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Gene: Lig1 (DNA ligase 1) Rattus norvegicus
Symbol: Lig1
Name: DNA ligase 1
Description: Exhibits DNA ligase activity. Involved in DNA repair. Localizes to the nucleus. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA ligase (ATP) 1; DNA ligase I; ligase I, DNA, ATP-dependent; LOC360304; MGC105416; polydeoxyribonucleotide synthase [ATP] 1
Homo sapiens (human) : LIG1 (DNA ligase 1)  HGNC  Alliance
Mus musculus (house mouse) : Lig1 (ligase I, DNA, ATP-dependent)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig1 (DNA ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG1 (DNA ligase 1)
Canis lupus familiaris (dog) : LIG1 (DNA ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig1 (DNA ligase 1)
Sus scrofa (pig) : LIG1 (DNA ligase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0175,356,212 - 75,394,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0176,723,841 - 76,762,378 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,728,892 - 73,767,429 (+)NCBIRGSC3.4rn4RGSC3.4
Celera169,539,708 - 69,578,250 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Lig1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621424
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.