Nfkbib (NFKB inhibitor beta) - Rat Genome Database

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Gene: Nfkbib (NFKB inhibitor beta) Rattus norvegicus
Analyze
Symbol: Nfkbib
Name: NFKB inhibitor beta
RGD ID: 621887
Description: Predicted to enable NF-kappaB binding activity. Involved in cytoplasmic sequestering of NF-kappaB and signal transduction. Located in cytosol. Orthologous to human NFKBIB (NFKB inhibitor beta); PARTICIPATES IN nuclear factor kappa B signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: I-kappa-B-beta; ikappaBbeta; ikB-B; ikB-beta; MGC93398; NF-kappa-B inhibitor beta; NF-kappa-BIB; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,046,292 - 84,053,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,046,295 - 84,053,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,456,147 - 89,463,702 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0197,915,267 - 97,922,812 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0191,212,004 - 91,219,559 (-)NCBIRnor_WKY
Rnor_6.0186,941,073 - 86,948,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,941,074 - 86,948,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,122,205 - 88,129,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,865,440 - 83,873,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,943,551 - 83,951,121 (-)NCBI
Celera178,438,451 - 78,446,021 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
apigenin  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (EXP)
auranofin  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CCCP  (ISO)
cerium trichloride  (ISO)
chloroform  (EXP)
chlorogenic acid  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproterone acetate  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Diosbulbin B  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
erythromycin estolate  (EXP)
fenofibrate  (EXP)
fenpyroximate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine  (ISO)
hexadecanoic acid  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
irbesartan  (ISO)
L-cysteine  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sincalide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thapsigargin  (ISO)
trichloroethene  (EXP,ISO)
vanadyl sulfate  (ISO)
vitamin E  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
5. Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins. Jaffray C, etal., J Gastrointest Surg. 2000 Jul-Aug;4(4):370-7; discussion 377-8.
6. Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia. Nakajima K, etal., Neurosci Lett. 2006 Jul 3;401(3):199-202. Epub 2006 Mar 31.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Inhibitory and stimulatory effects of lactacystin on expression of nitric oxide synthase type 2 in brain glial cells. The role of Ikappa B-beta. Stasiolek M, etal., J Biol Chem 2000 Aug 11;275(32):24847-56.
Additional References at PubMed
PMID:12477932   PMID:16822942   PMID:20060382   PMID:31451219  


Genomics

Comparative Map Data
Nfkbib
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,046,292 - 84,053,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,046,295 - 84,053,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,456,147 - 89,463,702 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0197,915,267 - 97,922,812 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0191,212,004 - 91,219,559 (-)NCBIRnor_WKY
Rnor_6.0186,941,073 - 86,948,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,941,074 - 86,948,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,122,205 - 88,129,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,865,440 - 83,873,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,943,551 - 83,951,121 (-)NCBI
Celera178,438,451 - 78,446,021 (-)NCBICelera
Cytogenetic Map1q21NCBI
NFKBIB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,899,666 - 38,908,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1938,899,700 - 38,908,893 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,390,306 - 39,399,529 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,082,455 - 44,091,374 (+)NCBINCBI36Build 36hg18NCBI36
Build 341944,082,454 - 44,091,373NCBI
Celera1936,193,052 - 36,201,968 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,837,132 - 35,846,241 (+)NCBIHuRef
CHM1_11939,390,808 - 39,399,934 (+)NCBICHM1_1
T2T-CHM13v2.01941,703,721 - 41,712,860 (+)NCBIT2T-CHM13v2.0
Nfkbib
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,457,676 - 28,466,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,457,676 - 28,466,937 (-)EnsemblGRCm39 Ensembl
GRCm38728,758,251 - 28,766,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,758,251 - 28,767,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,543,270 - 29,551,543 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,467,011 - 28,475,284 (-)NCBIMGSCv36mm8
Celera723,319,046 - 23,327,301 (-)NCBICelera
Cytogenetic Map7B1NCBI
Nfkbib
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468617,078 - 626,151 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468617,078 - 626,151 (-)NCBIChiLan1.0ChiLan1.0
NFKBIB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,554,486 - 44,565,128 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01936,005,797 - 36,015,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NFKBIB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,206,537 - 114,217,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,206,534 - 114,217,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,608,175 - 113,618,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,806,385 - 114,817,213 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,806,387 - 114,817,162 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,364,149 - 114,374,967 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,997,319 - 114,008,132 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,993,059 - 115,003,891 (-)NCBIUU_Cfam_GSD_1.0
Nfkbib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,422,102 - 13,429,688 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,850,058 - 1,862,035 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366611,850,185 - 1,857,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,703,647 - 47,712,654 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,703,644 - 47,712,661 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,241,118 - 43,250,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,518,909 - 33,529,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,518,963 - 33,529,891 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,540,577 - 11,552,485 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbib
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,259,577 - 12,266,642 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,259,567 - 12,266,642 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfkbib
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000027212
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat

