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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lig1
Name: DNA ligase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lig1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of LIG1 mRNAPMID:27181935
Lig1multiple interactionsEXP 6480464CTDFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of LIG1 mRNA]PMID:27181935
Lig1decreases expressionISOLIG1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of LIG1 mRNAPMID:29803840
Lig1multiple interactionsISOLIG1 (Homo sapiens)6480464CTD[TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of LIG1 mRNAPMID:36634904
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