Gene: LIG1 (DNA ligase 1) Homo sapiens
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Symbol:
LIG1
Name:
DNA ligase 1
Description:
Exhibits DNA ligase activity. Involved in base-excision repair. Localizes to the nucleoplasm. Implicated in inherited metabolic disorder and primary immunodeficiency disease.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
dna ligase i; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Lig1 (ligase I, DNA, ATP-dependent) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Lig1 (DNA ligase 1) RGD
RGD
Chinchilla lanigera (long-tailed chinchilla):
Lig1 (DNA ligase 1) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
LIG1 (DNA ligase 1) NCBI
Ortholog
Canis lupus familiaris (dog):
LIG1 (DNA ligase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Lig1 (DNA ligase 1) NCBI
Ortholog
Sus scrofa (pig):
LIG1 (DNA ligase 1) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Rattus norvegicus (Norway rat):
LOC100911727 (DNA ligase 1-like) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Lig1 (DNA ligase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Lig1 (ligase I, DNA, ATP-dependent)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
LOC100911727 (DNA ligase 1-like)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
lig1 (ligase I, DNA, ATP-dependent)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
CDC9
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
DNAlig1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
lig-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 19 48,115,445 - 48,170,603 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 19 48,618,702 - 48,673,852 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 19 53,310,515 - 53,365,372 (-) NCBI NCBI36 hg18 NCBI36 Build 34 19 53,310,514 - 53,365,372 NCBI Celera 19 45,483,843 - 45,538,716 (-) NCBI Cytogenetic Map 19 q13.33 NCBI HuRef 19 45,000,496 - 45,055,385 (-) NCBI HuRef CHM1_1 19 48,620,870 - 48,676,046 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Bloom syndrome IAGP RGD:8600319 8554872 ClinVar Annotator: match by term: Dna ligase i deficiency ClinVar PMID:1351188 , PMID:1581963 Bloom syndrome IAGP RGD:8600320 8554872 ClinVar Annotator: match by term: Dna ligase i deficiency ClinVar PMID:1581963 , PMID:19223467
Imported Annotations - CTD
urinary bladder cancer EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8631603
(+)-catechin multiple interactions EXP 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of LIG1 mRNA CTD PMID:24763279 1,1-dichloroethene increases expression ISO RGD:731764 6480464 vinylidene chloride results in increased expression of LIG1 mRNA CTD PMID:26682919 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:731764 6480464 Dinitrochlorobenzene results in increased expression of LIG1 mRNA CTD PMID:21404309 17alpha-ethynylestradiol affects expression ISO RGD:731764 6480464 Ethinyl Estradiol affects the expression of LIG1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO RGD:731764 6480464 Ethinyl Estradiol results in increased expression of LIG1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:731764 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731764 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG1 mRNA, AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LIG1 mRNA] CTD PMID:15034205 , PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731764 6480464 Tetrachlorodibenzodioxin results in decreased expression of LIG1 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731764 6480464 Tetrachlorodibenzodioxin affects the expression of LIG1 mRNA CTD PMID:21570461 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:621424 6480464 3 more ... CTD PMID:23196670 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA CTD PMID:28628672 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:731764 6480464 Oxazolone results in increased expression of LIG1 mRNA CTD PMID:21404309 4-hydroxyphenyl retinamide increases expression ISO RGD:731764 6480464 Fenretinide results in increased expression of LIG1 mRNA CTD PMID:28973697 5-fluorouracil affects response to substance EXP 6480464 LIG1 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of LIG1 protein CTD PMID:20106945 aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of LIG1 gene CTD PMID:27153756 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of LIG1 mRNA CTD PMID:16249480 ammonium chloride affects expression ISO RGD:621424 6480464 Ammonium Chloride affects the expression of LIG1 mRNA CTD PMID:16483693 arsane affects methylation EXP 6480464 Arsenic affects the methylation of LIG1 gene CTD PMID:25304211 arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of LIG1 gene CTD PMID:25304211 arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of LIG1 mRNA CTD PMID:15996700 benzo[a]pyrene increases expression ISO RGD:731764 6480464 Benzo(a)pyrene results in increased expression of LIG1 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of LIG1 intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:731764 6480464 Benzo(a)pyrene results in decreased expression of LIG1 mRNA CTD PMID:15034205 more ... benzo[a]pyrene multiple interactions ISO RGD:731764 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of LIG1 mRNA] CTD PMID:15034205 biphenyl-4-amine decreases expression EXP 6480464 4-biphenylamine results in decreased expression of LIG1 mRNA CTD PMID:24857880 bis(2-chloroethyl) sulfide multiple interactions EXP 6480464 CASP3 protein affects the reaction [Mustard Gas results in increased phosphorylation of LIG1 protein] CTD PMID:16906506 