Hif3a (hypoxia inducible factor 3 subunit alpha) - Rat Genome Database

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Gene: Hif3a (hypoxia inducible factor 3 subunit alpha) Rattus norvegicus
Analyze
Symbol: Hif3a
Name: hypoxia inducible factor 3 subunit alpha
RGD ID: 70332
Description: Enables DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; mitochondrion; and nuclear speck. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Biomarker of pulmonary hypertension. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; allethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HIF-3 alpha; HIF-3-alpha; HIF3 alpha 1; HIF3-alpha; HIF3-alpha-1; hypoxia inducible factor 3 alpha; hypoxia inducible factor 3 alpha subunit; hypoxia inducible factor 3, alpha subunit; hypoxia inducible factor 3a; hypoxia-inducible factor 3 alpha; hypoxia-inducible factor 3-alpha; Inhibitory PAS (Per/Arnt/Sim) domain protein; Ipas; MOP7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,846,196 - 86,878,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,850,554 - 86,877,838 (-)EnsemblGRCr8
mRatBN7.2177,718,110 - 77,750,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,722,471 - 77,749,758 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,102,824 - 83,130,220 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,666,890 - 91,694,278 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,857,927 - 84,885,322 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,976,318 - 78,997,869 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,976,318 - 78,997,869 (-)Ensemblrn6Rnor6.0
Rnor_5.0180,223,828 - 80,245,130 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,377,465 - 77,408,704 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,207,606 - 72,229,353 (-)NCBICelera
RGSC_v3.1177,455,581 - 77,486,815 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,10-phenanthroline  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
delphinidin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
graphite  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
metyrapone  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
mitochondrion  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)
transcription regulator complex  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Keith B, etal., Nat Rev Cancer. 2011 Dec 15;12(1):9-22. doi: 10.1038/nrc3183.
4. Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver. Kietzmann T, etal., Biochem J 2001 Mar 15;354(Pt 3):531-7.
5. Differential expression of three hypoxia-inducible factor-alpha subunits in pulmonary arteries of rat with hypoxia-induced hypertension. Li QF and Dai AG, Acta Biochim Biophys Sin (Shanghai). 2005 Oct;37(10):665-72.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Torii S, etal., Cell Death Differ. 2011 Nov;18(11):1711-25. doi: 10.1038/cdd.2011.47. Epub 2011 May 6.
Additional References at PubMed
PMID:9840812   PMID:11573933   PMID:12824304   PMID:16677454   PMID:16683694   PMID:16761101   PMID:18072084   PMID:21558328   PMID:28686686   PMID:29643458   PMID:29660430   PMID:33937412  
PMID:35132534  


