900 - 101,572,103 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589657   ⟹   XP_017445146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,042,777 - 96,060,008 (+)NCBI
Rnor_6.01101,554,679 - 101,572,103 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089504   ⟹   XP_038945432
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,040,407 - 96,060,008 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_071795   ⟸   NM_022400
- Peptide Label: precursor
- UniProtKB: G3V8U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229211   ⟸   XM_006229149
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008757635   ⟸   XM_008759413
- Peptide Label: isoform X2
- UniProtKB: Q6P784 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445146   ⟸   XM_017589657
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000028474   ⟸   ENSRNOT00000028474
RefSeq Acc Id: XP_038945432   ⟸   XM_039089504
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000095006   ⟸   ENSRNOT00000095787

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35854-F1-model_v2 AlphaFold O35854 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690046
Promoter ID:EPDNEW_R571
Type:multiple initiation site
Name:Bcat2_1
Description:branched chain amino acid transaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,554,626 - 101,554,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68948 AgrOrtholog
BioCyc Gene G2FUF-59671 BioCyc
BioCyc Pathway ILEUDEG-PWY [L-isoleucine degradation I] BioCyc
  ILEUSYN-PWY [L-isoleucine biosynthesis I (from threonine)] BioCyc
  LEU-DEG2-PWY [L-leucine degradation I] BioCyc
  VALDEG-PWY [L-valine degradation I] BioCyc
Ensembl Genes ENSRNOG00000020956 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028474 ENTREZGENE
  ENSRNOP00000028474.3 UniProtKB/TrEMBL
  ENSRNOP00000095006.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028474 ENTREZGENE
  ENSRNOT00000028474.6 UniProtKB/TrEMBL
  ENSRNOT00000095787.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.470.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623666 IMAGE-MGC_LOAD
InterPro Aminotrans_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminotrans_IV_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminotransferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B_amino_transII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCAT-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCAT-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCAT_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64203 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72449 IMAGE-MGC_LOAD
NCBI Gene 64203 ENTREZGENE
PANTHER PTHR11825 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcat2 PhenoGen
PIRSF BCAT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56752 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205167
TIGRFAMs ilvE_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKN8_RAT UniProtKB/TrEMBL
  BCAT2_RAT UniProtKB/Swiss-Prot
  G3V8U8 ENTREZGENE, UniProtKB/TrEMBL
  O35854 ENTREZGENE
  Q6P784 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Bcat2  branched chain amino acid transaminase 2  Bcat2  branched chain amino acid transaminase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Bcat2  branched chain amino acid transaminase 2, mitochondrial  Bcat2  branched chain aminotransferase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bcat2  branched chain aminotransferase 2, mitochondrial      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression follows stages I and II of lactogenesis and is specific to milk-producing epithelial acinar cells 62398
gene_expression expression follows stages I and II of lactogenesis and is specific to milk-producing epithelial acinar cells 67954
gene_function catalyzes the conversion of L-leucine and 2-oxoglutarate to 4-methyl-2-oxopentanoate and L-glutamate 67954
gene_protein protein products of 41.2 and 41.3 kDa 67954