bis(2-chloroethyl) sulfide increases phosphorylation EXP 6480464 Mustard Gas results in increased phosphorylation of LIG1 protein CTD PMID:16906506 , PMID:19845377 bis(2-chloroethyl) sulfide increases activity EXP 6480464 Mustard Gas results in increased activity of LIG1 protein CTD PMID:11428624 bisphenol A increases expression ISO RGD:621424 6480464 bisphenol A results in increased expression of LIG1 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LIG1 mRNA CTD PMID:29275510 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of LIG1 mRNA CTD PMID:30903817 bisphenol A multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA CTD PMID:28628672 Brevetoxin B increases expression EXP 6480464 brevetoxin 2 results in increased expression of LIG1 mRNA CTD PMID:20498034 cadmium dichloride increases expression ISO RGD:731764 6480464 Cadmium Chloride results in increased expression of LIG1 mRNA CTD PMID:15501611 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of LIG1 mRNA CTD PMID:21592394 calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of LIG1 mRNA CTD PMID:21592394 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of LIG1 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:731764 6480464 Nanotubes, Carbon analog results in increased expression of LIG1 mRNA, Nanotubes, Carbon results in increased expression of LIG1 mRNA CTD PMID:25554681 carmustine decreases expression ISO RGD:621424 6480464 Carmustine results in decreased expression of LIG1 mRNA CTD PMID:16005536 cefaloridine increases expression ISO RGD:621424 6480464 Cephaloridine results in increased expression of LIG1 mRNA CTD PMID:18500788 choline multiple interactions ISO RGD:731764 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LIG1 mRNA CTD PMID:22872676 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of LIG1 mRNA CTD PMID:27392435 , PMID:27594783 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of LIG1 mRNA CTD PMID:27392435 copper atom multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of LIG1 mRNA CTD PMID:20971185 copper(0) multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of LIG1 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of LIG1 mRNA CTD PMID:19549813 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression EXP 6480464 Coumestrol results in increased expression of LIG1 mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:731764 6480464 Cyclosporine results in decreased expression of LIG1 mRNA CTD PMID:17942131 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of LIG1 mRNA CTD PMID:20106945 more ... deoxynivalenol affects phosphorylation ISO RGD:731764 6480464 deoxynivalenol affects the phosphorylation of LIG1 protein CTD PMID:23811945 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA CTD PMID:28628672 diazinon increases methylation EXP 6480464 Diazinon results in increased methylation of LIG1 gene CTD PMID:22964155 dibutyl phthalate decreases expression ISO RGD:731764 6480464 Dibutyl Phthalate results in decreased expression of LIG1 mRNA CTD PMID:21266533 dichloroacetic acid increases expression ISO RGD:731764 6480464 Dichloroacetic Acid results in increased expression of LIG1 mRNA CTD PMID:28962523 dicrotophos increases expression EXP 6480464 dicrotophos results in increased expression of LIG1 mRNA CTD PMID:28302478 doxorubicin decreases expression ISO RGD:621424 6480464 Doxorubicin results in decreased expression of LIG1 mRNA CTD PMID:27181935 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of LIG1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:621424 6480464 Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of LIG1 mRNA] CTD PMID:27181935 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LIG1 mRNA CTD PMID:19167446 ethyl methanesulfonate increases expression EXP 6480464 Ethyl Methanesulfonate results in increased expression of LIG1 mRNA CTD PMID:23649840 folic acid multiple interactions ISO RGD:731764 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LIG1 mRNA CTD PMID:22872676 furan increases expression ISO RGD:621424 6480464 furan results in increased expression of LIG1 mRNA CTD PMID:22079235 , PMID:25539665 furan increases expression ISO RGD:731764 6480464 furan results in increased expression of LIG1 mRNA CTD PMID:20194422 hexadecanoic acid decreases phosphorylation EXP 6480464 Palmitic Acid results in decreased phosphorylation of LIG1 protein CTD PMID:28073184 imiquimod decreases expression ISO RGD:731764 6480464 imiquimod results in decreased expression of LIG1 mRNA CTD PMID:21878529 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIG1 mRNA CTD PMID:28628672 L-methionine multiple interactions ISO RGD:731764 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LIG1 mRNA CTD PMID:22872676 methotrexate decreases expression ISO RGD:621424 6480464 Methotrexate results in decreased expression of LIG1 mRNA CTD PMID:16005536 methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of LIG1 mRNA CTD PMID:23649840 miconazole decreases expression ISO RGD:621424 6480464 Miconazole results in decreased expression of LIG1 mRNA CTD PMID:22262564 mitomycin C decreases expression EXP 6480464 Mitomycin results in decreased expression of LIG1 mRNA CTD PMID:12760830 N(6),N(6)-dimethyladenine multiple interactions EXP 6480464 N(6), N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] CTD PMID:16700562 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of LIG1 mRNA CTD PMID:24810058 N-methyl-N'-nitro-N-nitrosoguanidine decreases expression EXP 6480464 Methylnitronitrosoguanidine results in decreased expression of LIG1 mRNA CTD PMID:12634122 