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Gene: Lig1 (DNA ligase 1) Rattus norvegicus
Symbol: Lig1
Name: DNA ligase 1
RGD ID: 621424
Description: Exhibits DNA ligase activity. Involved in DNA repair. Localizes to nucleus. Used to study epilepsy with generalized tonic-clonic seizures. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA ligase (ATP) 1; DNA ligase I; ligase I, DNA, ATP-dependent; LOC360304; MGC105416; polydeoxyribonucleotide synthase [ATP] 1
Homo sapiens (human) : LIG1 (DNA ligase 1)  HGNC  Alliance
Mus musculus (house mouse) : Lig1 (ligase I, DNA, ATP-dependent)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig1 (DNA ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG1 (DNA ligase 1)
Canis lupus familiaris (dog) : LIG1 (DNA ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig1 (DNA ligase 1)
Sus scrofa (pig) : LIG1 (DNA ligase 1)
Chlorocebus sabaeus (African green monkey) : LIG1 (DNA ligase 1)
Heterocephalus glaber (naked mole-rat) : Lig1 (DNA ligase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0175,356,212 - 75,394,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,356,220 - 75,394,758 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,723,841 - 76,762,378 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,728,892 - 73,767,429 (+)NCBIRGSC3.4rn4RGSC3.4
Celera169,539,708 - 69,578,250 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Lig1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621424
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.