Genomics

Comparative Map Data
Hif3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,846,196 - 86,878,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,850,554 - 86,877,838 (-)EnsemblGRCr8
mRatBN7.2177,718,110 - 77,750,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,722,471 - 77,749,758 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,102,824 - 83,130,220 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,666,890 - 91,694,278 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,857,927 - 84,885,322 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,976,318 - 78,997,869 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,976,318 - 78,997,869 (-)Ensemblrn6Rnor6.0
Rnor_5.0180,223,828 - 80,245,130 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,377,465 - 77,408,704 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,207,606 - 72,229,353 (-)NCBICelera
RGSC_v3.1177,455,581 - 77,486,815 (-)NCBI
Cytogenetic Map1q21NCBI
HIF3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,297,042 - 46,343,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,297,042 - 46,343,433 (+)Ensemblhg38GRCh38
GRCh371946,800,299 - 46,846,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,492,145 - 51,538,530 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1943,605,284 - 43,651,680 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,228,311 - 43,274,715 (+)NCBIHuRef
CHM1_11946,802,171 - 46,848,539 (+)NCBICHM1_1
T2T-CHM13v2.01949,124,507 - 49,170,893 (+)NCBIT2T-CHM13v2.0
Hif3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,764,918 - 16,796,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,765,432 - 16,796,352 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38717,030,993 - 17,062,427 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl717,031,507 - 17,062,427 (-)Ensemblmm10GRCm38
MGSCv37717,616,342 - 17,647,776 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36716,194,256 - 16,215,201 (-)NCBIMGSCv36mm8
Celera714,238,445 - 14,270,033 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Hif3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574495,953 - 518,397 (+)Ensembl
ChiLan1.0NW_004955574490,702 - 520,867 (+)NCBIChiLan1.0ChiLan1.0
HIF3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,400,319 - 52,483,212 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,307,702 - 54,354,329 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,243,290 - 43,326,146 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,815,809 - 51,862,039 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,815,809 - 51,862,039 (+)EnsemblpanPan2panpan1.1
HIF3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,479,456 - 109,504,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,479,128 - 109,504,274 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1108,954,428 - 108,983,166 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01110,001,737 - 110,030,481 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,001,055 - 110,030,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,677,813 - 109,706,546 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,312,160 - 109,341,081 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,181,254 - 110,209,992 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hif3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,676,862 - 18,705,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664294,975 - 323,149 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936664296,288 - 323,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIF3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,342,885 - 52,373,058 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1652,342,893 - 52,376,339 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,766,624 - 47,782,160 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIF3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,672,580 - 39,718,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,679,627 - 39,713,227 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607319,350,237 - 19,397,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hif3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,128,285 - 7,157,494 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248327,128,285 - 7,157,506 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hif3a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12172,016,485 - 172,042,606 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hif3a
200 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:44
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000023490
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 64 162 78 77 47 41 47 6 279 138 11 137 73 91 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023490   ⟹   ENSRNOP00000023490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,850,554 - 86,872,105 (-)Ensembl
mRatBN7.2 Ensembl177,722,471 - 77,744,023 (-)Ensembl
Rnor_6.0 Ensembl178,976,318 - 78,997,869 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099745   ⟹   ENSRNOP00000097060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,850,554 - 86,877,838 (-)Ensembl
mRatBN7.2 Ensembl177,722,471 - 77,749,758 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101762   ⟹   ENSRNOP00000087469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,850,554 - 86,872,062 (-)Ensembl
mRatBN7.2 Ensembl177,722,471 - 77,749,758 (-)Ensembl
RefSeq Acc Id: NM_001388512   ⟹   NP_001375441
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,850,554 - 86,877,838 (-)NCBI
mRatBN7.2177,722,471 - 77,749,758 (-)NCBI
RefSeq Acc Id: NM_022528   ⟹   NP_071973
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,850,554 - 86,872,105 (-)NCBI
mRatBN7.2177,722,471 - 77,744,023 (-)NCBI
Rnor_6.0178,976,318 - 78,997,869 (-)NCBI
Rnor_5.0180,223,828 - 80,245,130 (-)NCBI
RGSC_v3.4177,377,465 - 77,408,704 (-)RGD
Celera172,207,606 - 72,229,353 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089538   ⟹   XP_038945466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,846,196 - 86,878,527 (-)NCBI
mRatBN7.2177,718,110 - 77,750,448 (-)NCBI
RefSeq Acc Id: NP_071973   ⟸   NM_022528
- Peptide Label: isoform 1
- UniProtKB: Q9JHS2 (UniProtKB/Swiss-Prot),   F1LRL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023490   ⟸   ENSRNOT00000023490
RefSeq Acc Id: XP_038945466   ⟸   XM_039089538
- Peptide Label: isoform X1
- UniProtKB: Q9JHS2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001375441   ⟸   NM_001388512
- Peptide Label: isoform 2
- UniProtKB: Q9JHS2 (UniProtKB/Swiss-Prot),   A0A8I6GMD1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087469   ⟸   ENSRNOT00000101762
Ensembl Acc Id: ENSRNOP00000097060   ⟸   ENSRNOT00000099745
Protein Domains
bHLH   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHS2-F1-model_v2 AlphaFold Q9JHS2 1-662 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70332 AgrOrtholog
BioCyc Gene G2FUF-60577 BioCyc
Ensembl Genes ENSRNOG00000017198 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023490 ENTREZGENE
  ENSRNOT00000099745 ENTREZGENE
  ENSRNOT00000101762 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HIF_alpha_subunit UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold UniProtKB/Swiss-Prot
KEGG Report rno:64345 UniProtKB/Swiss-Prot
NCBI Gene 64345 ENTREZGENE
PANTHER HYPOXIA-INDUCIBLE FACTOR 1 ALPHA UniProtKB/Swiss-Prot
  HYPOXIA-INDUCIBLE FACTOR 3-ALPHA UniProtKB/Swiss-Prot
Pfam bHLH_HIF1A UniProtKB/Swiss-Prot
  HIF-1 UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS_11 UniProtKB/Swiss-Prot
PhenoGen Hif3a PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017198 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
UniProt A0A8I6A5W6_RAT UniProtKB/TrEMBL
  A0A8I6GMD1 ENTREZGENE, UniProtKB/TrEMBL
  A6J8F4_RAT UniProtKB/TrEMBL
  A6J8F5_RAT UniProtKB/TrEMBL
  F1LRL5 ENTREZGENE, UniProtKB/TrEMBL
  HIF3A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Hif3a  hypoxia inducible factor 3 subunit alpha  Hif3a  hypoxia inducible factor 3, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hif3a  hypoxia inducible factor 3, alpha subunit    hypoxia inducible factor 3a  Name updated 1299863 APPROVED
2002-06-10 Hif3a  hypoxia inducible factor 3a      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatocytes 68201