N-nitrosodiethylamine increases expression ISO RGD:731764 6480464 Diethylnitrosamine results in increased expression of LIG1 mRNA CTD PMID:17854601 N-nitrosodiethylamine multiple interactions ISO RGD:731764 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LIG1 mRNA] CTD PMID:17854601 nickel sulfate increases expression ISO RGD:731764 6480464 nickel sulfate results in increased expression of LIG1 mRNA CTD PMID:16100012 oxaliplatin multiple interactions ISO RGD:621424 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of LIG1 mRNA CTD PMID:25729387 oxaliplatin decreases expression ISO RGD:621424 6480464 oxaliplatin results in decreased expression of LIG1 mRNA CTD PMID:25729387 ozone multiple interactions ISO RGD:731764 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of LIG1 mRNA CTD PMID:25658374 paclitaxel decreases expression EXP 6480464 Paclitaxel results in decreased expression of LIG1 mRNA CTD PMID:15000894 paracetamol decreases expression ISO RGD:731764 6480464 Acetaminophen results in decreased expression of LIG1 mRNA CTD PMID:17942131 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of LIG1 mRNA CTD PMID:22230336 paracetamol multiple interactions ISO RGD:731764 6480464 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [Acetaminophen results in increased expression of LIG1 mRNA] CTD PMID:12540782 paracetamol increases expression ISO RGD:731764 6480464 Acetaminophen results in increased expression of LIG1 mRNA CTD PMID:12540782 pentachlorophenol increases expression ISO RGD:731764 6480464 Pentachlorophenol results in increased expression of LIG1 mRNA CTD PMID:23892564 phenethyl isothiocyanate decreases expression EXP 6480464 phenethyl isothiocyanate results in decreased expression of LIG1 mRNA CTD PMID:26678675 phenobarbital multiple interactions ISO RGD:731764 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIG1 mRNA] CTD PMID:19482888 phenobarbital increases expression ISO RGD:731764 6480464 Phenobarbital results in increased expression of LIG1 mRNA CTD PMID:19482888 , PMID:23091169 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of LIG1 mRNA CTD PMID:19159669 pirinixic acid increases expression ISO RGD:731764 6480464 pirinixic acid results in increased expression of LIG1 mRNA CTD PMID:23811191 progesterone decreases expression ISO RGD:621424 6480464 Progesterone results in decreased expression of LIG1 mRNA CTD PMID:20726854 progesterone decreases expression ISO RGD:731764 6480464 Progesterone results in decreased expression of LIG1 mRNA CTD PMID:16966611 resveratrol multiple interactions EXP 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of LIG1 mRNA CTD PMID:19167446 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of LIG1 mRNA CTD PMID:12760830 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of LIG1 mRNA CTD PMID:28595984 , PMID:29301061 sodium arsenite increases expression ISO RGD:731764 6480464 sodium arsenite results in increased expression of LIG1 mRNA CTD PMID:20643705 sodium arsenite decreases expression ISO RGD:731764 6480464 sodium arsenite results in decreased expression of LIG1 mRNA CTD PMID:20643705 sodium dichromate increases expression ISO RGD:621424 6480464 sodium bichromate results in increased expression of LIG1 mRNA CTD PMID:22110744 sodium dichromate decreases expression ISO RGD:731764 6480464 sodium bichromate results in decreased expression of LIG1 mRNA CTD PMID:22155349 sodium dichromate increases expression ISO RGD:731764 6480464 sodium bichromate results in increased expression of LIG1 mRNA CTD PMID:22155349 tamoxifen affects expression ISO RGD:731764 6480464 Tamoxifen affects the expression of LIG1 mRNA CTD PMID:17555576 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of LIG1 mRNA CTD PMID:15336504 tert-butyl hydroperoxide increases methylation EXP 6480464 tert-Butylhydroperoxide results in increased methylation of LIG1 gene CTD PMID:29432895 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of LIG1 mRNA CTD PMID:21592394 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of LIG1 mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:731764 6480464 Carbon Tetrachloride results in increased expression of LIG1 mRNA CTD PMID:27339419 tioguanine decreases expression ISO RGD:621424 6480464 Thioguanine results in decreased expression of LIG1 mRNA CTD PMID:16005536 titanium dioxide increases expression ISO RGD:731764 6480464 titanium dioxide results in increased expression of LIG1 mRNA CTD PMID:23557971 titanium dioxide affects expression ISO RGD:731764 6480464 titanium dioxide affects the expression of LIG1 mRNA CTD PMID:17656681 toluene 2,4-diisocyanate increases expression ISO RGD:731764 6480464 Toluene 2, 4-Diisocyanate results in increased expression of LIG1 mRNA CTD PMID:21404309 topotecan multiple interactions ISO RGD:621424 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of LIG1 mRNA CTD PMID:25729387 topotecan affects expression ISO RGD:621424 6480464 Topotecan affects the expression of LIG1 mRNA CTD PMID:25729387 Tributyltin oxide decreases expression ISO RGD:731764 6480464 bis(tri-n-butyltin)oxide results in decreased expression of LIG1 mRNA CTD PMID:17942131 trimellitic anhydride increases expression ISO RGD:731764 6480464 trimellitic anhydride results in increased expression of LIG1 mRNA CTD PMID:19042947 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of LIG1 mRNA CTD PMID:19140230 valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of LIG1 gene CTD PMID:29154799 wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] CTD PMID:16700562
Gene-Chemical Interaction Annotations
