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Gene: LIG1 (DNA ligase 1) Homo sapiens
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Symbol: LIG1
Name: DNA ligase 1
Description: Exhibits DNA ligase activity. Involved in base-excision repair. Localizes to the nucleoplasm. Implicated in inherited metabolic disorder and primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dna ligase i; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
Orthologs:
Mus musculus (house mouse) : Lig1 (ligase I, DNA, ATP-dependent)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lig1 (DNA ligase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig1 (DNA ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG1 (DNA ligase 1)
Canis lupus familiaris (dog) : LIG1 (DNA ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig1 (DNA ligase 1)
Sus scrofa (pig) : LIG1 (DNA ligase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,115,445 - 48,170,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371948,618,702 - 48,673,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,310,515 - 53,365,372 (-)NCBINCBI36hg18NCBI36
Build 341953,310,514 - 53,365,372NCBI
Celera1945,483,843 - 45,538,716 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,000,496 - 45,055,385 (-)NCBIHuRef
CHM1_11948,620,870 - 48,676,046 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LIG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731763
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.