Markers in Region
RH128905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,046,366 - 84,047,077 (+)MAPPERmRatBN7.2
Rnor_6.0186,941,148 - 86,941,858NCBIRnor6.0
Rnor_5.0188,122,280 - 88,122,990UniSTSRnor5.0
RGSC_v3.4183,865,515 - 83,866,225UniSTSRGSC3.4
Celera178,438,526 - 78,439,236UniSTS
RH 3.4 Map746.1UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 44 33 19 33 3 66 25 31 4
Low 12 13 8 8 8 8 8 10 10 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027212   ⟹   ENSRNOP00000027212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,046,727 - 84,053,862 (-)Ensembl
Rnor_6.0 Ensembl186,941,074 - 86,948,845 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098249   ⟹   ENSRNOP00000086277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,046,295 - 84,049,727 (-)Ensembl
RefSeq Acc Id: NM_030867   ⟹   NP_110494
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,046,292 - 84,053,862 (-)NCBI
Rnor_6.0186,941,073 - 86,948,845 (-)NCBI
Rnor_5.0188,122,205 - 88,129,977 (-)NCBI
RGSC_v3.4183,865,440 - 83,873,010 (-)RGD
Celera178,438,451 - 78,446,021 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110494 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF64191 (Get FASTA)   NCBI Sequence Viewer  
  AAH85729 (Get FASTA)   NCBI Sequence Viewer  
  EDM07877 (Get FASTA)   NCBI Sequence Viewer  
  Q9JIA3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_110494   ⟸   NM_030867
- UniProtKB: Q5U342 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027212   ⟸   ENSRNOT00000027212
RefSeq Acc Id: ENSRNOP00000086277   ⟸   ENSRNOT00000098249

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIA3-F1-model_v2 AlphaFold Q9JIA3 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689881
Promoter ID:EPDNEW_R406
Type:multiple initiation site
Name:Nfkbib_1
Description:NFKB inhibitor beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,948,639 - 86,948,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621887 AgrOrtholog
BioCyc Gene G2FUF-60221 BioCyc
Ensembl Genes ENSRNOG00000020063 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027212.4 UniProtKB/TrEMBL
  ENSRNOP00000086277.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027212.6 UniProtKB/TrEMBL
  ENSRNOT00000098249.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114624 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81525 UniProtKB/TrEMBL
MGC_CLONE MGC:93398 IMAGE-MGC_LOAD
NCBI Gene 81525 ENTREZGENE
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nfkbib PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5K2_RAT UniProtKB/TrEMBL
  F7F6B7_RAT UniProtKB/TrEMBL
  IKBB_RAT UniProtKB/Swiss-Prot
  Q5U342 ENTREZGENE, UniProtKB/TrEMBL
  Q9JIA3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Nfkbib  NFKB inhibitor beta  Nfkbib  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Nfkbib  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta  Nfkbib  nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nfkbib  nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta    I-kappa-B-beta  Name updated 1299863 APPROVED
2002-08-07 Nfkbib  I-kappa-B-beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process inhibits NOS2 induction 633403